81 results about "Antihypertensive medication" patented technology

The present invention relates to a combination, such as a combined preparation or pharmaceutical composition comprising: (a) compound of formula (I), and / or (II) or a pharmaceutically acceptable salt thereof; (b) at least one therapeutic agent selected from the group consisting of: an antihypertensive agent; an antidiabetics agent; a hypolipidemic agent; an antiplatelet agent; an antiobesity agent; an antithrombotic agent; an agent for diabetic vascular complications; and an agent for treatment of heart failure; or a pharmaceutically acceptable salts thereof, optionally in presence of a pharmaceutically acceptable carrier for separate, simultaneous or sequential use. The present invention also relates to a use of such combination for the treatment of mammal including human being. R1, R2, R3, R1, R2, R3, R4, R5, X, Y, A and B and m are as defined in the specification.

The medicine composition consists of one of ACE1, its active metabolism product and salt in treating effective amount of 0.5-100 mg, one or several kinds one B family vitamins in treating effective amount of 0.1-50 mg, and pharmaceutically acceptable carrier. The medicine composition of the present invention has the advantages of raising the treating effect of blood pressure lowering ACE1 medicine, strengthening the protecting effect of blood pressure lowering ACE1 medicine on target organ and reducing the incidence rate of hemorrhage of the ocular fundus, angina pectoris, myocardial infarction and other complications.

The invention provides a biodegradable subcutaneous implant rod used for long-acting pressure reduction. The biodegradable subcutaneous implant rod is a cylindrical implant rod prepared by mixing an antihypertensive drug with a biodegradable material--modified poly(glycerol-sebacate) which is used as a carrier. The implant rod is implanted into subcutaneous tissue of the human body after cobalt 60 irradiation sterilization; through slow degradation of modified poly(glycerol-sebacate), the drug is released, enters blood circulation and performs the effect of a pharmacological antihypertensive drug, and effective plasma concentration is guaranteed so as to achieve the purposes of long-term blood pressure reduction and blood pressure stabilization. The implant rod is totally degraded in one to two years, the drug is totally released at the same time, the implant rod turns into carbon dioxide, nitrogen, water and a few amount of glycerin which are absorbed by the human body and are then discharged out from the human body, so a treatment course of slow release administration is completed. The biodegradable subcutaneous implant rod can substantially reduce the attack rate of sudden cardio-cerebrovascular emergencies due to a patient misses a dose of a drug; and according to results of clinical verification, the biodegradable subcutaneous implant rod has an effective rate of 100% on primary hypertension adaptation diseases.

The invention relates to an antihypertensive pharmaceutical composition as well as a preparation method and application thereof, and belongs to the technical field of antihypertensive drugs. The pharmaceutical composition disclosed by the invention is prepared from isorhynchophylline and sinapine thiocyanate. The pharmaceutical composition is low in price, easy to obtain, definite in curative effect, low in toxic and side effect and capable of preventing and treating hypertension in a multi-target mode.

The invention relates to a pharmaceutical composition containing a calcium channel blocker and B vitamins. One or more of B vitamins and a pharmaceutically acceptable carrier are used. The pharmaceutical composition can improve the curative effect of calcium channel blockers and antihypertensive drugs, enhance the protective effect of calcium channel blockers on target organs, and reduce complications such as fundus hemorrhage, angina pectoris, myocardial infarction, cerebral apoplexy, heart failure, and renal failure. incidence of disease. Also provided is the application of the pharmaceutical composition in the preparation of medicines for preventing, treating and delaying hypertension complicated with hyperlipidemia. Through the implementation of the present invention, the pharmaceutical composition provided to patients not only has reliable curative effect, but also improves patient compliance, makes it convenient for patients to take medicine, reduces medical expenses, and has a good market prospect.

The invention provides a traditional Chinese medicine composition for treating hypertension insomnia, which is prepared from 10-20 parts of codonopsis pilosula, 10-20 parts of argehead atractylodes rhizom, 15-25 parts of astragalus membranaceus, 15-25 parts of dogwood, 10-20 parts of schisandra chinensis, 5-15 parts of cimicifugae foetidae, 5-15 parts of rhizoma zingiberis, 5-15 parts of cinnamon,2-10 parts of radix bupleuri and 2-10 parts of honey-fried liquorice root. The traditional Chinese medicine composition can reduce the systolic pressure and diastolic pressure levels of patients suffering from moderate hypertension and mild hypertension, and can effectively improve the sleeping state, improve the sleep quality and improve the quality of life of patients with hypertension. The invention also provides a preparation method of the traditional Chinese medicine composition for treating hypertension insomnia, and according to the preparation method, the traditional Chinese medicinecomposition can be prepared by heating and extracting the materials by taking water or ethanol with concentration of 50-95% as a solvent.

The application provides a new method for micronizing dihydropyridine antihypertensive drug raw materials, which relates to the technical field of biopharmaceutical preparations. A new method for micronizing dihydropyridine antihypertensive drug raw materials, comprising: dissolving the dihydropyridine antihypertensive drug raw materials in a first solvent, dissolving the first dihydropyridine antihypertensive drug raw materials The solvent is added to the second solvent to realize anti-solvent recrystallization of dihydropyridine antihypertensive drugs; the first solvent includes lower aliphatic alcohols or aliphatic ketones; the second solvent includes water, an aqueous solution containing electrolytes, or surfactants aqueous solution. The method can further improve the in vivo bioavailability of the oral preparations of felodipine and other dihydropyridine antihypertensive drugs.

The invention relates to a composition of polydextrose and a calcium ion antagonist, which can reduce the side effect of constipation caused by taking antihypertensive drugs by using polydextrose which is not absorbed by the intestine while reducing blood pressure by the calcium ion antagonist, and belongs to the technical field of compositions of polydextrose and a calcium ion antagonist and application thereof. According to the composition of polydextrose and a calcium ion antagonist, the mass ratio of the polydextrose to the calcium ion antagonist is from (20:1) to (5:1). The composition ofthe polydextrose and a calcium ion antagonist of the invention can solve the side effect of constipation caused by long-term use of the calcium ion antagonist, the latest action mechanism of the action is revealed, and the optimal combination ratio of the polydextrose and the calcium ion antagonist is provided; good application prospects are obtained.

The present invention relates to a kind of antihypertensive drug fosinopril sodium suitable for industrialized production and the preparation method of its key intermediate trans-4-phenyl-L-proline, wherein the key intermediate trans-4-phenyl The synthesis of base-L-proline has high chiral selectivity, and the method is simple and easy to operate.