590 results about "Specific adsorption" patented technology

The invention relates to a composite fiber. The composite fiber comprises a fiber carrier, and a graphene aerogel layer covering the outer side of the fiber carrier. According to the composite fiber provided by the invention, the relatively thin graphene aerogel layer covers the surface of the composite fiber, and a self surface shielding effect of existing graphene aerogel is overcome; the adsorption speed and adsorption efficiency of the graphene aerogel of the unit volume are improved; the fiber carrier of the composite fiber provided by the invention provides a bracket for the graphene aerogel and the mechanical strength is enhanced; when the composite fiber is used as an adsorption material, the composite fiber can be in seamless butt joint with an existing cigarette production process directly, and replaces an existing adsorption fiber so that the specific adsorption on benzopyrene polycyclic aromatic hydrocarbon type harmful substances can be realized; and meanwhile, other aromatic substances in smoke are kept so that the flavor and aroma of cigarettes are not influenced.

A new method is described to produce large volumes of low cost sterile, Water-for-Injection (WFI) grade water on-line, on-demand from potable water in order to meet the needs of dialysis therapies and other biological applications for sterile, injectable grade water. The source water is processed by a combination of membrane and column chromatographic methods including reverse osmosis, chemical sterilization, reduction of iodine sterilant to iodide, deionization, endotoxin-specific adsorption and polishing filtration in order to reduce contaminant levels below those specified by the US Pharmacopoeia.

The invention provides high sensitivity bioassay sensor systems in which non-specific adsorption of impurities such as, for example, proteins, in biological samples is inhibited. Polyethylene glycolated particles enclosing metal or semi-conductor which is in common with the sensor material are used for amplification.

The invention provides a corrosion inhibitor for inhibiting corrosion of magnesium alloy in automobile cooling liquid. The corrosion inhibitor consists of specific adsorption organic substance or / and film-forming inorganic substance, and water or / and ethanol. The corrosion inhibitor is a compound efficient anti-scale corrosion inhibitor, can well inhibit the corrosion of a magnesium alloy material in the cooling liquid in a wider temperature range, and has the characteristics of wide application range, low using amount, high efficiency, no toxicity or peculiar smell, full water dissolution, simple and convenient preparation, low cost, wide applicable temperature range, strong synergistic effect, convenient use, good comprehensive performance and the like. 100 to 1,000ppm corrosion inhibitor directly added into the automobile cooling liquid can inhibit the corrosion of the magnesium alloy, effectively inhibit the corrosion of the magnesium alloy material in the automobile cooling liquid at a normal temperature and a high temperature, and effectively protect the magnesium alloy.

A substrate surface on which either a substance to detect analyte or an analyte per se is immobilized, which surface is formed by a treatment of substrate surface with a liquid which contains uncrosslinked polymer based on polyethylene glycol chain segment, said treatment conducted either simultaneously with the immobilization of said substance or analyte or after said substance or analyte has been immobilized on said surface. The non-specific adsorption of impurity protein or the like which is co-existent in sample for assay is significantly restrained.

The invention relates to an endotoxin adsorbent, which in detail relates to a method of preparing endotoxin adsorbent for blood perfusion. The method employs spherical agarose gel with good biocompatibility as base material, employs epichlorohydrin, hexamethylene diamine, 1, 1'-carbonyldiimidazole as activating agent, and bonds polymyxin B for endotoxin removal. The invention is characterized in that it overcomes the toxicity of cyanogen bromide and instability of aglycone, improves the safty and reliability of operation, reducesnon-specific adsorption through bonding polymyxin B with 1, 1'-carbonyldiimidazole, and improves biocompatibility of adsorbent and suits for treating endotoxemia. The invention is also characterized by simple experimental procedure and high clearance for endotoxin.

The invention provides a preparation method for a print adsorbent of chitosan molecules, which relates to a preparation method for an adsorbent that can selectively remove perfluorooctane sulfonate (PFOS) in water. The preparation method adopts a molecular imprinting technique to construct a plurality of specific adsorption sites and the worthy adsorbent has remarkable selectivity adsorption to the PFOS in water. The method takes chitosan as raw material to prepare micro-cross linking chitosan beads; then the chitosan beads are printed with template molecules PFOS for 5 to 24 hours in an acid water solution, a mass ratio between the template molecules and the micro-cross linking chitosan beads is 0.005 to 0.06: 1, and reaction with a cross linker is carried out for 2 to12 hours after printing; the mass ratio between the volume of the cross linker and the micro-cross linking chitosan beads after being printed is 0.0125 to 0.119ml / g; finally, an organic solvent is used for eluting for 1 to 8 hours and the print adsorbent of chitosan molecules is obtained after freeze-drying. The adsorbent is suitable for adsorbing and removing PFOS in complicated water substances and is characterized by strong selectivity and being able to be reused.

The invention discloses a method for preparing a bisphenol A molecularly imprinted polymer. The method comprises the following steps of: adding bisphenol A, a functional monomer and porogen into a conical flask to ensure that the bisphenol A and the functional monomer are fully reacted, wherein the functional monomer is 2- vinylpyridine, and alpha-methacrylic acid, the porogen is chloroform and methylbenzene, the polarity of the chloroform and methylbenzene is low, and hydrogen bonds are not easily formed; adding initiator and a cross-linking agent, fully mixing and performing ultrasonic processing, introducing nitrogen to remove dissolved oxygen, and transferring into a thermostat water bath in a sealing state and performing thermal polymerization; and after reaction, taking out the obtained product, cooling to room temperature to obtain colloidal polymer, screening the colloidal polymer by using a 200-mesh molecular sieve, performing Soxhlet extraction by using acetic acid-methanol, washing the extract by using methanol, and drying under vacuum to obtain the bisphenol A molecularly imprinted polymer. The prepared bisphenol A molecularly imprinted polymer has the characteristics of specific adsorption to specific organic pollutant bisphenol A in industrial wastewater, high selectivity on a sample and high speed, accuracy and efficiency in enrichment and purification.

The present invention relates to a targeted magnetic nanoparticle drug and the preparation method thereof. The targeted magnetic nanoparticle drug comprises an effector molecule and a guidance molecule in a weight ratio of 1:0.0001-0.20. The aforesaid effector molecule is a magnetic particle, with a particle size of not more than 1000 nm and a specific adsorption rate (SAR) of 10-7000 W / gFe. The aforesaid guidance molecule comprises an antibody, a ligand or a magnetic particle. The particle size of the aforesaid targeted drug is 2-1000 nm. The targeted magnetic nanoparticle drug is prepared by coupling a magnetic particle and a guidance molecule in a weight ratio of 1:0.0001-0.20 in water, organic or inorganic substance or the mixed solution thereof. The resultant targeted magnetic nanoparticle drug can realize targeted magnetic hyperthermia treatment and targeted magnetic thermoablation treatment and prevention on the tumors, and effectively kill the cancer cells, and cure the malignant tumors.

The invention discloses a surface plasmon resonance and bio-sensing-based water chip. A light source, a beam expanding lens, a polarizer, an isosceles right-angle prism, a quarter wave plate, a polarization analyzer, an imaging lens and a planar array CCD are arranged in turn along the light direction, wherein the hypotenuse surface of the isosceles right-angle prism is plated with a gold film; biological modification is performed on the gold film so as to form a bio-sensitive film subjected to specific adsorption with impurities in aqueous solution to be detected; the refractive index change of the impurities to the aqueous solution to be detected is converted into light intensity change of reflected light; and the refractive index change is detected by using the SPR effect on the interface between the gold film and the isosceles right-angle prism so as to detect the concentration of substances in the solution. When the water chip is used, the concentration of various substances in the water can be detected at one time, a light path and a mechanical structure are simplified and the water detection efficiency is improved.

The invented corrosion inhibitor includes following percentages (weight) of constituent; rosin amine 10-40%, element acid 5-30%, thiourea and ramification of thiourea 5-30% and solvent 10-50%. According to molecular design method, the corrosion inhibitor is prepared by adopting macromolecular compounds, small molecule compounds and negative ions with specific adsorption. Thus, the inhibitor restrains the corrosion of pipeline made of carbon steels in wider temperature region and the environment containing CO2, no matter the surface of the pipeline is clean or covered by the film of corrosion product. The invention corrosion inhibitor provides the features of wide suitable area, small use level, high efficiency, easy to produce, avirulence and non-peculiar smell as well as complete water-solubility.

A PSA or VSA process for separating a gas flow, such as air, containing at least one first gas compound, such as nitrogen, which is preferentially adsorbed on at least one adsorbent, and at least one second gas compound, such as oxygen, which is adsorbed less preferentially on at least the one adsorbent than the first gas compound. The adsorbent used comprises particles of faujasite zeolite having a Si / Al ratio <1.5, such as a LSX zeolite, and containing 80 to 99% Li+ cations, 0.01 to 25% Na+ cations, 0.01% to 10% Mg2 cations, 0.01% to 10% Ca2+ cations and 0 to 3% K+ cations.

A new method is described to produce large volumes of low cost sterile, Water-for-Injection (WFI) grade water on-line, on-demand from potable water in order to meet the needs of dialysis therapies and other biological applications for sterile, injectable grade water. The source water is processed by a combination of membrane and column chromatographic methods including reverse osmosis, chemical sterilization, reduction of iodine sterilant to iodide, deionization, endotoxin-specific adsorption and polishing filtration in order to reduce contaminant levels below those specified by the US Pharmacopoeia.

The invention discloses a blood heavy metal ion adsorbent. With magnetic nano materials being carriers, the surfaces of the carriers are wrapped with ligand active groups in a modification mode, wherein the ligand active groups are capable of being combined with heavy metal ions and coordination compounds. The magnetic nano materials are magnetic iron-based compounds MFe2O4, wherein M is Fe2+ or Co2+ or Ni2+ or Zn2+ or Mg2+. The ligand active groups are one or more of -NH2, -SH2, -COOH and -OH. The invention further provides a preparation method of the blood heavy metal ion adsorbent and a blood perfusion device made from the blood heavy metal ion adsorbent. The surfaces of the magnetic nano-particles are modified, so that the blood heavy metal ion adsorbent is obtained and used for performing efficient selective or specific adsorption on one kind of heavy metal, it is avoided that because non-specific adsorption is performed on microelements in blood, the protein denatures and becomes inactive, and influences on the blood by the adsorbent and the risk of organism systematic complications are greatly reduced.

The invention relates to a fiber surface plasmon resonance glucose sensor with temperature self-compensation. The fiber surface plasmon resonance glucose sensor comprises a fiber core; a fiber cladding wraps the periphery of the fiber core; a fiber grating is written in a 10-30mm section of the fiber core; and a chromium layer, a gold film and a glucose molecule specific adsorption layer are arranged on the periphery of a 15-30mm section of the fiber cladding from inside to outside. Fiber is single mode fiber; the fiber grating is a long-period fiber grating or a tilted fiber grating; the thickness of the chromium layer is 3-5 nm; and the thickness of the gold film is 30-60 nm. The fiber surface plasmon resonance glucose sensor has the advantages of simple structure, small volume, anti-electromagnetic interference and corrosion resistance, can be easily combined with a tissue fluid transdermal extraction chip so as to manufacture a miniaturized instrument, and meanwhile, is suitable for implanted measurement. With the adoption of the fiber surface plasmon resonance glucose sensor with temperature self-compensation, the measurement errors arising from temperature and the interference on measurement caused by external environments can be reduced.

The present invention discloses a silica surface molecularly imprinted polymer with specific adsorption of DEHP and a preparation method and application thereof. The imprinted polymer is subjected to by activation treatment silica surface; KH-550 is used for aminated graft on the silica gel surface to obtain aminated silica gel; acrylic acid chloride with aminated silica gel are subjected to an acylation reaction for double bond modification of the silica gel; then AIBN as initiator is used for polymerization of a so that template molecule DEHP with functional monomer and a crosslinking agent on the double bond modified silica surface; and the template molecules are eluted. The present invention uses a two-step reaction for silica surface modification, and overcomes self-polymerization of silane coupling agent in the process, so that the silica surface is uniformly grafted with structure containing C=C; the method is in favor of synthesis of molecularly imprinted polymers on the silica surface, so the molecularly imprinted polymer can be evenly and firmly coat on the silica surface to improve its stability, and can be reused when used as a solid-phase extraction agent.

The invention discloses a method for preparing a magnetic molecularly-imprinted adsorbent and belongs to the technical field of preparation of environment-friendly functional materials. The method comprises the following steps of dispersing nanometer chitosan particles serving as stable particles in a solution as a water phase; mixing toluene serving as an oil-phase solvent and a pore-forming agent, methyl methacrylate serving as a functional monomer, ethylene glycol di(methacrylate) serving as a crosslinking agent, 2,2'-azobisisobutyronitrile serving as an initiator and magnetic carrier oil acid-modified nanometer ferriferrous oxide and molecularly-imprinted erythromycin to obtain a mixture serving as an oil phase; mixing the oil phase and the water phase to form a stable Pickering emulsion, preparing magnetically imprinted polymer microspheres by virtue of heat-induced reaction and applying the magnetically imprinted polymer microspheres in the adsorption and separation of erythromycin in an aqueous solution. The product has the imprinted hole and magnetic characteristics and is conducive to specific adsorption of target molecules, the magnetic carrier is conducive to the separation of the adsorbent and internal imprints can prevent the automatic falling and magnetic flux leakage of the target molecules after the target molecules are adsorbed and a better absorption effect is achieved.

The invention provides a method for detecting SERS of aflatoxin B1 molecules based on molecularly imprinted polymer coated gold core-shell nanoparticles, and relates to surface reinforced raman detection. According to the method, core-shell nano-particles taking gold nanoparticles as a core and molecularly imprinted polymer as a shell are synthesized by coating aflatoxin B1 molecularly imprinted polymer around the gold nanoparticles; the hole in the molecularly imprinted polymer can be used for specifically capturing the aflatoxin B1 molecules after template molecules in the molecularly imprinted polymer of the shell layer are eluted, and surface reinforced raman detection of aflatoxin B1 molecules can be realized since the aflatoxin B1 molecules are in an effective range of a gold nanoparticle plasma resonant magnetic field; and the molecularly imprinted polymer is obtained by eluting the molecularly imprinted shell layer prepared by using the aflatoxin B1 molecules as template molecules, and has highly specific adsorption for aflatoxin B1, and can be used as a SERS substrate for quantitative detection of aflatoxin B1. The method has the characteristics of high specificity and short sample analyzing time.

The invention relates to an artemisinin molecule imprinting polymer on the surface of porous microsphere silica gel. The artemisinin molecule imprinting polymer is prepared by adopting the steps of: selecting the porous microsphere silica gel as a basal material, taking vinyl triethoxysilane as a coupling agent, artemisinin as a template molecule, methacrylate and acrylamide as functional monomers, ethylene glycol dimethacrylate as a cross-linking agent and azodiisobutyronitrile as an initiating agent, preparing a polymer and removing the artemisinin in the polymer. The invention also provides a preparation method and an application method of the artemisinin molecule imprinting polymer on the surface of the porous microsphere silica gel. The artemisinin molecule imprinting polymer on the surface of the porous microsphere silica gel can separate the artemisinin from other structural analogues, such as artemether, and the like under normal pressure and temperature and supercritical conditions, is especially suitable for supercritical conditions and has specific adsorption property, selectivity and favorable mechanical stability; and the preparation method is simple, convenient and suitable for large-scale popularization and application.

The invention provides a membrane assisted separation of glycoprotein all N-linked carbohydrate chain and an identification method thereof, and solves problems of low reaction efficiency and identification of few types of carbohydrates in prior art. According to the invention, a molecular sieve effect of a membrane of 8-12KD is employed to separate carbohydrate chain released from glycoprotein from protein; on a molecular sieve of 10KD, an N-linked carbohydrate chain of the glycoprotein is released by a PNGase F enzyme; the N-linked carbohydrate chain flows out through repeated centrifugation, but the protein is retained on the membrane, thereby realizing separation of the carbohydrate chain. The method has obvious carbohydrate chain separation effect, and avoids by-products caused by non-specific adsorption and chemical reactions; besides, the method has high reaction efficiency and concise reaction steps.

The invention discloses a preparation method of a magnetic molecularly imprinted polymer for separating / purifying sudan I. The preparation method comprises the following steps of: dissolving the sudan I and methacrylic into acetonitrile; adding a cross-linking agent, an initiator and acetonitrile-based magnetic fluid; reacting in the absence of oxygen; separating microspheres generated by the reaction; and eluting the sudan I in the microspheres by adopting soxhlet extraction and drying. According to the preparation method disclosed by the invention, the magnetic fluid is added into the imprinted polymer; in the process of adsorbing and extracting a template molecule, the imprinted polymer can be directly added into a measured substance solution for adsorbing without being filled in a solid phase extraction column, and then imprinted polymer granules are gathered and separated by using a strong magnetic filed; and meanwhile, the imprinted polymer retains specific adsorption of the template molecule to the sudan, and thereby quick detection and analysis of the template molecule are realized.

The present invention is related to a recovery and purification method of (a) biological(s) of interest produced by cells retained in a bioreactor under appropriate conditions and by appropriate means for producing the biological(s) inside the bioreactor having a volume higher than 1,5 l culture, and cultivated at a high cell density, preferably at a cell density higher than 10x10<6 >cells / ml, said bioreactor being submitted to an acoustic sonoperfusion allowing the recovery of a sonoperfused medium from said bioreactor, characterised in that it is submitted thereafter directly to an Expanded Bed Specific Adsorption for the direct recovery and uninterrupted purification of said biological(s). The present invention is also related to a process unit for recovering and purifying said biological(s) of interest.

The invention discloses a detection method for trace protein of a Chinese medicinal injection, which is used for detecting the protein impurities of the Chinese medicinal injection so as to control the quality of the Chinese medicinal injection. The detection method is characterized by comprising the following steps of: 1) applying a Chinese medicinal injection sample on a protein specific adsorption film; 2) washing the sample application film with organic solvent-containing solution to wash away the natural color of dots of the Chinese medicinal injection; and 3) subsequently performing coomassie brilliant blue staining on the sample application film. If the protein contained in the Chinese medicinal injection is no less than 12mu g / ml, stable and differentiable blue can be displayed on the film. The detection sensitivity of the method is higher than that of a sulfosalicylic acid precipitation method, and the detection method has high anti-interference capacity and is suitable for the detection of the trace protein of all the Chinese medicinal injections.

The invention discloses a method for preparing aerogel with beta-cyclodextrin polymers. The method includes sequentially adding secondarily re-crystallized beta-cyclodextrin, polyethylene glycol and epichlorohydrin into sodium hydroxide solution and carrying out stirring reaction until hydrogel is formed; carrying out cold storage and soaking treatment on the hydrogel; carrying out freezing and freeze-drying treatment on the hydrogel to obtain the aerogel. The method has the advantages that processes are flexible, simple and convenient and are low in cost and short in gelation time; the polyethylene glycol is used as a soft-segment polymer, accordingly, the properties of the aerogel with the beta-cyclodextrin polymers further can be regulated and controlled, the apparent density of the aerogel prepared by the aid of the method can be regulated and controlled in the range of 0.1-0.7 g / cm<3>, and the aerogel is of a stable gel skeleton structure; the aerogel is high in porosity and has large specific surface areas and basic three-dimensional network structures, the catalytic, recognition, inclusion and sustained-release capacity of cyclodextrin can be kept, and the aerogel has specific adsorption capacity for aromatic organic matters such as toluene and aniline.

The invention provides a Cu<2+> chemical sensor, and a preparation method and application thereof. Based on an MOF nanomaterial, the invention combines with a Cu<2+> fluorescent probe to further prepare a Cu<2+> chemical sensor. The MOF nanomaterial ZIF-8 not only has specific adsorption capacity on Cu<2+>, but also has high porosity, high specific surface area, transition metal as center, chemical stability, regular structure, and diversified frame structure. A novel Cu<2+> sensor and fluorescent probe show good linear relationship with Cu<2+> ions, and the detection limit is 8.3*10<-9>mol / L and 5.2*10<-8>mol / L. The novel Cu<2+> sensor obtained by the present invention has a lower detection limit based on the original probe, and can be used for quantitative detection of Cu<2+> concentration the water.

The invention discloses a nano cuprous sulfide modified monolithic column material and a preparation method thereof. First a hybrid monolithic column skeleton is synthesized, certain thickness of cuprous oxide nanocubes are physically adsorbed on the surface, more stable cuprous sulfide can be obtained by processing with a sodium sulfide solution, and then a nano cuprous sulfide modified monolithic column can be obtained. The monolithic column prepared by the method has the characteristics of easy manufacture and high permeability of a conventional monolithic column, by introduction of nano cuprous sulfide, specific adsorption sites can be provided, and the nano cuprous sulfide has a strong adsorption effect on carboxyl, amino and nitrogen heterocyclic structures, and significantly improves the material specific surface area. The material is prepared into a capillary solid-phase extraction column to achieve high capacity concentration of kanamycin sulfate in milk in alkaline conditions.

The invention provides a soil conditioner and a preparation method thereof. The soil conditioner comprises, by weight, 12 to 20 parts of plant ash, 5 to 10 parts of phosphorous slag, 5 to 9 parts of quicklime, 2 to 5 parts of zeolite, 2 to 5 parts of attapulgite, 1 to 3 parts of Yilong seaweed ooze, 2 to 5 parts of Chinese magnoliavine residues, 2 to 5 parts of large-flowered skullcap root residues, 20 to 30 parts of straw, 8 to 13 parts of hickory nut shells, 0.02 to 0.04 part of rotenone, 10 to 15 parts of mangosteen shells, 3 to 5 parts of an EM microbial agent, 7 to 20 parts of urea phosphate, 8 to 14 parts of urea, 10 to 15 parts of biochemical potassium fulvate and 9 to 12 parts of gamma-polyglutamic acid. The invention has the beneficial effects that the soil conditioner has high porosity and has specific adsorption effect on heavy metal ions; the soil conditioner can adjust the pH value of soil, is rich in trace elements and can elemental N, elemental P and elemental K at the same time; and the soil conditioner allows soil to maintain high porosity and to be long in fertility maintenance time and good in water retention performance.

The invention relates to a full-spectrum super-resolution measuring method and a label-free biomolecule measurement system. The method and the system are characterized in that membrane layers with different thicknesses ranging from 300nm to 4500nm are arranged on a chip and used for encoding, then sample application is carried out on the chip by means of probe protein to form a biological chip, the probe protein of the biological chip is fully combined with a to-be-tested sample, a to-be-tested object in the to-be-tested sample is arranged on the probe protein through specific adsorption, light beams with light intensity of I0 are vertically cast on the biological chip, when the light beams are vertically cast on the biological chip only covered with the membrane layers, different reflection spectrums are produced due to the different thicknesses of the membrane layers, thickness encoding of the biological chip is achieved, by means of an interference extremum method, the thicknesses t of the membrane layers of the biological chip are decoded according to wavelengths of extreme points in a light spectrum, when the light beams are cast on the to-be-tested object combined with the probe protein, thickness changes of the membrane layers in the range delta occur, intensity amplitude differences are obtained through calculation, and the thickness of the to-be-tested object is obtained. The method and the system can be widely used in thickness measurement of biomolecules.

The invention provides a high selectivity tetracycline antibiotics molecularly imprinted polymer preparation method. The high selectivity tetracycline antibiotics molecularly imprinted polymer preparation method comprises the following steps of: dissolving template molecules, methacrylic acid (MAA, 6mmol), a cross-linking agent (TRIM, 3mL) and an initiating agent in a pore-forming agent, and carrying out vacuum water bath; and collecting obtained polymer microparticles after ending reaction to obtain molecularly imprinted polymers (MIPs) for detecting antibiotic residues. The high selectivity tetracycline antibiotics molecularly imprinted polymers prepared by the method show relatively good specific adsorption capacity for tetracycline, has high adsorption capacity, is very suitable as an adsorbent for solid-phase extraction and realizes purification and enrichment of trace tetracycline antibiotics in complex samples.