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Medicine for preventing and treating coronary heart disease and angina pectoris and its prepn and other use

A technology for angina pectoris and drugs for coronary heart disease, applied in the field of compound Danshen dropping pills, can solve the problems of low bioavailability, inability to meet the needs of first aid for patients with angina pectoris, and low content of active ingredients, etc.

Inactive Publication Date: 2002-05-15
TIANJIN TASLY PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are ordinary compound Danshen tablets and capsules on the market, but the production process of ordinary tablets and capsules is relatively backward, the content of active ingredients is low, and there is no quality control standard. They need to be taken orally and absorbed through the gastrointestinal tract, and the first-pass effect occurs in the liver. After being absorbed into the blood, the bioavailability is low and the absorption is slow, so it is not suitable for the first aid needs of patients with angina pectoris

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0765] Embodiment one 1. formula consumption

[0766] Danshen 41.06g Panax notoginseng 8.03g Borneol 0.46g

[0767] Excipient polyethylene glycol-6000 18g

[0768] Make 1000 drop pills 2. Extraction of Salvia Miltiorrhiza and Radix Notoginseng

[0769] Take the coarsely crushed Danshen and Panax notoginseng medicinal materials into the extraction tank, add 5 times the amount of water, decoct for 2 hours, filter, and carry out the second extraction of the filter residue, add 4 times the amount of water, decoct for 1 hour, filter, filter the residue Discard and combine the filtrates. The filtrate is concentrated under reduced pressure to a ratio of 1:0.9 to 1.1 between the volume of the medicinal solution (L) and the weight of the medicinal material (Kg). Slowly add 95% ethanol to make the alcoholic concentration of the medicinal solution at 69 to 71%, and let it stand for 12 hours. The supernatant of the medicinal solution after alcohol precipitation is taken, filtered, etha...

Embodiment 2

[0773] Embodiment two 1. formula consumption

[0774] Danshen 31.12g Panax notoginseng 9.21g Borneol 0.50g

[0775] Excipient polyethylene glycol-6000 20g

[0776] Make 1000 drop pills 2. The extraction of Salvia Notoginseng, the preparation and characteristics of the product are the same as in Example 1.

Embodiment 3

[0777] Embodiment three 1. formula consumption

[0778] Danshen 59.36g Panax notoginseng 6.38g Borneol 0.34g

[0779] Excipient polyethylene glycol-6000 21g

[0780] Make 1000 drop pills 2. The extraction of Salvia Notoginseng, the preparation and characteristics of the product are the same as in Example 1.

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Abstract

The present invention relates to traditional Chinese medicine for treating coronary heart disease and stenocardia is made from (by wt.%) salvia root 50-97%, notoginseng 2-48% and borneol 0.2-3%, in which the salvia root and notoginseng and hot extracted with water, then filtering, concentrating, alcohol precipitating, standing still, recovering ethyl alcohol, concentrating, into extractum, further blended with borneol and adjuvant polyglycol-6000 to form into product.

Description

technical field [0001] The invention relates to a medicine for preventing and treating angina pectoris of coronary heart disease and a preparation method thereof, in particular to a drop pill made from Chinese herbal medicine through a special extraction method through a specific process. The trade name is compound danshen drop pill. Background technique [0002] Compound Danshen Dripping Pill is an improvement and improvement on the basis of Compound Danshen Tablets (recorded in the Pharmacopoeia of the People's Republic of China in 1977, 1985, 1995 and 2000), but it is different from the compound in terms of prescription ratio, manufacturing process and clinical effect. Danshen tablets have significant differences. Since it was approved by the Ministry of Health of the People's Republic of China in 1993, millions of people have used it and obtained good social and economic benefits. So far, the prescription ratio and manufacturing process of Compound Danshen Dripping Pills...

Claims

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Application Information

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IPC IPC(8): A61P1/04A61P1/16A61P3/10A61P9/10A61P11/00A61P13/12A61P19/00A61P25/06
Inventor 阎希军吴遒峰叶正良李旭
Owner TIANJIN TASLY PHARMA CO LTD
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