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92 results about "Tanshinone I" patented technology
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Total tanshinone and total phenolic acid extract in red-rooted salvia root and its production
The invention is concerned with a kind of extract of total ketone of salviae miltiorrhizae and total phenolic acid and its produce method form radix Salviae Miltiorrhizae. The extract of total ketone of salviae miltiorrhizae has cryptotanshinone, tanshinone I, tanshinone IIA, methyl Tanshinon, dihydrotanshinon I and ramification. The extract of total phenolic acid has salvianolic acid A, salvianolic acid B, protocatechuic aldehyde and ramification. The extract can be got form one or arbitrary compound of extraction with solvent method, macroporous resin method, column chromatography and liquid-liquid counter-current chromatography. The summation of the content to each total ketone of salviae miltiorrhizae is 20 to 100 percnte (w / w) of the extract of total ketone of salviae miltiorrhizae, the contene of cryptotanshinone, tanshinone I and tanshinone IIA is 5 to 100 percent (w / w) of whole content of total ketone of salviae miltiorrhizae. The summation of the content to each total phenolic acid is 5 to 100 percent (w / w) of the extract of the radix salviae miltiorrhizae total phenolic acid. The content of salvianolic acid B is the 5 to 100 percent (w / w) of the whole salvianolic acid.
Owner:石任兵 +1
Process for extracting tanshinone
ActiveCN1670019ASolve permeabilitySolve the problem that the fat-soluble tanshinone in Danshen medicinal materials cannot be completely extractedCarbonyl compound separation/purificationAlcoholFiltration
The invention relates to a method for extracting tanshinone which comprises the following two steps: first, alcohol extraction process: separating the extraction liquid and dregs with the danshen liposolubility content from danshen medicine materical crude slices or disintegrated danshen medicinal materials by bath method, hypersonic extraction or microwave extraction in condition of normal temperature or heating, and reserving, adding correct concentration alcohol into the dregs, inverse flow extracting with heating to get the extraction, which combined with the extraction get from the first extraction, removing the solid impurities by the methods of filtration, centrifugation or deposition, and reserving. Second, isolation method separation: adding the medicine liquid get from the said alcohol extraction process to a macroreticular resinous adsorbent column, gradient eluting by alcohol with a finite concentration respectively to get the extraction I (with cryptotanshinone and dihydrotanshinone I) and extraction II (with tanshinone IIA and tanshinone I).
Owner:TIANJIN TASLY MORDEN TCM RESOURCES
Tanshinone I derivatives and pharmaceutical application thereof
InactiveCN1837200AGood water solubilityImprove bioavailabilityPowder deliveryOrganic active ingredientsMorpholineCyclohexylamine
Owner:秦引林
Tanshinone compounds and applications thereof
The invention relates to tanshinone compounds in the technical field of medicine and applications thereof. The tanshinone compounds contain tanshinone I, tanshinone IIA, cryptotanshinone and dihydrotanshinone I and the structural formulas are shown as below. The method of the invention uses the tanshinone compounds as the active ingredients of the androgen receptor antagonist; the compounds are used alone or used along with the excipient to prepare oral agents or non-oral agents for curing the diseases related to androgen.
Owner:SHANGHAI JIAO TONG UNIV
Tanshinone I derivatives and pharmaceutical application thereof
ActiveCN1837199AGood water solubilityImprove bioavailabilityPowder deliveryOrganic active ingredientsDosage formChemistry
The invention discloses a tanshinoneIderivant and application in pharmacy, which is characterized by the following: the constitutional formula is showed in the diagram; when X is -(CHR)n-, R=H or alkyl with one to eight carbons, n=0-8; or X is -(CR=CH)n-, R=H or the alkyl with one to eight carbons, n=1-4. The derivant can be produced medicinal agent for clinical application.
Owner:JIANGSU CAREFREE PHARM CO LTD
Antibiotic tanshinone extract, preparation method thereof, use and products produced thereby
InactiveCN101411745AHigh purityReasonable proportionAntibacterial agentsOrganic active ingredientsTanshinone IIAAntibiotic Y
The invention relates to an antibacterial tanshinone extract extracted from Salvia spp. roots, a preparation method thereof, application of the antibacterial tanshinone extract and products of the antibacterial tanshinone extract. The extract contains cryptotanshinone, dihydro-tanshinone, tanshinone I and tanshinone IIA, wherein the total weight content of the four compounds is 40 to 99 percent of the total weight content of the extract; the weight content of the cryptotanshinone is 50 to 95 percent of the total weight of the four compounds; the weight content of the dihydro-tanshinone is 5 to 30 percent of the total weight of the four compounds; the weight content of the tanshinone I is 0 to 20 percent of the total weight of the four compounds; and the weight content of the tanshinone IIA is 0 to 40 percent of the total weight of the four compounds. The preparation method comprises the steps of diacolation extraction and purification for two times. The extract is used for preparing antibacterial medicines or other products. The tanshinone extract obtained has high purity, more reasonable proportions of various compositions, and can exert better clinic effect.
Owner:BOTANIC CENTURY BEIJING
Method for increasing tanshinone content of salvia miltiorrhiza hairy roots by transferring SmGGPPS gene
InactiveCN101962650AIncreased total tanshinone contentGood effectComponent separationMicrobiological testing/measurementGene engineeringGrowth cycle
The invention belongs to the technology for gene engineering, and discloses a method for increasing tanshinone content of salvia miltiorrhiza hairy roots by transferring SmGGPPS gene. In the prior art, the growth cycle of the salvia miltiorrhiza is long; the tanshinone content is low, and the requirement of the human medical treatment for the tanshinone content cannot be met. The method comprisesthe following steps of: cloning a coding sequence of the SmGGPPS gene from salvia miltiorrhiza, and constructing a plant high-efficient expression vector; genetically transforming salvia miltiorrhizaleaves to obtain the salvia miltiorrhiza hairy roots with transferred SmGGPPS gene; analyzing the expression condition of the SmGGPPS gene in the transgenic salvia miltiorrhiza hairy roots by a semi-quantitative RT-PCR method; measuring the total tanshinone content including cryptotanshinone, tanshinone I and tanshinone II A of the transgenic salvia miltiorrhiza hairy roots by high performance liquid chromatography; and measuring the antioxidant activity of cryptotanshinone of the transgenic salvia miltiorrhiza hairy roots by a diphenyl picryl-hydrazyl (DPPH) method. The method has the advantages of obviously increased total tanshinone content of the salvia miltiorrhiza hairy roots, reliable effect, low cost of tanshinone, and no environmental pollution during manufacturing.
Owner:SHANGHAI NORMAL UNIVERSITY
Process for extracting tanshinone II A, cryptotanshinone, dihydro tanshinone and tanshinone I
Generally, tanshinone IIA, cryptotanshinone, dihydro tanshinone and tanshinone I are obtained through column chromatography, which has too lower content of effective component in the product, and is time consuming and material consuming. The present invention provides tanshinone IIA, cryptotanshinone, dihydro tanshinone and tanshinone I extracting process including column chromatography and simultaneous extraction with ethyl acetate, silica gel H, benzene, chloroform and 60-90# petroleum ether, and the extracting process has effectively raised content of effective component in the product.
Owner:王忠东 +1
Screening, identification and application of SmAP2/ERF82 transcription factor for regulating tanshinone biosynthesis
ActiveCN107699576APromote biosynthesisReduce contentPlant peptidesFermentationNucleotideControl line
The invention discloses a coding gene sequence of an AP2 / ERF transcription factor SmAP2 / ERF82 for regulating tanshinone synthesis. The SmAP2 / ERF82 gene provided by the invention has a nucleotide sequence as shown in the SEQ ID No.1. The gene encoded protein has an amino acid sequence as shown in the SEQ ID No.2. A SmAP2 / ERF82-RNAi vector and a SmAP2 / ERF82-overexpression vector are constructed in the invention. Through a genetic transformation method for transformation of red sage root, transgenic hairy roots are obtained. In comparison with a control line, contents of dihydrotanshinone I, cryptotanshinone, tanshinone I and tanshinone II A in the SmAP2 / ERF82-RNAi line are remarkably reduced, and contents of dihydrotanshinone I and cryptotanshinone in the SmAP2 / ERF82-overexpression line areremarkably raised. The SmAP2 / ERF82 provided by the invention has the function of positive regulation of tanshinone compound biosynthesis. The compounds have remarkable efficacy of treating cardiovascular diseases. The invention brings forth new ideas for the research on molecular mechanism for tanshinone synthesis regulation and lays a foundation for the biological research on synthesis of tanshinone.
Owner:INST OF MEDICINAL PLANT DEV CHINESE ACADEMY OF MEDICAL SCI
Method for using near infrared spectroscopy to measure contents of multiple components in radix et rhizoma salviae miltiorrhizae medicinal material
InactiveCN108732126ALow jump chanceLow responseComponent separationMaterial analysis by optical meansQuality assuranceMedicine
The invention provides a method for using a near infrared spectroscopy to measure contents of multiple components in a radix et rhizoma salviae miltiorrhizae medicinal material and application feasibility of the method in a Chinese patent medicine raw material quality assurance system is discussed. The method comprises the steps: utilizing a high performance liquid chromatography to measure contents of danshinolic acid B, rosmarinic acid, alkannic acid, tanshinone IIA, tanshinone I and cryptotanshinone in radix et rhizoma salviae miltiorrhizae as contrast values; utilizing near infrared diffusion reflection method to collect a sample spectrum, comparing different spectrum pretreating methods and modeling effects of modeling waveband and optimizing modeling parameters; utilizing a partial least squares (PLS) to respectively establish near infrared quantitative analysis models of danshinolic acid B, rosmarinic acid, alkannic acid and tanshinone components (tanshinone IIA plus tanshinoneI plus cryptotanshinone) in the radix et rhizoma salviae miltiorrhizae and evaluating the models. The quantitative analysis models established by the method disclosed by the invention can meet a requirement of quickly obtaining chemical information of massive radix et rhizoma salviae miltiorrhizae medicinal material samples.
Owner:TIANJIN TASLY PHARMA CO LTD
Composition Comprising Tanshinone Compounds Isolated From The Extract Of Salviae Miltiorrhizae Radix For Treating Or Preventing Cognitive Dysfunction And The Use Thereof
A composition comprising tanshinone compounds selected from the group consisting of miltirone, 1,2-didehydromiltirone, tanshinone IIA, tanshinone I and dihydrotanshinone I isolated from Salviae miltiorrhizae Bunge showing potent inhibiting effect on the aggregation and toxicity of beta-amyloid and recovering activity of memory learning disorder confirmed by Y maze study and Passive Avoidance study. Therefore it can be used as the therapeutics or health food for treating and preventing cognitive function disorder with safe.
Owner:DIGITAL BIO TECHNOLOGY CO LTD +1
Application of tanshinone compound used as specific inhibitor for CYP1 family
InactiveCN101518538AEnhanced inhibitory effectOrganic active ingredientsAntineoplastic agentsCancer treatmentDihydrotanshinone
The invention relates to the field of natural medicaments, in particular to a diterpenes compound in a radix salviae miltiorrhizae extract, mainly relates to the expression of a tanshinone compound in a reversal benzoapyrene-induced CYP1 enzyme, as well as application in the direct inhibition of the CYP1 enzyme activity. The invention discloses new pharmacological application of four types of tanshinones including tanshinone I, tanshinone II A, cryptotanshinone and dihydrotanshinone I, namely the four tanshinones not only can directly inhibit the activities of various subtype enzymes in the CYP1 family but also can reverse the up-regulation of a benzoapyrene-induced CYP1 function in Hep-G2 cells. The tanshinone compound has the development application prospect that the tanshinone compound can be developed into a supplementary drug for the treatment of cancer as a multi-drug resistant reversal agent and an anti-cancer health care product.
Owner:CHINA PHARM UNIV
Application of tanshinone I in preparation of medicine for treating psoriasis
InactiveCN102988370AEffective treatmentProved significant effectOrganic active ingredientsDermatological disorderPatient needClinical trial
The invention discloses application of tanshinone I in preparation of a medicine for treating psoriasis. The medicine comprises therapeutically effective amount of tanshinone I and medically acceptable vectors, wherein the content of tanshinone I is 1-99wt%. The tanshinone I can be prepared into clinically or medically acceptable preparations, including commonly-used oral solid preparations such as capsules and tablets, or external preparations such as emulsifiable paste or cream and gels; the preparations can be applied to a patient needing treatment in external use and oral ways; and the tanshinone I has an obvious effect of inhibiting HaCaT cell proliferation, and can be applied to preparation of the medicine for treating psoriasis. The medicine prepared by the tanshinone I has the beneficial effects that the remarkable effects are verified in animal experiments and clinical tests, and the safety is high; and the medicine is a novel medicine for treating the psoriasis, and has a good development prospect.
Owner:GUANGDONG HOSPITAL OF TRADITIONAL CHINESE MEDICINE
Tanshinone II A sodium sulfonate and method of determining tanshinone I sodium sulfonate in its preparation
ActiveCN1624474AAccurate measurementEasy to measureComponent separationChromatographic separationSilanes
The invention relates to a qualitative and quantitative measuring method for tanshinone IIA sodium mercuric thiocyana and tanshinone I sodium mercuric thiocyana in its preparation, including the following steps: 1) use highly efficient liquid phase chromatography method, choose at least one as filling material from octadecyl silane linking aerosol, and aerosol linking aerosol,; make methyl alcohol- -buffer solution as mobile phase 6 in which the volume rate of methyl alcohol is 9-90%, 8 is 0-90%, buffer solution is 5-90% and the PH value of it is 2-5; 2) inject the sample into the highly efficient liquid phase chromatograph to do chromatographic fractionation and ultraviolet test. The advantages are high accuracy, simple measurement and high reliability.
Owner:SHANDONG BESTCOMM PHARMA CO LTD
Radix salviae miltiorrhizae endophytic fungi and application thereof to promotion of growth of radix salviae miltiorrhizae/or synthesis of active ingredients
ActiveCN109706084APromote growth and developmentGood thickeningFungiMicroorganism based processesMicroorganismSalvianolic acid B
The invention relates to the technical field of microorganisms, and discloses radix salviae miltiorrhizae endophytic fungi and application thereof to promotion of growth of radix salviae miltiorrhizae / or synthesis of active ingredients. The invention provides the radix salviae miltiorrhizae endophytic fungi of which the preservation name is (phomaherbarum) D603, the preservation number is CGMCC No.16884, and the preservation unit is China center for microbial culture collection management committee general microbiology. Meanwhile, the invention also discloses application of the radix salviae miltiorrhizae endophytic fungi, and thus, the growth of the radix salviae miltiorrhizae can be effectively promoted, a main root of the radix salviae miltiorrhizae is thickened and lateral roots are developed, and the color of the surface of the root turns red; and moreover, the synthesis of tanshinone I, cryptotanshinone, dihydrotanshinone I, tanshinone IIA, tanshinol, rosmarinic acid and salvianolic acid B in the radix salviae miltiorrhizae can be effectively promoted.
Owner:ZHEJIANG SCI-TECH UNIV
Preparation method for extracting and purifying tanshinone monomeric compounds from red sage root
InactiveCN103665094AHigh extraction rateFacilitates efficient extractionSteroids preparationAlcoholTanshinone IIA
The invention discloses a preparation method for extracting and purifying tanshinone monomeric compounds from red sage root. The method comprises the steps: washing the red sage root by using water, smashing, carrying out multi-stage counter current extraction by using an alcohol-acid solution, carrying out column chromatography by using macroporous resin, carrying out gradient elution by using an ethanol-water solution, collecting the eluent, evaporating and concentrating the eluent at reduced pressure and carrying out vacuum drying to obtain effective components tanshinone I, tanshinone IIA and cryptotanshinone. The method disclosed by the invention has the advantages that the multi-stage counter current extraction is carried out by using the alcohol-acid solution, the macroporous resin is reusable and the ethanol-water solution serves as the solvent, so that the method is economical and practical, high-purity tanshinone I, tanshinone IIA and cryptotanshinone monomeric compounds can be conveniently and efficiently obtained and the purity of the monomeric compounds is up to more than 95%; and the method is simple in process, simple and convenient in operation and low in cost and is suitable for volume production.
Owner:NANJING HOPE PHARM
Method for extracting and preparing tanshinone compounds from dregs of radix salviae miltiorrhizae by virtue of saccharification pretreatment method
InactiveCN104497096ARealize resource utilizationImprove resource utilization efficiencyOrganic active ingredientsSteroidsDiseasePretreatment method
The invention discloses a method for extracting and preparing tanshinone compounds from dregs of radix salviae miltiorrhizae by virtue of a saccharification pretreatment method. The method comprises the steps of firstly carrying out saccharification treatment on waste dregs of radix salviae miltiorrhizae to damage cell wall cellulose, hemicelluloses and lignocelluloses, extracting treatment liquid by virtue of an organic solvent, concentrating extraction liquid to a certain volume, carrying out ethanol elution on a macroporous resin column, collecting optimized eluate parts, concentrating, and carrying out spray drying, so as to prepare chemical components of tanshinone. According to the method, the extraction rate can reach 80%-100%, and the purity can reach 70%-95%; the content of tanshinone IIA can reach 36%, the content of tanshinone I can reach 32%, the content of cryptotanshinone can reach 8%, the content of dihydrotanshinone can reach 9%, and the content of active ingredients is high. Experiment results prove that the tanshinone compounds have well efficacies of promoting blood circulation and removing stasis and can be used for preparing medicines or functional health products capable of preventing and treating cardiovascular and cerebrovascular diseases.
Owner:NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
Method for detecting tanshinone components, and application thereof
ActiveCN108663337ARapid determination of contentThe assay method is fastComponent separationMaterial analysis by optical meansSpectroscopyTanshinone IIA
The invention relates to a method for detecting tanshinone components, and an application thereof. The tanshinone components are dihydrotanshinone, cryptotanshinone, tanshinone I and tanshinone IIA. The method comprises the following steps: collecting samples to be tested in the extraction and concentration of Salvia miltiorrhiza, collecting the near infrared spectra of the samples to be tested bynear-infrared spectroscopy, and converting the near infrared spectra into the respective content of dihydrotanshinone, cryptotanshinone, tanshinone I and tanshinone IIA in every sample to be tested according to a selected model. The method has the advantages of fastness in detection of the respective content of the tanshinone components in a compound Salvia miltiorrhiza tablet, simplicity in thepreparation of the samples, and realization of online analysis.
Owner:GUANGZHOU BAIYUSN HUTCHISON WHAMPOA CHINESE MEDICINE
Medicinal composition containing tanshinon II A sodium sulfonate and its quality control method
InactiveCN1686103AIncrease polarityEasy to separatePowder deliveryOrganic active ingredientsSulfonateOrganic solvent
A medicinal composition is prepared from tanshinone II A-sodium sulfonate and the pharmacologically acceptable carrier, auxiliary and additive. Its quality control method features that the efficient liquid-phase chromatography is used to measure the content of tanshinone IIA-sodium sulfonate in it and the limited contents of tanshinone I-sodium sulfonate and tanshinone IIA.
Owner:SICHUAN UNIV
Application of salvia miltiorrhiza extract and quinone compounds in resisting coronavirus
PendingCN113679726ASmall toxicityOral administration is easy to implementOrganic active ingredientsAntiviralsSalvia extractTanshinone IIA
The invention discloses an application of a salvia miltiorrhiza extract and quinone compounds in resisting coronavirus. One or more compounds of tanshinone I, tanshinone IIA, cryptotanshinone, dihydrotanshinone I, beta-lapamoquinone, L-shikonin, 2-methoxy-1, 4-naphthoquinone, CPI-169, S3I-201 and plumbagin, pharmaceutically acceptable salts thereof, solvates thereof, solvates of the pharmaceutically acceptable salts thereof, or crystal forms thereof are applied in preparation of anti-coronavirus agents, medicines for treating and / or preventing diseases caused by coronavirus, and / or an inhibitor for inhibiting papaya-like protease. The compounds can well inhibit the activity of the papaya-like protease in the coronavirus and inhibit the replication ability of the coronavirus in cells so as to inhibit the activity of the coronavirus, and when the compounds are used for treating diseases caused by the coronavirus, the toxic and side effects are low, and oral administration is easy to implement.
Owner:SHANGHAI TECH UNIV
A high efficient liquid phase analysis method of sodium tanshinone IIA sulfonate
The invention is a high performance liquidoid analytical method of tanshinone IIA sodium sulfonate which employs the reverse-phase gradient elution method, The proportion of organic phase and aqueous phase is 0-80:20-40 at 0 minute -8 to 20 minutes,the proportion of organic phase and aqueous phase is 80-95:5-20 at 8 minutes to 20 minutes -20 to 40 minutes. The invention can detect the tanshinone IIA, tanshinone I sodium sulfonate and other relative substance in tanshinone IIA sodium sulfonate at the same time, resolve the shortage of general liquid phase analysis, effectively control the quality of raw material of tanshinone IIA sodium sulfonate and its preparation, quickly and conveniently detect the relative substance of raw material of tanshinone IIA sodium sulfonate and its preparation.
Owner:JIANGSU CAREFREE PHARM CO LTD
High-tanshinone salvia miltiorrhiza cultivation method
InactiveCN107493912AEasy to masterIncrease productionFertilising methodsPlant cultivationSocial benefitsEconomic benefits
The invention discloses a high-tanshinone salvia miltiorrhiza cultivation method. The method includes steps: (1) land preparation; (2) transplanting, namely subjecting seedlings obtained after seedling culture to transplanting pretreatment including (a) seedling selection, (b) root truncating treatment, (c) secondary airing and (d) root dipping treatment and seedling planting; (3) strong seedling cultivation; (4) topping and defloration; (5) water and fertilization regulation; (6) harvesting. By adoption of the high-tanshinone salvia miltiorrhiza cultivation method, salvia miltiorrhiza yield can be increased to keep yield per mu above 300kg while the tanshinone content of salvia miltiorrhiza is increased, the content of tanshinone in a salvia miltiorrhiza root system reaches 0.55%-0.75% and is much higher than a standard of 0.25% prescribed in a pharmacopeia, and the content of tanshinone in salvia miltiorrhiza cultivated according to the method can be stably kept in a range of 0.55%-0.75%. The high-tanshinone salvia miltiorrhiza cultivation method has advantages that raw material demands can be guaranteed, production cost of enterprises is reduced, and high economic benefits and social benefits are achieved.
Owner:SHANGHAI TRADITIONAL CHINESE MEDICINE CO LTD +2
Method for detecting tanshinone compounds in compound salvia tablets
ActiveCN102507822AQuality improvementFully reflect the qualityComponent separationDrug compoundTanshinone IIA
The invention relates to the field of drug compound detection, in particular to a method for detecting tanshinone compounds in compound salvia tablets. A plurality of components of the same type including dihydrotanshinone I, cryptotanshinone, tanshinone I and tanshinone IIA can be simultaneously detected by detecting the index component of the tanshinone IIA. The method is simple and convenient, is fine in universality and can be used for more completely reflecting the quality of the compound salvia tablets.
Owner:GUANGZHOU BAIYUSN HUTCHISON WHAMPOA CHINESE MEDICINE
Single-column cyclic separation system for preparing high-purity tanshinone compounds and method thereof
ActiveCN103772478ASimplify the process of finding the right solvent systemIncrease sampling volumeSteroids preparationMulti dimensionalChromatography column
The invention relates to a single-column cyclic separation system for preparing high-purity tanshinone compounds and a method thereof. The single-column cyclic separation system comprises three countercurrent chromatographic columns, three pumps, three detectors, three collectors and three six-way valves. The first countercurrent chromatographic column is taken as a starting separation column, the second countercurrent chromatographic column and the third countercurrent chromatographic column are used as mutually independent cyclic separation columns, the second six-way valve is used for connecting the first and second countercurrent chromatographic columns, and the third six-way valve is used for connecting the first and third countercurrent chromatographic columns; the multi-dimensional cyclic separation of tanshinone compounds can be realized by regulating the second six-way valve and the third six-way valve. The tanshinone compounds comprise dihydrotanshinone I, triiuganone B, methyl tanshinone ester, cryptotanshinone, tanshinone I and 1, 2-dihydrotanshinone. The single-column cyclic separation system and the method, provided by the invention, have the advantages of simple extraction and separation, short time, high product purity and continuous operation, and are suitable for industrial production.
Owner:ZHEJIANG UNIV
Application of salvia miltiorrhiza bge I sodium sulfonate in the preparation of medicine and its medicine made by the same
ActiveCN101036637AEnhance pharmacological effectsPositive onset quicklyPowder deliveryOrganic active ingredientsCoronary heart diseaseImpurity
Application of tanshinone I sulfonic sodium for preparing drug and the drug produced thereby are disclosed in the invention, which belongs to a novel use art of the tanshinone I sulfonic sodium. Generally, the tanshinone I sulfonic sodium is an impurity of the tanshinone II sulfonic sodium and is already known as functions of resisting bacteria and eliminating inflammation and the like. The invention provides that the tanshinone I sulfonic sodium can be adapted to prepare drug for treating coronary heart disease, or anti-cancer drugs, capable of producing various formulation drugs used by per os or injection. In addition, new function of the tanshinone I sulfonic sodium is developed, which is safe, effective, has strong pharmacological action and excellent prospect in medicine.
Owner:NANJING HEALTHNICE MEDICAL TECH +1
Method for detecting compound salvia miltiorrhiza tablet
ActiveCN101904897ADetection of active ingredientsAccurate detectionHydroxy compound active ingredientsComponent separationTanshinone IIAEthyl acetate
The invention provides a method for detecting a compound salvia miltiorrhiza tablet, which comprises the following steps of: providing a test sample solution of a compound salvia miltiorrhiza tablet to be detected; selecting one of dihydrotanshinone I, cryptotanshinone, tanshinone I, tanshinone IIA and borneol for dissolving in ethyl acetate to be used as a contrast sample solution; and detecting the test sample solution by using a mixture of petroleum ether and acetone as a developing solvent through adopting a thin-layer chromatography. In the invention, the mixture of the petroleum ether and the acetone is used as the developing solvent; compared with the benzene-contained developing solvent used in the prior art, the developing solvent used by the invention has no poison; and in addition, a detecting result indicates that the developing solvent used by the invention can accurately detect active components of the compound salvia miltiorrhiza tablet.
Owner:GUANGZHOU BAIYUSN HUTCHISON WHAMPOA CHINESE MEDICINE
Radix salviae miltiorrhizae extract nanocrystalline self-stabilization Pickering emulsion and preparation method thereof
ActiveCN110141600AHave stable propertiesPharmaceutical non-active ingredientsEmulsion deliverySalvianolic acid BAdditive ingredient
The invention belongs to the field of preparations, and particularly relates to radix salviae miltiorrhizae extract nanocrystalline self-stabilization Pickering emulsion and preparation method thereof. According to the radix salviae miltiorrhizae extract nanocrystalline self-stabilization Pickering emulsion disclosed by the invention, a radix salviae miltiorrhizae extract of which the salvianolicacid B content is 60-100mg / g, the tanshinol content is 3-10mg / g, the rosmarinic acid content is 3-10mg / g, the tanshinone II A content is 5-20mg / g, the cryptotanshinone content is 2-10mg / g and the tanshinone I content is 3-10mg / g is used as a raw material medicine, and the radix salviae miltiorrhizae extract, an oil phase and an aqueous phase are prepared into oil-in-water Pickering emulsion. The nanocrystalline self-stabilization Pickering emulsion having stability properties is prepared through using the radix salviae miltiorrhizae extract containing water-soluble medicine effect ingredientsand insoluble medicine effect ingredients of radix salviae miltiorrhizae at the same time as the raw material medicine, wherein the water-soluble ingredients of salvianolic acid B and the like are distributed in the aqueous phase, and insoluble ingredients of tanshinone and the like are partially distributed in the oil phase and are partially adsorbed on an emulsion droplet interface, so that theemulsion is stabilized.
Owner:SOUTHWEST UNIVERSITY
Use of tanshinone in resisting uric acid nephropathy
InactiveCN107913277AGood treatment effectLower creatinineOrganic active ingredientsSkeletal disorderAntioxidantAdditive ingredient
The invention relates to the field of natural medicine, in particular to a use of ethyl acetate extract of Salvia miltiorrhiza, namely tanshinone, in the preparation of drugs to resist uric acid nephropathy, and a use thereof in the preparation of antioxidant drugs. The drugs containing tanshinone are applied to treat uric acid nephropathy, particularly to prevent or treat hyperuricemia, gout andhyperuricemia-induced chronic nephropathy. Tanshinone mainly includes diterpene phenanthraquinone ingredients such as tanshinone IIA, 15,16-dihydrotanshinone I, cryptotanshinone and miltirone; owing to their synergy, the ingredients have better therapeutic effect in terms of prevention and treatment of uric acid nephropathy than single tanshinone IIA and the clinically common drug allopurinol under single dosage. When the four ingredients, tanshinone IIA, 15,16-dihydrotanshinone I, cryptotanshinone and miltirone, are combined in the optimal ratio of 6:3:6:4 into a tanshinone mixture, best prevention and treatment effect is provided for mouse uric acid nephropathy; through the use of the tanshinone combinations, Kunming mice co-modeled with adenine and oteracil potassium are significantly lower than model groups in terms of blood uric acid, creatinine and urea nitrogen, and kidney protection is achieved.
Owner:CHINA PHARM UNIV
Total tanshinone and total phenolic acid extract in red-rooted salvia root and its production
Owner:石任兵 +1
Method for increasing content of tanshinone in salviae miltiorrhizae roots through salt stress
InactiveCN107996374AIncrease tanshinone contentIncrease contentCultivating equipmentsSoilless cultivationAlkali soilTanshinone IIA
The invention provides a method for increasing the content of tanshinone. The method specifically comprises the following steps of selecting salviae miltiorrhizae plants robust in growth, and conducting liquid culture for two months to make the salviae miltiorrhizae plants adapt to the aquatic environment; then adding NaCl into a culture solution so that after stress treatment is conducted for 8 hours, the content of tanshinone in salviae miltiorrhizae roots can be increased. By means of the method for increasing the content of tanshinone in the salviae miltiorrhizae roots through NaCl stresstreatment, a liquid culture method is adopted, NaCl is added into the culture solution, and the salviae miltiorrhizae plants of which the content of tanshinone is increased are obtained. After the NaCl stress treatment, the content of detected total tanshinone (tanshinone I, tanshinone IIA and cryptotanshinone) detected in the salviae miltiorrhizae roots is obviously increased compared with a control group. The average content of tanshinone in the salviae miltiorrhizae roots subjected to the NaCl stress treatment is 1.3 times or above of that in the control group. The content of tanshinone insalviae miltiorrhizae roots can be effectively increased, and the method is easy to operate and low in cost and provides technical reference for saline-alkali soil cultivation of a medicinal plant ofsalviae miltiorrhizae.
Owner:TIANJIN CITY AGRI BIO TECH RES CENT
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