224 results about "Acute pancreatitis" patented technology

Methods and compositions for the treatment of acute pancreatitis in a mammal. Particular compositions comprise a binding element, a translocation element, and a therapeutic element able to prevent accumulation of digestive enzymes within the pancreas.

Methods and compositions for the treatment of acute pancreatitis in a mammal. Particular compositions comprise a binding element, a translocation element, and a therapeutic element able to prevent accumulation of digestive enzymes within the pancreas.

A composition comprising a water-soluble and stable complex formed by an alkyl ether derivative of gamma-cyclodextrin and curcumin and optionally comprising non-complexed cyclodextrin, the molar ratio of curcumin to cyclodextrin being between 1:1 and 1:6, and a method of manufacturing such a composition. The water-soluble and stable complex of curcumin is useful in therapy, e.g. for treatment of cancer, leukemia, myocardial infarction, stroke, sepsis, acute lung injury, acute liver failure, acute tubular necrosis, acute pancreatitis, radiation injury and other life-threatening conditions in a human or animal subject, as well as for preserving human or animal organs, tissues or cells at a hypothermic temperature.

This invention provides methods of determining the risk of AP development in an individual, as well as the diagnosis, prognosis, and treatment of acute pancreatitis (AP) in an individual, by determining the presence or absence of significantly high levels of free serum DNA in the subject relative to levels in a healthy individual. In other embodiments, the invention further provides methods of determining the risk of severe AP development, prognosis, diagnosis, and treatment of a severe form of acute pancreatitis based upon the presence of significantly high levels of free serum DNA in the subject relative to an individual who has and maintains a mild form of acute pancreatitis.

The present invention is directed to a method of using compounds of Formula (I) to inhibit Cathepsin B. Specifically the compounds of the present invention are useful as therapeutic agents for the treatment of tumor invasion, metastasis, Alzheimer's Disease, arthritis, inflammatory diseases such as chronic and acute pancreatitis, inflammatory airway disease, and bone and joint disorders, including osteoporosis, osteoarthritis, rheumatoid arthritis, psoriasis, and other autoimmune disorders, liver fibrosis, including liver fibrosis associated with HCV, all types of steatosis (including non-alcoholic steatohepatitis) and alcohol-associated steatohepatitis, non-alcoholic fatty liver disease, forms of pulmonary fibrosis including idiopathic pulmonary fibrosis, pathological diagnosis of interstitial pneumonia following lung biopsy, renal fibrosis, cardiac fibrosis, retinal angiogenesis and fibrosis / gliosis in the eye, schleroderma, and systemic sclerosis. The compounds of Formula (I) are also useful for treating subjects with both HCV and fibrosis in a mammal, particularly liver fibrosis, and subjects affirmatively diagnosed or at risk for both HCV and liver fibrosis.

The present invention is directed to a method of using compounds of Formula (I) to inhibit Cathepsin B. Specifically the compounds of the present invention are useful as therapeutic agents for the treatment of tumor invasion, metastasis, Alzheimer's Disease, arthritis, inflammatory diseases such as chronic and acute pancreatitis, inflammatory airway disease, and bone and joint disorders, including osteoporosis, osteoarthritis, rheumatoid arthritis, psoriasis, and other autoimmune disorders, liver fibrosis, including liver fibrosis associated with HCV, all types of steatosis (including non-alcoholic steatohepatitis) and alcohol-associated steatohepatitis, non-alcoholic fatty liver disease, forms of pulmonary fibrosis including idiopathic pulmonary fibrosis, pathological diagnosis of interstitial pneumonia following lung biopsy, renal fibrosis, cardiac fibrosis, retinal angiogenesis and fibrosis / gliosis in the eye, schleroderma, and systemic sclerosis. The compounds of Formula (I) are also useful for treating subjects with both HCV and fibrosis in a mammal, particularly liver fibrosis, and subjects affirmatively diagnosed or at risk for both HCV and liver fibrosis.

The invention discloses an immunochromatographic test strip for rapidly detecting acute pancreatitis and a preparation method thereof. The test strip is formed by sticking a sample pad, a glass fiber membrane labeling pad, a nitrocellulose coating membrane and absorbent paper to a substrate in sequence through lap joint, wherein a highly specific monoclonal antibody of trypsinogen-2 labeled by a biotin-avidin-colored latex complex is coated on the glass fiber membrane labeling pad; the nitrocellulose coating membrane comprises a detection region and a control region; the detection region is coated by another specific monoclonal antibody of trypsinogen-2 with epitope different from that of the labeled monoclonal antibody on the glass fiber membrane labeling pad; and the control region is coated by an anti-mouse antibody. Compared with radioimmunoassay and enzyme linked immunosorbent assay (ELISA), the test strip has the advantages of safety, simpleness and convenience in operation, suitability for single human / sample detection, rapidness and the like, dispenses with special skills, is free of trauma, is easy in result reading and can realize timely in-situ and family self-detectionof acute pancreatitis.

The present invention relates to a method of using trans-3,5,4′-trihydroxybibenzyl, also known as dihydro-resveratrol for treating acute pancreatitis in a subject in needs thereof. More particularly, the present invention relates to a method of using dihydro-resveratrol, its derivatives and / or chemical variants as a remedial agent. The present invention particularly relates to the amelioration of tissue injury for the management of acute pancreatitis associated pulmonary injury of a subject.

The invention discloses a method for rapidly classifying and identifying mycobacterium tuberculosis by the aid of the mass-spectrometric technique. The method includes the steps of PCR (polymerase chain reaction) amplification, SAP (severe acute pancreatitis) enzymatic digestion, transcription and nuclease digestion, purification, mass spectrometer detection and the like. A nucleic acid fingerprint spectrum database of the mycobacterium tuberculosis is established based on the method. The mycobacterium tuberculosis in samples to be detected can be rapidly identified according to mass spectrum peak diagrams generated by experiments, and results can be widely applied to typing and classification of the mycobacterium tuberculosis and the fields of environmental sanitation, public security quarantine and the like.

The invention discloses a Chinese herbal preparation for treating the acute pancreatitis. The Chinese herbal preparation comprises the following raw materials in parts by weight: 5 to 20 parts of safflower, 5 to 20 parts of Chinese angelica, 8 to 20 parts of picrorhiza, 8 to 20 parts of officinal magnolia bark, 10 to 18 parts of peach kernel, 10 to 18 parts of trichosanthes root, 10 to 20 parts of pangolin scales, 8 to 15 parts of Chinese thorowax, 8 to 15 parts of red paeony root, 10 to 18 parts of corydalis tuber, 2 to 8 parts of liquorice, 15 to 25 parts of capillary wormwood herb, 8 to 15 parts of mirabilite, 8 to 20 parts of immature bitter orange, 15 to 40 parts of little caulis sargentodoxae and 12 to 25 parts of dahurian patrinia herb. The Chinese herbal preparation has the advantages that the source of the raw materials is extensive and the price is low; the Chinese herbal preparation is accurate in clinical curative effect when being used for treating the acute pancreatitis, and compared with western medicine treatment, the Chinese herbal preparation has the advantages that complications are reduced effectively and the recovery time is shortened; a preparation method provided by the invention is simple and feasible; the prepared preparation is convenient to take and use.

The invention relates to a Chinese medicinal composition for treating acute pancreatitis. The Chinese medicinal composition is prepared from the following active pharmaceutical ingredients in parts by weight: 1 to 200 parts of red paeony root and 1 to 60 parts of raw rhubarb. The invention further provides an application of the Chinese medicinal composition. A traditional Chinese medicine compound preparation of the invention has the advantages that raw materials are commonly used traditional Chinese medicines to result in low price, the preparation is simple and the use is convenient, and has a remarkable curative effect for the acute pancreatitis by matching with the conventional western medicine therapy after years of clinical applications and pharmacological researches. In view of increase of incidence of the acute pancreatitis year by year, the traditional Chinese medicine compound preparation of the invention has the characteristics of no toxicity and capacity of being taken for a long term, thereby having wider market prospects.

A composition comprising a water-soluble and stable complex formed by an alkyl ether derivative of gamma-cyclodextrin and curcumin and optionally comprising non-complexed cyclodextrin, the molar ratio of curcumin to cyclodextrin being between 1:1 and 1:6, and a method of manufacturing such a composition. The water-soluble and stable complex of curcumin is useful in therapy, e.g. for treatment of cancer, leukemia, myocardial infarction, stroke, sepsis, acute lung injury, acute liver failure, acute tubular necrosis, acute pancreatitis, radiation injury and other life-threatening conditions in a human or animal subject, as well as for preserving human or animal organs, tissues or cells at a hypothermic temperature.

The present invention provides one kind of amylopsin activity detecting solution and its use. The present invention makes it possible to realize the routine monitoring of pancreas function and the clinical detection of acute pancreatitis.

The invention discloses a Chinese herbal medicine for treating acute pancreatitis. The Chinese herbal medicine is prepared from the following medicines in parts by weight: 20-30 parts of radix bupleuri, 20-30 parts of bitter orange, 15-25 parts of radix paeoniae rubra, 25-35 parts of rhizoma cyperi, 25-35 parts of the rhizome of chuanxiong, 30-40 parts of salvia, 30-40 parts of rhizoma corydalis, 30-40 parts of radix scutellariae, 30-40 parts of areca nut, 25-35 parts of figwortflower picrorhiza rhizome, 30-40 parts of Chinaberry seed and 20-30 parts of cape jasmine. The Chinese herbal medicine is prepared by adding 1600 parts by weight of water, after the water is boiled, decocting the medicines with slow fire for 20-30 minutes, filtering the decoction and collecting the supernatant, decocting the supernatant three times, bottling and uniformly mixing the supernatant decocted three times and then sterilizing the supernatant under a high temperature for later use. Radix bupleuri is taken as the monarch, bitter orange and radix paeoniae rubra are taken as the ministers, rhizoma cyperi, the rhizome of chuanxiong, salvia and rhizoma corydalis are taken as the assistants, and radix scutellariae, areca nut, figwortflower picrorhiza rhizome, Chinaberry seed and cape jasmine are taken as the guides. The Chinese herbal medicine has the following beneficial effects: the Chinese herbal medicine is convenient to prepare and use, is safe and does not have side effects.