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A traditional Chinese medicine composition for treating renal hypertension and its preparation method and application

A technology of renal hypertension and composition, which is applied in the preparation of the traditional Chinese medicine composition, and in the field of traditional Chinese medicine composition for effectively treating renal hypertension, can solve problems such as exacerbation of renal disease and acute renal failure, and achieve improvement of blood pressure and reduction of renal failure. Sexual hypertension, the effect of small dosage

Active Publication Date: 2017-08-25
SHUGUANG HOSPITAL AFFILIATED WITH SHANGHAI UNIV OF T C M
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, what is not satisfactory is that there are many kidney diseases, such as renal hypertension caused by the only functioning kidney, severe bilateral renal artery stenosis, and progressive nephropathy. The use of such drugs may aggravate the kidney disease or even lead to acute renal failure. , so some patients with renal hypertension cannot benefit from it

Method used

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  • A traditional Chinese medicine composition for treating renal hypertension and its preparation method and application
  • A traditional Chinese medicine composition for treating renal hypertension and its preparation method and application
  • A traditional Chinese medicine composition for treating renal hypertension and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Embodiment 1 design uniform design table:

[0020] Use the DPSVT.05 version data processing system to generate U 20 (20 8 ) table, using U 20 (20 8 ) table arranges factors and levels, and each row represents a new group of 20 groups. Table 1, as shown below:

[0021] Table 18 Factor 10 Level 20 Experiment Uniform Design Use Table

[0022]

Embodiment 2

[0023] Embodiment 2: determine experimental scheme

[0024] On the basis of the previous research, taking the 8 traditional Chinese medicines in the Yiqiyang TCM prescription as the investigation factors, X1, X2, X3, X4, X5, X6, X7, and X8 represent Huangqi, Shufuzi, Atractylodes macrocephala, Radix Paeoniae Alba, and Poria cocos, respectively. , Zedoary, Tinglizi, Plantago, 10 levels were taken for each factor (the level is the daily dose per kilogram of body weight of rats), and the uniform design experimental plan was determined by the quasi-level method. The dose range of X1, X7, X8 is 0.9-5.4g, the dose range of X2 is 0.27-1.8g, the dose range of X3, X4 is 0.54-2.16g, the dose range of X5 is 0.675-2.7g, and the dose range of X6 is 0.45-1.8g . The experimental results are shown in Table 2.

[0025] Table 2 Experimental scheme

[0026]

Embodiment 3

[0027] Example 3: Screening the main effect traditional Chinese medicine and optimal dosage for improving renal hypertension and protecting the kidneys

[0028] 1 Screen the main effect traditional Chinese medicine for improving renal hypertension and the optimal dose:

[0029] 1) The arterial blood pressure of the left forelimb in rats with coarctation of the abdominal aorta was significantly increased at 4, 8, 12, 20, and 24 weeks (P<0.05, P<0.05, P<0.05, P<0.05, P<0.05 ) (see Table 3).

[0030] Table 3 Blood pressure list of rats with coarctation of the abdominal aorta at 4, 8, 12, 20, and 24 weeks after modeling

[0031]

[0032] Note: Compared with the sham operation group, *P<0.05, **P<0.01; the same below

[0033] 2) Evenly design the blood pressure of each group and obtain the regression equation through stepwise regression analysis: Y sbp =166.26+2.342*Astragalus*Ezhu-1.433*Cooked Aconite*Tinglizi: Y dbp =128.239-1.497*Tinglizi*Poria cocos. The regression equa...

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Abstract

The invention discloses a traditional Chinese medicine composition for treating renal hypertension. The traditional Chinese medicine composition for treating renal hypertension is prepared from the following medicinal raw materials in parts by weight: 3-20 parts of prepared aconite root, 10-60 parts of astragalus root, 7.5-30 parts of pachyma cocos, 10-60 parts of roripa Montana and 5-20 parts of rhizoma zedoariae. In addition, the invention further discloses a preparation method and application of the traditional Chinese medicine composition for treating renal hypertension. Experiments show that the traditional Chinese medicine composition disclosed by the invention has the functions of definitely reducing renal hypertension and protecting the kidneys, and can continuously improve the blood pressure condition of patients suffering from renal hypertension; the composition disclosed by the invention is conveniently taken with a small dosage and has reliable curative effect.

Description

[0001] Technical field: [0002] The invention belongs to the field of traditional Chinese medicine and relates to a traditional Chinese medicine composition, in particular to a traditional Chinese medicine composition for effectively treating renal hypertension; in addition, the invention also relates to a preparation method and application of the traditional Chinese medicine composition. [0003] Background technique: [0004] Renal hypertension accounts for 10% of the total number of hypertensive patients and is one of the most important causes of secondary hypertension. In clinical practice, it is more difficult to treat and control than essential hypertension. [0005] Currently, according to the guidelines issued by ACC / AHA, angiotensin converting enzyme inhibitors (angiotensin converting enzyme inhibitors, ACEI), angiotensin II receptor antagonist (Angiotensin II receptor antagonist, ARB), calcium channel blocker (calcium channel blocker , CCB) and β-receptor blocker (β...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/9066A61P9/12A61P13/12
CPCA61K9/0095A61K9/14A61K9/1652A61K9/20A61K9/48A61K36/076A61K36/31A61K36/481A61K36/714A61K36/9066A61K2236/331A61K2236/39A61K2236/51A61K2300/00
Inventor 刘永明蒋梅先鲁成宋磊
Owner SHUGUANG HOSPITAL AFFILIATED WITH SHANGHAI UNIV OF T C M
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