The invention relates to a preparation method and a quality control method of a traditional Chinese medicine Danmo capsule for treating chronic kidney disease. The prescription of the traditional Chinese medicine compound preparation is composed of 9 traditional Chinese medicines, namely yerbadetajo, glossy privet fruit, salvia root, honeysuckle, motherwort, rehmannia root, madder, wolfberry bark and scorpion. The preparation method of the Danmo capsule comprises the steps of: pretreatment by water extraction and alcohol precipitation, forming of capsule content particles by one-step granulation, encapsulation, sub-packaging and external packaging. In the quality control method, thin layer identification of the yerbadetajo, the glossy privet fruit, the salvia root and the honeysuckle is established, and the content of salvianolic acid B is determined by high performance liquid chromatography. Compared with the original preparation process and quality standard, the traditional Chinese medicine Danmo capsule prepared in the invention is the I capsule, so that the compliance of patients in administration is improved, the moisture resistance of the capsule is improved, the content of the effective component salvianolic acid B is also greatly improved, and the quality standard of the preparation is improved.