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Application of berberine as cell M3 receptor inhibitor

A technology of berberine and inhibitor, which is applied in the field of berberine as a cell M3 receptor inhibitor, can solve the problem that the target of berberine is not clear.

Inactive Publication Date: 2017-12-15
吴蕾
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the specific target of berberine is still unclear

Method used

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  • Application of berberine as cell M3 receptor inhibitor
  • Application of berberine as cell M3 receptor inhibitor
  • Application of berberine as cell M3 receptor inhibitor

Examples

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Embodiment Construction

[0058] The present invention finds for the first time that: (1) berberine can inhibit Ca in pancreatic acinar cells caused by acetylcholine 2+ signal; (2) the target of berberine is the M3 receptor on the membrane of pancreatic acinar cells; (3) berberine antagonizes the intracellular Ca in pancreatic acinar cells induced by L-arginine 2+ Signal boost.

[0059] The following examples take pancreatic cells as an example to illustrate and prove that berberine is an effective M3 receptor inhibitor, which can be effectively applied to the treatment of various diseases, such as: acute pancreatitis, lung cancer, colon cancer, autoimmune Immune sialadenitis, asthma, inflammation of the airways, treating lung disease, cardiovascular disease, reducing panic attacks, or treating overactive bladder.

[0060] 1. Materials and methods

[0061] 1. Experimental animals

[0062] Experimental animals were uniformly 6-month-old male, healthy adult wild-type mice (CD1), weighing 40-60 g, purc...

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Abstract

The invention discloses application of berberine or other pharmaceutically acceptable salts in preparing a M3 receptor selective inhibitor medicine. The medicine is used for treating acute pancreatitis, lung cancers and colon cancers, self-immunity sialadenitis, asthma, respiratory tract inflammation, lung diseases and cardiovascular diseases, relieving panic, or treating excessive activity of bladders, and is used for inhibiting the enhancing of Ca<2+> signals in pancreatic acinar cells caused by M3 receptor-mediated acetyl choline and L-arginine.

Description

technical field [0001] The present invention relates to the use of berberine as a cell M3 receptor inhibitor. Background technique [0002] Muscarinic acetylcholine receptors are acetylcholine receptors that form a receptor-G protein complex of seven transmembrane domains in the cell membrane of certain neurons and cells. Extracellular signaling molecules (ligands, such as acetylcholine Ach) activate the intracellular G protein after binding to this receptor, and start the transmission of signals in the cell. Muscarinic acetylcholine receptors play multiple roles in the body. For example, acetylcholine released from postganglionic fibers in the parasympathetic nervous system activates muscarinic receptors to produce a series of autonomic postganglionic cholinergic fiber excitation effects, including Inhibition of heart activity, contraction of bronchial smooth muscle, contraction of gastrointestinal smooth muscle, contraction of bladder detrusor muscle, contraction of iris ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4375A61P1/18A61P35/00A61P37/00A61P1/02A61P11/06A61P11/00A61P9/00A61P25/00A61P13/10
CPCA61K31/4375
Inventor 吴杰薛春
Owner 吴蕾
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