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Drop pills of general glycosides of picrorhiza rhizome, and preparation method

A technology of huanglian and glycoside dropping pills, applied in the field of huanglian total glycosides dropping pills and preparation thereof, can solve the problems of rebound, easy to produce explosive jaundice, etc., achieves high bioavailability, is beneficial to labor protection, and low production cost Effect

Inactive Publication Date: 2007-10-10
魏秀华
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, there are many adverse reactions of anti-hepatitis B drugs used clinically, such as lamivudine, ganciclovir and other nucleoside drugs, which have strong anti-HBV effects, but long-term use produces drug resistance, especially lamivudine , there will be a severe rebound after drug withdrawal, prone to fulminant jaundice

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Take 1000g of Huhuanglian, add 75% ethanol to reflux and extract twice, each time for 2 hours, combine the extracts, recover ethanol under reduced pressure, refrigerate at 2°C for 24 hours, filter, add water to dilute the filtrate to 500ml, and apply macroporous resin Column, elute respectively with water, 10% ethanol, 60% ethanol, collect the darker part of the color band of 60% ethanol elution part, reclaim ethanol, dilute to 100ml, put on silica gel column, use methanol: trichloromethane (1 :9) eluting, collecting the eluate, recovering the solvent under reduced pressure, and recrystallizing with acetone to obtain pale yellow crystals, which are the total glycosides extract of Coptis chinensis.

[0025] The yield of the total glycosides extract of berberine obtained by the process is not less than 0.5%, and the content is not less than 80% in terms of berberine II.

[0026] Take 50g of the total glycosides extract of Coptis chinensis, add 100g of polyethylene glycol ...

Embodiment 2

[0028] Take 1000g of Huhuanglian, add 80% ethanol to reflux and extract twice, each time for 2 hours, combine the extracts, recover ethanol under reduced pressure, refrigerate at 4°C for 24 hours, filter, add water to dilute the filtrate to 600ml, and apply macroporous resin Column, elute respectively with water, 15% ethanol, 70% ethanol, collect the darker part of the color band of 70% ethanol elution part, reclaim ethanol, dilute to 100ml, go up silica gel column, use methanol: trichloromethane (2 : 8) eluting, collecting the eluate, recovering the solvent under reduced pressure, and recrystallizing with acetone to obtain pale yellow crystals, which are the total glycosides extract of Coptis chinensis.

[0029] The yield of the total glycosides extract of berberine obtained by the process is not less than 0.5%, and the content is not less than 80% in terms of berberine II.

[0030] Take 50g of the total glycosides extract of Coptis chinensis, add 100g of polyethylene glycol ...

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PUM

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Abstract

A dripping pill of general picroside for protecting liver and preventing and treating hepatitis is prepared from the general picroside extracted from figwortflower picrorhiza rhizome and the medicinal matrix chosen from polyethanediol, sodium stearate, glycerin and gelatin. Its preparing process is also disclosed.

Description

technical field [0001] The invention discloses a total glycosides dripping pill of berberine rhizome and a preparation method thereof, which belong to the field of traditional Chinese medicine preparations. Background technique [0002] Hepatitis B virus (HBV) infection has become a global hazard. Of the 6 billion people in the world, about 2 billion are infected with HBV, and 350 million are chronically infected with HBV, of which 25% to 40% will eventually die of liver cirrhosis or hepatocellular carcinoma, and the number of deaths due to hepatitis B-related diseases is as high as 100 every year Thousands of cases. 15% to 20% of chronic hepatitis B patients with active virus replication develop liver cirrhosis within 5 years, while the 5-year survival rate of patients with chronic liver cirrhosis is only 55%. The risk of hepatocellular carcinoma in patients with hepatitis B is 200 times higher than that in non-hepatitis B patients. China is a large country with hepatiti...

Claims

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Application Information

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IPC IPC(8): A61K36/80A61K9/20A61P1/16A61P31/20
Inventor 魏秀华
Owner 魏秀华
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