The invention discloses a preparation method of a 10-vanilloyl
catalpol. The preparation method of the 10-vanilloyl
catalpol comprises the following steps of 1, preparing figwortflower
picrorhiza rhizome powder and putting it aside for next use, 2, preparing gauze bags and putting then aside for next use, 3, putting the figwortflower
picrorhiza rhizome powder into the gauze bags to obtain
drug bags with the figwortflower
picrorhiza rhizome powder, 4, putting the
drug bags with the figwortflower picrorhiza rhizome powder into an extraction container, carrying out extraction, and merging filtrate to obtain an
ethanol extracted liquid of figwortflower picrorhiza rhizome, 5, standing the
ethanol extracted liquid of figwortflower picrorhiza rhizome, 6, feeding the
ethanol extracted liquid of figwortflower picrorhiza rhizome into a plate-frame-type
filter press by a pump and carrying out filter pressing to obtain ethanol filtrate, 7, putting the ethanol filtrate into a distiller and carrying out
distillation to obtain ethanol extract, 8, adding the ethanol extract into
chromatography silica gel to obtain mixed
silica gel powder for next use, 9, adding eluants into
chromatography silica gel, 10, adding the mixed silica gel powder obtained by the step 8 into a
chromatography column and carrying out immersion, 11, carrying out chromatography
elution, 12 preparing eluants of
ethyl acetate and ethanol and carrying out treatment to obtain a discolored liquid, and 13, carrying out
distillation of the discolored liquid to recover a
solvent and to obtain ethanol extract, mixing the ethanol extract and silica gel, and cooling to obtain the precipitated 10-vanilloyl
catalpol. The preparation method provided by the invention realizes extraction of 10-vanilloyl catalpol of figwortflower picrorhiza rhizome and improves an extraction rate.