100 results about "Prednisone acetate" patented technology

The invention belongs to the field of microbial pharmaceutics and pharmaceutical engineering, specifically relates to a production method of prednisone acetate by microbial transformation with Arthrobacter simplex as bacteria strain and hydrocortisone acetate as substrate. The method uses Arthrobacter simplex as bacteria strain and comprises the following steps of: performing primary seed culture, performing second fermentation culture, adding hydrocortisone acetate into the fermentation liquid of Arthrobacter simplex to transform hydrocortisone acetate into prednisone acetate, filtering, and collecting cake to obtain prednisone acetate. The bacteria can be prepared into double liquid phase, broken cells or protoplast, each of which has high transformation ratio. The inventive production method replaces cortisone acetate with hydrocortisone acetate as raw material, and has the advantages of high yield, simple process, good economical and practical performance, and less use of harmful reagents; and is important for steroids production with biotransformation method.

The invention belongs to the technical field of medicines and discloses a medicament for treating dental ulcer of infants. Gentamycin sulfate chewable tablets, prednisone acetate tablets, vitamin C tablets and vitamin B complex tablets (each tablet comprises main components of 13mg of vitamin B, 21.5mg of vitamin B, 60.2mg of vitamin B, 10mg of niacinamide and 1mg of dextro calcium pantothenate ) are used as raw materials, are mixed in the ratio according to different characteristics of each medicinal raw material, are dried at low temperature, ground, evenly blended and sterilized and subjected to other treatments and are prepared into western medicine powder or a spraying agent. The invention has the characteristics of new formula, simple manufacture and remarkable effect; and raw materials for preparing medicaments have wide source and low price, so the cost of medicinal products is reduced. Used by 120 infants suffered from infant dental ulcer, the total effective rate reaches 100 percent and special toxic and side effects are not found.

The invention discloses a synthetic method of desonide. The synthetic method is characterized by carrying out elimination reaction on prednisone acetate by using sulfur dioxide in the presence of a first catalyst and an inert gas, then carrying out oxidation reaction on a product after elimination by using an oxidant in the presence of a second catalyst, then carrying out condensation treatment on a product after oxidation by using acetone in the presence of a third catalyst, carrying out selective reduction on a product after condensation in the presence of a fourth catalyst and finally carrying out hydrolysis reaction on a product after reduction in the presence of a fifth catalyst, thus preparing desonide. The synthetic method has the beneficial effects that desonide can be obtained by using prednisone acetate as the raw material and carrying out elimination, oxidation, condensation, reduction and hydrolysis; all the solvents in the synthetic process are recycled and reused, heavy metals do not participate in reaction in the reaction process, the technical process is mild and the energy consumption is low, so that the synthetic method is environment-friendly and clean.

The invention discloses a preparation method of prednisone acetate, which comprises the following steps: by using dihydroxy progesterone dehydrogenate as a raw material, carrying out iodination reaction to obtain an iodination product, carrying out replacement reaction to obtain a substitution product, and finally, carrying out oxidation reaction to obtain the prednisone acetate. The dihydroxy progesterone dehydrogenate, which is used as the raw material for the first time, is sequentially subjected to iodination, replacement and oxidation reaction to obtain the high-purity prednisone acetate. The method has the advantages of short technical route, high product quality, high yield and low cost, and is suitable for large-scale industrial production.

The present invention relates to a production method of prednisone hydrolysate. Said production method includes the following steps: using intermediate prednisone acetate as raw material, using chloroform and methyl alcohol mixed solution as solvent, using potassium hydroxide solution as catalyst, making them be reacted at low temperature, neutralizing, concentrating to make crystallization, cooling, filtering and drying so as to obtain the prednisone hydrolysate. Said invention can raise its yield and quality.

The present invention relates to a kind of aseptic fly maggot plant biological pesticide and its production method. It is made up by using fly maggot as main raw material, adding antibiotic, aspirin, acetaminophen, prednisone acetate and plant extract through a certain preparation process. When it is used, it can be diluted by adding clean water or dissolved, and can be directly sprayed on the diseased plant, and can be used for killing various injurious insects of crops, vegetables and fruit trees.

The invention relates to new anti-inflammatory medicine with a bone protection function and composed of glucocorticoid and salvia extract. The new medicine has a better curative effect than existing anti-inflammatory action obtained by singly using the glucocorticoid, is free from damage to bones by the glucocorticoid and is new medicine with the bone protection function. The new anti-inflammatory medicine is composed of prednisone acetate and tanshinol, the optimal ratio of the formula is 1:4, and namely the new anti-inflammatory medicine contains 5 mg of prednisone acetate and 20 mg of tanshinol. The new anti-inflammatory medicine comprises the optimal combination of the prednisone acetate, the tanshinol, salvianolic acid B and protocatechualdehyde. The selected salvia extract includes known components with definite chemical structures and stable ingredients and easy to extract, and the compound prescription can be registered as a chemical drug and be approved to produce. The new anti-inflammatory medicine can replace various kinds of glucocorticoid medicine used clinically in China currently.

The invention provides a Chinese-Western compound pharmaceutical preparation for treating rheumatoid arthritis. The Chinese-Western compound pharmaceutical preparation comprises traditional Chinese medicine components and Western medicine components, wherein main materials of the traditional Chinese medicine components comprise beautiful sweetgum fruit, potentilla multifida, scorzonera divaricata, daphne kiusianavar. atrocaulis, brassica caulorapa Pasq., kohlrabi rhizoma curcumae, gentiana pubigera Marq., hypericum attenuatum, carpesium abrotanoides, dryopteris cycadina, glycine max (L.) Merr., cicada ecdysis, orchis, vaccinium laetum Diels, polytrchum commune, fissistigma oldhamii, loranthus parasiticus, garden balsam stem, rhynchelytrum repens, centipeda, thesium chinense Turcz., chinaroot greenbier rhizome, radix Et rhizoma nardostachyos, whorlleaf stonecrop herb, triblemma lanceum (Thunb.) Ching, vaccinium fragile Franch. var. mekongense (W. W. Sm.) Sleum., aralia undulata, boenninghausenia albiflora (Hook.) Meiss., and bottle gourd peel. The Western medicine components comprise prednisone acetate, chondroitin sulfate, acetaminophen, ribavirin, dextran, acetylsalicylic acid, docosahexenoic acid, casein phosphopeptides, evamisole hydrochloride and sorbitol. The pharmaceutical preparation is obvious in effect and low in cost.

A medicine for treating toothache, dental marrow inflammation and periodontitis is prepared from VB1, VC, aminopyrine, phenacetin, coffeine, austrominal, prednisone acetate, and safflower.