Radix salviae miltiorrhizae extract nanocrystalline self-stabilization Pickering emulsion and preparation method thereof
A nanocrystalline suspension and extract technology, which can be used in the fields of emulsion delivery, drug combination, and pharmaceutical formulations, and can solve the problems of complex extract components and limited drug-loading capacity of emulsions.
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[0041] The preparation method of the Danshen extract nanocrystal self-stabilizing Pickering emulsion of the present invention comprises the following steps:
[0042] A. Prepare the primary suspension: dissolve the salvia miltiorrhiza extract in an organic solvent, add it into water with a pH value of 9-13 under stirring, continue heating and stirring to evaporate the organic solvent, and obtain the primary suspension A;
[0043] B. Preparation of nanocrystal suspension: Homogenize the primary suspension A obtained in step A to obtain nanocrystal suspension B through high-pressure homogenization;
[0044] C. Preparation of nanocrystalline self-stabilizing Pickering emulsion: the nanocrystalline suspension B obtained in step B is mixed with oil phase macrogol glycerol oleate, and homogenized under high pressure to obtain nanocrystalline self-stabilizing Pickering emulsion of Salvia miltiorrhiza extract.
[0045] In the above-mentioned preparation method:
[0046] The organic so...
Embodiment 1
[0140] The preparation method of embodiment 1 salvia miltiorrhiza extract nanocrystal self-stabilizing Pickering emulsion, comprises the following steps:
[0141] (1) Weigh 80 mg of the salvia miltiorrhiza extract raw material, add it to 5 mL of ethanol, shake it in a constant temperature water bath at 50 ° C for 4 hours, pour it into 40 ml of pure water with an initial pH value of 9, stir and evaporate the ethanol at 60 ° C, and obtain the primary suspension A ;
[0142] (2) The primary suspension A is homogeneously circulated 10 times under the condition of 600bar to prepare the nanocrystal suspension B;
[0143] (3) Mix the prepared nanocrystal suspension B with 4ml of the mixed oil phase (baldwood volatile oil: polyethylene glycol oleic acid glyceride = 2:1), and then use a high-pressure homogenizer to circulate under the condition of 600bar 10 times, a self-stable Pickering emulsion formulation can be prepared.
[0144] The particle size was detected by photon correlati...
Embodiment 2
[0145] The preparation method of embodiment 2 Danshen extract nanocrystal self-stabilizing Pickering emulsion, comprises the following steps:
[0146] (1) Weigh 160mg of salvia miltiorrhiza extract raw material drug, add 5ml of acetone: ethanol (1:1) mixed solvent, oscillate in a constant temperature water bath at 50°C for 4h, inject into 40ml of pure water with an initial pH value of 9, stir and evaporate at 60°C Remove the organic solvent to obtain primary suspension A;
[0147] (2) The primary suspension A is homogeneously circulated 20 times under the condition of 800bar to prepare the nanocrystal suspension B;
[0148] (3) Mix the prepared nanocrystal suspension B with 4ml of mixed oil phase (balm balm volatile oil: macrogol glycerol oleate=1:2), and then use a high-pressure homogenizer to circulate at 800bar After 20 times, a self-stable Pickering emulsion formulation can be obtained.
[0149] The particle size was detected by photon correlation spectroscopy (PCS), and...
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