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Compound antihypertensive drug tablet and application thereof

A compound and tablet technology, applied in the field of medicine, can solve the problems of severe side effects and high cost of combined antihypertensive drugs, and achieve the effects of small side effects, reducing the occurrence of cardiovascular events, and reducing side effects

Pending Publication Date: 2020-02-07
北京市石景山区高血压联盟研究所
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] Therefore, the problem to be solved by the present invention is to overcome the high cost of combined antihypertensive drugs in the prior art and the defects of serious side effects, thereby providing a novel compound antihypertensive drug tablet, which not only reduces the dosage of single drugs dosage, which reduces the actual number of drugs that patients take, thereby reducing drug side effects and increasing patient compliance

Method used

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  • Compound antihypertensive drug tablet and application thereof
  • Compound antihypertensive drug tablet and application thereof
  • Compound antihypertensive drug tablet and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-10

[0063] The list of Examples 1-10 is as follows:

[0064] Examples 1-5 are figure 1 Shown structure: wherein amlodipine constitutes the inner core layer of the tablet, hydrochlorothiazide forms a hydrochlorothiazide layer, which is coated on the outer side of the inner core layer; amiloride is in the form of granules and is dispersed in auxiliary materials to form an amiloride layer The inner core layer, the hydrochlorothiazide layer and the amiloride layer are respectively provided with a film coating layer; the outer side of the amiloride layer is provided with a film coating layer.

[0065] The main ingredients are as follows:

[0066]

[0067]

[0068] The film coating ingredients: polymer coating materials containing hydroxypropyl methylcellulose (or hydroxypropyl cellulose or polyvinyl acetate phthalate), polyethylene glycol, talc, titanium dioxide and pigments , Can be purchased commercially, such as OPADRYY-1-7000 produced by Shanghai Colorcon Coating Technology Co., Ltd. Su...

Embodiment 6-10

[0075] The list of Examples 6-10 is as follows:

[0076] Examples 6-10 are figure 2 The structure shown: wherein amlodipine constitutes the inner core layer of the tablet, hydrochlorothiazide forms a hydrochlorothiazide layer, which is coated on the outer side of the inner core layer; amiloride is granular and is dispersed in the hydrochlorothiazide layer; the inner core layer, hydrochlorothiazide A film coating layer is arranged between the layers; a film coating layer is arranged outside the hydrochlorothiazide layer.

[0077] The main ingredients are as follows:

[0078]

[0079]

[0080] In Examples 7-10, OPADRYY-1-7000 film coating material produced by Shanghai Colorcon Coating Technology Co., Ltd. was used as the medium film coating ingredient, and the amount was 3% of the tablet weight;

[0081] Pharmaceutical excipients are selected as the drug filler microcrystalline cellulose, the disintegrant crospovidone, and the lubricant magnesium stearate. The purpose is to make the dr...

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Abstract

The invention discloses a compound antihypertensive drug tablet. The compound antihypertensive drug tablet is prepared from the following components amlodipine or a pharmaceutical salt of the amlodipine, amiloride or an inorganic acid salt or an organic acid salt of the amiloride and hydrochlorothiazide or an inorganic acid salt or an organic acid salt of the hydrochlorothiazide. According to thecompound antihypertensive drug tablet, the dosage of a single drug is reduced, the number of drugs actually taken by patients is further reduced, and thus the side effects of the drugs are reduced, and the compliance of the patients to take the drugs is increased.

Description

Technical field [0001] The invention relates to the field of medicine, in particular to a compound antihypertensive medicinal tablet and its use. Background technique [0002] Cardiovascular and cerebrovascular diseases have become the first cause of death among Chinese residents. Hypertension is the main factor leading to cardiovascular diseases such as stroke, coronary heart disease, congestive heart failure, and a large number of clinical trials at home and abroad have confirmed that reducing the blood pressure level of hypertensive patients can significantly reduce the incidence of cardiovascular and cerebrovascular diseases and cause disability Rate and mortality. The latest epidemiological data show that more than 240 million adults in my country suffer from hypertension. How to effectively control the blood pressure of people with hypertension to prevent stroke and cardiovascular events is a major public health problem facing our country. [0003] At present, there are ma...

Claims

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Application Information

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IPC IPC(8): A61K9/28A61K31/549A61K31/4965A61K31/4422A61P9/12A61P9/04A61P9/10
CPCA61K9/2054A61K9/209A61K31/4422A61K31/4965A61K31/549A61P9/00A61P9/04A61P9/10A61P9/12A61K2300/00
Inventor 胡爱华周宪梁陆培培张宇清王文刘力生
Owner 北京市石景山区高血压联盟研究所
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