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38results about How to "Improve antihypertensive effect" patented technology
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Compound preparation of calcium antagonist and timishatan for reducing blood pressure and its use
ActiveCN1679954AUnique Pharmacological PropertiesPharmacological properties are slowOrganic active ingredientsCardiovascular disorderReflexREFLEX DECREASE
The invention discloses a compound preparation of calcium antagonist and timishatan for reducing blood pressure and its use. The inventive compound preparation is composed of following components by weight portion: 10-160 portion of timishatan, 0.5-50 protion of calcium antagonist. The calcium antagonist expands blood vessel to induce reflex sympathetic nerve excitement and the timishatan antagonizes neurohormone activity which is able to release from the sympathicus over-activation in the CCB blood pressure reduction, reduce the adverse effect induced by CCB treatment, provide all-around protection of the target organ such as heart, brain and kidney. The association of two acts synergistic effect to reduce blood pressure.
Owner:SUZHOU DAWNRAYS PHARM CO LTD
Pharmaceutical composition of atenolol/amlodipine/folacin compound and uses thereof
InactiveCN101406472AImprove antihypertensive effectTake a small doseOrganic active ingredientsCardiovascular disorderDiseaseSide effect
The invention relates to a pharmaceutical composition containing atenolol, amlodipine, or folic acid compounds and application thereof. The pharmaceutical composition contains an officinal dosage of the atenolol, an officinal dosage of the amlodipine or levamlodipine, an officinal dosage of the folic acid compounds, and a pharmaceutical acceptable carrier. The dosage of the atenolol is between 5 and 50 milligrams, the dosage of the amlodipine or the levamlodipine is between 0.5 and 5.0 milligrams, and the dosage of the folic acid type compounds is between 0.2 and 1.6 milligrams. The pharmaceutical composition has the following advantages: the pharmaceutical composition enhances the hypertension curative effect through multi-target synergistic hypotensive action, and reduces the taking dosage of the amlodipine simultaneously, that is, just about one fourth of the original dosage can achieve the same hypotensive effect and reduce the side effects and medical expenses; and more importantly, the pharmaceutical composition can effectively prevent and treat or delay various complications of high blood pressure cardiovascular and cerebrovascular diseases such as cerebrovascular disorder and the like through dual targets (Hcy and blood pressure) on the basis of reducing toxic side effects. Besides, the pharmaceutical composition ensures that patients can take medicine conveniently.
Owner:史克勇
Risk assessment method and device based on literature data and server
ActiveCN106156483AIncrease awarenessImprove antihypertensive effectMedical informaticsText database indexingGraphicsCognition
The invention provides a risk assessment method and device based on literature data and a server. The method comprises: acquiring all article abstract data of a biomedical literature database; establishing an abstract database of articles related to adverse reactions of certain antihypertensive drugs through limiting a medical subject heading; establishing a data index for measuring article quality related to the adverse reactions of the certain antihypertensive drugs; extracting information of articles, authors, journals, publication types and adverse reactions of the certain antihypertensive drug in each article related to the certain antihypertensive drugs according to the abstract database; and constructing a weighting heterogeneous graphic according to the extracted information and data and sorting to obtain ranking information of the adverse reactions of the certain antihypertensive drugs. The method provided by the invention can recommend the ranking information of the adverse reactions of all types of the antihypertensive drugs, so that the use risk of the antihypertensive drugs is evaluated, the cognition on the risks of the antihypertensive drugs by low-experience and grass-roots doctors and patients is improved, adverse events are reduced and the antihypertensive curative effect is improved.
Owner:李雪 +6
Lercanidipine hydrochloride and losartan potassium compound preparation and preparation method thereof
ActiveCN102600146AReduce adverse reactionsImprove protectionOrganic active ingredientsMetabolism disorderTolerabilitySodium starch
Owner:ZHAOKE PHARMA HEFEI
Preparation method of burdock blood pressure reduction tea
InactiveCN103109960AStabilize chlorogenic acid contentImprove antihypertensive effectTea substituesChlorogenic acidMedicine
The invention discloses a preparation method of burdock blood pressure reduction tea. The method comprises the following steps of: dicing burdock, so that the burdock is easily dissolved in water to improve the utilization rate of tea; adopting a cooking machine processing technology, so that the original taste of the burdock is effectively changed to be the mellow taste accepted by common people; heating and controlling temperature and a pH value by using a 40% ethanol solution; alcoholizing chlorogenic acid of burdock dices in the burdock and stabilizing the content of the chlorogenic acid in the tea, wherein the chlorogenic acid is mainly used for blood pressure reduction, the content of burdock is 0.86g per 100g, the burdock is difficultly volatilized, and the blood pressure reduction efficiency is improved; drying the burdock after the special process under the condition that the air pressure is 0.5Pa and the temperature is controlled to be below 25-30 DEG C according to the characteristic of the chlorogenic acid in the burdock so that the content of the chlorogenic acid in the burdock is further stabilized; and frying the burdock at a low temperature to obtain the burdock blood pressure reduction tea.
Owner:QINGDAO HAOTIAN FOOD
Application method of radix paeoniae alba to preparation of drug for treating high blood pressure
ActiveCN108743676AThe actual curative effect cannot be improvedBlood pressure drops fasterNatural extract food ingredientsFood ingredient functionsWestern medicineAlcohol
The invention relates to a preparation technology of a drug and aims at providing an application method of a drug for treating high blood pressure. The preparation technology comprises the following steps: taking radix paeoniae alba, grinding into powder, carrying out alcohol extraction and carrying out water extraction treatment on residues subjected to the alcohol extraction; respectively concentrating an extracting solution and then combining; adding accessories according to a conventional pharmaceutical processing method to obtain a drug dosage form for treating the high blood pressure. According to the preparation method disclosed by the invention, an extract obtained by an alcohol-water extracting method of the radix paeoniae alba has an outstanding curative effect of treating the high blood pressure: after the drug is administrated, the lowering speed of blood pressure is remarkably increased recently, the lowering amplitude is significantly improved, and the antihypertensive effect of the drug can exceed that of western medicine irbesartan. Compared with conventional water extraction, the application method disclosed by the invention has the advantages that the component loss is reduced, further the effectiveness is improved, the radix paeoniae alba is promoted to be completely utilized by a human body through oral medication, and the curative effect is improved. The drug selectively adjusts patients with the high blood pressure and has no influence on normal blood pressure.
Owner:HANGZHOU DANHE PHARM CO LTD
Compound antihypertensive medicament
InactiveCN101756972ASuitable for long-term useGood blood pressure effectOrganic active ingredientsCardiovascular disorderNifedipineSide effect
The invention discloses a compound preparation for treating hypertension, which comprises 5-30mg of nifedipine and 12.5-75mg of atenolol. The product of the invention overcomes the defect that a side effect is markedly enhanced caused by increasing the medicament dosage for ensuring the curative effect when the nifedipine and the atenolol are clinically used at present and one medicament is singly used, and provides a new compound preparation. The nifedipine and the atenolol are combined, and the curative effect has synergistic and complementary actions; the tolerance of patients is increased, the compliance is improved, the dosage is decreased, an adverse reaction is lightened, and the compound preparation is convenient to take and has low price.
Owner:JIANGSU JIBEIER PHARMA
Compound preparation for treating hypertension
InactiveCN1579389AImprove toleranceSuitable for long-term useCardiovascular disorderTolerabilityLarge dose
The invention discloses a compound preparation for curing hypertension. The invention contains ingredients with following day doses: 0.5-2.5mg of indapamide and 1.25-5mg of piaster. The pressure relief effect is excellent than one single medicine with a large dose, and it can eliminate the bad reaction caused by one single medicine, prevents the compensation reaction caused by using one single medicine to relief blood pressure, upgrades the patience of sufferer, upgrades the compliance.
Owner:GUANGDONG CARDIOVASCULAR INSITITUTE
Compound preparation of calcium antagonist and timishatan for reducing blood pressure and its use
ActiveCN1298389CImprove efficacyGood effectOrganic active ingredientsCardiovascular disorderNeurohormonesMechanism of action
Owner:SUZHOU DAWNRAYS PHARM CO LTD
Antihypertensive medicament
InactiveCN101757005ASuitable for long-term useGood blood pressure effectOrganic active ingredientsCardiovascular disorderSide effectTolerability
The invention discloses a complex preparation for curing hypertension. The preparation comprises 2 to 50mg of fosinopril and 5 to 30mg of hydrochlorothiazide. The invention overcomes the defect that obviously increased side effects are caused by increasing the medicament dosage to ensure the curative effect in single medicament when the fosinopril and the hydrochlorothiazide are used clinically, and provides the novel compound preparation. By combining the fosinopril and the hydrochlorothiazide, the ntihypertensive medicament has synergic and complementary curative effect. The compound preparation has the advantages of increasing tolerance of patients, improving compliance, reducing dosage and lightening adverse reactions, along with convenient administration and low price.
Owner:JIANGSU JIBEIER PHARMA
Method for preparing antihypertensive preparation
InactiveCN101756974ASuitable for long-term useGood blood pressure effectOrganic active ingredientsCardiovascular disorderTolerabilityIncreased tolerance
The invention discloses a complex preparation for curing hypertension. The preparation comprises 2.5 to 50mg of felodipine and 2 to 40mg of candesartan. The preparation overcomes the defect that obviously increased side effects caused by increasing the medicament dosage to ensure the curative effect in single medicament when the felodipine and the candesartan are used clinically, and provides the novel complex preparation. Combination of the felodipine and the candesartan has synergic and complementary curative effect. The complex preparation increases tolerance of patients, improves compliance, reduces dosage, lightens adverse reactions, is convenient for taking, and has low price.
Owner:JIANGSU JIBEIER PHARMA
Compound formulation for treating hypertension
InactiveCN1292747CGood curative effectImprove toleranceOrganic active ingredientsCardiovascular disorderTolerabilityOlmesartan
Owner:GUANGDONG CARDIOVASCULAR INSITITUTE
Compound formulation for treating hypertension
InactiveCN1605340AImprove toleranceSuitable for long-term useHeterocyclic compound active ingredientsCardiovascular disorderTolerabilityOlmesartan
The present invention discloses one kind of hypertension treating compound preparation. The compound preparation contains Indapamide in 0.5-2.5 mg and Olmesartan in 2.5-40 mg as daily dosage. Compared with the single component hypertension treating medicine with relatively great dosage, the present invention has superior blood pressure lowering effect, no negative effect caused by some one medicine component, no compensated reaction, increased patient's tolerance and raised compliance.
Owner:GUANGDONG CARDIOVASCULAR INSITITUTE
Novel antihypertensive drug
InactiveCN101756976ASuitable for long-term useGood blood pressure effectOrganic active ingredientsCardiovascular disorderTolerabilitySide effect
The invention discloses a compound preparation for curing hypertension, which includes 2-10mg of felodipine and 5-50mg of metoprolol. The invention provides a novel compound preparation which solves the problem that when only one of felodipine and metoprolol is used clinically, in order to ensure the curative effect, the dosage of the drug is increased, which leads to obvious increase of the side effects. Felodipine and metoprolol are used together, so synergic and complementary curative effect can be produced. The novel antihypertensive drug enhances the tolerance of the patient, improves the compliance and reduces the dosage and the adverse reaction, and is convenient to take and cheap in price.
Owner:JIANGSU JIBEIER PHARMA
Burdock tea cake with health care function and preparation method thereof
InactiveCN109619471AUnique natural flavorSimple processFood ingredient functionsChlorogenic acidAlcohol
The invention provides a burdock tea cake with a health care function and a preparation method thereof. The preparation method comprises the steps that fresh burdock which is not damaged by worms areselected and refrigerated in a refrigeration house, the refrigerated burdock is cleaned and peeled in clear water and then put into a disinfected container for standby, the burdock is naturally cooledat room temperature, and the cooled burdock is sliced and ground into powder by using a pulverizer, so that the burdock powder is easily dissolved into water. By using a boiling machine processing technology, the original taste of the burdock is effectively changed, the tea cake has a mellow taste which can be accepted by most people, the burdock is heated and alcoholized with 30% ethyl alcohol solution under the conditions that the temperature and the pH value are controlled, and chlorogenic acid elements rich in the burdocks are extracted. The product prepared by using the method is not contaminated by dust in the indoor and outdoor environments, the refrigerated burdock can be saccharified, and the burdock tea cake prepared by using the method is fragrant, sweet and mellow.
Owner:江苏济善堂健康管理有限公司
Compound blood pressure reducing pharmaceutical composition, compound blood pressure reducing pharmaceutical preparation and purpose ofcompound blood pressure reducing pharmaceutical preparation
PendingCN110755429AImprove responseFast onset of blood pressure reductionOrganic active ingredientsPill deliveryMedication takingAntihypertensive medication
Owner:北京市石景山区高血压联盟研究所
Levoamlodipine fumarate eutectic drug as well as preparation method and application thereof
PendingCN112022849AImprove antihypertensive effectHigh biosecurityOrganic active ingredientsOrganic compound preparationMolecular compositionPhysical chemistry
The invention provides a levoamlodipine fumarate eutectic drug; the chemical general formula of the eutectic drug is (C20H25ClN2O5). (C4H4O4) 0.5. (Y) n, wherein Y is a crystal water molecule or an ethanol molecule, and n is more than or equal to 0 and less than or equal to 2. The eutectic drug is crystallized in a monoclinic system and a P21 chiral space group, and the cell size beta is 111.8-112.4 degrees. The levoamlodipine fumarate eutectic drug provided by the invention has definite crystal form, crystallographic parameters and definite atomic space position, and is different from any commercially available levoamlodipine eutectic drug in molecular composition and crystal form. Raw materials are wide and easy to obtain, the preparation method is simple, particle crystal forms are clear, and quality control and large-scale production are easy.
Owner:FUDAN UNIV +1
Novel compound anti-hypertensive drug
InactiveCN104758285ASuitable for long-term useGood blood pressure effectOrganic active ingredientsCardiovascular disorderTolerabilitySide effect
The invention discloses a compound preparation used for treating hypertension, particularly a novel compound anti-hypertensive drug which comprises 5-20 mg of nitrendipine and 5-50 mg of metoprolol. The novel compound anti-hypertensive drug solves the problem that when nitrendipine and metoprololare are clinically used at present, side effects are obviously increased to guarantee the curative effect by increase of drug dose since only one of nitrendipine and metoprololare is put into use. According to the novel compound preparation, nitrendipine and metoprololare are used together to achieve synergetic and complementary curative effects; and the novel compound anti-hypertensive drug increases the tolerance of patients, improves the compliance, is reduced in dose to relieve adverse reaction, and is convenient to take and low in price.
Owner:JIANGSU JIBEIER PHARMA
Compound preparation containing benidipine hydrochloride and benazepril hydrochloride, as well as application thereof
InactiveCN102389431AImprove antihypertensive effectLower doseHeterocyclic compound active ingredientsCardiovascular disorderRenal HypertensionsSide effect
The invention discloses a compound preparation containing benidipine hydrochloride and benazepril hydrochloride, as well as application thereof, wherein preparation containing benidipine hydrochloride and benazepril hydrochloride serve as effective components of the medicament. According to the compound preparation, the defects of large dose and high side effect of single drug are overcome, and the compound preparation disclosed by the invention is obtained by compounding the benidipine hydrochloride and benazepril hydrochloride. Oral preparations with different forms can be prepared by the preparation, due to synergic and complementary effects of medicaments, the compound preparation has reinforced treatment effect, the medicament dose is reduced in clinical application, adverse reaction of a patient is lightened, and the compound preparation can be accepted easily. The compound preparation has remarkable treatment effect in mild and severe hypertension, and is suitable for hypertension patient with cardiovascular remodeling, and patients with renal hypertension, hypertension with renal damage or with diabetic renal damage. Furthermore, the compound preparation has low price, simple preparation and easy popularization and application.
Owner:济南龙华医药技术有限公司
Anti-hypertensive preparation
InactiveCN104758283ASuitable for long-term useGood blood pressure effectOrganic active ingredientsCardiovascular disorderHypertension medicationsTolerability
The invention discloses a compound preparation used for treating hypertension, and particularly relates to an anti-hypertensive preparation. The anti-hypertensive preparation comprises 0.5-5 mg of amlodipine and 5-100 mg of irbesartan. In order to solve the problem that at present, when either amlodipine or irbesartan is clinically used, the drug dose is increased to guarantee the curative effect, and accordingly, side effects are remarkably increased, the invention provides a novel compound preparation in which amlodipine and irbesartan are used together to take a collaborative and complementary curative effect. Therefore, the tolerance of a patient is increased, the compliance is improved, the dosage is reduced to further reduce adverse reaction, and the anti-hypertensive preparation is convenient to take and low in price.
Owner:JIANGSU JIBEIER PHARMA
Compound antihypertensive preparation
InactiveCN101756973ASuitable for long-term useGood blood pressure effectOrganic active ingredientsCardiovascular disorderTolerabilitySide effect
The invention discloses a compound preparation for treating hypertension, which comprises 1-10mg of felodipine and 10-100mg of telmisartan. The product of the invention overcomes the defect that a side effect is markedly enhanced caused by increasing the medicament dosage for ensuring the curative effect when the felodipine and the telmisartan are clinically used at present and one medicament is singly used, and provides a new compound preparation. The felodipine and the telmisartan are combined, and the curative effect has synergistic and complementary actions; the tolerance of patients is increased, the compliance is improved, the dosage is decreased, an adverse reaction is lightened, and the compound preparation is convenient to take and has low price.
Owner:JIANGSU JIBEIER PHARMA
Compound preparation containing benidipine hydrochloride and valsartan and application thereof
ActiveCN102362865AImprove antihypertensive effectLower doseCardiovascular disorderHeterocyclic compound active ingredientsValsartanAngor pectoris
The invention discloses a compound preparation containing benidipine hydrochloride and valsartan and an application thereof, wherein benidipine hydrochloride and valsartan are used as effective medicinal components of the preparation. Prepared by combination of drugs, the compound preparation for reducing pressure has good curative effects, less side effect and high cost performance, is taken once a day, is convenient to take, and can be used to raise drug compliance of patients. The preparation provided by the invention can be made into different oral dosage forms. Due to synergy and complementation of drugs, the treatment effect of the compound preparation is enhanced. The preparation provided by the invention has an obvious effect of treating hypertension and also can be applied to treat angina pectoris and protect kidney function. The preparation can be routinely used for patients with hypertension, myocardial infarction, heart failure, proteinuria, diabetes and the like, and is especially suitable for patients who are not tolerant to ACE inhibitor. The preparation is cheap, is simple to prepare, and is convenient for popularization and application.
Owner:SHANDONG SBOND PHARMA
A method for preparing medicine for treating hypertension with Radix Paeoniae Alba and Dendrobium officinale
ActiveCN108635511BBlood pressure drops fasterImprove long-term antihypertensive effectNatural extract food ingredientsFood ingredient functionsOral treatmentEfficacy
Owner:HANGZHOU DANHE PHARM CO LTD
Compound antihypertensive drug tablet and application thereof
PendingCN110755397ALow costGood treatment effectOrganic active ingredientsDrageesOrganic acidPharmaceutical Substances
The invention discloses a compound antihypertensive drug tablet. The compound antihypertensive drug tablet is prepared from the following components amlodipine or a pharmaceutical salt of the amlodipine, amiloride or an inorganic acid salt or an organic acid salt of the amiloride and hydrochlorothiazide or an inorganic acid salt or an organic acid salt of the hydrochlorothiazide. According to thecompound antihypertensive drug tablet, the dosage of a single drug is reduced, the number of drugs actually taken by patients is further reduced, and thus the side effects of the drugs are reduced, and the compliance of the patients to take the drugs is increased.
Owner:北京市石景山区高血压联盟研究所
Preparation method of compound antihypertensive preparation
InactiveCN101756994ASuitable for long-term useGood blood pressure effectOrganic active ingredientsCardiovascular disorderSide effectHydrochlorothiazide
The invention discloses a compound preparation for treating hypertension, which comprises 10-100mg of metoprolol and 5-50mg of hydrochlorothiazide. The product of the invention overcomes the defect that a side effect is markedly enhanced caused by increasing the medicament dosage for ensuring the curative effect when the metoprolol and the hydrochlorothiazide are clinically used at present and one medicament is singly used, and provides a new compound preparation. The metoprolol and the hydrochlorothiazide are combined, and the curative effect has synergistic and complementary actions; the tolerance of patients is increased, the compliance is improved, the dosage is decreased, an adverse reaction is lightened, and the compound preparation is convenient to take and has low price.
Owner:JIANGSU JIBEIER PHARMA
Novel compound antihypertensive preparation
InactiveCN101757004ASuitable for long-term useGood blood pressure effectOrganic active ingredientsCardiovascular disorderFosinoprilTolerability
The invention discloses a novel compound antihypertensive preparation which comprises 50-200mg of irbesartan and 5-30mg of fosinopril. Aiming at solving the problem that currently when only one of irbesartan and fosinopril is used clinically, in order to ensure the curative effect, the dosage of the drug is increased, which leads to obvious increase of the side effects, the invention provides a novel compound preparation. Irbesartan and fosinopril are used together, so synergic and complementary curative effect can be produced. The novel compound antihypertensive preparation enhances the tolerance of the patient, improves the compliance and reduces the dosage and the adverse reaction, and is convenient to take and cheap in price.
Owner:JIANGSU JIBEIER PHARMA
Method for preparing novel compound anti-hypertension preparation
InactiveCN104758293ASuitable for long-term useGood blood pressure effectOrganic active ingredientsCardiovascular disorderTolerabilitySide effect
The invention discloses a compound preparation for treating hypertension. The compound preparation comprises 1-10 mg of benidipine and 5-50 mg of hydrochlorothiazide. The novel compound preparation provided by the invention solves the problem that when benidipine and hydrochlorothiazide are clinically used at present, side effects are obviously increased by increase of drug dose since only one of benidipine and hydrochlorothiazide is put into use. According to the novel compound preparation, benidipine and hydrochlorothiazide are used together to achieve synergetic and complementary curative effects; and the novel compound preparation increases the tolerance of patients, improves the compliance, is reduced in dose to relieve adverse reaction, and is convenient to take and low in price.
Owner:JIANGSU JIBEIER PHARMA
Strawberry drink with pressure reducing function
InactiveCN108056473AImprove antihypertensive effectReduce bitter tasteFood ingredient functionsGerminationBroad beans
The invention discloses strawberry drink with a pressure reducing function. The strawberry drink is prepared from concentrated strawberry juice, purple perilla seeds, flax seeds, alfalfa and other components through processing. The processing method comprises the following steps: (1) preparing the concentrated juice, namely, pulping strawberry; adding water; heating; and ultrasonically oscillating; (2) extracting with ethyl alcohol, namely, crushing purple perilla seeds, flax seeds and alfalfa; then soaking into 70% ethyl alcohol in a pressure increase manner; digesting with medium fire; and washing twice with absolute ethyl alcohol; (3) extracting germ, namely, soaking wheat in water; accelerating germination at normal temperature; soaking with table water; then moving out and pulping; adding water; and stirring at high speed; (4) extracting liquid, crushing hawthorn, lycium barbarum, folium ginkgo and broad bean flower; then adding water and sodium chloride; and correspondingly ionizing and performing protease hydrolyzing; and (5) mixing, namely, mixing the concentrated strawberry juice, the alcohol-extracted powder, the wheat germ extractive and the extracting solution; adding pectinase; stirring at high speed; sterilizing; and then canning to obtain the pressure-reduction drink.
Owner:解清华
A risk assessment method, device and server based on literature data
ActiveCN106156483BIncrease awarenessImprove antihypertensive effectMedical informaticsDrug referencesGraphicsCognition
Owner:李雪 +6
Compound formulation for treating hypertension
InactiveCN1263448CAvoid complicationsGood curative effectOrganic active ingredientsCardiovascular disorderTolerabilityCeliprolol
Owner:GUANGDONG CARDIOVASCULAR INSITITUTE
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