Somatostation a aqua prepn and its prepn process and application

Abstract

The present invention relates to one kind of somatostation aqua preparation and its preparation process and application in preparing medicine for preventing and treating serious acute esophagus varicose hemorrhage, acute gastric and duodenal ulcer hemorrhage, acute erosive gastritis, acute hemorrhagic gastritis, etc. The preparation consists of somatostation in 0.1-1000 mg each 0.1-500 ml, medicinal supplementary material, which may be mannitol, polyglycol, cyclodextrin, etc., and water. The preparation process includes compounding, sterilizing, packing, and other steps. The somatostation aqua preparation has high stability, easy preparation and other features, and has wide application foreground in preparing medicine for preventing and treating serious acute esophagus varicose hemorrhage, acute gastric and duodenal ulcer hemorrhage, acute erosive gastritis, acute hemorrhagic gastritis, etc.

Description

Technical field [0001] The invention relates to the field of medicines and their preparations. The core of the invention is to provide a new preparation of somatostatin, its preparation method and its preparation for the prevention and treatment of severe acute esophageal varices bleeding, severe acute gastric or duodenal ulcer bleeding, acute erosive gastritis or Application in drugs for hemorrhagic gastritis, postoperative complications of pancreatic surgery, biliary or intestinal fistula, diabetic ketoacidosis and other diseases. Background technique [0002] Somatostatin is a fourteen peptide, and its amino acid sequence is as follows: [0003] [0004] Somatostatin molecular formula is C 76 H 104 N 18 O 19 S 2 , The molecular weight is 1638. [0005] Somatostatin is a cyclic polypeptide hormone secreted by D cells, mainly distributed in the gastrointestinal tract and central nervous system, of which the gastrointestinal tract accounts for 70%, and its main function is to i...

AI Technical Summary

Problems solved by technology

[0012] Like other polypeptide substances, the preparation of somatostatin is limited by factors such as its stability in aqueous solution. At present, there is only freeze-dried powder injection of somatostatin on the market. This dosage form needs to be dissolved when it is used. While increasing the operation steps, it also increases the chance of drug contamination

The present invention just aims at the single situation of present somatostatin dosage form, has created the aqueous solution preparation of somatostatin, has solved the stability problem of somatostatin in aqueous solution, and this is the main purpose of the present invention

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