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Patch preparation

A preparation and patch technology, which is applied in the direction of film/sheet adhesive, adhesive, sheet conveying, etc. The effect of small deviation and high permeability

Inactive Publication Date: 2016-12-28
NITTO DENKO CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the pressure-sensitive adhesive layer in the above-mentioned patch, in the case where a copolymer having a carboxyl group is contained therein and the drug is basic, there is a problem that the carboxyl group is affected by the action of the basic drug to disturb the drug. release from the patch, thereby reducing drug availability
However, the hydroxyl group may be affected by the action of basic drugs, resulting in deviations in the pressure-sensitive adhesive properties, such as the problem of increased viscosity during storage, etc.

Method used

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Examples

Experimental program
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Effect test

Embodiment 1

[0064] 52 parts by weight (in terms of solid content) as the polymer (A1) of component (A), 3 parts by weight of component (B), 5 parts by weight of tulobuterol as component (C) and 40 parts by weight Parts of isopropyl myristate as an organic liquid component were mixed, and an appropriate amount of ethyl acetate was added for concentration adjustment, and the contents were stirred to obtain a uniform pressure-sensitive adhesive solution. The prepared pressure-sensitive adhesive solution was applied on the release-treated surface of a release sheet made of polyester having a thickness of 75 μm in such a manner that the thickness after drying was 50 μm, followed by drying at 80° C. for 5 minutes to form a pressure-sensitive adhesive layer . Subsequently, a polyester film with a thickness of 4 μm and a film with a thickness of 12 g / m 2 A laminate of nonwoven fabric made of polyester by basis weight was used as a support, and the surface of the nonwoven fabric of the support wa...

Embodiment 2

[0066] Except changing the amount of polymer (A1) as component (A) into 50 parts by weight (in terms of solid content); and changing the amount of component (B) into 5 parts by weight, with the same The patch preparation of the aspect of the present invention was obtained in the same manner.

Embodiment 3

[0068] Except changing the amount of polymer (A1) as component (A) into 43 parts by weight (in terms of solid content); and changing the amount of component (B) into 12 parts by weight, with the same The patch preparation of the aspect of the present invention was obtained in the same manner.

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Abstract

The invention provides a patch preparation, which includes a support and a pressure-sensitive adhesive layer formed on one surface of the support. The pressure-sensitive adhesive layer includes: (A) a polymer prepared by copolymerizing monomer components including a hydroxyl group-containing monomer and an alkyl (meth)acrylate monomer; (B) a polymer prepared by copolymerizing monomer components including a methyl methacrylate monomer and a butyl methacrylate monomer; and (C) a basic drug, provided that bisoprolol and a salt thereof are excluded. The patch preparation is capable of inhibiting a deviation in pressure-sensitive adhesive properties of the pressure-sensitive adhesive layer even elapsing a long period of time until it is used after production and is capable of keeping favorable pressure-sensitive adhesive properties.

Description

technical field [0001] One aspect of the invention relates to a patch formulation. Background technique [0002] Skin-adhesive patch preparations include a pressure-sensitive adhesive layer formed on one or both surfaces of a support and are intended to be administered from the skin to the body through the pressure-sensitive adhesive layer to prevent or treat diseases locally or throughout the body . [0003] Such patch formulations are required to exhibit sufficient pressure-sensitive adhesiveness when adhered to the skin and to be able to be peeled and removed from the skin after use without contamination of the skin surface (eg, adhesive deposits, stickiness, etc.). In addition, it is desirable that the patch preparation is less irritating to the skin. [0004] Patent Document 1 discloses a patch using an acrylic pressure-sensitive adhesive obtained by polymerizing an alkyl (meth)acrylate with a monomer that can Monomer copolymerized with alkyl (meth)acrylates and free...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K47/32
CPCA61K9/7053A61L15/44A61L15/58A61K9/7061C08L33/06C09J7/385C09J7/38C09J133/066C09J133/08C09J133/10C09J2301/302A61K31/137A61K31/27A61K31/428A61K47/14
Inventor 立川悠雨山智阿部绘梨子中村哲也漆原直子石仓准青柳和宏井上祥孝横内阳田中智也
Owner NITTO DENKO CORP
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