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100 results about "Prednisone acetate" patented technology
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Pred Forte (prednisolone acetate ophthalmic suspension) is a steroid medicine used to treat eye swelling caused by allergy, infection, injury, surgery, or other conditions.
Preparation method of 16alpha-hydroxyprednisolone
The invention discloses a preparation method of 16alpha-hydroxyprednisolone, which comprises the following steps: by using a compound I prednisone acetate as an initial raw material, carrying out esterification reaction, reduction reaction, elimination reaction, oxidation reaction and hydrolysis reaction to obtain the end product VI 11beta,16alpha,17alpha,21-tetrahydroxyprogsteroid-1,4-diene-3,20-dione, i.e. 16alpha-hydroxyprednisolone. By using the cheaper initial raw material, the method has the advantages of shorter reaction steps, feasible reaction steps, higher yield and higher economy and safety for production, and is more suitable for industrial production. The method avoids using the traditional virulent product for bis-hydroxy oxidation, enhances the reaction safety and operability, simplifies the multiple protection and deprotection operation steps, greatly shortens the synthesis route, lowers the production cost, basically prevents the three-site carbonyl groups from being simultaneously reduced in the reduction process, greatly reduces the side reactions, and enhances the yield and quality of the reduction reaction.
Owner:江西赣亮医药原料有限公司
Method for producing prednisolone acetate
InactiveCN101210259AStrong response specificityEasy to operateMicroorganism based processesFermentationMicrobial transformationArthrobacter simplex
The invention belongs to the field of microbial pharmaceutics and pharmaceutical engineering, specifically relates to a production method of prednisone acetate by microbial transformation with Arthrobacter simplex as bacteria strain and hydrocortisone acetate as substrate. The method uses Arthrobacter simplex as bacteria strain and comprises the following steps of: performing primary seed culture, performing second fermentation culture, adding hydrocortisone acetate into the fermentation liquid of Arthrobacter simplex to transform hydrocortisone acetate into prednisone acetate, filtering, and collecting cake to obtain prednisone acetate. The bacteria can be prepared into double liquid phase, broken cells or protoplast, each of which has high transformation ratio. The inventive production method replaces cortisone acetate with hydrocortisone acetate as raw material, and has the advantages of high yield, simple process, good economical and practical performance, and less use of harmful reagents; and is important for steroids production with biotransformation method.
Owner:TIANJIN UNIV OF SCI & TECH
Preparation method of triamcinolone acetonide
The invention discloses a preparation method of triamcinolone acetonide. A compound I prednisone acetate which is taken as a starting material is subjected to a primary elimination reaction, an oxidation reaction, a condensation reaction, a reduction reaction, a secondary elimination reaction, a hydrolysis reaction, an epoxidation reaction and a fluorination reaction, so that an end-product IX, 9-fluoro-11beta, 21-dihydroxyl-16a,17-[(1-methyl ethylidene) bi(oxo)]-pregnen steroid-1,4-diene-3, 20-diketone, namely triamcinolone acetonide, is obtained. The preparation method of the triamcinolone acetonide has the advantages that a relatively cheap starting raw material is adopted, each reaction step can be relatively easily realized, and yield is relatively high, so that production is more economic and safer, and the triamcinolone acetonide is more applicable to industrial production; a multi-step protection and deprotection operation is simplified, a synthetic route is greatly shortened, and production cost is reduced; possibility that a three-position carbonyl group is reduced in a reduction process is almost zero, so that side effects are greatly reduced, and yield and quality of the reduction reaction are improved.
Owner:江西赣亮医药原料有限公司
Preparation method of prednisone acetate or analogues thereof
InactiveCN103601782AStarting materials are readily availableHigh and stable yieldSteroidsBulk chemical productionSNiSilanes
Owner:HUNAN NORCHEM PHARMACEUTICAL CO LTD
Method for preparing prednisone acetate
InactiveCN108588163AImprove conversion rateImprove refining efficiencyMicroorganism based processesFermentationArthrobacter simplexSolvent
Owner:ZHEJIANG XIANJU PHARMA
Preparation method of prednisolone
The invention relates to a preparation method of prednisolone. The preparation method comprises the steps of sequentially carrying out 3, 20-keto protective reaction, 11-keto reduction reaction, 21-hydroxyl esterification reaction, 3, 20-keto deprotection reaction and 21-acetic ester hydrolysis reaction by taking prednisone acetate as a raw material to obtain prednisolone. The invention provides a novel synthesis route sequentially comprising the steps of esterifying and deprotecting; nitrosification quenching reaction and resin hydrolysis reaction are omitted in the deprotection process; and ester hydrolysis reaction is finished under the protection of a mixed solvent and inert gases, so that the condition that byproducts are produced by hydrolysis reaction is avoided. The preparation method is novel in process route, simple and rapid in operation process, low in production cost and suitable for large-scale industrial production.
Owner:HUAZHONG PHARMA
Western medicine powder for treating dental ulcer of infant
InactiveCN101797262ALittle side effectsGood curative effectAntibacterial agentsPowder deliverySide effectVitamin C
The invention belongs to the technical field of medicines and discloses a medicament for treating dental ulcer of infants. Gentamycin sulfate chewable tablets, prednisone acetate tablets, vitamin C tablets and vitamin B complex tablets (each tablet comprises main components of 13mg of vitamin B, 21.5mg of vitamin B, 60.2mg of vitamin B, 10mg of niacinamide and 1mg of dextro calcium pantothenate ) are used as raw materials, are mixed in the ratio according to different characteristics of each medicinal raw material, are dried at low temperature, ground, evenly blended and sterilized and subjected to other treatments and are prepared into western medicine powder or a spraying agent. The invention has the characteristics of new formula, simple manufacture and remarkable effect; and raw materials for preparing medicaments have wide source and low price, so the cost of medicinal products is reduced. Used by 120 infants suffered from infant dental ulcer, the total effective rate reaches 100 percent and special toxic and side effects are not found.
Owner:齐凤芹 +2
Capsule for treating rhinitis
InactiveCN101297862ADefinite curative effectHigh cure rateCapsule deliveryRespiratory disorderPeppermintsExisting Treatment
The invention pertains to the technical field of drugs for treatment for rhinitis, which can solve the problem of low effective rate of the existing treatment method of rhinitis. A rhinitis capsule is prepared by the following pharmaceutical raw materials: biond magnolia flower, siberian cocklour fruit, Szechuan lovage rhizome, dahurian angelica root, fineleaf schizonepeta herb, divaricate saposhnikovia root, Chinese thorowax root, baicalin, manchurian wildginger, platycodon root, peppermint, liquoric root, membranous milkvetch root, Chinese angelica, metronidazole, vitamin B1, chlorpheniramine maleate and prednisone acetate. The drug of the invention effectively combines the traditional Chinese medicine and the western medicine and learns from each other to offset the weaknesses; the clinical applications show that the efficacy is exact and the cure rate is high.
Owner:赵军海
Medicament for treating dysentery
The invention discloses a drug for curing dysentery, which is produced by uniformly mixing the active pharmaceutical ingredients with the parts by weight: 625 of oxytetracycline, 625 of chloramphenicol, 1000 of sulfamethoxazole, 500 of furazolidone, 200 of methylbenzylamine pyrimidine, 50 of extractum belladonnae, 2500 of sodium bicarbonate and 25 of prednisone acetate to produce into powder, tablet or capsule and other formulation. The drug for curing dysentery has the advantages that the effective rate for curing the dysentery is 100%, the cure rate is 99.99%, and the sufferer can be recovered between 24 to 48 hours; in addition, the drug also has the advantages of fast therapeutic effect, short treatment cycle and low treatment cost.
Owner:刘廷剑
Synthetic method of desonide
The invention discloses a synthetic method of desonide. The synthetic method is characterized by carrying out elimination reaction on prednisone acetate by using sulfur dioxide in the presence of a first catalyst and an inert gas, then carrying out oxidation reaction on a product after elimination by using an oxidant in the presence of a second catalyst, then carrying out condensation treatment on a product after oxidation by using acetone in the presence of a third catalyst, carrying out selective reduction on a product after condensation in the presence of a fourth catalyst and finally carrying out hydrolysis reaction on a product after reduction in the presence of a fifth catalyst, thus preparing desonide. The synthetic method has the beneficial effects that desonide can be obtained by using prednisone acetate as the raw material and carrying out elimination, oxidation, condensation, reduction and hydrolysis; all the solvents in the synthetic process are recycled and reused, heavy metals do not participate in reaction in the reaction process, the technical process is mild and the energy consumption is low, so that the synthetic method is environment-friendly and clean.
Owner:ZHEJIANG XIANJU JUNYE PHARM CO LTD
Novel maintenance liquid for mantle pieces of pinctada martensii and preparation method thereof
InactiveCN101724598AHigh retention rateIncrease the rate of high-quality beadsAnimal cellsDistilled waterPinctada martensii
The invention relates to novel maintenance liquid for mantle pieces of pinctada martensii and a preparation method thereof. The maintenance liquid consists of NaCl, KCl, MgCl2, CaCl2 and prednisone acetate. The preparation method comprises the steps of: weighing and dissolving the NaCl, the KCl, the MgCl2, the CaCl2 and the prednisone acetate into double distilled water sequentially; and regulating a PH value to between 7.8 and 8.0 by adopting NaHCO3. The maintenance liquid has the advantages that the process is simple, the cost is low, the nucleus retaining rate and the high-quality pearl rate of pearl-culturing mollusk of the pinctada martensii can be improved obviously, and the quality and yield of pearls are improved.
Owner:GUANGDONG OCEAN UNIVERSITY
A kind of synthetic method of desonide
Owner:ZHEJIANG XIANJU JUNYE PHARM CO LTD
Preparation method for prednisone acetate and intermediate of same
The invention relates to the field of preparation of steroid drugs and an intermediate of the same, and in particular relates to a preparation method for prednisone acetate. The method comprises the steps of taking 11 alpha, 17 alpha-dyhydroxy Pregnene-1,4-diene-3,20-dione as an initial material, oxidizing to obtain 17 alpha-hydroxy Pregnene-1,4-diene-3,11,20-trione, and carrying out iodization reacting to obtain the prednisone acetate. The invention provides a novel oxidation technology more suitable for production of the intermediate of the prednisone acetate, the synthesis path has the characteristics of low cost and simple operation, environment pollution pressure can be greatly reduce, and the yield and quality of the prednisone acetate can reach a satisfactory level.
Owner:JIANGSU YUANDA XIANLE PHARMA
Zhuifeng huaci wine for treating arthromyodynia and preparation method thereof
ActiveCN103251695ASuitable for treatmentExcitatory nerveOrganic active ingredientsAntipyreticAngelica Sinensis RootMonkshood Root
The invention relates to a zhuifeng huaci wine for treating arthromyodynia and a preparation method thereof, belonging to the technical field of traditional Chinese medicaments. The wine has the main materials of processed semen strychni, sliced aconite, cassia bark, angelica sinensis, rhizoma ligustici wallichii, radix paeoniae alba, prepared Sichuan aconite root, prepared kusnezoff monkshood root and notoginseng, and an auxiliary material of prednisone acetate tablets. The preparation method of the wine comprises the following steps of: firstly grinding all the materials into powder; selecting 1.5kg of distilled spirit of which the alcoholic content is 38-45 degrees, which is brewed from paddies; putting the traditional Chinese medicament powder into a jar, and sealing and soaking for 1-3 months; and finally filtering to obtain the zhuifeng huaci wine. The zhuifeng huaci wine prepared by the method has the effects of expelling wind, removing dampness, exciting the nerve and spinal cord, activating meridians to stop pain and softening bone spurs, and is suitable for arthromyodynia patients in the department of orthopaedics.
Owner:王向云
Method for preparing steroids and novel intermediate compound used therein
InactiveCN101117350AHigh yieldThe yield of iodine replacement is improvedSteroidsBulk chemical productionColor ScaleGlucocorticoid
The present invention relates to an improved preparation method of glucocorticoids steroid, in particular to the preparation methods of prednisolone acetate, cortisone, prednisolone or hydrocortisone. The present invention also relates to a new intermediate compound used in the process of preparing the compounds. The present invention provides a new synthetic route of iodo first and opening the ring after, improving the selectivity of final products, reducing the impurity content of the products, and satisfying the color scale of glucocorticoids drugs, thereby conquering the disadvantages of preparing 17 alpha- hydroxyl at first, and then preparing 21-hydroxyl or the derivatives during the process of preparing 17 alpha, 21-hydroxyl steroid or the derivatives of prior art.
Owner:TIANJIN PHARMA GROUP CORP
Oral ulcer mucoadhesive film and preparation method thereof
InactiveCN106551979AGood flexibilityHigh tensile strengthHydroxy compound active ingredientsTetracycline active ingredientsSide effectOral ulcers
The invention provides an oral ulcer mucoadhesive film and a preparation method thereof. The oral ulcer mucoadhesive film is prepared by honeysuckle flower, menthol, vitamin B [2], borneol, tetracaine hydrochloride, sorbic acid, prednisone acetate, chlortetracycline hydrochloride, glycerin, stevioside, ethanol PVA 17-88 and purified water. Compared with the prior art, the film has good flexibility and tensile strength, can rapidly being expended and dissolved when meets water, a high-density protection drug film layer is formed on the oral cavity mucous membrane, and the effect for rapidly relieving swelling and pain with long term can be reached; oral cavity mucous membrane is employed for direction drug administration, the drug can be directly effected on the disease, simultaneous treatment of principal and subordinate symptoms can be reached, curative effect is fully performed; a lattice impression technology is employed on the technology, administration with divided dose is accurate, curative effect is increased, quality is stable, the oral ulcer mucoadhesive film has no toxic and side effect for oral cavity, and is safe and effective; and has the advantages of small volume, light weight, and convenient carrying and usage.
Owner:刘从荡
Preparation method of prednisone acetate
The invention discloses a preparation method of prednisone acetate, which comprises the following steps: by using dihydroxy progesterone dehydrogenate as a raw material, carrying out iodination reaction to obtain an iodination product, carrying out replacement reaction to obtain a substitution product, and finally, carrying out oxidation reaction to obtain the prednisone acetate. The dihydroxy progesterone dehydrogenate, which is used as the raw material for the first time, is sequentially subjected to iodination, replacement and oxidation reaction to obtain the high-purity prednisone acetate. The method has the advantages of short technical route, high product quality, high yield and low cost, and is suitable for large-scale industrial production.
Owner:ZHEJIANG XIANJU PHARMA
Production method of prednisone hydrolysate
The present invention relates to a production method of prednisone hydrolysate. Said production method includes the following steps: using intermediate prednisone acetate as raw material, using chloroform and methyl alcohol mixed solution as solvent, using potassium hydroxide solution as catalyst, making them be reacted at low temperature, neutralizing, concentrating to make crystallization, cooling, filtering and drying so as to obtain the prednisone hydrolysate. Said invention can raise its yield and quality.
Owner:TIANJIN TIANYAO PHARM CO LTD
Prednisone acetate tablets and preparation method thereof
InactiveCN110840854AHigh dissolution rateQuality improvementOrganic active ingredientsPharmaceutical non-active ingredientsSucroseMedicine
The invention discloses prednisone acetate tablets and a preparation method thereof, which comprises, by weight, 4.22% of prednisone acetate, 64.50% of corn starch, 28.50% of sucrose, 1.41% of sodiumcarboxymethyl starch, 0.67% of sodium lauryl sulfate, and 0.70% of magnesium stearate; quality parameters of the prednisone acetate tablets include moisture of < / =5.0%, content of 93.0-107.0% and friability of < / =0.8%. According to the preparation method, micronization of prednisone acetate is implemented first, so that the dissolution rate of the prednisone acetate tablets is effectively improved; the prednisone acetate is fully mixed with the corn starch material; the quality is stable, the impurity content is low, the moisture is low, and the prednisone acetate tablet scan be directly absorbed and digested by a human body after being taken by the human body.
Owner:安徽金太阳生化药业有限公司
Aseptic fly-maggot plant-biological pesticide and its production method
The present invention relates to a kind of aseptic fly maggot plant biological pesticide and its production method. It is made up by using fly maggot as main raw material, adding antibiotic, aspirin, acetaminophen, prednisone acetate and plant extract through a certain preparation process. When it is used, it can be diluted by adding clean water or dissolved, and can be directly sprayed on the diseased plant, and can be used for killing various injurious insects of crops, vegetables and fruit trees.
Owner:黄作秀
Prednisone acetate micro-tablet and preparation method thereof
PendingCN113304115AImprove complianceImprove brittlenessOrganic active ingredientsAntipyreticEthylic acidBULK ACTIVE INGREDIENT
The invention discloses a prednisone acetate micro-tablet and a preparation method thereof. The micro-tablet comprises prednisone acetate serving as an active component and pharmaceutic adjuvants, the mass percentage of the active ingredient prednisone acetate in the micro-tablet is 2%-20%. The preparation method of the prednisone acetate micro-tablet comprises the following steps: pretreating the raw and auxiliary materials, premixing, performing wet granulation, totally mixing, and tabletting to obtain the prednisone acetate micro-tablet. The raw materials and the auxiliary materials are mixed according to a set proportion and then crushed, and the particle size of the crushed mixed powder is controlled, so that the production process is improved, the loss of the raw materials is reduced, and the problem that the dissolution speed of the tablet is relatively low is solved.
Owner:CISEN PHARMA
Prednisolone acetate preparation method
The present invention relates to a prednisolone acetate preparation method which is as follows: prednisolone acetate can be obtained by successive 3-site and 20-site keto-protection reaction, 11-site keto-reduction reaction, 21-site hydroxyl esterification reaction and 3-site and 20-site keto-deprotection reaction of prednisone acetate as a raw material. A new synthetic route of first esterification and then deprotection is provided, nitrosification quenching reaction and resin hydrolysis reaction can be omitted in the deprotection step, the technical process is greatly simplified, the cost of production is reduced, and the method is suitable for mass production.
Owner:HUAZHONG PHARMA
Method for treating prednisone acetate mother liquor
The invention relates to the technical field of chemical pharmacy, in particular to a method for treating prednisone acetate mother liquor. The method comprises the following steps: (1) adding a solvent and alkali liquor into the prednisone acetate mother liquor to carry out hydrolysis reaction; (2) after the hydrolysis reaction is finished, adjusting the reaction liquid to be neutral, concentrating under reduced pressure until a large amount of crystals are separated out, and performing suction filtration to obtain a hydrolysate crude product; (3) adding the hydrolysate crude product into a solvent, and refining to obtain a hydrolyzed refined product; (4) adding the hydrolyzed refined substance and a catalyst into a solvent, and reacting with acetic anhydride to obtain a mixture of prednisone acetate and cortisone acetate; and (5) fermenting and dehydrogenating the mixture to obtain the prednisone acetate. According to the treatment method, the prednisone acetate in the prednisone acetate mother liquor can be recycled, particularly, the prednisone acetate in the mother liquor can be recycled, the treatment cost is saved, and the yield of the prednisone acetate is increased; The method can well remove the dehydrogenation RSA and RSA impurities, and is stable in processand simple to operate.
Owner:HENAN LIHUA PHARMA
New anti-inflammatory medicine with bone protection function and composed of glucocorticoid and salvia extract
The invention relates to new anti-inflammatory medicine with a bone protection function and composed of glucocorticoid and salvia extract. The new medicine has a better curative effect than existing anti-inflammatory action obtained by singly using the glucocorticoid, is free from damage to bones by the glucocorticoid and is new medicine with the bone protection function. The new anti-inflammatory medicine is composed of prednisone acetate and tanshinol, the optimal ratio of the formula is 1:4, and namely the new anti-inflammatory medicine contains 5 mg of prednisone acetate and 20 mg of tanshinol. The new anti-inflammatory medicine comprises the optimal combination of the prednisone acetate, the tanshinol, salvianolic acid B and protocatechualdehyde. The selected salvia extract includes known components with definite chemical structures and stable ingredients and easy to extract, and the compound prescription can be registered as a chemical drug and be approved to produce. The new anti-inflammatory medicine can replace various kinds of glucocorticoid medicine used clinically in China currently.
Owner:GUANGDONG MEDICAL UNIV
Preparation method of prednisone acetate and intermediate thereof
The invention relates to a preparation method of a steroid drug and an intermediate thereof, in particular to a preparation method of prednisone acetate and an intermediate thereof. The preparation method comprises the following steps: taking 17 alpha-hydroxyl progesterone which is industrially produced on a large scale as a raw material; carrying out mixed microorganism fermentation at first, and meanwhile introducing 11-position hydroxyl and 1,2-position double bonds to obtain 11 alpha, 17 alpha-dihydroxypregna-1,4-dien-3, 20-dione intermediate; then carrying out oxidizing reaction to obtain 17 alpha-hydroxypregna-1,4-dien-3, 11, 20- trione; and finally carrying out iodine replacement reaction to obtain prednisone acetate. The technological difficulty that C11-position carbonyl and 1,2-position double bonds cannot be introduced perfectly in a production process of the prednisone acetate is solved. Meanwhile, the process route has the characteristics of low cost and simplicity in operation; and pressure of environmental pollution can be greatly reduced.
Owner:JIANGSU YUANDA XIANLE PHARMA
Ointment for treating skin disease and its production method
InactiveCN1709266AGood anti-inflammatory effectHigh cure rateOrganic active ingredientsAllergic dermatitisDisease
The present invention relates to an ointment for external application for curing dermatosises of psoriasis, neurodermatitis, allergic dermatitis, cutaneous pruritus, beriberi, mosquito bite and infantile eczema, etc. with obvious therapeutic effect. Said ointment is made up by using (by wt%) 30-60% of tramcinolone acetonide acetate urea cream, 15-30% of compound sulfamethoxazole, 10-20% of prednisone acetate and 10-20% of chlorpheniramine maleate. Besides, said invention also provides its production method and concrete steps.
Owner:王贵玉
Chinese-Western compound pharmaceutical preparation for treating rheumatoid arthritis
InactiveCN105148199ANo side effectsReduce dosageOrganic active ingredientsAnthropod material medical ingredientsOrchisBottle gourd
The invention provides a Chinese-Western compound pharmaceutical preparation for treating rheumatoid arthritis. The Chinese-Western compound pharmaceutical preparation comprises traditional Chinese medicine components and Western medicine components, wherein main materials of the traditional Chinese medicine components comprise beautiful sweetgum fruit, potentilla multifida, scorzonera divaricata, daphne kiusianavar. atrocaulis, brassica caulorapa Pasq., kohlrabi rhizoma curcumae, gentiana pubigera Marq., hypericum attenuatum, carpesium abrotanoides, dryopteris cycadina, glycine max (L.) Merr., cicada ecdysis, orchis, vaccinium laetum Diels, polytrchum commune, fissistigma oldhamii, loranthus parasiticus, garden balsam stem, rhynchelytrum repens, centipeda, thesium chinense Turcz., chinaroot greenbier rhizome, radix Et rhizoma nardostachyos, whorlleaf stonecrop herb, triblemma lanceum (Thunb.) Ching, vaccinium fragile Franch. var. mekongense (W. W. Sm.) Sleum., aralia undulata, boenninghausenia albiflora (Hook.) Meiss., and bottle gourd peel. The Western medicine components comprise prednisone acetate, chondroitin sulfate, acetaminophen, ribavirin, dextran, acetylsalicylic acid, docosahexenoic acid, casein phosphopeptides, evamisole hydrochloride and sorbitol. The pharmaceutical preparation is obvious in effect and low in cost.
Owner:于莉
Medicine for treating toothache
A medicine for treating toothache, dental marrow inflammation and periodontitis is prepared from VB1, VC, aminopyrine, phenacetin, coffeine, austrominal, prednisone acetate, and safflower.
Owner:王明贤
Medicine for treating toothache
InactiveCN100484535CQuick cureDigestive systemHeterocyclic compound active ingredientsAminophenazonPharmaceutical drug
Owner:王明贤
Preparation method of prednisone acetate
InactiveCN112608969AThe product quality is quiteHigh yieldMicroorganism based processesFermentationBiotechnologyOrganic solvent
The invention discloses a preparation method of prednisone acetate, and the method comprises the following steps: adding a hydrophilic organic solvent into Arthrobacter simplex fermentation broth, and adding 8-12% of prednisone acetate micropowder; finally, adding a lipophilic organic solvent for fermentation reaction; and after the fermentation reaction is finished, filtering or centrifuging the product, performing separating, decolorizing and crystallizing to obtain prednisone acetate. The quality of the product prepared by the preparation method is equivalent to that of the product in the prior art, but the yield is slightly higher, the single-batch yield is higher, the production efficiency is higher, and the preparation method is more suitable for large-scale industrial production.
Owner:HUAZHONG PHARMA
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