Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Qianliexin capsule quality evaluation method based on multi-index active ingredient measurement

An active ingredient, the technology of Qianliexin, applied in the field of quality evaluation of Qianliexin capsules based on the determination of multi-index active ingredients, can solve the problem of inability to fully reflect the multi-components and multi-target points of traditional Chinese medicine prescriptions, unable to meet the quality control of finished medicines, and unable to reflect the overall medicine Quality and other issues, to achieve the effects of sensitive and reliable detection methods, guaranteed effectiveness and safety, and more comprehensive analysis capabilities

Active Publication Date: 2017-01-25
SHANDONG ANALYSIS & TEST CENT
View PDF4 Cites 10 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the 2015 edition of "Pharmacopoeia of the People's Republic of China" (Part One) only uses thin-layer chromatography combined with reference substance paeoniflorin and reference medicinal materials Myrrha and Angelica dahurica for identification, or uses high-performance liquid chromatography to determine the content of imperatorin, The quality control index is single, which cannot fully reflect the characteristics of multi-components and multi-targets in traditional Chinese medicine prescriptions
However, the current research on the analysis and determination of the chemical components of Qianliexin Capsules only analyzes one of the components. For example, Ji Guoming et al. used HPLC to determine the content of imperatorin in Qianliexin Capsules; Lun Lijun et al. determined the content of Qianliexin Capsules by HPLC. The content of paeoniflorin in Chinese medicine, Shi Xuehong et al. also used HPLC method to determine the content of salvianolic acid B in Qianliexin capsules. As mentioned above, these studies only tested and analyzed a certain component in Qianliexin capsules. It cannot reflect the overall quality of pharmaceuticals and cannot meet the quality control of finished drugs in actual production

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Qianliexin capsule quality evaluation method based on multi-index active ingredient measurement
  • Qianliexin capsule quality evaluation method based on multi-index active ingredient measurement
  • Qianliexin capsule quality evaluation method based on multi-index active ingredient measurement

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] 1 Instruments and materials

[0033] Agilent 1260 high performance liquid chromatography (autosampler, gradient pump, column thermostat, diode array detector); 1 / 100,000 electronic analytical balance (SARTOURIUS BSA), fingerprint similarity evaluation software is "TCM Chromatographic Fingerprint Similarity Evaluation System" (National Pharmacopoeia Commission 2004A); SB-5200D High Power Digital Control Ultrasonic Instrument (Ningbo Xinzhi Biotechnology Co., Ltd.).

[0034] Chromatographic column: American Agilent ZORBAX SB-C 18 (4.6mm×250mm, 5μm), Swedish Kromasil 100-5C 18(4.6mm×250mm, 5μm). Gallic Acid (Lot No. 149-91-7), Chlorogenic Acid (Lot No. 327-97-9), Caffeic Acid (Lot No. 331-39-5), Braciferin (Lot No. 53452-16-7), Iso Quercitrin (batch number 482-35-9), salvianolic acid B (batch number 115939-25-8), salvianolic acid A (batch number 96574-01-5), cryptotanshinone (batch number 35825-57-1), standard The purity of the products were all ≥98%, and they were all...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a Qianliexin capsule quality evaluation method based on multi-index active ingredient measurement. The Qianliexin capsule quality evaluation method is characterized by comprising the following steps: on the basis of an efficient liquid chromatography-electrospray time of flight mass spectrum technology, measuring eight active ingredients in the Qianliexin capsule, and constructing a Qianliexin capsule HPLC (High Performance Liquid Chromatography) fingerprint chromatogram, wherein the eight active ingredients are respectively gallic acid, chlorogenic acid, caffeic acid, vaccarin, isoquercitrin, salvianolic acid B, salvianolic acid A and cryptotanshinone. The efficient liquid chromatography-electrospray time of flight mass spectrum technology is simultaneously adopted to measure the eight active ingredients in the Qianliexin capsule and construct the Qianliexin capsule HPLC fingerprint chromatogram, and meanwhile, the Qianliexin capsule quality evaluation method is used for evaluating the quality of a Qianliexin capsule medicine, and the eight active ingredients and the chromatogram realize mutual corroboration so as to more comprehensively reflect the quality of the Qianliexin capsule medicine to be favorable for researching and guaranteeing the quality of Qianliexin capsule medicine raw materials and preparations.

Description

technical field [0001] The invention belongs to the technical field of medical detection, and in particular relates to a method for evaluating the quality of Qianliexin capsules based on the determination of multi-index active ingredients. Background technique [0002] Qianliexin Capsules are recorded in the "Pharmacopoeia of the People's Republic of China" 2015 Edition (Part One), mainly composed of peach kernel (stir-fried), myrrh (stir-fried), salvia miltiorrhiza, red peony root, safflower, eupatorium, wangbuliuxing (stir-fried) , Saponaria thorn, Patrinia, Dandelion, Toosendan, Angelica dahurica, Shiwei, Lycium barbarum and other medicinal flavors, has the effect of promoting blood circulation, removing blood stasis, clearing heat and dampness, and is clinically used to treat blood stasis, coagulation, and damp-heat betting. Symptoms of chronic prostatitis and benign prostatic hyperplasia, the curative effect is remarkable, and it is widely used. [0003] At present, th...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02G01N30/72
CPCG01N30/02G01N30/7266
Inventor 赵恒强赵志国王晓刘倩于金倩闫慧娇刘伟耿岩玲
Owner SHANDONG ANALYSIS & TEST CENT
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com