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Method for treating prednisone acetate mother liquor

A prednisone acetate and treatment method technology, applied in the field of chemical pharmacy, can solve the problems of inability to dehydrogenate, impurity removal, and no public report on treatment methods, etc., to achieve reduced treatment costs, ideal yield, good yield and purity Effect

Active Publication Date: 2021-06-01
HENAN LIHUA PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] At present, through many solvent crystallization attempts, the impurities cannot be removed, and the hydrogenation cannot be dehydrogenated
A large amount of mother liquor can only be temporarily stored in the warehouse. At present, there is no public report on the treatment method at home and abroad.

Method used

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  • Method for treating prednisone acetate mother liquor
  • Method for treating prednisone acetate mother liquor

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] A processing method of prednisone acetate mother liquor, comprising the following methods:

[0036] (1) The source of prednisone acetate mother liquor: the crude cortisone acetate is used for dehydrogenation of biological joint rod fermentation, and the organic solvent is refined for many times to obtain prednisone acetate. The mother liquor produced during the refining process is mainly composed of cortisone acetate pine and prednisone acetate, the mother liquor is put back into the fermentation dehydrogenation, and then refining can still obtain qualified prednisone acetate, and the mother liquor obtained by refining the mother liquor includes the main components of the following mass fractions: about 42% of cortisone acetate, 25% of prednisone acetate, about 13% of dehydro-RSA, about 7% of RSA, 6% of unknown large impurities and many other small impurities are processed for this mother liquor;

[0037] Under the protection of nitrogen, add 50g of prednisone acetate m...

Embodiment 2

[0043] A processing method of prednisone acetate mother liquor, comprising the following methods:

[0044] (1) The source of prednisone acetate mother liquor: the crude cortisone acetate is used for dehydrogenation of biological joint rod fermentation, and the organic solvent is refined for many times to obtain prednisone acetate. The mother liquor produced during the refining process is mainly composed of cortisone acetate pine and prednisone acetate, the mother liquor is put back into the fermentation dehydrogenation, and then refining can still obtain qualified prednisone acetate, and the mother liquor obtained by refining the mother liquor includes the main components of the following mass fractions: about 48% of cortisone acetate, 21% of prednisone acetate, about 14% of dehydro-RSA, about 7% of RSA, 8% of unknown large impurities and many other small impurities are processed for this mother liquor;

[0045] Under the protection of nitrogen, add 50g of prednisone acetate m...

Embodiment 3

[0051] A processing method of prednisone acetate mother liquor, comprising the following methods:

[0052] (1) The source of prednisone acetate mother liquor: the crude cortisone acetate is used for dehydrogenation of biological joint rod fermentation, and the organic solvent is refined for many times to obtain prednisone acetate. The mother liquor produced during the refining process is mainly composed of cortisone acetate pine and prednisone acetate, the mother liquor is put back into the fermentation dehydrogenation, and then refining can still obtain qualified prednisone acetate, and the mother liquor obtained by refining the mother liquor includes the main components of the following mass fractions: about 28% of cortisone acetate, 40% of prednisone acetate, about 12% of dehydro-RSA, about 8% of RSA, 8% of unknown impurities, and many other small impurities are processed for this mother liquor;

[0053] Under the protection of nitrogen, add 50g of prednisone acetate mother...

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PUM

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Abstract

The invention relates to the technical field of chemical pharmacy, in particular to a method for treating prednisone acetate mother liquor. The method comprises the following steps: (1) adding a solvent and alkali liquor into the prednisone acetate mother liquor to carry out hydrolysis reaction; (2) after the hydrolysis reaction is finished, adjusting the reaction liquid to be neutral, concentrating under reduced pressure until a large amount of crystals are separated out, and performing suction filtration to obtain a hydrolysate crude product; (3) adding the hydrolysate crude product into a solvent, and refining to obtain a hydrolyzed refined product; (4) adding the hydrolyzed refined substance and a catalyst into a solvent, and reacting with acetic anhydride to obtain a mixture of prednisone acetate and cortisone acetate; and (5) fermenting and dehydrogenating the mixture to obtain the prednisone acetate. According to the treatment method, the prednisone acetate in the prednisone acetate mother liquor can be recycled, particularly, the prednisone acetate in the mother liquor can be recycled, the treatment cost is saved, and the yield of the prednisone acetate is increased; The method can well remove the dehydrogenation RSA and RSA impurities, and is stable in processand simple to operate.

Description

technical field [0001] The invention relates to the technical field of chemical pharmacy, in particular to a treatment method of prednisone acetate mother liquor. Background technique [0002] The chemical name of prednisone acetate is: 17α, 21-dihydroxypregna-1,4-diene-3,11,20-trione 21-acetate, which is a synthetic glucocorticoid, mainly used in various Acute severe bacterial infection, severe allergic disease, collagen disease (lupus erythematosus, nodular periarteritis, etc.), rheumatism, rheumatoid arthritis, nephrotic syndrome, severe bronchial asthma, thrombocytopenic purpura, granulocytosis hypothalamus, acute lymphoblastic leukemia, various adrenal insufficiency, exfoliative dermatitis, pemphigus, neurodermatitis, eczema, etc., its chemical structural formula is: [0003] [0004] The preparation method of prednisone acetate is usually the product obtained by dehydrogenating the crude cortisone acetate by fermentation of biological joint rods and refining it wit...

Claims

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Application Information

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IPC IPC(8): C07J5/00
CPCC07J5/0053
Inventor 陈玉真金晓慧姬卫忠张海涛李合兴宋张胜
Owner HENAN LIHUA PHARMA
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