The invention relates to a synthesis technology of
bisoprolol. The technical scheme of the technology comprises the following steps: (1) using 4-hydroxybenzyl
alcohol and isopropoxyethanol to perform the etherification reaction, using strongly acidic
styrene type cation exchange resin as catalyst to ensure the alcoholic hydroxyl group etherification reaction to perform under the conditions of
room temperature and no
solvent; (2) adding
sodium hydroxide and epoxychloropropane in the
reaction product in the step (1) to ensure phenolic hydroxyl group to perform the etherification reaction; and (3) adding the
reaction product in the step (2) in
isopropamide, reacting by using
boron hydride as catalyst, and preparing
bisoprolol. By using the synthesis technology of the invention, the alcoholic hydroxyl group etherification reaction can be performed under the conditions of
room temperature and no
solvent, the processes of extraction, washing and reduced pressure
distillation are simplified;
boron hydride is used as catalyst to ensure the
amination reaction to perform under a low temperature; the overall yield is increased to above 50%; and the synthesis technology is suitable for industrial production. The
solvent used by the technology of the invention can be recycled through
distillation; resinic
solid acid catalyst can be recycled; and yield and product purity are high.