226 results about "Acute pancreatitis" patented technology

Methods and compositions for the treatment of acute pancreatitis in a mammal. Particular compositions comprise a binding element, a translocation element, and a therapeutic element able to prevent accumulation of digestive enzymes within the pancreas.

The invention discloses a method for building a helicobacter pylori nucleic acid fingerprint spectrum, which comprises PCR (polymerase chain reaction) amplification, SAP (severe acute pancreatitis) enzymatic digestion, transcription and nuclease digestion, purification, mass spectrometer detection and the like. A helicobacter pylori nucleic acid fingerprint spectrum database is set up on the basis of the method. According to the generated mass peak spectrum of the experiment, the helicobacter pylori of a sample to be detected can be quickly identified, so the method can be widely applied in the fields of helicobacter pylori types and classification, environmental sanitation, public safety qunarantine and the like.

The invention discloses a test card for rapidly diagnosing pancreatic trauma and acute pancreatitis and a preparation method of the test card. The test card comprises a plastic shell, a bottom lining and detection modules, wherein the plastic shell is provided with a sampling hole and an observation window, and the sampling hole and the observation window are fixed with transparent waterproof films. The bottom lining is provided with multiple longitudinally parallel arranged slots; and the number of the detection modules is consistent to that of the bottom lining, and the detection modules are glued into the slots of the bottom lining. Each detection module comprises chromatographical membranes, combination pads, sample pads, filtration pads and water sucking pads. The chromatographical membranes are provided with test lines and quality control lines, the test lines are TAP (thiamphenicol) polyclonal antibodies, and the quality control lines are covered rabbit anti-mice immune globulin antibodies. The test card for rapidly diagnosing pancreatic trauma provided by the invention is capable of quickly and accurately diagnosing the diseases such as pancreatic trauma and acute pancreatitis, and adding multiple samples simultaneously for positive control and negative control, and has the advantages of being convenient and rapid to detect, high in flexibility and accuracy, stable in property and cheap in cost.

A composition comprising a water-soluble and stable complex formed by an alkyl ether derivative of gamma-cyclodextrin and curcumin and optionally comprising non-complexed cyclodextrin, the molar ratio of curcumin to cyclodextrin being between 1:1 and 1:6, and a method of manufacturing such a composition. The water-soluble and stable complex of curcumin is useful in therapy, e.g. for treatment of cancer, leukemia, myocardial infarction, stroke, sepsis, acute lung injury, acute liver failure, acute tubular necrosis, acute pancreatitis, radiation injury and other life-threatening conditions in a human or animal subject, as well as for preserving human or animal organs, tissues or cells at a hypothermic temperature.

This invention provides methods of determining the risk of AP development in an individual, as well as the diagnosis, prognosis, and treatment of acute pancreatitis (AP) in an individual, by determining the presence or absence of significantly high levels of free serum DNA in the subject relative to levels in a healthy individual. In other embodiments, the invention further provides methods of determining the risk of severe AP development, prognosis, diagnosis, and treatment of a severe form of acute pancreatitis based upon the presence of significantly high levels of free serum DNA in the subject relative to an individual who has and maintains a mild form of acute pancreatitis.

The invention discloses a prediction model for organ failure induced by acute pancreatitis, and the model comprises the following steps: S100, preprocessing patient information, and recording events and time nodes by means of {Variables, Time}; s200, sorting the events according to a time sequence, and filling missing values by adopting a Decay mechanism; and S300, carrying out one-hot coding on the data by using an Embedded mechanism, mapping the data to a real vector space, normalizing the data and then inputting the normalized data into a Phased LSTM model. Time gate output is calculated according to the interval time of a patient from admission to the time node of the event, the model training process is accelerated by utilizing the output result of the time gate, the neuron of the output layer is 2, and a softmax function is adopted as an activation function. According to the method, heterogeneous multi-dimensional data can be processed, time information can be flexibly used, andmeanwhile, the judgment of the model is closer to a description of a disease natural process in the real world.

The present invention provides a compound emodin baicalein injection for curing acute pancreatitis and its preparation method. Said invention adopts the combination of ultrasonic wave method and conventional method to respectively extract effective component emodin and baicalein pure products from rhubarb and scutellaria root, then adopts the following steps: adding the emodin and baicalein pure products and required correspondent auxiliary material into hot injection water, using NaOH solution to regulate pH, adding active carbon, heating to foiling, cooling and filtering by using microporous filtration membrane, adding injection water to total quantity, filling and sterilizing for 30 min at 115 deg.C so as to obtain the injection, cold-storing said injection for 1 week, filtering, filling and freeze-drying, sealing so as to obtain the freeze-dried powder injection finished product.

The invention relates to emodin solid dispersion, a drug-containing pellet core, a colonic targeted micropill, and applications of the three. The emodin solid dispersion is prepared from emodin and a carrier material, wherein the carrier material is one or several selected from poloxamer 188, poloxamer 407, Kollidon 12 PF, Kollidon VA 64, Kollicoat IR or Soluplus, and the weight ratio of emodin to the carrier material is 1:2-1:15. The drug-containing pellet core and the colonic targeted micropill both contain the emodin solid dispersion. The emodin solid dispersion is substantially improved in solubility of indissolvable drug emodin; and the targeted micropill helps to realize colonic positioning release in vivo / vitro of emodin, and has substantial protective effect on intestinal barrier of a rat severe acute pancreatitis pancreatitis model.

The invention discloses application of parthenolide as a platelet-activating factor (PAF) inhibitor. The parthenolide can be used as a safe PAF antagonist to be applied to treatment, auxiliary treatment and prevention of diseases such as thrombus, atherosclerosis, ischemic cardio-vascular disease, cerebral ischemia, acute pancreatitis, endotoxic shock, asthma, hepatic fibrosis and hepatocirrhosis, injury of nerve, gastrointestinal ulcer and necrosis, psoriasis, systemic lupus erythematosus and acquired immune deficiency syndrome related to platelet-activating factor.

The invention discloses an S100 family-based acute pancreatitis severity prediction model and detection method thereof, and belongs to the technical field of acute pancreatitis detection. The acute pancreatitis severity prediction model is established by utilizing S100A6, S100A8, S100S9, S100A11, S100A12 and S100P in the S100 protein family; and for severe acute pancreatitis, the prediction modelhas a diagnosis sensitivity of 92.30%, a specificity of 84.70%, a false positive rate of 15.30% and a false negative rate of 7.70%. Compared with the present clinically used scale detection and imaging diagnosis, the prediction model has reduced subjectivity, is more correct and has a quantitative detection effect.

Provided by the present invention are methods of treating a variety of disorders including AIDS, arthritis (rheumatoid arthritis, osteoarthritis, spondyloarthropathies), antibiotic induced diarrheal diseases (Closbidium difficile), multiple sclerosis, osteoporosis, gingivitis, peptic ulcer disease, esophagitis, diabetes, retinitis, uveitis, reperfusion injury after myocardial infarction (MI) or cerebral vascular accident (CVA), aphthous ulcers (oral), atherosclerosis (plaque rupture), prevention of tumor metastases, asthma, preeclampsia, acute pancreatitis, psoriasis, infertility and allergic disorders such as rhinitis, conjunctivitis, and urticaria.

The Chinese medicine enema for treating acute pancreatitis consists of rhubarb decoction and Glauber salt in certain weight ratio. It is rectum administrated to reach blood medicine concentration the same as that of vein administration but no influence of digestive enzyme and gastric acid. The medicine may be used to combine with Western medicine in treating acute pancreatitis to reach high curative rate.

The invention discloses a drug for treating severe acute pancreatitis. The drug is made from bupleurum, corydalis tuber, oriental wormwood, fermented soybean, immature orange fruit, white atractylodes rhizome, oriental water plantain and Chinese aloe according to a certain weight proportion. The drug has protective effect on the intestinal barrier function under the condition of the severe acute pancreatitis, can lower intestinal tract permeability, lighten endotoxemia and inflammatory reaction, and has greater influence on outcome of diseases.

The present invention is directed to a method of using compounds of Formula (I) to inhibit Cathepsin B. Specifically the compounds of the present invention are useful as therapeutic agents for the treatment of tumor invasion, metastasis, Alzheimer's Disease, arthritis, inflammatory diseases such as chronic and acute pancreatitis, inflammatory airway disease, and bone and joint disorders, including osteoporosis, osteoarthritis, rheumatoid arthritis, psoriasis, and other autoimmune disorders, liver fibrosis, including liver fibrosis associated with HCV, all types of steatosis (including non-alcoholic steatohepatitis) and alcohol-associated steatohepatitis, non-alcoholic fatty liver disease, forms of pulmonary fibrosis including idiopathic pulmonary fibrosis, pathological diagnosis of interstitial pneumonia following lung biopsy, renal fibrosis, cardiac fibrosis, retinal angiogenesis and fibrosis / gliosis in the eye, schleroderma, and systemic sclerosis. The compounds of Formula (I) are also useful for treating subjects with both HCV and fibrosis in a mammal, particularly liver fibrosis, and subjects affirmatively diagnosed or at risk for both HCV and liver fibrosis.

The invention discloses an immunochromatographic test strip for rapidly detecting acute pancreatitis and a preparation method thereof. The test strip is formed by sticking a sample pad, a glass fiber membrane labeling pad, a nitrocellulose coating membrane and absorbent paper to a substrate in sequence through lap joint, wherein a highly specific monoclonal antibody of trypsinogen-2 labeled by a biotin-avidin-colored latex complex is coated on the glass fiber membrane labeling pad; the nitrocellulose coating membrane comprises a detection region and a control region; the detection region is coated by another specific monoclonal antibody of trypsinogen-2 with epitope different from that of the labeled monoclonal antibody on the glass fiber membrane labeling pad; and the control region is coated by an anti-mouse antibody. Compared with radioimmunoassay and enzyme linked immunosorbent assay (ELISA), the test strip has the advantages of safety, simpleness and convenience in operation, suitability for single human / sample detection, rapidness and the like, dispenses with special skills, is free of trauma, is easy in result reading and can realize timely in-situ and family self-detectionof acute pancreatitis.

The present invention relates to a method of using trans-3,5,4′-trihydroxybibenzyl, also known as dihydro-resveratrol for treating acute pancreatitis in a subject in needs thereof. More particularly, the present invention relates to a method of using dihydro-resveratrol, its derivatives and / or chemical variants as a remedial agent. The present invention particularly relates to the amelioration of tissue injury for the management of acute pancreatitis associated pulmonary injury of a subject.

The invention discloses a method for rapidly classifying and identifying mycobacterium tuberculosis by the aid of the mass-spectrometric technique. The method includes the steps of PCR (polymerase chain reaction) amplification, SAP (severe acute pancreatitis) enzymatic digestion, transcription and nuclease digestion, purification, mass spectrometer detection and the like. A nucleic acid fingerprint spectrum database of the mycobacterium tuberculosis is established based on the method. The mycobacterium tuberculosis in samples to be detected can be rapidly identified according to mass spectrum peak diagrams generated by experiments, and results can be widely applied to typing and classification of the mycobacterium tuberculosis and the fields of environmental sanitation, public security quarantine and the like.

The invention discloses a Chinese herbal preparation for treating the acute pancreatitis. The Chinese herbal preparation comprises the following raw materials in parts by weight: 5 to 20 parts of safflower, 5 to 20 parts of Chinese angelica, 8 to 20 parts of picrorhiza, 8 to 20 parts of officinal magnolia bark, 10 to 18 parts of peach kernel, 10 to 18 parts of trichosanthes root, 10 to 20 parts of pangolin scales, 8 to 15 parts of Chinese thorowax, 8 to 15 parts of red paeony root, 10 to 18 parts of corydalis tuber, 2 to 8 parts of liquorice, 15 to 25 parts of capillary wormwood herb, 8 to 15 parts of mirabilite, 8 to 20 parts of immature bitter orange, 15 to 40 parts of little caulis sargentodoxae and 12 to 25 parts of dahurian patrinia herb. The Chinese herbal preparation has the advantages that the source of the raw materials is extensive and the price is low; the Chinese herbal preparation is accurate in clinical curative effect when being used for treating the acute pancreatitis, and compared with western medicine treatment, the Chinese herbal preparation has the advantages that complications are reduced effectively and the recovery time is shortened; a preparation method provided by the invention is simple and feasible; the prepared preparation is convenient to take and use.

The invention discloses a kit and method for simultaneously detecting the content of multiple components in plasma and application of the kit, and belongs to the technical field of biology. The kit comprises a detecting solution R1, a detecting solution R2, antibiont marker positive quality control serum, antibiont marker negative quality control serum and a wash concentrate. The content of trypsinogen TPSII, SSA, hs-CRP, PCT and resistin in the human plasma is detected jointly based on latex enhanced turbidimetric immunoassay; and acute abdominal pain diseases caused by acute pancreatitis, other abdominal viscera inflamatory lesions, acute gastrointestinal ulcers and the like can be troubleshot, and the purpose of identifying the common acute abdominal pain diseases is achieved through multi-index joint detecting.

A compound of formula (I) or a salt thereof are provided:wherein R1, X and R3 are defined in the specification, useful in the treatment of disorders mediated by KMO such as acute pancreatitis, chronic kidney disease, other conditions associated with systemic inflammatory response syndrome (SIRS), Huntington's disease, Alzheimer's disease, spinocerebellar ataxias, Parkinson's disease, AIDS-dementia complex, amylotrophic lateral sclerosis (ALS), depression, schizophrenia, sepsis, cardiovascular shock, severe trauma, acute lung injury, acute respiratory distress syndrome, acute cholecystitis, severe burns, pneumonia, extensive surgical procedures, ischemic bowel, severe acute hepatic disease, severe acute hepatic encephalopathy or acute renal failure.

The invention discloses application of microbial flora in acute pancreatitis. The microbial flora is Ruminococcus_gauvreauii_group. The microbial marker has high sensitivity and high specificity during prediction of acute pancreatitis. Through detection of the abundance of the microbial marker, subjects can be warned, and risks can be reduced further through dietary adjustment or medical intervention.

The invention discloses a loop type bile external drainage tube which comprises a straight tube, an elastic loop tube I and an elastic loop tube II which are connected in sequence. The elastic loop tube I and the elastic loop tube II are in a shape of an Archimedes curve as a whole. A through hole containing the head portion of the elastic loop tube II is formed in the side wall of the elastic loop tube I. The through hole is located in the plane where the Archimedes curve is located. In a working state, the curve is tensioned, so that the head portion of the elastic loop tube II enters the through hole. The tension force of the elastic loop tube I on the wall of a bile duct is increased while the curve is tensioned, and the probability of disengaging of the loop type bile external drainage tube is lowered. After the curve is tensioned, the head portion of the elastic loop tube II enters the through hole, and the wall of the bile duct is not damaged. In the drainage tube pulling out process, stimulation to the bile duct mucosa, the duodenal papilla, the gastrointestinal tract mucosa and the pharyngolaryneal mucosa is avoided, and the acute cholangitis, the acute pancreatitis, upper gastrointestinal bleeding and other complications can be avoided. In the tube pulling out process, the discomfort of a patient can be greatly reduced.

The invention relates to a traditional Chinese medicine preparation for treating acute pancreatitis, which is prepared from the following pharmaceutical raw materials in parts by weight: 15 parts of white paeony root, 15 parts of costus root, 15 parts of golden thread, 15 parts of dwarf lilyturf tuber, 15 parts of stir-fried membranous milkvetch root, 15 parts of rhizoma corydalis and 15 parts of Chinese magnoliavine fruit; and the preparation can be prepared into powder, capsule preparation, tablets, pills, granules and oral liquid preparation prepared by applying the modern preparation process or the traditional preparation process. The selected pharmaceutical raw materials can jointly play the effects of suppressing hyperactive liver, subsiding yang, nourishing blood, astringing yin, clearing heat, eliminating dampness, invigorating qi and consolidating exterior, and is used for treating the acute pancreatitis. The clinical application finds that the traditional Chinese medicine preparation has low cost, exact efficacy and no toxicity or side effects.

The invention discloses application of berberine or other pharmaceutically acceptable salts in preparing a M3 receptor selective inhibitor medicine. The medicine is used for treating acute pancreatitis, lung cancers and colon cancers, self-immunity sialadenitis, asthma, respiratory tract inflammation, lung diseases and cardiovascular diseases, relieving panic, or treating excessive activity of bladders, and is used for inhibiting the enhancing of Ca<2+> signals in pancreatic acinar cells caused by M3 receptor-mediated acetyl choline and L-arginine.

The present invention provides one kind of amylopsin activity detecting solution and its use. The present invention makes it possible to realize the routine monitoring of pancreas function and the clinical detection of acute pancreatitis.

The invention relates to a new pyrimido-oxazine compound. With the compound, the increment of amylase-lipase activity of sera of rats with acute pancreatitis can be remarkably inhibited, and the watercontent of pancreatic tissues of the rats with acute pancreatitis can be remarkably reduced, so that the compound has a favorable treatment effect on acute pancreatitis. In addition, compared with anexisting medicine gabexate, the treatment effect is more remarkable.