3468results about How to "Inhibit aggregation" patented technology

The present invention provides compositions and methods for silencing gene expression by delivering nucleic acid-lipid particles comprising a siRNA molecule to a cell.

Matrixes doped with semiconductor nanocrystals are provided. In certain embodiments, the semiconductor nanocrystals have a size and composition such that they absorb or emit light at particular wavelengths. The nanocrystals can comprise ligands that allow for mixing with various matrix materials, including polymers, such that a minimal portion of light is scattered by the matrixes. The matrixes of the present invention can also be utilized in refractive index matching applications. In other embodiments, semiconductor nanocrystals are embedded within matrixes to form a nanocrystal density gradient, thereby creating an effective refractive index gradient. The matrixes of the present invention can also be used as filters and antireflective coatings on optical devices and as down-converting layers. Processes for producing matrixes comprising semiconductor nanocrystals are also provided. Nanostructures having high quantum efficiency, small size, and/or a narrow size distribution are also described, as are methods of producing indium phosphide nanostructures and core-shell nanostructures with Group II-VI shells.

Matrixes doped with semiconductor nanocrystals are provided. In certain embodiments, the semiconductor nanocrystals have a size and composition such that they absorb or emit light at particular wavelengths. The nanocrystals can comprise ligands that allow for mixing with various matrix materials, including polymers, such that a minimal portion of light is scattered by the matrixes. The matrixes are optionally formed from the ligands. The matrixes of the present invention can also be utilized in refractive index matching applications. In other embodiments, semiconductor nanocrystals are embedded within matrixes to form a nanocrystal density gradient, thereby creating an effective refractive index gradient. The matrixes of the present invention can also be used as filters and antireflective coatings on optical devices and as down-converting layers. Processes for producing matrixes comprising semiconductor nanocrystals are also provided. Nanostructures having high quantum efficiency, small size, and/or a narrow size distribution are also described, as are methods of producing indium phosphide nanostructures and core-shell nanostructures with Group II-VI shells.

A series of Pt(II) complexes having the following formula are disclosed:

• • X₁ and X₂ independently are C or N, X₁ can also locate at another position of the hexagonal ring, when X₁ is N;
  • R₁ is H, C1–C8 alkyl, or C1–C4 perfluoroalkyl, R₂ is H, R₁ and R₂ together are C4–C8 alkylene, or R₁ and R₂ together are bridged carbocyclic C4–C12 alkylene, when X₂ is C;
  • R₁ is H, C1–C8 alkyl, or C1–C4 perfluoroalkyl, and R₂ is omitted, when X₂ is N;
  • R₇ is H or methyl, and R₈ is omitted, when X₁ is N;
  • R₇ is H or methyl, R₈ is H or methyl, or R₇ and R₈ together are

when X₁ is C.

Novel chromatographic materials for chromatographic separations, columns, kits, and methods for preparation and separations with a superficially porous material comprising a substantially nonporous core and one or more layers of a porous shell material surrounding the core. The material of the invention is comprised of superficially porous particles and a narrow particle size distrution. The material of the invention is comprised of a superficially porous monolith, the substantially nonporous core material is silica; silica coated with an inorganic/organic hybrid surrounding material; a magnetic core material; a magnetic core material coated with silica; a high thermal conductivity core material; a high thermal conductivity core material coated with silica; a composite material; an inorganic/organic hybrid surrounding material; a composite material coated with silica; a magnetic core material coated with an inorganic/organic hybrid surrounding material; or a high thermal conductivity core material coated with an inorganic/organic hybrid surrounding material.

A process for manufacturing a porous metal-containing material is provided. For example, a composition is provided comprising particles dispersed in at least one solvent, the particles comprising at least one polymer material and at least one metal-based compound. The solvent can be substantially removed from the composition, and the polymer material can be substantially decomposed, thereby converting the solvent-free particles into a porous metal-containing material. In addition, metal-containing materials produced in accordance with the above process and their use in implantable medical devices can be provided.

The disclosure provides fusion polypeptides and constructs useful in delivering anionically charged nucleic acid molecules including diagnostics and therapeutics to a cell or subject. The fusion constructs include a protein transduction domain and a nucleic acid binding domain, or a protein transduction domain and a nucleic acid that is coated with one or more nucleic acid binding domains sufficient to neutralize an anionic charge on the nucleic acid. Also provided are methods of treating disease and disorders such as cell proliferative disorders.

This invention generally relates to cationic oil-in-water emulsions that can be used to deliver negatively charged molecules, such as an RNA molecule. The emulsion particles comprise an oil core and a cationic lipid. The cationic lipid can interact with the negatively charged molecule thereby anchoring the molecule to the emulsion particles. The cationic emulsions described herein are particularly suitable for delivering nucleic acid molecules (such as an RNA molecule encoding an antigen) to cells and formulating nucleic acid-based vaccines.

The present inventors identified aggregation of embryonic stem cells and embryoid bodies (EBs) as the cause of the difficulty in generating large numbers of the embryonic stem cells (ES) cell-derived tissues. To counter this, the invention provides a novel bioprocess where aggregation of spheroid forming cells, such as embryonic stem cells and spheroids, such as EBs is controlled, such as by encapsulation of within a matrix. As a result, EBs can be generated with high efficiency and cultured in high cell density, well-mixed systems. Well-mixed conditions facilitate measurement and control of the bulk media conditions and allow for the use of scalable bioreactor systems for clinical production of tissue. Therefore, the invention enables generation of ES cell-derived tissue on a clinical scale. The invention is also applicable to any spheroid-forming cells and other types of pluripotent cells.

The invention provides a number of methods for enhancing the aqueous solubility of an active ingredient which is insoluble or sparingly soluble in water. In one preferred embodiment, solubilization of the active ingredient is enhanced by combining it with beta-cyclodextrin in an aqueous complexation medium comprising beta-cyclodextrin and a negatively- or positively-charged compound which forms an inclusion or non-inclusion complex with beta-cyclodextrin and its inclusion complexes.

Provided are a nano-scale LED assembly and a method for manufacturing the same. First, a nano-scale LED device that is independently manufactured may be aligned and connected to two electrodes different from each other to solve a limitation in which a nano-scale LED device having a nano unit is coupled to two electrodes different from each other in a stand-up state. Also, since the LED device and the electrodes are disposed on the same plane, light extraction efficiency of the LED device may be improved. Furthermore, the number of nano-scale LED devices may be adjusted. Second, since the nano-scale LED device does not stand up to be three-dimensionally coupled to upper and lower electrodes, but lies to be coupled to two electrodes different from each other on the same plane, the light extraction efficiency may be very improved. Also, since a separate layer is formed on a surface of the LED device to prevent the LED device and the electrode from being electrically short-circuited, defects of the LED electrode assembly may be minimized. Also, in preparation for the occurrence of the very rare defects of the LED device, the plurality of LED devices may be connected to the electrode to maintain the original function of the nano-scale LED electrode assembly.

The invention relates to a method for preparing large-scale graphene through supercritical carbon dioxide exfoliation. Supercritical carbon dioxide is adopted as an exfoliant, a surfactant is adopted as a dispersant, graphite powder and the dispersant are put in an autoclave, the carbon dioxide is pumped in the autoclave and circularly flows in a supercritical state, and then the pressure is reduced quickly to be normal pressure; the process is repeated so that the materials undergo pressure increment and pressure reduction several times; and the layers of the graphene is controlled by controlling the times of pressure increment and pressure reduction, so as to prepare the large scale graphene. Compared with the prior art, the invention has the advantages as follows: large-scale (hundreds of micrometers) high-quality graphene can be prepared; the method belongs to physical exfoliation, the treatment conditions are mild, and the quality of the graphene cannot be damaged; besides, the carbon dioxide used in the method is nontoxic, cheap and easy to obtain, and the technology is simple.

The back pressure adjustment apparatus for a liquid ejection head has: a container having a liquid accommodating chamber which is connected to the liquid ejection head and accommodates liquid to be supplied to the liquid ejection head, and a gas accommodating chamber which accommodates gas; a movable film which separates the liquid accommodating chamber and the gas accommodating chamber, and forms a portion of whole walls of the liquid accommodating chamber; and a pressure adjustment device which causes all or a portion of the movable film to deform so as to adjust pressure of the liquid accommodated in the liquid accommodating chamber.

A method for preparing a graphene oxide/white carbon black/rubber nanocomposite material is described. The prepared graphene oxide/white carbon black/rubber nanocomposite material contains nanoscale graphene oxide and white carbon black that are highly dispersed. The nanocomposite material has a relatively high modulus, excellent wear resistance and tear resistance, a relatively low rolling resistance, and at the same time has a low air-permeability and excellent self-healing capability.

A light emitting apparatus has: a support; a wiring layer that is formed on the support; and an LED element that is flip-chip mounted on the wiring layer formed on the support. The wiring layer has: a conductive layer that is formed on the support and is electrically connected to an electrode of the LED element; and a reflection layer that is formed on the conductive layer that has a light reflection property to allow a radiated light from the LED element to be reflected thereon. The reflection layer is of a material that generates no intermetallic compound to a material of the conductive layer.