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A pueraria root scutellaria and coptis medicinal composition

A technology of pueraria chinensis and a composition, which is applied in the field of pueraria chinensis pharmaceutical compositions, can solve the problems of difficult quality control, low content of active ingredients, many impurities, etc., and achieves the effects of easy quality control and stable curative effect.

Inactive Publication Date: 2008-04-09
SOUTHERN MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The 2005 edition of the Pharmacopoeia recorded the preparations of this prescription as Gegenqinlian Tablets and Pellets, but these preparations are directly made from raw medicinal powder or crude extracts and extracts of medicinal materials, the extraction process is simple, and the content of each active ingredient in the prescription is low. , the quality is difficult to control, and the curative effect cannot be guaranteed to be stable
Using this method to prepare Gegen Qinlian Decoction, the transfer rate of puerarin, baicalin and berberine in the medicinal materials can reach more than 65%, but this method still adopts the crude extraction method for the medicinal materials, and the obtained extract contains more impurities

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0074] Example 1 (granules)

[0075] Take 1000g of kudzu root, add 6 times the amount of water to decoct for 0.5h, filter, then add 4 times the amount of water to decoct for 0.5h, filter, combine the two filtrates, concentrate to 0.1g medicinal materials / ml, and the specific adsorption capacity is 1.0g / ml (medicinal material weight / resin volume) passes through the D-101 macroporous resin column, that is, fill the column with 1Kg macroporous resin. First elute with 3 times column volume of deionized water, then 30% ethanol solution with 3 times column volume, collect the eluate, remove the solvent under reduced pressure, and dry to obtain the Pueraria root extract, which contains 58% of the total isotropic flavonoids. Take 375g of Scutellaria baicalensis, add 6 times the amount of water to decoct for 1 hour, filter, then add 4 times the amount of water to decoct for 1 hour, filter, combine the two filtrates, dilute the filtrate to 0.04g medicinal materials / ml, and the specifi...

example 2

[0077] Example 2 (capsules)

[0078]Take 1000g of kudzu root, add 12 times the amount of 95% ethanol for reflux extraction for 1 hour, filter, then add 10 times the amount of 95% ethanol for reflux extraction for 1 hour, filter, combine the two filtrates, recover the solvent under reduced pressure, and obtain a liquid extract, dilute with water To a certain concentration, add 2.5 times the volume of ethyl acetate to extract twice, collect the upper layer extract, recover the solvent under reduced pressure, and dry to obtain the Pueraria root extract, which contains 40% of Puerariae total isoflavones. Take 375g of Scutellaria baicalensis powder, reflux extraction with 6 times and 4 times the amount of 60% ethanol twice, each time for 2 hours, filter, and recover the ethanol from the filtrate under reduced pressure, make up distilled water to 15 times the amount of the medicinal material, add dilute hydrochloric acid to adjust the pH to 1-2 , adjust the pH to 1.5-2 at 70°C, keep...

example 3

[0080] Example 3 (pills)

[0081] Take 1000g of kudzu root, add 10 times the amount of 40% ethanol for ultrasonic extraction for 2.0 hours, filter, then add 8 times the amount of 40% ethanol for ultrasonic extraction for 2.0 hours, filter, combine the two filtrates, recover the solvent under reduced pressure, and obtain a liquid extract. Add water to dilute to a certain concentration, add 2.5 times the volume of ethyl acetate to extract twice, collect the upper layer extract, recover the solvent under reduced pressure, and dry to obtain the Pueraria root extract, which contains 53% of Pueraria root total isoflavones. Take 375g of Scutellaria baicalensis, crush it into a coarse powder, add an equal amount of 95% ethanol to infiltrate for 2 hours, put it in a percolation cylinder, continue to add 2 times the amount of 95% ethanol, cover it and let it stand for 24 hours, collect the initial filtration liquid, continue to add 3 times the volume of 95% ethanol to infiltrate Drain, ...

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PUM

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Abstract

The invention provides Gegenqinlian medicine composition. The active ingredients of the composition consists of extractive with the following weight ratio: 40 to 86 parts of kudzuvine root extractive, 35 to 65 parts of baikal skullcap root extractive, 15 to 36 parts of goldthread root extractive, and 10 to 20 parts of licorice root extractive; the main effective parts of the four kinds of extractive respectively have the content that the kudzuvine root extractive contains 40 to 85 percent of total isoflavone of the kudzuvine roots, the baikal skullcap root extractive contains 60 to 90 percent of total flavone of the baikal skullcap roots, the goldthread root extractive contains 50 to 85 percent of total alkaloid of the goldthread roots, and the licorice root extractive contains 12 to 30 percent of glycerrhizic acid; the four kinds of extractive are obtained by respectively extracting each raw material medicine in the traditional formula, namely the Gegenqinlian formula, extracting in different ways according to the properties of the effective parts of the different medicines, and refining. The composition of the invention can be used for preparing preparation for treating bacillary dysentery, acute enteritis, and infantile virus diarrhea.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine, in particular to a traditional Chinese medicine composition, especially a Pueraria chinensis medicinal composition. Background technique [0002] Gegen Qinlian Decoction comes from "Treatise on Febrile Diseases·Taiyang Chapter". It is a famous prescription of medical sage Zhang Zhongjing. It has good curative effect on treating bacillary dysentery, acute enteritis and viral diarrhea in children. The 2005 edition of the Pharmacopoeia recorded the preparations of this prescription as Gegenqinlian Tablets and Pellets, but these preparations are directly made from raw medicinal powder or crude extracts and extracts of medicinal materials, the extraction process is simple, and the content of each active ingredient in the prescription is low. , the quality is difficult to control, and the curative effect cannot be guaranteed to be stable. [0003] On October 25, 2006, the State Intellectua...

Claims

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Application Information

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IPC IPC(8): A61K36/718A61K9/14A61K9/16A61K9/20A61K9/48A61P1/12
CPCY02A50/30
Inventor 罗佳波谭晓梅
Owner SOUTHERN MEDICAL UNIVERSITY
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