31 results about "Bisoprolol" patented technology

A Bisoprolol patch, wherein the skin penetration rate of Bisoprolol after 24 hours is 15 to 60% of the maximum skin penetration rate thereof, shows a little difference between the maximum level of the concentration in blood and the minimum level thereof in repeated administration and, therefore, scarcely exhibits side effects. Moreover, it achieves the quick development of the drug effect owing to the stabilization of the concentration in blood within a short time.

Disclosed is an adhesive patch which effectively inhibits the occurrence of oozing or squeezing out of the adhesive layer component from the exposed area of the adhesive layer of the adhesive patch during storage, and also inhibits the occurrence of oozing of bisoprolol or salts of same from the adhesive layer thereby preventing reduction of drug content. A backing material, a release liner and an adhesive layer respectively, along with the entire adhesive patch, are shaped into a planar rectangle wherein the corners of the adhesive patch are formed into convex shapes on the rear surface on the backing material side. Further, the adhesive patch has a central part and edges wherein the corners of the rectangular shape of the central part can also be formed into convex shapes, and furthermore it can be provided with built-up articulated sections between two or more adjacent convex parts wherein the thickness of the adhesive patch is thinner than the thickness of the adhesive layer at each convex part. If the release liner is provided with a split at the back, the split should not traverse the convex parts.

The invention provides a patch preparation, which includes a support and a pressure-sensitive adhesive layer formed on one surface of the support. The pressure-sensitive adhesive layer includes: (A) a polymer prepared by copolymerizing monomer components including a hydroxyl group-containing monomer and an alkyl (meth)acrylate monomer; (B) a polymer prepared by copolymerizing monomer components including a methyl methacrylate monomer and a butyl methacrylate monomer; and (C) a basic drug, provided that bisoprolol and a salt thereof are excluded. The patch preparation is capable of inhibiting a deviation in pressure-sensitive adhesive properties of the pressure-sensitive adhesive layer even elapsing a long period of time until it is used after production and is capable of keeping favorable pressure-sensitive adhesive properties.

A composite medicine in the various forms for treating cardiovascular disease such as coronary heat disease, hypertension, etc is prepared from bisoprolol and candesartan in the mole ratio of 1: (1-2).

It is intended to provide an adhesive preparation which has a low irritation to the skin surface, is excellent in stability of bisoprolol in the preparation and further is capable of continuously administrating a pharmacologically effective amount of bisoprolol to the living body. The adhesive preparation 10 has a support 1 and an adhesive layer 2 which is layered on one surface of the support 1. The adhesive layer 2 is characterized by containing bisoprolol, polyisobutylene, a tackifier and an organic liquid component which is compatible with polyisobutylene and the tackifier. By this, the adhesive preparation having good skin adhesiveness, low skin irritation and reduced pain or adhesive residue at the time of removal from the skin surface can be provided. Further, the adhesive preparation in which the stability of bisoprolol in the adhesive preparation is excellent and the pharmacologically effective amount of bisoprolol can be continuously administrated to the living body through the skin surface is provided.

The invention belongs to the technical field of medicine and relates to an indapamide bisoprolol percutaneous patch and a preparation method thereof. The indapamide bisoprolol percutaneous patch is composed of a back liner layer, a medicine-carrying pressure-sensitive adhesive layer and an anti-bonding layer. The medicine-carrying pressure-sensitive adhesive layer includes indapamide, bisoprolol free alkali or a organic acid ion pair compound thereof, a pressure-sensitive adhesive and a percutaneous absorption promoter, wherein a total medicine amount of the indapamide, bisoprolol free alkali or the organic acid ion pair compound thereof accounts for 0.5-5.5 wt% of the total weight of the medicine-carrying pressure-sensitive adhesive layer and a molar ratio of the indapamide to the bisoprolol free alkali or the organic acid ion pair compound thereof is 0.5:1-2:1. According to the invention, two-way regulation of a percutaneous penetrating capability of indapamide and bisoprolol in the percutaneous patch can be achieved and equal-speed penetration of the indapamide and the bisoprolol from the percutaneous patch is achieved.