104 results about "Deficiency disease" patented technology

The invention discloses flour for diabetes food therapy. The flour is prepared with the following weight parts of raw materials: 45-55 parts of 366 wheat red dog flour, 6-8 parts of oat, 6-8 parts of glycitein, 6-8 parts of pueraria root, 6-8 parts of yam, 6-8 parts of corn silk, and 7-9 parts of pumpkin powder. The preparation method includes that the raw materials are grinded into powder and then evenly mixed. The invention can completely solve the problem that the deficiency disease of the diabetes patients is caused by excessive diet, can ensure the body to evenly absorb all nutritious ingredients, can effectively control the blood sugar and urine sugar rise of the diabetes patients, and can reduce the rate to get diabetes for ordinary people which have not got diabetes yet.

A ganoderma tea for improving immunity and preventing heart disease, hypertension, diabetes, cancer and Se-deficiency disease is proportionally prepared from Tai-mountain ganederma, wolfberry fruit, jujube, fleece flower root, chrysanthemum flower, ganoderma spore powder and the extract of tea through weighing, washing, extracting, concentrating, mixing, granulating, drying and packing.

The invention discloses a five colors five grains health caring dumpling. The basic ingredients of the stuffing is fresh peeled shrimp, sea cucumber and fresh fish flesh, which contains rich protein, folic acid, pantothenic acid, unsaturated fatty acid which are easily absorbed, and has low fat and rich balanced nutrition; the wrapper and stuffing of the five colors five grains dumpling contains a plurality of vitamins, microelements and meal fibers, especially rich in the microelements of organic calcium, iron, zincum and selenium, which are balanced and can be absorbed easily. The five colors five grains health caring dumpling in the invention avoids the current 'rich man's disease', and the various diseases caused by unbalanced nutrition, unbalanced acid-base and un balanced yin-yang brought by high protein, high fat, ultra-fine wheaten food, and a plurality of vitamin, microelement and meal fiber deficiency diseases; has the main functions of invigorating spleen, whetting appetite, nourishing yin and strengthening kidney; and achieves the aims of supplementing qi, nourishing blood, clearing heat, absorbing clots, promoting diuresis, lowering lipid, lowering blood pressure and tranquilizing mind.

The invention discloses a nucleic acid hybridization membrane strip used for diagnosing G6PD (Glucose-6-phosphate Dehydrogenase) deficiency diseases, comprising a substrate on which specific mutation detection probes are fixed; each mutation detection probe corresponds to a G6PD gene mutational site; the G6PD gene mutational site is at least one of cDNA95, cDNA392, cDNA487, cDNA493, cDNA592, cDNA871, cDNA1004, cDNA1024, cDNA1376, cDNA1381, cDNA1387 and cDNA1388; each mutation detection probe comprises 15-20 base sequences; and the middle position in the sequence comprises mutation base of theG6PD gene corresponding to the middle position of the sequence. The nucleic acid hybridization membrane strip has the advantages of high accuracy and strong specificity, and capacity of detecting a gene recessive carrier and the like.

The invention discloses a G6PD (Glucose-6-Phosphate Dehydrogenase) deficiency disease gene detection kit, comprising a gene chip, wherein a mutation detection probe designed for the gene mutation site of glucose-6-phosphate dehydrogenase and a corresponding normal control probe are arranged on the gene chip; the mutation detection probe is at least one sequence among SEQ ID Nos: 1-13 or reverse complementary sequences of the sequences; the normal control probe is at least one sequence among SEQ ID Nos: 4-14 or reverse complementary sequences of the sequences. The G6PD deficiency disease gene detection kit further comprises a group of primers for amplifying the gene sequence of the clinical sample G6PD, wherein the DNA sequences of the primers are as shown in SEQ ID Nos: 25-34. The G6PD deficiency disease gene detection kit is capable of directly diagnosing the genotype of a target to be detected and greatly reducing the rate of missed diagnosis of female heterozygote; and the detection time is shorted to about 3.5 hours so that quick detection of G6PD gene is realized.

The invention relates to a clinical therapeutic medicine for recombined human growth hormone (rhGH) deficiency disease. Carbowax rhGH medicine is made up of carbowax and rhGH by conjuncting The manufacturing process mainly includes providing a buffer system of PH4.0-9.0, enabling rhGH and carbowax react 2-48 hours in the buffer system, obtaining purification through separating and purifying process, the temperature should be controlled in 4-37 DEG C. The invention has advantages of easy purification, long effect time and be convenient for industrial production.

The invention discloses a selenium-rich health wine and a production method thereof. The selenium-rich health wine consists of the following compositions in part by weight: 10 to 20 parts of tremella, 10 to 20 parts of common macrocarpium fruit, 10 to 20 parts of siberian solomonseal rhizome, 10 to 20 parts of rhodiola rosea, 10 to 20 parts of glutinous rice, 10 to 20 parts of selenium-rich malt,10 to 20 parts of distiller's yeast, 0.5 to 1 part of dried yeast, 0.1 to 0.2 part of basidiomycete and 0.5 to 1 part of seasoning. Chinese medicinal materials such as the tremella, the common macrocarpium fruit, the siberian solomonseal rhizome, the rhodiola rosea and the glutinous rice with the health care function are adopted as raw materials, and organic selenium, namely the selenium-rich malt is added into the wine to facilitate absorbing a selenium element by a human body. The brewed health wine has the effects of activating blood, removing stasis, regulating fat, reducing blood pressure, nourishing Qi, replenishing kidney, improving immunity and the like; and the added selenium-rich malt can replenish the selenium element for the human body, has the effects of resisting oxidation and aging, releasing toxin and the like and also can prevent the occurrence of cardiopathy and certain selenium-deficiency diseases.

The invention discloses a red cell G6PD lack disease dual-enzyme ratio check method, a relative agent box and a relative method, belonging to blood check technical field. The invention checks the ascending speeds A and B when G6PD catalyzes G6P and 6GPD catalyzes 6PG of one sample at 340nm absorbance, to directly process judgment based on the ratio between A and B. The agent box is composed of R2 / G6P, R2 / 6PG, and R1 buffer liquids. And the method comprises that first preparing hemolysis liquid of object sample, processing test directly on a dual-channel automatic biochemical machine which can directly calculate out the ratio between A and B. The invention has accurate check, simple and quick operation, low cost, and wide application for checking G6PD lack disease.

The invention discloses a preparation method of a starch-based zinc-rich nutrition enhancer. The method comprises: preparing starch raw materials into starch milk with a mass percent concentration of 5%-12%, adjusting the pH to 4.5-6.5, stirring in an enclosed container at 95-99 DEG C for gelatinization; cooling, adding debranching enzyme, stirring at 45-65 DEG C for reaction; adjusting the pH to 5.5-7.0, adding alpha-amylase, stirring at 45-110 DEG C for reaction, adjusting the pH to 2.5-3.0, performing enzyme deactivation to obtain an amylase solution; adjusting the temperature to 50-80 DEG C, adding a zinc salt solution, adjusting the pH to 5.0-8.0, stirring for reaction; adjusting the pH to 4.5, cooling to room temperature, performing refrigeration in a refrigerator; and performing acid pickling, washing, drying, and crushing to obtain the product. The product of the invention is rich in zinc trace element, can be used as a food additive to be added into food and health-care food, and has very good improvement effect on nutrition deficiency diseases caused by lack of zinc.

The present invention concerns cyclic compounds, compositions comprising the cyclic compounds, linkers, a method of preparing a carrying agent:cyclic compound adduct, a method for treating disorders such as proliferation disorders (e.g., malignancies), bone deficiency diseases, and autoimmune diseases, and a method for suppressing the growth of, or inducing apoptosis in, cells (e.g., malignant cells).

The invention relates to a lick brick for a ruminant animal, and specifically discloses a composite premixed feed lick brick for a grazing yak. The composite premixed feed lick brick for grazing yak comprises salt, cement, bentonite, urea, ammonium chloride, calcium formate, a flavoring agent, calcium hydrophosphate, ferrous sulfate, copper sulfate, zinc sulfate, magnesium sulfate, manganese sulfate, sodium selenite, cobalt chloride, calcium iodate, rumensin and composite multi-vitamins; and the density of the lick brick is 1.8-2.1 g / cm<3>. The composite premixed feed lick brick is researched and developed according to the physiological property of the grazing yak, provides sufficient microelements and vitamins for the grazing yak, and additionally complements part of the non-protein nitrogen, so that the defect of lack of a protein source for the grazing yak fed with forage grass is avoided, the feed intake and the digestive efficiency of the grazing yak are effectively improved, the growing and fattening speed of the yak is increased, the quality of beef is improved, the immunity of the yak is strengthened, the deficiency disease and the metabolic disease of the yak are effectively prevented, and the culture benefit is improved.

The invention relates to primers for detecting gene mutation caused by G6PD deficiency disease. The primers are as shown in SEQ ID NO: 1-32. The invention further relates to probes for detecting gene mutation caused by G6PD deficiency disease. The probes are as shown in the sequences SEQ ID NO: 33-67. The invention further relates to a kit for detecting gene mutation caused by G6PD deficiency disease. The kit comprises a PCR reaction liquid I, a PCR reaction liquid II and a PCR reaction liquid III. The kit for detecting gene mutation caused by G6PD deficiency disease provided by the invention has the advantages of high coverage rate, high detection rate of female heterozygote, low cost and high accuracy.

The invention discloses a method and primer for detecting gene mutation relevant to the hereditary blood coagulation factor XI(F11). The primer comprises 15 pairs of primers with amplification detecting all-exon sequences. The Sanger sequencing technology and the sequencing primers are adopted. Hereditary blood coagulation factor XI(F11) deficiency disease all-exon and relevant mutation can be fast detected. The detecting result completed through the method and primer is accurate, diagnosis of the hereditary blood coagulation factor XI(F11) deficiency disease can be assisted, and the method and primer have important reference significance on early intervention, early treatment and antenatal diagnosis.

The invention discloses a microelement composition for improving the reproductive performance of breeding hens. Each 1 kilogram of the composition comprises the following components by mass: 2 to 4 grams of chalcanthite, 20 to 30 grams of ferrous sulfate monohydrate, 20 to 35 grams of zinc sulfate monohydrate, 10 to 30 grams of manganese sulfate monohydrate, 2 to 5 grams of potassium iodide, 3 to4 grams of sodium selenite, and 943 to 892 grams of carrier. The microelement composition is used for the breeding hens, and can maintain the normal vital movements of the breeding hens, improve the immunity, the disease resistance and the anti-stress capability, prevent deficiency diseases, reduce the feed consumption, and improve the laying rate, and the fertility rate and the hatchability of hatching eggs. The composition has no toxic side effects and has small influence on the environment.

The invention discloses a microelement composition for improving the production performance of layer chicken. 1kg of the composition comprises the following compositions: 3 to 6g of copper sulfate pentahydrate, 15 to 30g of ferrous sulfate monohydrate, 15 to 30g of monohydrate zinc sulphate, 10 to 30g of monohydrous manganese sulphate, 2 to 5g of potassium iodide, 2 to 4g of sodium selenite and 953 to 895g of carrier. The microelement composition for the layer chicken can maintain normal activity of the layer chicken, improve the immunity, disease resistance and stress resistance, prevent deficiency disease, reduce feed consumption, improve laying rate, and has no toxic or side effect and has little influence on environment.

The production process of natural mineral lick includes the steps of compounding materials, stirring, pressing to form, air -drying, and packing. The materials include table salt, natural mineral lick additive and water. The natural mineral lick contains rich Ca, P, Na, Cl and other macro elements as well as Fe, Cu, Mn, Zn, Se and other trace elements. It can maintain the balance of electrolyte in the body of ox, sheep and other ruminant, prevent and treat various mineral nutrient deficiency diseases of animal, such as pica, white muscle disease, nutritional anemia, etc, raise feed utilizing rate, through setting near to the food trough, water trough, etc for the animal to lick.

The invention discloses a pigment marigold flower health-card tea and a production method thereof. The pigment marigold flower health-card tea disclosed by the invention comprises pigment marigold flower, chrysanthemum morifolium ramat, honeysuckle flower, and the method comprises the following steps of: processing raw material, throwing the material and uniformly mixing, smashing, sterilizing through microwave, and packaging. The pigment marigold flower health-card tea comprises medicinal and edible plant, lutein is supplemented to people who suffer from lutein deficiency disease, the immunity of human body is improved, and the pigment marigold flower health-card tea is low in cost and is suitable for mass production.

Disclosed herein is a simple method for the treatment of antigen-deficiency diseases, by orally administering to a subject a therapeutically effective amount of the deficient antigen, wherein the antigen is not present in a liposome. In one embodiment, the method increases hemostasis in a subject having hemophilia A or B, by orally administering to the hemophiliac a therapeutically effective amount of the appropriate clotting factor other than in a liposome, sufficient to induce oral tolerance and supply exogenous clotting factor to the subject.

A method for synthesis of senior spice high-value musk spice cyclopentadecanolide (macrocyclic musk lactone) from malania oleifera oil is provided; the cyclopentadecanolide is prepared by taking the malania oleifera oil as raw material through saponification, acidification, recrystallization, ozonization, reduction, esterification and ring closing. The method has the advantages of high yield, good benefits and low cost, and overcomes the defects of complex production process, relatively low yield, relatively high cost and no formation of market advantages in the prior art. The malania oleifera oil contains 40%-60% of 15-tetracosenic acid, and is an ideal raw material for synthesis of the high-value musk spice. The 15-tetracosenic acid is an essential nutrient for brain development, has important roles in improving the cranial nerve activity and preventing encephalasthenia, has good curative effect on cardiovascular and human body autoimmune deficiency diseases, and can be used as medicines and health care products.

The invention discloses a traditional Chinese medicine preparation for treatment of deficiency of five viscera, which solves the problem of poor curative effect on treating deficiency of the five viscera at present. The formula of the traditional Chinese medicine preparation comprises the following components in parts by weight: 50-70 parts of astragalus membranaceus, 20-40 parts of codonopsis pilosula, 20-40 parts of angelica sinensis, 20-40 parts of radix rehmanniae praeparata, 10-20 parts of tuckahoe, 8-12 parts of gizzard-membrane of chicken, 10-20 parts of fructus psoraleae, 20-40 parts of mulberry, 20-40 parts of spina date seed, 20-40 parts of cortex albiziae and 20-40 parts of tuber fleeceflower stem. The traditional Chinese medicine preparation for treatment of deficiency of the five viscera of the invention has brand-new composition and pure traditional Chinese medicine ingredients, also has the functions of invigorating qi and enriching the blood, strengthening the spleen in transportation, nourishing and invigorating the spleen, nourishing the heart and relieving the mental strain, and further has better curative effect to various deficiency diseases, particularly good healing effect when patients have deficiency symptoms caused by neurasthenia after operation and radiochemotherapy as well as excessive mental stress and pressure, and has non-toxic side effect.

The present invention discloses tea polyphenol-Mn complex and its preparation process. The tea polyphenol-Mn complex is prepared through complexing polyphenol and bivalent Mn, and contains (C22H14O11)2Mn, C22H14O11Mn, (C15H12O7)2Mn, C15H12O7Mn, (C22H14O10)2Mn and C22H14O10Mn as main components. The complexing reaction has high yield. The tea polyphenol-Mn complex has both the bioactivity of tea polyphenol and biological effect of Mn, and may be used as health food additive and medicine for preventing and treating manganese deficiency disease.

The present invention relates to methods of monitoring and assessing sialic acid deficiency treatment as well as to methods of predicting / determining responsiveness to treatment for a sialic acid deficiency using biomarkers. Sialic acid deficiencies include for example Hereditary Inclusion Body Myopathy (HIBM).

The invention relates to a traditional Chinese medicine composition for treating a spleen and kidney yang-deficiency disease. The traditional Chinese medicine composition comprises the following traditional Chinese medicine raw materials in parts by weight: 10-30 parts of roasted rhizoma atractylodis macrocephalae, 5-25 parts of rhizoma corydalis, 5-20 parts of cimicifugae foetidae, 10-40 parts of astragalus membranaceus, 5-25 parts of eucommia ulmoides, 5-20 parts of baked ginger, 5-25 parts of poria, 5-20 parts of rhizoma drynariae, 5-25 parts of rhizoma cibotii, 5-20 parts of mangnolia officinalis, 5-25 parts of honeysuckle, 5-10 parts of fructus evodiae, 5-20 parts of ginseng, 5-25 parts of pericarpium citri reticulatae, 5-20 parts of myristica fragrans, 5-25 parts of nutgrass galingale rhizome, 5-10 parts of cassia twig, 5-20 parts of angelica sinensis, 5-25 parts of fructus amomi, 5-20 parts of dried radix rehmanniae, 5-25 parts of myrrh, and 5-15 parts of radix glycyrrhizae preparata. The traditional Chinese medicine composition disclosed by the invention has the effects of invigorating the spleen and the kidneys, soothing the liver and regulating flow of vital energy, supporting yang and checking diarrhea, and eliminating cold to stop pain, and is significant in curative effect on the spleen and kidney yang-deficiency disease, and reliable in action.

The invention relates to an adult cow licking brick, which contains 65 to 80 parts of salt, 5 to 15 parts of bentonite, 10 to 20 parts of premix and 1 to 5 parts of molasses. Because the licking brick contains the bentonite and the bentonite contains multiple trace elements and mineral substances, mineral substance deficiency diseases of cows such as allotriophagy, white muscle disease, parturient paresis of high yield cows, alimentary anemia and the like can be effectively prevented and treated.

The invention discloses a combination of trace mineral elements and vitamins for pet cats. The combination has rich content and enough nutrients, and can prevent the food deficiency disease of the pet cats. The combination of the trace mineral elements and the vitamins for the pet cats consists of 200000-500000IU of VA, 50000-60000IU of VD3, 2000-5000IU of VE, 5-15mg of VK3, 300-800mg of VB1 300-600mg, VB2 200-500mg, pantothenic acid, 3000-8000mg of nicotinic acid, 300-800mg of VB6, 50-100mg of folic acid, 5-10mg of biotin, 1-3mg of VB12, 100000-300000mg of sinkaline, 50.71-121.70g of magnesium sulfate, 0.5-1.5g of sodium selenite and 187.4-706.3g of carriers. With adequate trace mineral elements and vitamins necessary for the health and development of the pet cats, the combination can achieve the effect of preventing the food deficiency disease of the pet cats.

The invention relates to a parenteral ketogenic nutrient solution and a preparation method thereof. The nutrient solution is prepared from in per 100 mL of injection water, by mass, 1.80-3.3 g of amino acid, 6.5-8.0 g of fatty substances, 0.2-0.7 g of glucose, 28.93 mg of vitamins, 327.33 mg of mineral substances, 1.32-1.49 g of an emulgator and 2.34-4.29 mmol of sodium acetate, and all the substances are dissolved in the injection water. According to the formula of the high-fat low-sugar low-amino acid nutrient solution, the nutrient solution is used for well treating intractable epilepsy andother hereditary metabolic diseases such as glucose carrier deficiency disease, pyruvate dehydrogenase deficiency disease and part of tumors and fills the gap of a parenteral ketogenic nutrient solution technology.

The invention belongs to the field of water-soluble fertilizer processing, and in particular relates to a chelated earthworm amino acid water-soluble micronutrient fertilizer and a preparation method thereof. The chelated earthworm amino acid water-soluble micronutrient fertilizer is characterized by consisting of the following components in parts by mass: 1-3 parts of citric acid, 50-60 parts of an earthworm amino acid chelation solution, 7-27 parts of ferrous sulfate, 10-27 parts of zinc sulfate, 7-27 parts of manganese sulfate and 2-12 parts of monopotassium phosphate. Due to the adoption of the chelated earthworm amino acid water-soluble micronutrient fertilizer, the micro-element nutrition deficiency disease of plants can be treated, the earthworm amino acid chelation solution is used as the liquid phase, the earthworm amino acid chelation solution contains 18 earthworm amino acids, through chelation reaction of the amino acid chelation solution and microelements like zinc, ferrum and manganese, the activity of enzyme inside plant bodies can be rapidly activated through the effective components, absorption of plants on macroelements like nitrogen, phosphorus and potassium can be accelerated, the utilization rate of the fertilizer can be increased, and conversion of carbohydrate inside plant bodies can be promoted, the yield can be increased, the content of chlorophyll of leaves can be increased, the cold resistance and the salt resistance can be improved, and the disease resistance and the adverse resistance of crops can be improved.

The invention provides hydrogen-selenium rice, composition of the hydrogen-selenium rice and a preparation method of the hydrogen-selenium rice. The hydrogen-selenium rice is composed of rice, and resistant starch, selenium-enriched yeast and ethylenediaminetetraacetic acid ferric sodium salt which can generate hydrogen gas in large intestines, so that the rice is named as the hydrogen-selenium rice. The hydrogen gas can be used for neutralizing free radicals in bodies. Selenium is a necessary microelement for human bodies and can be used for preventing and inhibiting tumors and resisting ageing; and China is a selenium-deficiency country so that a manner of enriching selenium in the rice is the best way for supplementing selenium. Iron deficiency anemia is one of nutrition deficiency diseases with the high morbidity in China; in estimation of Global Burden of Diseases in 2004, disability-adjusted life years (DALYs) caused by iron deficiency in every 100,000 people in China are 189 and rank 99th in 192 member countries; and the total loss of the whole country is 247.9 billion and ranks second last in the member countries. When people supplement iron through drugs, about 2000 yuan needs to be paid every year; 400-600 yuan needs to be paid when people eat health-care products to supplement iron; and the ideal effect can be realized by only spending additional 2-3 yuan when people eat iron-enriched rice.

The invention discloses a portable ecological negative ion generator. The portable ecological negative ion generator is characterized by comprising a shell, and an ecological negative ion generator, a fullerene releaser, a lithium battery power supply and a circuit board that are mounted in the shell, wherein the ecological negative ion generator, the fullerene releaser, the lithium battery power supply and the circuit board are connected mutually; a guiding hole is formed in the shell; a guiding wire for eliminating electric arc is arranged in the guiding hole; and the guiding wire is connected with the circuit board. The portable ecological negative ion generator can instantaneously generate tens of millions of economic negative ions / cubic centimeter for realizing air ecologicalization in a surrounding environment; the generated ecological negative ions have a treatment effect on human body, specifically for negative ion deficiency disease; meanwhile, the generated ecological negative ions have diseases prevention and health care functions on healthy people; the portable lithium battery power supply is provided with electric power storage equipment and can be used for charging and storing electric energy, and is small in size, portable, and capable of satisfying requirements of occasions without power supply; and in addition, the portable lithium battery power supply can work continuously for more than 14 hours, and can work for even longer in an intermittent manner.

The present invention provides water soluble triptolide derivatives of formula I, II, IIIa, and IIIb, which have high immunosuppressive activity and in which R1 and R2 have the same meanings as defined in claims. The present invention also provides chemically synthetic methods of the triptolide derivatives of formula I, II, IIIa, and IIIb, and the use of the triptolide derivatives in the treatment of autoimmune deficiency diseases and inflammatory diseases correlated with immunosuppression.