81 results about "Licorice acid" patented technology

The synchronous extraction and separation method for glycyrrhizic acid, glycyrrhizic flavone and glycyrrhizic polysaccharide comprises: extracting the licorice powder with solvent for 1-3 times by cold seepage, warm leaching or reflux; mixing and condensing on reduced pressure the liquid; extracting with organic solvent, condensing to recover the solvent and obtain the coarse glycyrrhizic flavone; adding 95% ethanol into the extracted residue to adjust ethanol concentration as 50-80%, holding at low or normal temperature to obtain coarse glycyrrhizic polysaccharide by drying the precipitate ; condensing the supernatant, adjusting pH value to 1.5-2.0 with H2SO4 or HCl, holding at low or normal temperature, removing the supernatant, and obtaining coarse glycyrrhizic acid by cleaning with cold water or acid and drying the precipitate. This invention has simple process, improves comprehensive utilization level, and reduces cost for deep process.

A process for extracting licoflavone, glycyrrhizic acid and licopolyose from licorice root incldues such steps as extracting licoflavone using alcohol, extracting glycyrrhizic acid from residual dregs using alkaline clean water, boiling its residual dregs in clean water, and alcohol separating to prepare licopolyose. Its advantages are continuous extraction and the highest utilization rate.

The present invention discloses preparation process of licoflavone from licorice and licorice slag, and features licoflavone is extracted from crushed licorice or licorice slag after extracting glycyrrhetic acid through adding organic solvent for soaking, filtering, and concentrating the filtrate; and that the prepared licoflavone contains licochalcone, isoliquiritigenin, glabidin, liquiritin, liquiritigenin and other components. The preparation process is simple, high in yield and suitable for industrial production.

specifically a process for extracting glycyrrhizic acid from licorice roots, wherein the glycyrrhizic acid is extracted from the licorice root rapidly and effectively by using the method of microwave auxiliary extraction, and then organic extracting agent, e.g. tributyl phosphate, trialkyl phosphine oxide, isooctanol, n-hexyl alcohol, isopentyl alcohol are used for solvent extraction, after stewing or centrifugal phase-splitting, the glycyrrhizic acid will be enriched in organic phase, by using water as solution, and regulating the pH of the miscible liquids to 6.0-12.0, the inverse extraction for glycyrrhizic acid can be carried out, thus obtaining the aqueous solution of the enriched glycyrrhizic acid, and the refined glycyrrhizic acid is obtained through decoloration, acidification, stewing, centrifugal deposition and drying.

The invention provides a quality detection method for pharmaceutical compositions for treating stroke and vasculitis through a TLC qualitative identification method for Dendrobium nobile, pilose asiabell root, scrophularia root, licorice root, astragalus root, glycyrrhizic acid,wherein a HPLC content determination process and content regulation are conducted to sweet-scented osmanthus glycoside and astragalus root saponins. The invention discloses the research development of the preparation fingerprint pattern and optimization for conditions of the fingerprint pattern apparatus including chromatographic column, mobile phase and detecting wave length, as a result the liquid phase fingerprint spectrogram standard for the oral liquid preparations is drafted.

The invention provides Gegenqinlian extractive which is obtained by mixing four medicines of kudzuvine roots, baikal skullcap roots, goldthread roots, and licorice roots in the weight ratio of 8: 3: 3: 2, extracting effective parts and refining. The extractive has the main effective parts in the following weight percentage: total isoflavone of the kudzuvine roots is 13.5 to 21.0 percent, total flavone of the baikal skullcap roots is 20.5 to 32.5 percent, total alkaloid of the goldthread roots is 10.5 to 18.5 percent, and glycerrhizic acid is 2.0 to 5.0 percent. Through adding medicinal auxiliary materials into the extractive, and adopting a conventional method, various peroral preparation for treating bacillary dysentery, acute enteritis, and infantile virus diarrhea can be prepared.

The invention relates to the technical field of the traditional Chinese medicine and in particular to the quality standard of a pharynx-clearing dropping pill which is made from the raw materials of a natural indigo, liquorice, myrobalam, menthol, borneol, artificial cow-bezoar, polyglycol 6000. The item of physicochemical identification in the former quality standard is deleted; the thin layer identification of the borneol and the menthol, the thin layer identification of indigotin or indirubin and cholic acid or deoxycholic acid and the item of mensuration of bilirubin content are revised; the thin layer identification of the myrobalam, the layer identification of the liquorice and the item of the mensuration and detection of glycyrrhizic acid content are added, and the quantitative index of the liquorice content in each pill can not be less than 32 microgrammes, which is calculated according to the glycyrrhizic acid (C42H62O16). The invention improves the controllability of the quality standard of the pharynx-clearing dropping pill and further ensures the internal quality of the product, and the invention has great meaning for promoting the product sale and guaranteeing the medication safeness for the patient.

The present invention relates to a medicine composite with imidazoline acceptor excitation activity, and preparation method of said medicine composite and its application. Said medicine composite contains the extracts of Chinese medicinal materials of prunella spike, gentian root, leonurus, white peony root and licorice. Said medicine composite can be used for preparing the medicines for curing heart failure, arrhythmia, dementia for curing heart failure, arrhythmia, dementia and reducing blood pressure, etc.

The invention provides a method for extracting glycyrrhizic acid and liquorice flavonoid by using a continuous countercurrent ultrasonic extraction machine. The scheme process comprises the following steps of: 1, conveying liquorice subjected to treatment into an extraction pipe of the continuous countercurrent ultrasonic extraction machine through a quantitative feeder and inputting an extracting solvent into the extraction pipe from a dreg-discharging end of the ultrasonic extraction machine; 2, performing countercurrent ultrasonic extraction on the liquorice and the extracting solvent in the extraction pipe at the temperature of between 30 and 60 DEG C and under normal pressure; 3, after countercurrent ultrasonic extraction, discharging the liquorice dreg from a dreg-discharging port of the ultrasonic extraction machine, treating the liquorice dreg, recovering the solvent, and discharging the extracting solution from a liquid-discharging port of the ultrasonic extraction machine; 4, performing dreg liquid separation on the extracting solution and concentrating by using a concentrating tank to obtain a concentrated solution; and 5, performing solid liquid separation on the concentrated solution, drying the obtained solid to obtain a liquorice flavonoid product, adjusting pH value of the separated liquid by using inorganic acid, performing solid liquid separation, drying the separated solid to obtain a glycyrrhizic acid finished product, and concentrating and drying the separated liquid to obtain a mixture of angelica polysaccharide, liquorice flavonoid and glycyrrhizic acid.

The invention provides Gegenqinlian medicine composition. The active ingredients of the composition consists of extractive with the following weight ratio: 40 to 86 parts of kudzuvine root extractive, 35 to 65 parts of baikal skullcap root extractive, 15 to 36 parts of goldthread root extractive, and 10 to 20 parts of licorice root extractive; the main effective parts of the four kinds of extractive respectively have the content that the kudzuvine root extractive contains 40 to 85 percent of total isoflavone of the kudzuvine roots, the baikal skullcap root extractive contains 60 to 90 percent of total flavone of the baikal skullcap roots, the goldthread root extractive contains 50 to 85 percent of total alkaloid of the goldthread roots, and the licorice root extractive contains 12 to 30 percent of glycerrhizic acid; the four kinds of extractive are obtained by respectively extracting each raw material medicine in the traditional formula, namely the Gegenqinlian formula, extracting in different ways according to the properties of the effective parts of the different medicines, and refining. The composition of the invention can be used for preparing preparation for treating bacillary dysentery, acute enteritis, and infantile virus diarrhea.

The invention discloses a method for extracting a liquorice flavoring extract for a cigarette additive from glycyrrhizic-acid produced waste liquid, belonging to a production method of the cigarette additive. The method sequentially comprises the following steps of: (1) neutralization: adjusting the pH value of the glycyrrhizic-acid produced waste liquid to 7-8; (2) primary membrane impurity removal: processing the waste liquid by adopting inorganic ceramic membrane separating equipment with the bore diameter of 30-100 nm and then collecting filter liquid; (3) electro-osmosis desalination: desalinating by utilizing an electro-osmosis device to reduce the conductivity of the filter liquid to 2500-3000 mus / cm; (4) secondary membrane refined concentration: carrying out refined concentration by using a nanofiltration membrane separating device, wherein a membrane element is a nanofiltration membrane with the separating bore diameter of 1-2 nm; and (5) spray drying: carrying out spray drying on the refined concentrate to obtain liquorice flavoring powder for the cigarette additive. The method is scientific and reasonable, is convenient to operate, easy to implement and can obtain the extract with high purity, and thus, the method is suitable for serving as the cigarette additive.

The invention relates to an extraction and preparation method for licorice effective ingredients, mainly to a method for simultaneously extracting effective ingredients like glycyrrhizic acid, glycyrrhiza flavonoid and a licorice flavoring agent from licorice. The method comprises the following steps: with glycyrrhizic acid as a raw material, carrying out extraction so as to obtain licorice residue and extract liquid and subjecting the licorice residue to ethanol extraction so as to obtain a crude glycyrrhiza flavonoid product; removing impurities in the licorice extract liquid by using an ultrafiltration membrane device, carrying out concentration by using a nanofiltration membrane device, subjecting a nanofiltration membrane concentrate to acid precipitation and drying a precipitate so as to obtain glycyrrhizic acid; and subjecting a supernatant produced after acid precipitation to concentration with the nanofiltration membrane device and carrying out drying so as to obtain the licorice flavoring agent. The method adopts membrane separation technology for impurity removal and concentration of the extract liquid, so working conditions are mild, product purity and quality are guaranteed, and yield of licorice effective ingredients is high; the method has the advantages of simple production flow, low cost, small pollution, reusability of a nanofiltration membrane filtrate generated in production process, reduction in consumption of raw water and great decrease of waste water discharge.

The invention provides glycyrrhizic acid removal glycyrrhiza flavonoid for treating a canker disease and a medicament composition thereof. The preparation method comprises the following steps: taking wastewater generated by producing glycyrrhizic acid and waste dregs as raw materials and then carrying out a series of steps like alkalization reaction, separate deacidification, acid-base conversion, macro porous resin absorption and purification and the like. In a prepared sample, the content of the glycyrrhiza flavonoid is high and can maximally reach 98 percent, and the content of the glycyrrhizic acid is very low and is only 0.1-1 percent; and the glycyrrhiza flavonoid is further prepared into various preparations suitable for clinical application. The glycyrrhizic acid removal glycyrrhiza flavonoid and the preparation method thereof adopts the acid-base reaction, conversion and traditional Chinese medicine modern separation and purification technology and has the advantages of novel process, suitable industrialized production and strong practicability.

The invention relates to a method for producing glabridin from glycyrrhiza residue, mainly comprising the following processes of: concentrating the glycyrrhiza residue into syrup after aqueous extraction; carrying out activated carbon adsorption after dissolving in methanol; washing by using hot methanol; adsorbing methanol washing solution by macroporous adsorption resin AB-8; washing by using water and alcohol respectively; collecting and concentrating alcohol washing solution; recrystallizing by using organic solvent with 3-5 times amount; and obtaining the glabridin after drying. The method uses the methanol for dissolving syrupy extracting solution, the activated carbon adsorption method elution can be avoided, and the phenomenon of mixed solvent does not occur, thus avoiding the situations in the existing process for extracting and preparing the glabridin of long synthetic step, high cost, a large number of used organic solvents and not being beneficial to environmental protection, and also effectively simplifying procedures and reducing the production cost; especially by using the residue of the glycyrrhizic acid for extraction, the wastes are changed into valuables, the time is saved and the product content is high. The method can also be applied to extract glabridin directly from glycyrrhiza.

The invention discloses a method for detecting contents of baicalin, forsythin, indirubin and glycyrrhizic acid in Qingreling granules. The method comprises the following steps: pretreating the Qingreling granules to prepare a sample to be detected, and injecting the sample to be detected to a high performance liquid chromatograph for detecting to obtain a high performance liquid chromatogram of the sample to be detected; and calculating the contents of the baicalin, the forsythin, the indirubin and the glycyrrhizic acid in the sample to be detected according to the peak areas of corresponding absorption peaks in the high performance liquid chromatogram of the sample to be detected and a standard curve of each standard sample. The method disclosed by the invention can be used for measuring the components of the baicalin under the content determination items of the Qingreling granules in the first part of Pharmacopoeia of the People's Republic of China published in 2010, and also can be used for additionally measuring the content of the forsythin in fructus forsythiae, the content of the indirubin in folium isatidis and the content of the glycyrrhizic acid in liquorice and greatly improving the quality control standard of the Qingreling granules. Proved through content measurement methodology, the method completely conforms to the specification and is an advanced quality control method. The method can be used for shortening the detection time and reducing the detection cost.

The invention belongs to the technical field of Chinese patent drug, relating to a quality control method for infantile cough syrup as Chinese medicine preparation, which is prepared from Chinese herbal medicines as raw materials, comprising the following steps: with the reference substances of figwort, lilyturf root and Sarsasapogenin, distinguishing whether the prescription of the infantile cough syrup contains the compounds of figwort, lilyturf root and Sarsasapogenin with thin layer chromatography; and with the reference substance of mono-ammonium glycyrrhizinate, detecting the content of glycyrrhizic acid in the prescription of the infantile cough syrup with high performance liquid chromatography; therefore, the quality standard is relatively perfect, and the quality control of the medicine is improved due to the amended quality standard.

A quality control method for the Chinese medicine í‹Calming oral liquidíŒ features that a thin-layer chromatography is used for identification to white atractylodes rhizome, fleece flower stem and hairyvien agrimonia herb, and an efficient liquid-phase chromatography is used to measure the content of glycyrrhizic acid.

The invention discloses a honey-fried licorice root formula particle and preparation and quality control methods thereof. The formula particle uses honey-fried licorice root decoction pieces as raw materials, and the decoction pieces are processed by the technological processes of twice water extraction, vaccum concentration, sponging drying and the like to gain the honey-fried licorice root formula particle; and one gram of honey-fried licorice root formula particle is equivalent to 3 to 5 grams of crude medicines, the content of glycyrrhizic acid in the formula particle is not lower than 2.0 percent, and the quality of the honey-fried licorice root decoction pieces and the honey-fried licorice root formula particle is respectively discriminated by the infrared fingerprint spectra. The honey-fried licorice root formula particle of the invention has the advantages of integrated and advanced production process, specific and controllable quality control standard and advanced and realizable process, and a test method related to the quality standard is scientific, advanced, fast and highly operable. Proved by a lot of experiments, the ingredient of a herbal decoction prepared by the honey-fried licorice root formula particle of the invention is equivalent to the ingredient of the mixed simmer liquid of the honey-fried licorice root contained classical formula, the full ingredient formula particle process is achieved, and the process of the invention is proved to be reasonable; and the invention applies the infrared spectroscopy technology to the quality control of the traditional Chinese medicines, thereby fast solving the principal problem of traditional Chinese medicine truth discrimination in the macroscopic quality control of the traditional Chinese medicines.

Glycyrrhizic acid double salt and its pharmaceutics are prepared from start materials of glycyrrhizic acid to (sophocarpidine ) matrine with weight ratio of 1 to 1-10 by: putting raw materials into organic solvent with weight ratio of 1 to 10- 100 , reflux heating at 25-80deg.C for 1-5 hours , recovering organic solvent , then drying the solid resultant to get the products. Solvent is alcohol or methanol or acetone. This pharmaceutics can be used in therapy of acute or chronic hepatitis, virus hepatitis and hepatic injury.

Substance mixtures are proposed, comprising(a) terpenes,(b) propane-1,3-diol, and optionally(c) active substances selected from the group consisting of(c1) rebaudiosides or plant extracts comprising them,(c2) steviosides or plant extracts comprising them,(c3) monatin,(c4) naringin,(c5) chalcones and hydrochalcones,(c6) mogrosides or plant extracts comprising them,(c7) rubusosides or plant extracts comprising them, and(c8) glycyrrhizic acid or plant extracts comprising it.

The invention relates to a method for determining the contents of morphine and glycyrrhizic acid in a compound liquorice tablet in the field of analysis. The method comprises the following chromatographic conditions: a chromatographic column is a C18 column utilizing octadecylsilane chemically bonded silica as a filling agent, and the particle size is 5 microns; the column temperature is 30-40 DEG C; the flow speed is 1.3ml / min-1.7ml / min; the detection wavelengths are 210nm and 250nm; the sample feeding amount is 10-25 microliters; and flow phases are a phosphate buffer solution and ethanol. The method is used for detecting the contents of morphine and glycyrrhizic acid in the compound liquorice tablet by virtue of an HPLC method and has the advantages that a reagent is easily available, the operation is simple and convenient, the time is short, the precision is high, the detection cost is low, and the like.

The invention discloses a using method of a potato bacterial wilt-resistant drug. The using method comprises the following steps: A, preparing a stock solution comprising the following components: streptomycin sulfate, a 25% cuaminosulfate aqueous solution, a 2% formalin solution, licorice acid, chlorogenic acid, polyoxin, radix ampelopsis and dried orange peel; B, cultivating potatoes: selecting disease-free seed potatoes, soaking the seed potatoes for 1.5-2 hours by using 400-fold stock solution in a volume ratio, taking out and rinsing the seed potatoes with clear water, and planting, wherein when the seed potatoes are cut into blocks, a cutter is soaked and sterilized by 75% alcohol; C, in case of the bacterial wilt, adding water to dilute the stock solution to 600 folds for spraying potato plants; D, adding water to dilute the stock solution to 500 folds for irrigating roots at the same time of spraying in the step C. The using method is simple; used components are simple in mixture ratio; the using method is convenient; through the adoption of the method, a good effect of treating the bacterial wilt of the potatoes can be achieved.

The invention discloses a quality control method of Sijunzi (Chinese name) decoction. The content of ginsenoside Rg1, ginsenoside Re, ginsenoside Rb1 and glycyrrhizic acid is measured at the same time by the high performance liquid chromatography; the content measurement method of the four ingredients comprises the following steps of: preparation of a reference solution, preparation of a test solution and content measurement, wherein the ginsenoside Re, the ginsenoside Rg1, the ginsenoside Rb1, and glycyrrhizic acid in the ammonium glycyrrhetate content in set values respectively are 12.0mg, 10.0mg, 18.0mg and 28.0mg. The quality standard is simple, and the quality of a drug can be better controlled. The quality control method disclosed by the invention is strong in specificity and good in reproducibility, so that the security, effectiveness and quality control of the drug are really reflected.

The invention discloses an extraction method for increasing content of glycyrrhizic acid in leftover materials of liquorice. The method is characterized by comprising process steps as follows: 1) the leftover materials of the liquorice are prepared; 2) two times of extraction solutions are mixed; 3) acid precipitate is subjected to suction filtration; 4) coarse glycyrrhizic acid powder is washed; 5) the coarse glycyrrhizic acid powder is purified; 6) a glycyrrhizic acid eluent is prepared. According to the method, glycyrrhizic acid is not refined with a macro-porous adsorption resin method, glycyrrhizic acid in the liquorice can be extracted and refined efficiently, the process is simple, the cost is low, and the leftover materials of the liquorice can be utilized reasonably.

The invention discloses a traditional Chinese medicinal composition of poria and coix seeds and a quality control method of the traditional Chinese medicinal composition. Specifically, the invention relates to the method for implementing quality control on poria and coix seed particles, wherein the method comprises an operation of conducting content determination on glycyrrhizic acid by virtue of an HPLC method; the poria and coix seed particles consist of the following medicinal raw materials: 400 parts by weight of the poria, 400 parts by weight of dioscorea opposita, 300 parts by weight of fried semen lablab album, 200 parts by weight of semen nelumbinis, 200 parts by weight of the coix seeds which are stir-baked with bran, 200 parts by weight of fructus amomi, 200 parts by weight of radix platycodonis and 400 parts by weight of radix glycyrrhizae; and the poria and coix seed particles are prepared in accordance with a method as prescribed within the Direction. The particles provided by the invention are excellent in clinical curative effect; and an excellent technical effect, as prescribed within the Direction, can be achieved.

The invention relates to the field of bath supplies, in particular to licorice root extract-containing shower gel for adults. The licorice root extract-containing shower gel for the adults is preparedfrom the following components in parts by weight: 7-14 parts of sodium laureth sulfate, 2-7 parts of betaine type zwitterionic surfactant, 1-5 parts of N-acyl sarcosinate, 0.3-6 parts of alkyl glycoside, 1-5 parts of coconut acid methyl monoethanol amide, 0.6-3 parts of trehalose fatty acid ester, 0.1-5 parts of hydrolyzed corn starch, 0.5-2 parts of licorice root extract, 0.1-2 parts of dipotassium glycyrrhizinate, 0.1-8 parts of polyol moisturizing agent, 0.1-0.5 part of bactericide, 0.1-2 parts of viscosity modifier, 0-0.1 part of essence and 55-75 parts of purified water.

Disclosed is use of glycyrrhetinic acid or glycyrrhizic acid in preventing or treating radiation injury of soft tissue. Therefore, glycyrrhetinic acid or glycyrrhizic acid can be used for preparing medicaments for preventing or treating radiation injury of soft tissue. The medicament prepared from glycyrrhetinic acid or glycyrrhizic acid has advantages of low cost, good curative effect, low toxicity and side effect during administration in long term and so on. Glycyrrhetinic acid or glycyrrhizic acid can also be used for preparing health care products, foods or food additives for preventing or treating radiation injury of soft tissue.

The invention discloses a method for measuring paeoniflorin, hesperidin and glycyrrhizic acid in stomach-nourishing granules. The method comprises the following steps: pretreating the stomach-nourishing granules into a sample to be measured, injecting the sample to be measured into a high performance liquid chromatograph for testing to obtain a high performance liquid chromatography spectrogram of the sample to be measured, and calculating the contents of paeoniflorin, hesperidin and glycyrrhizic acid in the sample to be measured according to the peak area of the corresponding absorption peak in the high performance liquid chromatography spectrogram of the sample to be measured and the standard curve of each standard substance. According to the method, the components of paeoniflorin under the stomach-nourishing granule content determination item in version 1 in pharmacopoeia of the people's republic of China in 2010 are measured, the content of hesperidin in dried tangerine or orange peel and glycyrrhizic acid content in liquorice are measured, the quality control standard of the stomach-nourishing granules is greatly improved, the content determination methodology validation of the method completely accords with the provision, and the method is an advanced quality control method; and moreover, the time and detection cost can be saved, and the product quality can be effectively controlled.

The invention discloses a making method of liquorice and dark plum ginger, belonging to the field of food processing. The making method is characterized in that raw materials include 50kg of fresh and tender ginger slices, 8kg of dark plum juice, 20kg of saccharose, 80g of albumen syrup, 3kg of liquorice powder, 15g of sodium benzoate and 100g of jasmine powder. The making method comprises the process flows of treating the raw materials; sugaring; baking; and packaging. The making method has the beneficial effects that the liquorice and dark plum ginger is semitransparent, strong in ginger smell, elastic, tough and proper in sweetness and sourness and has the unique flavor of ginger as well as the sourness and sweetness of the dark plums. The liquorice and dark plum ginger is capable of irritating gastrointestinal mucus membranes, promoting the secretion of saliva, gastric juice and digestive juice, enhancing gastrointestinal peristalsis and taking the effects of appetizing and tonifying the spleen because of being rich in unique gingerol and also has the effects of relieving summer heat and refreshing, resisting to oxidation and inhibiting tumor. The making method is simple in operation and convenient to use; and the liquorice and dark plum ginger is a nutritive and health delicious food.