Method for preparing picroside I

A technology of picroside and rhizoma rhizoma is applied in the field of research and development of new traditional Chinese medicines, and achieves the effects of low production cost, rapid separation and purification method, and favorable industrialized production.

Active Publication Date: 2008-05-28
北大世佳科技开发有限公司
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Problems solved by technology

There is no report about the preparation method of berberine I and its application in the preparation of medicines for the treatment of hepatitis B

Method used

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  • Method for preparing picroside I
  • Method for preparing picroside I

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Effect test

Embodiment 1

[0174] The preparation method of embodiment 1 berberine I

[0175] Get 3000g of Coptis chinensis medicinal material (3.19% of the content of berberine I in the medicinal material), be ground into the medicated powder of crossing 10 mesh sieves. Reflux with 70% ethanol that is 12 times the weight volume (v / w) of the medicinal material, and the obtained percolation solution is concentrated at 60° C. to a concentrated solution with a relative density of 1.18 to 1.20. The resulting concentrated solution is diluted with water, centrifuged, and the obtained supernatant is The speed of 1.2L / Kg.h passes through the D-101 macroporous adsorption resin column (resin diameter: height = 1:10, the amount of resin is 2.5 times the weight of the medicinal material), after the medicinal liquid has completely flowed into the resin, use 20 times the medicinal material in sequence Water by weight volume (v / w), 32 times the weight volume of medicinal materials (v / w) 15% ethanol elutes impurities, ...

Embodiment 2

[0176] The preparation method of embodiment 2 berberine I

[0177] Get 84kg of Coptis chinensis medicinal material (3.19% of the content of berberine I in the medicinal material), be ground into the medicated powder of crossing 10 mesh sieves. Percolate with 70% ethanol at a speed of 8 times the weight volume (v / w) of the medicinal material, and the obtained percolation solution is concentrated at 60° C. to a concentrated solution with a relative density of 1.18 to 1.20. The obtained concentrated solution is diluted with water, centrifuged, and the obtained supernatant is Through the ZTC type resin column, after the medicinal liquid flows into the resin completely, use 18 times the weight volume (v / w) of the medicinal material (v / w) of water, 25 times the weight volume (v / w) of the medicinal material 15% ethanol to elute the impurities, and then use 25 times the weight volume (v / w) of the medicinal material to elute the impurities. The weight volume (v / w) of the medicinal mate...

Embodiment 3

[0178] [Embodiment 3] Preparation process of berberine I for injection

[0179] Prescription: berberine I60.0g, made into 1000 sticks.

[0180] Preparation method: Take 60.0g of Pipericillin I, add about 2800mL of water for injection, dissolve in a water bath at 65°C, add a total preparation amount of 2.0‰ activated carbon (6.0g), stir for half an hour, filter, add water to the filter to 3000mL, and then Graded filtration with 0.45 μm and 0.22 μm microporous membranes, the filtrate was quantitatively dispensed into 10 mL vials at 3 mL per bottle, freeze-dried, backfilled with high-purity nitrogen, stoppered, capped, and packaged.

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Abstract

The invention relates to the research and development technical field of new Chinese medicine, in particular to a preparation method of kutkoside I, which uses advanced extraction, separation and purification technique to extract the effective component kutkoside I for treating hepatitis B from picrorhiza rhizome medicinal material, while the content of the kutkoside I is higher than 90%. The inventive preparation method has low cost, simple operation and industrialization production support.

Description

technical field [0001] The present invention is a divisional application of the 200410098646.4 invention patent application. The filing date of the original application is December 15, 2004. The invention name of the original application is the application of berberine I in the preparation of drugs for treating hepatitis B and its preparation and preparation method. The invention belongs to the field of research and development of new traditional Chinese medicines, and in particular relates to a preparation method of berberine I. Background technique [0002] As we all know, China is a big country with hepatitis B disease. At present, it is estimated that there are more than 600 kinds of medicines for the treatment of viral hepatitis in the world, but there is no satisfactory treatment medicine so far. Dr. Han Sang-tae, Permanent Honorary Chairman of the Western Pacific Region of the World Health Organization, said that the most commonly used drugs for the treatment of hepa...

Claims

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Application Information

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IPC IPC(8): C07H17/04A61K31/7048A61P1/16A61P31/14
Inventor 周亚伟
Owner 北大世佳科技开发有限公司
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