43 results about "Renal Hypertensions" patented technology

Sympathetic nerves run through the adventitia surrounding renal arteries and are critical in the modulation of systemic hypertension. Hyperactivity of these nerves can cause renal hypertension, a disease prevalent in 30-40% of the adult population. Hypertension can be treated with neuromodulating agents (such as angiotensin converting enzyme inhibitors, angiotensin II inhibitors, or aldosterone receptor blockers), but requires adherence to strict regimens and often does not reach target blood pressure threshold to reduce risk of major cardiovascular events. A minimally invasive solution is presented here to reduce the activity of the sympathetic nerves surrounding the renal artery by locally delivering neurotoxic or sympathetic nerve-blocking agents into the adventitia. Extended elution of these agents may also be accomplished in order to tailor the therapy to the patient.

Sympathetic nerves run through the adventitia surrounding renal arteries and are critical in the modulation of systemic hypertension. Hyperactivity of these nerves can cause renal hypertension, a disease prevalent in 30-40% of the adult population. Hypertension can be treated with neuromodulating agents (such as angiotensin converting enzyme inhibitors, angiotensin II inhibitors, or aldosterone receptor blockers), but requires adherence to strict regimens and often does not reach target blood pressure threshold to reduce risk of major cardiovascular events. A minimally invasive solution is presented here to reduce the activity of the sympathetic nerves surrounding the renal artery by locally delivering neurotoxic or sympathetic nerve-blocking agents into the adventitia. Extended elution of these agents may also be accomplished in order to tailor the therapy to the patient.

The invention relates to a medicinal composition using Efonidipine as the active constituent, the process for preparation and use thereof, which also contains pharmaceutically acceptable auxiliary materials, and can be used for the treatment of primary hypertension, severe hypertension and renal hypertension. The composition can be prepared into tablets, capsules, dispersible tablets, soft capsules, chewable tablets, buccal tablets, buccal tablets, dried suspending agents, and dripping pills.

The invention relates to a Chinese medicinal preparation for treating kidney diseases and process for preparation, wherein the medicament is prepared from the following Chinese medicinal herbs (by weight portion): red sage root 20-30 parts, barbat skullcap 5-10 parts, safflower 5-10 parts, Japanese felt fern leaf. 5-10 parts, honeysuckle flower 5-10 parts, rheum officinale 10-15 parts, capsule of weeping forsythia 5-10 parts, licorice root 3-6 parts, poria cocos wolf 10-15 parts, panax notoginseng saponins 1-1.5 parts.

A method of reducing renal hypertension applied for electrically stimulating a target zone of an organism having a symptom of renal hypertension by using an electronic stimulation device. The electronic stimulation device comprises at least one electronic stimulation unit. The electronic stimulation unit includes at least one first electrode and at least one second electrode. The method includes the following steps. The electrical stimulation unit is placed near the target zone. The electrical stimulation unit generates an electrical stimulation signal and the electrical stimulation signal is introduced to the target zone so as to stimulate the target zone. An electric field is generated between the first electrode and the second electrode and covers the target zone. The strength of the electric field ranges from 100V / m to 1000V / m.

The invention discloses a traditional Chinese medicine composition for treating hypertension, which takes Ligusticum wallichii, uncaria and radix ophiopogonis as raw materials. The test result shows that the Ligusticum wallichii, the uncaria and the radix ophiopogonis have excellent interaction after compatibility of medicines, and can obviously lower the systolic pressure and the diastolic pressure of model animals with spontaneous hypertension and renal hypertension, and pressure reduction effect is long-lasting. The composition has the advantages of reasonable compound prescription and appropriate compatibility proportion, has the function on calming liver wind, nourishing yin and invigorating the circulation of blood and has definite curative effect on hypertension patients with the symptom of yin deficiency and yang excess as well as blood stasis obstructing the collaterals. The composition can be prepared into medically-acceptable solid oral preparations, such as tablets, capsules (soft capsules or hard capsules), granules and the like, can be used for treating hypertension, and is safe, effective and convenient to use.

The invention relates to a preparation method and an application of an effective part of dracocephalum heterophyllum benth. The method comprises the steps that an aboveground part of the dracocephalum heterophyllum benth is smashed, extracted by an organic solvent, namely alcohol, and subjected to macroporous resin separation and purification to form the effective part of the dracocephalum heterophyllum benth. A preliminary activity screening test proves that the effective part of the dracocephalum heterophyllum benth obtained by the method has functions of lowering renal hypertension and rat blood pressure, and enhancing diastole and systole, and can also effectively prevent and treat hypertension complications including myocardial hypertrophy, renal injuries and vascular endothelial injuries. The method is simple in technology, low in production cost, and easy to control, and does not require high temperature or high pressure equipment, and the quality of the effective component is stable.

The invention discloses kumquat essential oil and a preparation method and application thereof. The kumquat essential oil is a pure natural substance extracted from kumquat fruits. The kumquat essential oil is obtained through dry steaming extraction, main active ingredients and content in the kumquat essential oil are measured by utilizing GC-MS, and then a hypertension animal model test is established, so that the kumquat essential oil and the active ingredients thereof are proved to be capable of obviously reducing vasoconstriction pressure and regulating vasodilatation factors such as angiotensin II and the like and also capable of relieving target organ damage caused by hypertension; and a cell test proves that the kumquat essential oil is capable of regulating the angiotensin II to induce HUVEC cell viability. Therefore, the kumquat essential oil has good prevention and treatment effects on renal hypertension.

The invention discloses bepiastine. A formula consists of the following components by weight: 666g of bear gall powder and 3,200g of mile swertia, wherein a mile swertia raw material is required to be taken from a nationally-specified place, i.e., Mile in Yunnan Province; and the content of bear gall powder is required to reach a national medicament standard. A preparation method comprises the following steps of: extracting mile swertia twice by taking water as a solvent at the temperature of 80-90 DEG C, every time for 4 hours; combining extracting solutions; filtering with a micro water filter membrane; concentrating a filtrate in vacuum at a low temperature into thick paste of 1.30-1.35 (50 DEG C); drying into dry extract under reduced pressure; smashing the bear gall powder, mile swertia and dry extract respectively; sieving with a 120-mesh sieve, mixing uniformly and sterilizing; pilling with diluted ethanol, drying and preparing to 1,000g; and inspecting, performing split charging and warehousing. The formula of the bepiastine is scientific and reasonable, the requirements of mile swertia and bear gall powder raw materials are strict, a bepiastine product has stable quality and a perfect production process, and production conditions are consistent with Good Manufacturing Practice (GMP), i.e., a medicament production GMP standard. The bepiastine product has remarkable curative effects on the treatment of acute and chronic hepatitis, cholecystitis and gall-stone, resisting of arrhythmia, reduction in cholesterol in blood and triglyceride and prevention of hyperlipoidemia and renal hypertension. After long-term use, the bepiastine is free from untoward effects, and is safe and reliable.

The invention discloses a fortunella margarita extract as well as a preparation method and application thereof. The fortunella margarita extract is a pure natural substance extracted from fortunella margarita fruits. The fortunella margarita extract is obtained through ethanol reflux extraction, the main active ingredients and content in the fortunella margarita extract are determined by using GC-MS, and a hypertension animal model establishment test proves that the fortunella margarita extract and the active ingredients thereof can obviously reduce vasodilation pressure, regulate angiotensinII and other vasodilation factors, and besides, relieve target organ damage caused by hypertension. Cell tests prove that the HUVEC cell viability induced by the angiotensin II can be regulated. Therefore, the fortunella margarita extract has a good prevention and treatment effect on renal hypertension.

The invention discloses a kumquat extract, a preparation method and application thereof. Kumquat extract is a kind of pure natural substance extracted from kumquat fruit. The present invention obtains the kumquat extract by ethanol reflux extraction, utilizes GC-MS to measure the main active components and content in the kumquat extract, and then proves that the kumquat extract and its active components can Significantly reduce vasoconstrictive blood pressure, regulate vasodilator factors such as angiotensin II, and at the same time reduce target organ damage caused by high blood pressure; through cell experiments, it has been proved that it can regulate the viability of HUVEC cells induced by angiotensin II. Therefore, kumquat extract has a good preventive effect on renal hypertension.

The invention discloses a traditional Chinese medicine composition for treating renal hypertension. The traditional Chinese medicine composition for treating renal hypertension is prepared from the following medicinal raw materials in parts by weight: 3-20 parts of prepared aconite root, 10-60 parts of astragalus root, 7.5-30 parts of pachyma cocos, 10-60 parts of roripa Montana and 5-20 parts of rhizoma zedoariae. In addition, the invention further discloses a preparation method and application of the traditional Chinese medicine composition for treating renal hypertension. Experiments show that the traditional Chinese medicine composition disclosed by the invention has the functions of definitely reducing renal hypertension and protecting the kidneys, and can continuously improve the blood pressure condition of patients suffering from renal hypertension; the composition disclosed by the invention is conveniently taken with a small dosage and has reliable curative effect.

The invention discloses a kumquat essential oil, a preparation method and application thereof. Kumquat essential oil is a kind of pure natural substance extracted from kumquat fruit. The present invention obtains kumquat essential oil through dry steam extraction, uses GC-MS to measure the main active components and content in the kumquat essential oil, and then establishes a hypertensive animal model test to prove that the kumquat essential oil and its active components can significantly reduce blood vessel Systolic blood pressure, regulating angiotensin II and other vasodilatory factors, while reducing target organ damage caused by high blood pressure; through cell experiments, it has been proved that it can regulate angiotensin II to induce HUVEC cell viability. Therefore, kumquat essential oil has a good preventive effect on renal hypertension.