Beta-adrenergic receptor retarder and vitamins B-containing pharmaceutical composition and applications thereof
A receptor blocker and B vitamin technology, applied in the field of pharmacy, can solve the problems of high fatality rate, disability, consumption of medical resources, etc., and achieve the effect of reducing drug side effects and target organ damage
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
Embodiment 1
[0027] Embodiment 1. prepares compound atenolol folic acid sheet (1000 pieces amount)
[0028]
[0029] Preparation method: crush the raw and auxiliary materials through an 80-mesh sieve, and dry the auxiliary materials for later use. Take 25g of atenolol and 0.4g of folic acid and mix them evenly according to the method of equal increase, and then add starch, microcrystalline cellulose, sodium carboxymethyl starch and low-substituted hydroxypropyl cellulose according to the prescription amount, and mix them evenly according to the method of equal increase. Mix, use 5% povidone K29 / 30-95% ethanol solution to make a soft material, granulate with a 20-mesh sieve, dry at 40°C for about 2 hours, granulate with a 18-mesh sieve, and control the water content of the granules to 2-3%. The dried granules are mixed evenly with magnesium stearate, the semi-finished product is detected, the content is measured, and it is compressed into 1000 tablets with a tablet machine. Pay attentio...
Embodiment 2
[0030] Embodiment 2. preparation compound bisoprolol 5-methyltetrahydrofolate sheet (1000 pieces amount)
[0031]
[0032] Preparation method: crush the raw and auxiliary materials through an 80-mesh sieve, and dry the auxiliary materials for later use. Take 5g of bisoprolol and 0.4g of 5-methyltetrahydrofolic acid and mix them uniformly according to the method of equal increase, and then add starch, microcrystalline cellulose, sodium carboxymethyl starch and low-substituted hydroxypropyl cellulose according to the prescription amount, and press etc. Mix evenly by increasing the amount, use 5% povidone K29 / 30-95% ethanol solution to make a soft material, granulate with a 20-mesh sieve, dry at 40°C for about 2 hours, granulate with a 18-mesh sieve, and control the water content of the granules to 2 -3%, the dried granules are mixed evenly with magnesium stearate, the semi-finished product is detected, and the content is measured, and compressed into 1000 tablets with a table...
Embodiment 3
[0033] Example 3. Preparation of compound metoprolol folic acid double-layer sustained-release tablets (1000 pieces)
[0034] Recipe:
[0035]
[0036]
[0037] Preparation:
[0038] (1) Metoprolol slow-release layer: mix metoprolol, hydroxypropyl methylcellulose and stearyl alcohol through an 80-mesh sieve evenly according to the prescription amount, add 5% ethyl cellulose alcohol solution to make soft Material, granulated with a 20-mesh sieve, dried at 60°C for 2 hours, granulated with an 18-mesh sieve, then added with magnesium stearate, mixed evenly, and inspected for quality.
[0039] (2) Folic acid layer: take 0.4g of folic acid, mix and sieve it with microcrystalline cellulose according to the method of equal increase, then add starch, sodium carboxymethyl starch and low-substituted hydroxypropyl cellulose, mix evenly, and use 5% polystyrene Vitone K29 / 30-95% ethanol solution to make soft material, granulate with 20-mesh sieve, dry at 40°C for about 2 hours, gr...
PUM
Abstract
Description
Claims
Application Information
- R&D Engineer
- R&D Manager
- IP Professional
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com