37 results about "Excessive activity" patented technology

A system and method for detecting fraud when facilitating a payment transaction over a global wide area network. The method comprises receiving a sale information, receiving a payment information from a buyer, and analyzing a transaction information for fraud. If the analyzing indicates fraud, an enhanced transaction information is communicated to a human for fraud analysis. In one embodiment, the method comprises performing rule-based analyses to determine whether the transaction appears to be fraudulent. Rule-based analyses may include suspect data rules and velocity rules. Velocity rules generally determine whether there has been excessive activity that may lead to a conclusion that the transaction may be fraudulent. Suspect data rules are used to determine whether the billing, shipping, selling addresses, telephone numbers, and account numbers, and other data are in a syntactically correct format and whether they exist. In one embodiment, the method further comprises performing simple screening of the transaction information. In one embodiment, the method further comprises seeking approval from a third party such as a financial institution based on the payment information. The method may be implemented as part of a system that includes personal computers, server computers, and other personal computing devices, some of which may communicate over the Internet, and others which may communicate via dedicated communication lines.

A system and method for detecting fraud when facilitating a payment transaction over a global wide area network. The method comprises receiving a sale information, receiving a payment information from a buyer, and analyzing a transaction information for fraud. If the analyzing indicates fraud, an enhanced transaction information is communicated to a human for fraud analysis. In one embodiment, the method comprises performing rule-based analyses to determine whether the transaction appears to be fraudulent. Rule-based analyses may include suspect data rules and velocity rules. Velocity rules generally determine whether there has been excessive activity that may lead to a conclusion that the transaction may be fraudulent. Suspect data rules are used to determine whether the billing, shipping, selling addresses, telephone numbers, and account numbers, and other data are in a syntactically correct format and whether they exist. In one embodiment, the method further comprises performing simple screening of the transaction information. In one embodiment, the method further comprises seeking approval from a third party such as a financial institution based on the payment information. The method may be implemented as part of a system that includes personal computers, server computers, and other personal computing devices, some of which may communicate over the Internet, and others which may communicate via dedicated communication lines.

Transcutaneous electrical and magnetic nerve stimulation devices and methods generate energy that is delivered noninvasively to selected nerve fibers within the patient to treat lower urinary tract disorders. The disorders comprise overactive bladder, urge incontinence, stress, incontinence, urge frequency, non-obstructive urinary retention and interstitial cystitis / painful bladder syndrome. In preferred embodiments, a posterior tibial nerve of a patient is stimulated non-invasively to treat bladder disorders.

The present invention is directed to the prevention, reversal and medical treatment of lower urinary tract dysfunction including bladder instability and other related diseases as described below including urinary flow problems, urgency and incontinence as a result of prostate hyperplasia (BPH) and to the prevention, reversal and medical treatment of irritable bowl syndrome (IBS) with special focus on the diarrhea-predominant and mixed diarrhea-constipation type IBS, both in human beings and animals.

The present disclosure is directed to a transcutaneous nerve stimulation device and system for treating overactive bladder (OAB) and its symptoms. The devices and systems described herein are intuitively shaped to enable proper placement by the user to stimulate the user's tibial nerve.

A system and method for detecting fraud when facilitating a payment transaction over a global wide area network. The method comprises receiving a sale information, receiving a payment information from a buyer, and analyzing a transaction information for fraud. If the analyzing indicates fraud, an enhanced transaction information is communicated to a human for fraud analysis. In one embodiment, the method comprises performing rule-based analyses to determine whether the transaction appears to be fraudulent. Rule-based analyses may include suspect data rules and velocity rules. Velocity rules generally determine whether there has been excessive activity that may lead to a conclusion that the transaction may be fraudulent. Suspect data rules are used to determine whether the billing, shipping, selling addresses, telephone numbers, and account numbers, and other data are in a syntactically correct format and whether they exist. In one embodiment, the method further comprises performing simple screening of the transaction information. In one embodiment, the method further comprises seeking approval from a third party such as a financial institution based on the payment information. The method may be implemented as part of a system that includes personal computers, server computers, and other personal computing devices, some of which may communicate over the Internet, and others which may communicate via dedicated communication lines.

The present invention relates to one kind of 3, 4-dihydro-1H-2-benzopyran-1-ketone compounds, and provides the preparation process of these compounds. These compounds have LAR and PTPsigma inhibiting effect, and may be used in treating various types of diabetes, obesity and their complication as well as other diseases caused by excessive activity or over expression of PTP-LAR and / or PTPsigma, such as tumor and nervous degenerative disease.

Treatments are disclosed for inflammatory, autoimmune, or other disorders characterized by excessive activity of calprotectin, a protein that normally defends against microbial infections by sequestering available zinc, at a site of infection. Excessive calprotectin activity, which can cause zinc deficiencies in localized tissues, can create or aggravate various disorders. However, ingestion of systemic (oral) zinc supplements tends to activate offsetting mechanisms, and such supplements therefore usually are ineffective. Accordingly, targeted treatments are disclosed herein for suppressing and controlling excessive calprotectin activity, in local tissues. Such methods include targeted injections of zinc solutions, and plasmapheresis treatment. Screening tests also are described for identifying non-protein drugs that can either (i) bind specifically to the zinc-binding sites of calprotectin, or (ii) suppress the release of calprotectin by neutrophil cells.

The invention relates to a bird damage prevention method, and particularly discloses a power transmission line insulation bird damage prevention method which is suitable for a 35 kV to 220 kV line. The structure main points are as follows: a lead insulation sheath, a metal fitting insulation protection box and an insulation hot melt wrapped belt are arranged; the lead at the cross-arm side of a power transmission line is wrapped by the lead insulation sheath; the metal fitting insulation protection box is adaptive to metal fittings connected with leads in terms of shape, and the metal fittings are wrapped by the metal fitting insulation protection box; and the insulation hot melt wrapped belt is wound on insulator chain grading rings connected with the metal fittings. According to the invention, breakthroughs are made in the adoption of an idea of insulating and isolating bird damage, and various line damage traces of the activities of birds are isolated so that the method is quite practical and also reliable in bird damage prevention effectiveness, the rate of trip-out failures caused by the bird damage can be effectively reduced, and the safe and reliable operation of the power transmission line can be guaranteed, thus excessive activities that interfere with the birds are unnecessary, peaceful co-existence with the birds can be realized, and the ecological environment is protected.

According to various embodiments of the present disclosure, there is provided a hypermotor activity detection system, including: a video capture device configured to monitor a patient and obtain a video input; and a processing system configured to process the video input, including: a optical flow module configured to carry out an optical flow analysis on a video input region determined from the video input, and further determine a flow field magnitude of the video input region; a local motion reference module including: a division module configured to divide the video input region into a plurality of sub-windows; a sub-window flow module configured to determine a sub-window flow field magnitude for each of the plurality of sub-windows; a local motion magnitude module configured to obtain a magnitude of local motion based on the sub-window flow field magnitude for each of the plurality of sub-windows; and a local motion comparison module configured to compare the magnitude of local motion with a local motion threshold for a predetermined number of observation frames to obtain a local motion reference value. Further, a corresponding method for detecting hypermotor activity is provided.

This invention relates to bicyclic amide, carbamate or urea derivatives and salts thereof which are useful as active ingredients of pharmaceutical preparations. The bicyclic amide, carbamate or urea derivative of the present invention has vanilloid receptor (VR1) antagonistic activity, and can be used for the prophylaxis and treatment of diseases associated with VR1 activity, in particular for the treatment of urological diseases or disorders, such as detrusor overactivity (overactive bladder), urinary incontinence, neurogenic detrusor oeractivity (detrusor hyperflexia), idiopathic detrusor overactivity (detrusor instability), benign prostatic hyperplasia, and lower urinary tract symptoms; chronic pain, neuropathic pain, postoperative pain, rheumatoid arthritic pain, neuralgia, neuropathies, algesia, nerve injury, ischaemia, neurodegeneration, stroke, and inflammatory disorders such as asthma and chronic obstructive pulmonary (or airways) disease (COPD).

The present invention relates to a monoclonal antibody capable of neutralising cathepsin B. In particular, the present invention is concerned with the use of such an antibody for the detection or treatment of diseases associated with an over-expression and / or excessive activity of cathepsin B, such as cancer or arthritis.

The invention discloses application of berberine or other pharmaceutically acceptable salts in preparing a M3 receptor selective inhibitor medicine. The medicine is used for treating acute pancreatitis, lung cancers and colon cancers, self-immunity sialadenitis, asthma, respiratory tract inflammation, lung diseases and cardiovascular diseases, relieving panic, or treating excessive activity of bladders, and is used for inhibiting the enhancing of Ca<2+> signals in pancreatic acinar cells caused by M3 receptor-mediated acetyl choline and L-arginine.

The invention provides an excessive activity-preventing infusion seat for children. The excessive activity-preventing infusion seat comprises a seat main frame structure, an infusion plate structure, an attending structure and an infusion frame. An object holding plate is connected with a first armrest via two first unit aluminum hinges. The infusion plate is installed on the upper end of a second armrest; a child fixing plate is mounted on the lower end of the infusion plate; the infusion plate is connected with the second armrest via two second unit aluminum hinges. The upper end of an attending stool seat base plate is provided with a first concave lower slide rail and the upper end of the attending stool seat base plate is provided with a second concave lower slide rail; the second concave lower slide rail is arranged on the right side of the first concave lower slide rail; the right end of a hydraulic cylinder is provided with a pedal device and the upper end of the hydraulic cylinder is connected with a sliding rod; the outer side of the sliding rod is provided with a fixing sleeve; the upper end of the sliding rod is provided with a supporting frame and the lower end of the supporting frame is provided with a weight sensor; the lower end of the weight sensor is provided with an infusion lift hook. The excessive activity-preventing infusion seat is convenient to use, can hold objects, is suitable for both children and adults, facilitates observation of infusion conditions and facilitates rest of attending people.

This invention relates to tetrahydro-naphthalene derivatives of formula (I) in which the variable groups are as defined in the specification and claims, and tautomeric and stereoisomeric forms and salts thereof which are useful as active ingredients of pharmaceutical preparations. The tetrahydro-naphthalene derivatives of the present invention have an excellent activity as VR1 antagonists and are useful for the prophylaxis and treatment of diseases associated with VR1 activity, in particular for the treatment of urinary incontinence, urge urinary incontinence, overactive bladder, chronic pain, neuropathic pain, postoperative pain, rheumatoid arthritic pain, neuralgia, neuropathies, algesia, nerve injury, ischaemia, neurodegeneration, stroke, inflammatory disorders, asthma and COPD. The compounds, pharmaceutical compositions containing them, and methods of treatment using them are disclosed and claimed.

The invention discloses a nitrogen-containing heterocyclic substituted pyrrolidine formyl thiomorpholin DPP-IV inhibitor, a preparation method therefor and use thereof. Specifically, the invention relates to a compound shown in a formula (I), a stereisomer thereof and pharmaceutically acceptable salt thereof mentioned in the description. The invention further relates to a pharmaceutical composition comprising the compound, use of the compound in preparing drugs for treating and / or preventing diseases or illnesses associated with DDP-IV excessive activity or DPP-IV overexpression and a method of treating associated diseases by using the compound. The compound disclosed by the invention has the effect of effectively inhibiting the activity of DDP-IV. The FORMULA is shown in the description.

The present invention relates to a method for determining likelihood of an individual of developing a psychiatric disorder. More particularly, the method of the invention is based on the identification of genetic variations in genes involved in the modulation of melatonin and their consequences on such pathway for the determination of whether an individual is susceptible of being afflicted by a psychiatric disorder such as autism spectrum disorders (ASD), Deficits and Hyper Activity Disorder (ADHD) and anorexia.

The invention relates to a method for using (-) apholate to prepare the drug that treats urinary tract infection and bladder disease. Wherein, the (-)apholate (methanesulfonic acid or alcaine) can treat blood pressure and heart weaker than (+-) apholate (methanesulfonic acid or alcaine) and (+)apholate (methanesulfonic acid or alcaine). Therefore, its side effect is less than them. The invention can strengthen the eccentric heart muscle contract force, and the (+-) apholate (methanesulfonic acid or alcaine) and (+)apholate (methanesulfonic acid or alcaine) will restrain said force.

Thin film substrates are electroplated with copper from low internal stress, high ductility acid copper electroplating baths. During the copper electroplating process the thin film substrates can warp or bow. To address the problem of warping or bowing during copper electroplating the thin film substrate is held by a securing means which inhibits the thin film substrate from excessive activity.

An object of the present invention is to provide a novel compound having a strong opening action with respect to KCNQ2-5 channels. A compound represented by the general formula (I) (wherein the definition of each group is as described in the specification) is provided. The compound represented by the general formula (I) has a strong opening action with respect to KCNQ2-5 channels, and therefore is useful as a prophylactic and / or therapeutic agent for a KCNQ2-5 channel-related disease (for example, dysuria, overactive bladder, or the like).

The invention relates to an experimental animal caudal vertebra swing device and an application thereof. The device comprises a base, a motor, a rocking bar component, an animal placing platform, a caudal vertebra head end fixing rack and a caudal vertebra tail end fixing rack, wherein the animal placing platform is fixed on the base; the caudal vertebra head end fixing rack is fixed at one end of the animal placing platform; the motor is fixed below the base; one end of the rocking bar component is connected on the motor; the other end of the rocking bar component is fixedly connected with the caudal vertebra tail end fixing rack; the caudal vertebra tail end fixing rack and the caudal vertebra head end fixing rack are arranged at the same height; and the motor drives the caudal vertebra tail end fixing rack to swing through the rocking bar component, so that the experimental animal caudal vertebra with two ends fixed by the caudal vertebra head end fixing rack and the caudal vertebra tail end fixing rack respectively swing. Compared with the prior art, the device can realize dynamic acceleration and swing on an experimental animal tail intervertebral disc to simulate long-time activities or excessive activities, namely overtime and super-amplitude activities of the intervertebral disc, so that influence of different swing effects to the intervertebral disc is observed.

Thin film substrates are electroplated with copper from low internal stress, high ductility acid copper electroplating baths. During the copper electroplating process the thin film substrates can warp or bow. To address the problem of warping or bowing during copper electroplating the thin film substrate is held by a securing means which inhibits the thin film substrate from excessive activity.

The invention relates to a drug compound for treating disease of lower urinary tract, which comprises drug active component, drug carrier or shaping agent, wherein the drug active component is terraazoles and amiloripin. The disease of lower urinary tract relates to prostatitis increment, lower urinary tract syndrome and bladder excessive activities, in particular to treat lower urinary tract syndrome and bladder excessive activities induced by prostatitis increment. And the inventive drug can be used treat the high blood pressure concomitant with lower urinary tract, to effectively control blood pressure and resolve the lower urinary tract disease, compared with single terraazoles or amiloripin drug, to improve the health quality of patient.

The invention provides novel compositions and compounds that inhibit CatSper channel activity, that preferentially inhibits sperm hyperactivity over sperm motility, or both. The compounds of the invention are useful as contraceptive agents that may be adminstered to males, females, or concurrently to both sexual partners. The invention further provides methods of conducting drug discovery business and of conducting a reproductive medicine business. The invention also provides methods of identifying compounds that modulate sperm hypermotility.

The invention provides an anastomosis nail for an anastomat. The anastomosis nail for the anastomat comprises a 'II'-shaped anastomosis nail body die-casted by a degradable magnesium alloy, the 'II'-shaped anastomosis nail body is provided with a nail body, two vertical taper nails are molded at the two ends of the nail body, a transverse rib is molded on the nail body face, a guiding groove is molded on the lower surface of the nail body face, and multiple barbs are molded on the periphery of the two vertical taper nails. The anastomosis nail for the anastomat has the advantages that the twovertical taper nails are molded at the two ends of the nail body, the transverse rib is molded on the nail body face, so that the anastomosis nail is pierced into human tissue or organs very easily when performing suture, the operation is fast, the anastomosis is safe, the brought trauma is very little, the anastomosis nail has enough suture strength, the barbs are molded on the periphery of the vertical taper nails molded at the two ends of the nail body, so that the sutured anastomosis nail bonds the human tissue or organs more tightly and cannot be easily break away from the human tissue ororgans due to excessive activity caused by external forces.

The present invention provides a compound of the formula (I) and the pharmaceutically acceptable salts and solvates thereof, which is useful for treating bladder over-activity or urinary incontinence.

The invention discloses a grounding claw, which comprises a long rod body, wherein a plurality of columnar structures are formed on the rod body; one side, opposite to the columnar structures, of the rod body is provided with a notch; a bulge is formed in the middle of the notch; and the two ends of the rod body have convex structures. The notch is connected to a welding point of the grounding claw, and the area of metal required to be heated is reduced during welding by virtue of the added bulge. Due to the bulge, the original notch is changed into two notches. During welding, a welding head can be directly contacted with solder paste, and thus the welding speed is enhanced. The convex structures designed at the two ends of the rod body aims to avoid excessive activity space after the grounding claw is arranged in a connector, and have the functions of positioning and preventing movement during welding, and reducing poor welding. After the grounding claw is welded by a welding machine, the welding yield reaches 100 percent.

The invention provides a substituted olefin compound, and a preparation method and application thereof. Specifically, the application provides a substituted olefin compound, a stereoisomer, prodrug, solvate, and pharmaceutically acceptable salt or ester of the substituted olefin compound, a preparation method of the substituted olefin compound, and an application in preparing medicines for treating diseases relative to an excessive activity of estrogen receptors (such as ERalpha).