Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Application of extract of total glucosides of picrorhiza in preparing medicines for preventing and treating fatty liver

A glucoside extract and picroside technology are applied in the field of picroside total glucosides extract in the field of preparing medicines for preventing and/or treating fatty liver, and can solve the problems of aggravating fatty liver disease, affecting liver function, liver toxicity and the like

Active Publication Date: 2012-05-23
TIANJIN INSTITUTE OF PHARMA RESEARCH
View PDF2 Cites 4 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although some lipid-regulating drugs have a short-term effect on fatty liver, they affect liver function, make blood lipids more concentrated in the liver for metabolism, and increase the burden on the liver. Long-term use has potential liver toxicity, which will aggravate the condition of fatty liver

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of extract of total glucosides of picrorhiza in preparing medicines for preventing and treating fatty liver
  • Application of extract of total glucosides of picrorhiza in preparing medicines for preventing and treating fatty liver
  • Application of extract of total glucosides of picrorhiza in preparing medicines for preventing and treating fatty liver

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Crush 20 kg of Coptis chinensis into coarse powder, soak in 60L of water for 2 hours, put it into a percolation cylinder, infiltrate with water, collect 240L of percolation liquid, and concentrate to a concentrate equivalent to 1g of medicinal material / mL. By D101 macroporous adsorption resin, wash away impurities with water, then elute with 60% (volume / volume) aqueous ethanol, concentrate the eluent, and dry under reduced pressure to obtain 2.8 kilograms of the total glycosides extract of Coptis chinensis, wherein the total glycosides content reaches 70% (weight / weight), 22.5% (weight / weight) of berberine II, and 13.9% (weight / weight) of berberine I. In addition, it also contains berberine III, berberine IV, 6- Feruloyl catalpol and 6-isoferuloyl catalpol.

[0029] Take 1.2 kg of the above-mentioned total glycosides extract of Coptis chinensis, add 1.6 kg of starch, 400 g of microcrystalline cellulose, granulate, pack into capsules, and each capsule contains 30 mg of t...

Embodiment 2

[0031] 20 kg of Coptis chinensis medicinal material is crushed into coarse powder, soaked in 60L of 30% (volume / volume) ethanol aqueous solution for 12 hours, put into the percolation cylinder, percolate with 30% (volume / volume) ethanol aqueous solution, collect 240L percolation Liquid, concentrated to a concentrated solution equivalent to 1g medicinal material / mL. Through the AB-8 macroporous adsorption resin, wash away impurities with water, then elute with 50% (volume / volume) ethanol aqueous solution, concentrate the eluate, and dry under reduced pressure to obtain 2.6 kilograms of the total glycosides extract of Coptis chinensis, wherein the total glycosides The content reaches 75% (weight / weight), 22.8% (weight / weight) of berberine II, and 14.6% (weight / weight) of berberine I. In addition, it also contains berberine III, berberine IV, 6-feruloyl catalpol and 6-isoferuloyl catalpol.

[0032] Take 1.1 kg of the above-mentioned total glycosides extract of Coptis chinensis, ad...

Embodiment 3

[0034] Grind 20 kg of Coptis chinensis into coarse powder, reflux 3 times with 60 L of 20% (volume / volume) ethanol aqueous solution, 2 hours each time, 80 L each time, combine the extracts, concentrate to the concentration equivalent to 1 g of medicinal materials / mL liquid. Through the HPD100 macroporous adsorption resin, wash away the impurities with water and 20% (volume / volume) ethanol aqueous solution, then elute with 40% (volume / volume) ethanol aqueous solution, concentrate the eluent, and dry under reduced pressure to obtain Coptis chinensis. 3 kg of glycoside extract, wherein the total glycoside content reaches 60% (weight / weight). It contains 21.6% (weight / weight) of berberine Ⅱ and 13.5% (weight / weight) of quincetin Ⅰ. In addition, it also contains quintoside Ⅲ, 4, 6-feruloyl catalpol and 6-isoferuloyl catalpol alcohol.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides an application of an extract of total glucosides of picrorhiza in preparing medicines for preventing and / or treating fatty liver and other related diseases. A preparation method of the extract of total glucosides of picrorhiza comprises the following steps: extracting picrorhiza by using a C1-C5 fatty alcohol solution having a concentration of 0-95 (v / v), removing C1-C5 fatty alcohol from the extracting solution, and then filtering; letting the filtrate pass through macroporous adsorption resin, and eluting the filtrate by using a C1-C5 fatty alcohol solution having a concentration of 0-30 (v / v), and discarding the eluent; eluting by using a C1-C5 fatty alcohol solution having a concentration of 40-100 (v / v), and removing the solvent in the eluent. The extract of total glucosides of picrorhiza prepared by the invention can be prepared into medicines for preventing and / or treating alcoholic and non-alcoholic fatty liver, acute fatty liver or chronic fatty liver, and further can prevent the formation of hepatic fibrosis.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicines, and relates to the use of a total glycosides extract of berberine, in particular to the use of a total glycosides extract of berberine in preparing medicines for preventing and / or treating fatty liver. Background technique [0002] The liver is an important organ for fat metabolism. Under normal circumstances, the weight of fat accounts for 3% to 5% of the total weight of the liver. Normal people contain 4 to 5g of lipids per 100g of liver wet weight, of which phospholipids account for more than 50%, triglycerides account for 20%, and free fatty acids account for 20%. , cholesterol is about 7%, and the rest is cholesterol fat and so on. When the lipid accumulation in the liver cells exceeds 5% of the wet weight of the liver, or when more than 1 / 3 of the liver parenchyma is fatty per unit area in histology, it is called fatty liver. The pathogenesis of fatty liver has not yet been fu...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K36/80A61P1/16
Inventor 侯文彬赵专友周福军徐旭单淇张新鑫华洁
Owner TIANJIN INSTITUTE OF PHARMA RESEARCH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com