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Radix salviae miltiorrhizae extract nanocrystalline self-stabilization Pickering emulsion and preparation method thereof

A nanocrystalline suspension and extract technology, which can be used in the fields of emulsion delivery, drug combination, and pharmaceutical formulations, and can solve the problems of complex extract components and limited drug-loading capacity of emulsions.

Active Publication Date: 2019-08-20
SOUTHWEST UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, traditional Pickering emulsions may still have the following two problems: ①Pickering emulsions mostly use silica nanoparticles as solid particles to stabilize emulsion droplets when administered orally, and there are potential safety problems; ②Drugs are mainly dissolved in the oil phase, The solubility of the oil phase directly limits the drug loading capacity of the emulsion
However, the inventor's research group has always used monomer compounds as raw materials to prepare nanocrystalline self-stabilizing Pickering emulsions, and has not yet applied this new drug nanocrystalline self-stabilizing Pickering emulsion preparation to traditional Chinese medicine extracts with complex components.
Compared with the monomer, the composition of the extract is complex, often containing a variety of water-soluble components and insoluble components, as well as macromolecular impurities such as proteins and polysaccharides; neither the extract nanocrystal suspension nor its Pickering emulsion has been reported

Method used

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  • Radix salviae miltiorrhizae extract nanocrystalline self-stabilization Pickering emulsion and preparation method thereof
  • Radix salviae miltiorrhizae extract nanocrystalline self-stabilization Pickering emulsion and preparation method thereof
  • Radix salviae miltiorrhizae extract nanocrystalline self-stabilization Pickering emulsion and preparation method thereof

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preparation example Construction

[0041] The preparation method of the Danshen extract nanocrystal self-stabilizing Pickering emulsion of the present invention comprises the following steps:

[0042] A. Prepare the primary suspension: dissolve the salvia miltiorrhiza extract in an organic solvent, add it into water with a pH value of 9-13 under stirring, continue heating and stirring to evaporate the organic solvent, and obtain the primary suspension A;

[0043] B. Preparation of nanocrystal suspension: Homogenize the primary suspension A obtained in step A to obtain nanocrystal suspension B through high-pressure homogenization;

[0044] C. Preparation of nanocrystalline self-stabilizing Pickering emulsion: the nanocrystalline suspension B obtained in step B is mixed with oil phase macrogol glycerol oleate, and homogenized under high pressure to obtain nanocrystalline self-stabilizing Pickering emulsion of Salvia miltiorrhiza extract.

[0045] In the above-mentioned preparation method:

[0046] The organic so...

Embodiment 1

[0140] The preparation method of embodiment 1 salvia miltiorrhiza extract nanocrystal self-stabilizing Pickering emulsion, comprises the following steps:

[0141] (1) Weigh 80 mg of the salvia miltiorrhiza extract raw material, add it to 5 mL of ethanol, shake it in a constant temperature water bath at 50 ° C for 4 hours, pour it into 40 ml of pure water with an initial pH value of 9, stir and evaporate the ethanol at 60 ° C, and obtain the primary suspension A ;

[0142] (2) The primary suspension A is homogeneously circulated 10 times under the condition of 600bar to prepare the nanocrystal suspension B;

[0143] (3) Mix the prepared nanocrystal suspension B with 4ml of the mixed oil phase (baldwood volatile oil: polyethylene glycol oleic acid glyceride = 2:1), and then use a high-pressure homogenizer to circulate under the condition of 600bar 10 times, a self-stable Pickering emulsion formulation can be prepared.

[0144] The particle size was detected by photon correlati...

Embodiment 2

[0145] The preparation method of embodiment 2 Danshen extract nanocrystal self-stabilizing Pickering emulsion, comprises the following steps:

[0146] (1) Weigh 160mg of salvia miltiorrhiza extract raw material drug, add 5ml of acetone: ethanol (1:1) mixed solvent, oscillate in a constant temperature water bath at 50°C for 4h, inject into 40ml of pure water with an initial pH value of 9, stir and evaporate at 60°C Remove the organic solvent to obtain primary suspension A;

[0147] (2) The primary suspension A is homogeneously circulated 20 times under the condition of 800bar to prepare the nanocrystal suspension B;

[0148] (3) Mix the prepared nanocrystal suspension B with 4ml of mixed oil phase (balm balm volatile oil: macrogol glycerol oleate=1:2), and then use a high-pressure homogenizer to circulate at 800bar After 20 times, a self-stable Pickering emulsion formulation can be obtained.

[0149] The particle size was detected by photon correlation spectroscopy (PCS), and...

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Abstract

The invention belongs to the field of preparations, and particularly relates to radix salviae miltiorrhizae extract nanocrystalline self-stabilization Pickering emulsion and preparation method thereof. According to the radix salviae miltiorrhizae extract nanocrystalline self-stabilization Pickering emulsion disclosed by the invention, a radix salviae miltiorrhizae extract of which the salvianolicacid B content is 60-100mg / g, the tanshinol content is 3-10mg / g, the rosmarinic acid content is 3-10mg / g, the tanshinone II A content is 5-20mg / g, the cryptotanshinone content is 2-10mg / g and the tanshinone I content is 3-10mg / g is used as a raw material medicine, and the radix salviae miltiorrhizae extract, an oil phase and an aqueous phase are prepared into oil-in-water Pickering emulsion. The nanocrystalline self-stabilization Pickering emulsion having stability properties is prepared through using the radix salviae miltiorrhizae extract containing water-soluble medicine effect ingredientsand insoluble medicine effect ingredients of radix salviae miltiorrhizae at the same time as the raw material medicine, wherein the water-soluble ingredients of salvianolic acid B and the like are distributed in the aqueous phase, and insoluble ingredients of tanshinone and the like are partially distributed in the oil phase and are partially adsorbed on an emulsion droplet interface, so that theemulsion is stabilized.

Description

technical field [0001] The invention belongs to the field of preparations, and in particular relates to a nano-crystal self-stabilizing Pickering emulsion of salvia miltiorrhiza extract and a preparation method thereof. Background technique [0002] Pickering emulsions are emulsions that are stabilized by adsorption of solid particles at the oil-water interface, forming a film structure. There are three main types of solid particles used: ① Inorganic salts, such as silicon dioxide, clay, ferric oxide, etc.; ② Nano-synthetic materials, such as carbon nanotubes, nanosheets, gold nanoparticles-graphene oxide hybrids, etc. ; ③ biodegradable materials, such as starch, cellulose, soybean protein, fat, chitosan and so on. Compared with traditional emulsions, Pickering emulsions do not require the use of surfactants, have better safety, and have better stability against mergers. They are a potentially excellent drug delivery system and have been used for oral administration. For e...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/537A61K9/107A61K47/14A61P9/00A61K36/48
CPCA61K9/107A61K36/48A61K36/537A61K47/14A61P9/00A61K2300/00
Inventor 张继芬徐晓玉张焦王帆
Owner SOUTHWEST UNIVERSITY
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