Danofloxacin mesylate microsphere formulation for livestock and poultry and preparation method thereof
A technology of dafloxacin mesylate and microspheres, which is applied in the direction of medical preparations containing active ingredients, pharmaceutical formulas, block delivery, etc., can solve the problems of short elimination half-life of dafloxacin and inconvenient clinical application, etc. Achieve the effect of prolonging the effective action time, increasing the drug content and encapsulation efficiency, and good dispersion
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Embodiment 1
[0028] (1) Weigh 1.2g of gelatin in 8ml of water, put it in a constant temperature water bath at 60°C, until the gelatin is completely swollen, add 0.15g of dafloxacin mesylate to it, and make it completely dissolve in the gelatin aqueous solution;
[0029] (2) Add 60ml of liquid paraffin and 1.8ml of Span 80 into a 250ml round bottom flask, stir to make it evenly mixed;
[0030] (3) Slowly add the dafloxacin mesylate gelatin aqueous solution dropwise (0.8ml / min) into the liquid paraffin containing emulsifier in a constant temperature water bath at 60°C, stir magnetically at a stirring speed of 800r / min, and emulsify for 15min , to form an emulsion, and quickly transfer the emulsion to an ice-water bath to lower the temperature below 5°C;
[0031] (4) Continue to stir, add 60ml of isopropanol dropwise therein, continue to stir and continue to stir for 1h. Then add dropwise 4ml of chemical cross-linking agent formaldehyde, the dropping rate is about 1.5ml per minute, continue ...
Embodiment 2
[0035] (1) Precisely weigh 0.8g of gelatin in 8ml of water, put it in a constant temperature water bath at 60°C, until the gelatin is completely swollen, add 0.4g of dafloxacin mesylate to it, and make it completely dissolve in the gelatin aqueous solution;
[0036] (2) Add 60ml of liquid paraffin and 1.8ml of Span 80 into a 250ml round bottom flask, stir to make it evenly mixed;
[0037] (3) Slowly add the dafloxacin mesylate gelatin aqueous solution dropwise (2ml / min) into the liquid paraffin containing emulsifier under the condition of 60°C constant temperature water bath, stir magnetically, the stirring speed is 900r / min, and emulsify for 15min, To form an emulsion, quickly transfer the emulsion to an ice-water bath to lower the temperature below 5°C;
[0038] (4) Continue to stir, add 60ml of isopropanol dropwise therein, continue to stir and continue to stir for 1h. Add 5ml of the chemical cross-linking agent dextran (dextran) dropwise therein, at a rate of about 0.5ml ...
Embodiment 3
[0042] (1) Accurately weigh 1.2g of gelatin and 0.24g of polyethylene glycol in 8ml of water, place in a constant temperature water bath at 60°C, until the gelatin is completely swollen, add 0.30g of dafloxacin mesylate to it, and dissolve it completely;
[0043] (2) Add 60ml of liquid paraffin and 1.5ml of Span 80 into a 250ml round bottom flask, stir to make it evenly mixed;
[0044] (3) Slowly add the dafloxacin mesylate gelatin aqueous solution dropwise (1.5ml / min) into the liquid paraffin containing surfactant under the condition of constant temperature water bath at 60°C, stir magnetically, the stirring speed is 1000r / min, and emulsify After 15 minutes, an emulsion is formed, and the emulsion is quickly transferred to an ice-water bath to lower the temperature below 5°C;
[0045] (4) Continue to stir, add 60ml of isopropanol dropwise therein, continue to stir and continue to stir for 1h. Then dropwise add 5ml of chemical cross-linking agent glutaraldehyde, the rate of a...
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