164 results about "Macrogol" patented technology

In the present invention the microsphere has coated bFGF as medicine, and matrix of lactic acid-glycol copolymer (PLA-PEG). The slow-releasing bFGF microsphere is prepared by using PVA-PEG mixed liquid as dispersing medium and through evaporation and mechanical stirring. It has excellent slow-releasing performance of over two-week releasing period. Its freeze dried powder has good dispersivity and low organic solvent residue. The present invention can be used for local administration or vein administration of treating fracture, bone defect and other diseases.

Provided herein is a combination therapy comprising a compound of Formula I and peginterferon alfa-2a, or another interferon analog. The combination therapy is useful for the treatment of HBV infection. Also provided herein are compositions comprising a compound of Formula I and peginterferon alfa-2a, or another interferon analog.

The invention relates to a preparation method and application of a reduction-response-type pegylation (PEG) nanomedicine composition. The nanomedicine composition is characterized by being prepared by coupling the PEG with a medicine via disulfide bonds which are sensitive in reduction. Thus, the water solubility of the medicine is improved; the in-vivo behavior of the medicine is also improved. Meanwhile, the full release and the activity of the medicine are ensured by utilizing the characteristic that the disulfide bonds in the PEG medicine, which are sensitive in reduction, can be specifically degraded in a tumor site. Thus, a good tumor treatment scheme is provided.

The present invention relates to a kind of cyclopeptide derivative containing natural or artificial amino acid substituted active thymosin alpha-1 segemnt, and its preparation process, medicine composition and their medicines for treating or preventing diseases related to immune deficiency, hypoimmunity, etc.

The invention a calcipotriol betamethasone ointment prepared from caprylocaproyl macrogolglycerides. Under the conditions of high speed cutting and a homogeneous state, calcipotriol micronized particles with particle size range being 5-110 microns and the micronized particles of betamethasone dipropionate are uniformly dispersed to caprylocaproyl macrogolglycerides, affinities of caprylocaproyl macrogolglycerides and a commonly used ointment matrix are utilized to obtain the uniform ointment with uniformly distributed particle size. Furthermore, the stability of resisting high temperature (50 DEG C) is better, and is beneficial to improving the quality and the stability of a medicine.

The present invention overcomes the problems associated with existing drug delivery systems by delivering cannabinoids transdermally. Preferably, the cannabinoids are delivered via an occlusive body (i.e., a patch) to alleviate harmful side effects and avoid gastrointestinal (first-pass) metabolism of the drug by the patient. A first aspect of the invention provides a method for relieving symptoms associated with illness or associated with the treatment of illness in a mammalian subject, comprising the steps of selecting at least one cannabinoid from the group consisting of cannabinol, cannabidiol, nabilone, levonantradol, (−)-HU-210, (+)-HU-210, 11-hydroxy-Δ9-THC, Δ8-THC-11-oic acid, CP 55,940, and R(+)-WIN 55,212-2, selecting at least one permeation enhancer from the group consisting of propylene glycol monolaurate, diethylene glycol monoethyl ether, an oleoyl macrogolglyceride, a caprylocaproyl macrogolglyceride, and an oleyl alcohol, and delivering the selected cannabinoid and permeation enhancer transdermally to treat an illness.

A method for treating hepatitis by use of polyethanediol modified human arginase I, and its application are disclosed.

A nanoparticle of camptothecin derivative for preparing the antineoplastic medicines is prepared from gycol-poly-gamme-benzylglutamic acide block copolymer and camptothecin, and is composed of the hydrophobic core and the hydrophilic shell.

A liposome composition used to prepare the medicines for treating tumor, cardiovascular and cerebrovascular disease, altitude ischemia and insomnia is prepared from the mixture of aspirin, prostaglandin E1, antioxidant, 2-hydroxypropyl-beta-dextrin and gamma-dextrin, the mixture of hydrogenated soybean lecithin and yolk lecithin, and the mixture of soybean sterol, polyethanediol-2000, VC and glycine. Its preparing process is also disclosed.

The invention relates to a danofloxacin mesylate microsphere preparation, which is prepared by the following steps: adding gelatin, or gelatin and polyglycol, or gelatin and polyglycol as well as xanthan gum into water, and adding danofloxacin mesylate for dissolution to obtain a water phase; adding an emulsifying agent into liquid petrolatum to mix evenly to obtain an oil phase; and adding the water phase into the oil phase, emulsifying, cross linking and solidifying the mixed phases and removing supernatant to obtain the danofloxacin mesylate microsphere preparation for livestock and birds. The preparation adopts an emulsifying and condensing method to wrap the danofloxacin mesylate in microspheres, can release slowly after using the microspheres for intramuscular injection, and prolong elimination half-life of medicament in vivo. The preparation technology has the advantages of simple operation, low requirements on preparation equipment and conditions, round shape of the obtained microspheres, and good dispersing property in water solution; and can prolong effective acting time of the medicament in vivo after intramuscular injection for pigs.

The invention belongs to the technical field of medical dressings for repairing burn skin wounds, and provides a double-sustained-release drug-loaded hydrogel dressing with double-layer microspheres entrapped by a semi-interpenetrating network. Acrylic acid is used as a pH-sensitive monomer. The pH / temperature dual-sensitive intelligent hydrogel takes methacrylic acid 2-ethyl ester and oligomeric (ethylene glycol) methyl ether methacrylate as temperature-sensitive monomers, and an anti-inflammatory drug gentamicin sulfate is entrapped; the preparation method comprises the following steps: preparing a calcium alginate core sphere entrapped with bovine serum albumin through a high-voltage electrostatic instillation method, coating the surface of the core sphere with a chitosan shell layer entrapped with an antibacterial drug azithromycin to form a double-layer microsphere, and loading the double-layer microsphere into the hydrogel to obtain the hydrogel dressing capable of precisely and slowly releasing two drugs and one protein. According to the pH / temperature change of a wound surface microenvironment, the hydrogel can achieve accurate controlled release of drugs and improve the utilization rate of the drugs, and is a novel double-sustained-release drug-loaded hydrogel dressing with a semi-interpenetrating network combined double-layer microsphere structure and good comprehensive performance.

Low-generation dendrimers containing a high density of surface hydroxyl groups, and methods of synthesis thereof are provided. In particular, oligo ethylene glycol (OEG)-like dendrimers with a high surface functional groups at relatively low generations (e.g. ˜120 hydroxyls in the third generation, with a size of just 1-2 nm) is described. Dendrimer formulations including one or more prophylactic, therapeutic, and / or diagnostic agents, and methods of use thereof are also described. The formulations are suitable for topical, enteral, and / or parenteral delivery for treating one or more diseases, conditions, and injuries in the eye, the brain and nervous system (CNS), particularly those associated with pathological activation of microglia and astrocytes.

The invention belongs to the field of traditional Chinese medicine and process for preparation, which is a dropping pill used for curing sudden deafness. Basic ingredients of the invention are constituted by following medicaments: astragalus root, kudzu root, ligusticum chuanxiong, acorus gramineus soland, salvia miltiorrhizae, bupleurum root, cimicifuga foetida, medlar, scutellaria root, lumbricus, lanceolata, peach kernel, safflower, uncaria and proper amount of auxiliary materials, wherein the auxiliary materials are chosen from carbowax-1000-8000 or the mixture of the compositions. The highly effective and quick-effective function of the invention is particularly suitable for curing sudden deafness, the invention can improve the blood supply of inner ear, advance the functional recovery of hair cells of the inner ear, inhibit self immune response, clear free radicals of body and improve auditory acuity, and the sudden deafness can not easily recur after being cured. The invention is a pure traditional Chinese medicine preparation with no side effect and easy administration, which contains no hormone substance. The invention overcomes the defects and shortcomings of original traditional Chinese medicine preparation. The invention can be made into tablets, granules, capsules, pills, oral liquid, dropping pills and the like, and can be used for curing patients with other types of sensorineural hearing loss or tinnitus.