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35 results about "Tulobuterol" patented technology
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Tulobuterol (INN) is a long-acting beta2-adrenergic receptor agonist, marketed in Japan as a transdermal patch under the name Hokunalin tape (ホクナリンテープ). Currently, it is only legal in 7 countries: Japan, Germany, China, South Korea, Bangladesh, Pakistan, and Venezuela. It is available in India also.
Tulobuterol containing pressure-sensitive adhesive, transdermal paster, and its preparing method and use
ActiveCN1640388ALow costImprove productivityOrganic active ingredientsRespiratory disorderTransdermal patchPolymer science
The present invention discloses a transcutaneous plaster containing tulobuterol, its preparation method and application. The pressure-sensitive adhesive used by said invention is a hot-melt pressure-sensitive adhesive whose melting point is 50-250 deg.C. the described hot-melt pressure-sensitive adhesive is an adhesive made up by using thermoplastic polymer as main raw material, and hs the hot-melting and pressure-sensitive double characteristics. Said product contains no organic solvent, and its coating speed is quick, and its cost is low.
Owner:YABAO PHARMA GRP CO LTD
Percutaneous plaster and its preparation method
InactiveCN1565523ALess pollutionFast coating speedMedical devicesUnknown materialsTransdermal patchMedicine
Owner:SHANGHAI MODERN PHARMA ENG INVESTIGATION CENT
Tulobuterol-containing aquogel patch and preparation method thereof
InactiveCN101590028AModerate viscositySeepage occursOrganic active ingredientsRespiratory disorderOrganic acidDistilled water
The invention discloses a tulobuterol-containing aquogel patch, which comprises tulobuterol, a macromolecular framework material, a crosslinker, a crosslinking regulator, a humectant and distilled water, wherein the crosslinker is a combination of more than two organic acids; and at least one organic acid is tartaric acid and at least the other organic acid is selected from citric acid, gluconic acid, lactic acid, malic acid and malicaicd. The invention also discloses a method for preparing the tulobuterol-containing aquogel patch. The tulobuterol-containing aquogel patch and the preparation method of the invention make the cohesion of aquogel matrix so stable that the matrix avoids cloth penetration, hardening and other phenomena; the patch is proper in viscosity and insusceptible to falling off after being adhered and can be stripped without causing pains; and the method is controllable in gel time and can meet requirements for industrial large-scale production.
Owner:SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
Tulobuterol adhesive patch
InactiveCN1905866AExcellent Adhesive PropertiesFacilitated releaseOrganic active ingredientsPharmaceutical non-active ingredientsPermeationSkin irritant
Owner:NIPRO PATCH
Tulobuterol adhesive patch
InactiveUS20070154535A1Good skin permeabilityFacilitated releaseBiocideOrganic active ingredientsSkin permeabilityPlasticizer
The present invention provides a tulobuterol adhesive patch comprising (a) a support, (b) an acrylic pressure-sensitive adhesive layer containing the percutaneously absorbing drug tulobuterol and if necessary a lipophilic oily plasticizer, and (c) a release liner, laminated in that order, wherein the acrylic pressure-sensitive adhesive is a copolymer obtained by copolymerizing an acrylic monomer which is acetoacetoxyalkyl (meth)acrylate with one or more other vinyl monomers, to yield a tulobuterol adhesive patch with excellent release and skin permeability of tulobuterol from the pressure-sensitive adhesive layer, low skin irritation and excellent safety.
Owner:NIPRO PATCH
Method for industrial production of tulobuterol
InactiveCN110172028ANo pollution in the processAvoid it happening againOrganic compound preparationCarbonyl compound preparation by oxidationFiltrationReaction temperature
The invention discloses a method for industrial production of tulobuterol. The method comprises the following steps of 1, preparation of an intermediate II, wherein chloroacetophenone and an oxidant containing DMSO are added into a reaction kettle in sequence, a reaction is carried out for 1-1.5 hours under the condition of heat preservation, stirring is conducted until the reaction is completelyfinished, and through quenching, extraction, washing and concentration, the intermediate II is prepared; 2, preparation of a crude tulobuterol product, wherein the intermediate II, tert-butylamine, analcohol solvent and sodium borohydride are added into the reaction kettle in sequence and stirred, the reaction temperature is controlled, stirring is conducted until the reaction is completely finished, after concentration, extraction, washing and drying with a drying agent, filtration is conducted, and a filtrate is concentrated and recrystallized to obtain the crude tulobuterol product I; 3, refining of the tulobuterol, wherein the crude tulobuterol product I, an organic solvent and activated carbon for refinement of injection are recrystallized to obtain the refined tulobuterol. The industrial production method is green in reaction and simple in step and causes little pollution to the environment, the purity of the product is up to 99.95% or above, and the tulobuterol contains few impurities.
Owner:ANHUI HEALSTAR PHARM CO LTD
Adhesive skin patch
InactiveUS20070077285A1Dissolution stabilityEffective absorptionOrganic active ingredientsBiocideMeth-Carbon chain
The present invention provides an adhesive skin patch that permits excellent and prolonged percutaneous absorption of tulobuterol and that can be stably applied to the skin for a long period of time with less skin irritation. The adhesive skin patch comprises a base material and a medicated layer provided on one surface of the base material. The medicated layer contains 1 to 30% by weight of a resolvent, 40 to 98% by weight of a pressure-sensitive adhesive, and tulobuterol. The resolvent contains an aliphatic alcohol having a branched-chain structure or a double bond in its C8 to C30 carbon chain. The pressure-sensitive adhesive is a copolymer obtained by copolymerizing monomers containing 70% by weight or more of an alkyl(meth)acrylate whose alkyl group has 6 to 20 carbon atoms.
Owner:SEKISUI CHEM CO LTD
Preparation method of tulobuterol
PendingCN111205194AReduce usageEasy to operateOrganic compound preparationPreparation by hydroxy group additionChlorobenzeneBiochemical engineering
The invention provides a preparation method of tulobuterol. The technical problems of potential safety hazard, complicated post-treatment and the like in the existing method are solved. According to the method, a compound 1-(2-chlorphenyl)-2-tert-butylaminoethanol is synthesized from industrially available 2-chlorostyrene through a two-step reaction. The method is short in reaction step, mild in reaction condition, simple and convenient to operate, high in yield and good in application and development prospect, and can be used for preparing tulobuterol.
Owner:SHANDONG DYNE MARINE BIOTECHCAL PHARM HLDG CO LTD
Tulobuterol patch and preparation method thereof
ActiveCN102552221AImprove solubilityGuaranteed chemical stabilityOrganic active ingredientsPharmaceutical non-active ingredientsMedicineMass ratio
The invention discloses a tulobuterol patch and a preparation method thereof. The tulobuterol patch consists of a back lining layer, a medicine-carrying pressure-sensitive adhesive layer and an anti-adhesive layer, wherein the medicine-carrying pressure-sensitive adhesive layer has a double-layer structure; and in the double-layer structure, a mass ratio of one layer which contacts the back lining layer and the other layer which contacts the anti-adhesive layer is (1:3)-(3:1). The preparation method comprises the following steps of: dissolving tulobuterol and a pressure-sensitive adhesive auxiliary material in a good solvent; and during preparation, coating two layers, namely coating a first layer, placing at room temperature, so that the solvent is volatilized fully, and coating a secondlayer to obtain a percutaneous absorption-type tulobuterol patch. The preparation process for the tulobuterol percutaneous absorption preparation is simple and can be used for producing the tulobuterol patch; and by the prepared tulobuterol patch, medicines can be released slowly at a constant speed, so the tulobuterol patch meets the requirements of preparations for treating asthma diseases.
Owner:MICROBE EPIDEMIC DISEASE INST OF PLA MILITARY MEDICAL ACAD OF SCI
A kind of synthetic method of compound tulobuterol
ActiveCN105439875BReduce usageEasy to operateOrganic compound preparationAmino compound preparationAlcoholTert-Butylamine
The invention relates to a synthesis method for compound tulobuterol. The technical problems that potential safety hazards exist in an existing method, and cost is high are solved. The method includes the following steps of a, an olefination reaction, wherein 1-(2-chlorphenyl)-1-ethyl alcohol serves as an initial raw material, and in the presence of a catalyst and acid, a heating reaction is conducted to generate 2-chloro-styrene; b, a cyclization reaction, wherein 2-chloro-styrene serves as a raw material, and in the presence of alkali and an oxidizing agent, an epoxidation reaction is conducted to obtain 2-(2-chlorphenyl) ethylene oxide; c, a ring-opening reaction, wherein 2-(2-chlorphenyl) ethylene oxide serves as a raw material and reacts with tert-butylamine to obtain compound 1-(2-chlorphenyl)-2-tert-butylamino ethanol. The synthesis method can be used for preparing tulobuterol.
Owner:SHANDONG DYNE MARINE BIOTECHCAL PHARM HLDG CO LTD
Patch for treating cough and asthma and preparation thereof
InactiveCN103202823ALess irritatingImprove securityOrganic active ingredientsPharmaceutical non-active ingredientsFormularyPharmaceutical drug
The present invention relates to a patch for treating cough and asthma and preparation thereof. The invention provides a tulobuterol patch which is prepared by orderly laminating (a) a support layer, (b) an acrylic pressure-sensitive adhesive agent layer containing a transdermally-absorptive drug of tulobuterol and if needed, a lipophilic oily plasticizer, and (c) a peeling pad. The tulobuterol in the patch can be absorbed transdermally and sustainably release drugs with a drug sustained action of up to twenty-four hours; the patch has a simple formula and a simple preparation process.
Owner:HENAN LINGRUI PHARMA +1
Synthesis method for compound tulobuterol
ActiveCN105439875AReduce usageEasy to operateOrganic compound preparationAmino compound preparationSynthesis methodsEthyl Chloride
The invention relates to a synthesis method for compound tulobuterol. The technical problems that potential safety hazards exist in an existing method, and cost is high are solved. The method includes the following steps of a, an olefination reaction, wherein 1-(2-chlorphenyl)-1-ethyl alcohol serves as an initial raw material, and in the presence of a catalyst and acid, a heating reaction is conducted to generate 2-chloro-styrene; b, a cyclization reaction, wherein 2-chloro-styrene serves as a raw material, and in the presence of alkali and an oxidizing agent, an epoxidation reaction is conducted to obtain 2-(2-chlorphenyl) ethylene oxide; c, a ring-opening reaction, wherein 2-(2-chlorphenyl) ethylene oxide serves as a raw material and reacts with tert-butylamine to obtain compound 1-(2-chlorphenyl)-2-tert-butylamino ethanol. The synthesis method can be used for preparing tulobuterol.
Owner:SHANDONG DYNE MARINE BIOTECHCAL PHARM HLDG CO LTD
Method for synthesizing tulobuterol
ActiveCN110590569AEasy to operateOperating economyOrganic compound preparationCarbonyl compound preparationTulobuterolBy-product
The invention discloses a method for synthesizing tulobuterol. According to the method, 1-(2-chlorophenyl)-2-bromoethanone (compound 3) and 1-(2-chlorophenyl)-2,2-dibromoethanone (compound 10) can besimultaneously utilized to synthesize the tulobuterol. In an original route, the compound 10 is a by-product of synthesis of the compound 3, and about 10-15% of the compound 10 is not fully utilized.The method provided by the invention can improve the synthesis yield of the tulobuterol, is simple to operate, is environmentally friendly, is low in cost and is suitable for industrial production.
Owner:HANGZHOU BIO SINCERITY PHARMA TECH CO LTD
Tulobuterol transdermal patch and preparation method thereof
ActiveCN108853065AControlled release rateReduce adverse reactionsOrganic active ingredientsRespiratory disorderMaintenance therapyTransdermal patch
The invention relates to a tulobuterol transdermal patch and belongs to the field of transdermal medicinal preparation. According to the tulobuterol transdermal patch disclosed by the invention, tulobuterol is prepared into a drug reservoir; the tulobuterol transdermal patch is prepared from tulobuterol, a penetration enhancer, carbopol and polysiloxane pressure sensitive adhesive; specific matrixcombination and use amount are utilized to for controlling drug release speed, and finally, the purpose of stably releasing drugs for 24 hours is achieved. The tulobuterol transdermal patch is pastedand applied before sleeping, and the plasma concentration can reach peak concentration from late night to early morning when a respiratory function of a patient is prone to reduce; thus, the respiratory function can be improved, a cumulative effect is avoided when the tulobuterol transdermal patch is continuously used, and untoward effects of drugs are reduced. Furthermore, the tulobuterol transdermal patch disclosed by the invention is less affected by environment change, can be stably stored for a long time and can be applied to long-time maintenance therapy of bronchial asthma and chronicobstructive pulmonary disease patients.
Owner:SHANDONG UNIV
Immune-electrochemistry sensor for detecting seven beta-adrenergic receptor agonists, and manufacture method and application of immune-electrochemistry sensor
ActiveCN106645699AHigh sensitivityEasy to handleMaterial electrochemical variablesAdrenergic receptor agonistsElectrochemistry
The invention discloses an immune-electrochemistry sensor for detecting seven beta-adrenergic receptor agonists, and a manufacture method and application of the immune-electrochemistry sensor. The immune-electrochemistry sensor comprises a substrate glass electrode, and a film layer and a detection layer which sequentially coat the surface of the substrate glass electrode, wherein the material of the detection is a beta-agonist general hapten 4-(4-(2-terttert-butylamino) 1-ethoxy) phenylbutyric acid solution. The method comprises the following steps: firstly dispensing graphene / chitosan dispersion liquid on the surface of the clean substrate glass electrode, drying to form a film formation layer, dispensing the 4-(4-(2-terttert-butylamino) 1-ethoxy) phenylbutyric acid solution on the surface of the film layer, and then drying. The sensor is based on the cross immunoreactions of a beta-agonist broad specificity antibody on various beta-agonists, and can realize the detection of seven beta-agonists including clenbuterol, salbutamol, mabuterol, brombuterol, cimbuterol, tulobuterol and terbutaline.
Owner:NANJING NORMAL UNIVERSITY
Transepidermal drug delivery system containing tulobuterol
InactiveUS20110182971A1Easy maintenanceIncrease stickinessBiocideOrganic active ingredientsMedicineAcid value
Disclosed is a pharmaceutical composition containing tulobuterol. More specifically, disclosed is a transepidermal drug delivery system including a drug layer containing tulobuterol and a natural rubber-based adhesive material, and a supporter adhered to one surface of the drug layer to support the drug layer, wherein the natural rubber-based adhesive material comprises 10 to 40 parts by weight of a natural rubber, 54.5 to 85 parts by weight of a rosin ester resin and an acid value controller, and the drug layer has a thickness of 25 μm to 75 μm.
Owner:SINSIN PHARMA
Transdermal absorption preparation for treating asthma
ActiveCN110115710AModerate adhesionImprove plasticityOrganic active ingredientsPharmaceutical non-active ingredientsPlasticizerTulobuterol
The invention discloses a transdermal absorption preparation for treating asthma. The preparation contains a supporting body, an adhesive layer and a protection layer. The adhesive layer comprises 28.65-57.31% of an acrylic ester pressure-sensitive adhesive, 10.74-25.07% of viscosity-increasing resin, 3.58-14.33% of a plasticizer, and a tulobuterol as an active substance according to the total mass of the adhesive. In addition, the preparation further contains a transdermal accelerant for accelerating the transdermal absorption and a stabilizer for improving the stability of the pharmaceuticalpreparation.
Owner:BEIJING TIDE PHARMA
External application preparation containing tulobuterol pharmaceutical composition
ActiveCN108403669AIncrease permeationIncrease profitOrganic active ingredientsPharmaceutical non-active ingredientsSolubilityExternal application
The present invention discloses an external application preparation containing a tulobuterol pharmaceutical composition, particularly a skin external application preparation containing a tulobuterol and crotamiton pharmaceutical composition. According to the present invention, by adding crotamiton, the solubility of tulobuterol is increased, the use of organic solvents is effectively avoided, theactive substance loss caused by the evaporation of the organic solvent is reduced, and the stability of the preparation is increased, such that the treatment effect of the drugs cannot be affected inthe case of the long-term storage while the environmental pollution is reduced, and the adverse reactions of the patient after the medication are reduced.
Owner:BEIJING TIDE PHARMA
Tulobuterol patch
InactiveCN103127032AOrganic active ingredientsRespiratory disorderAnti-asthmatic drugControlled release
The invention relates to a transdermal absorption preparation with anti-asthmatic drug tulobuterol and salt as active ingredients, in particular to a tulobuterol patch. The transdermal absorption preparation is capable of controlling release of the tulobuterol continuously and has long-term storage stability at the same time, and tulobuterol particles can not be formed on a drug layer.
Owner:DAE HWA PHARMA
Stable tulobuterol percutaneous absorption preparation
ActiveCN112826809AStable release rateFully effectiveOrganic active ingredientsInorganic non-active ingredientsDrug release ratePharmaceutical drug
Owner:BEIJING TIDE PHARMA
Tulobuterol adhesive patch
InactiveUS7939100B2Good skin permeabilityGood effectBiocideAdhesive dressingsSkin permeabilityPlasticizer
Owner:NIPRO PATCH
Tulobuterol patch and preparation method thereof
ActiveCN102552221BSimple manufacturing processModerate viscosityOrganic active ingredientsPharmaceutical non-active ingredientsMass ratioMedicine
Owner:MICROBE EPIDEMIC DISEASE INST OF PLA MILITARY MEDICAL ACAD OF SCI
Method for preparing beta-arylamino alcohol drugs such as tulobuterol, clorprenaline, dichloroisoprenaline and sotalol
ActiveCN110143886AEasy to operateShort reaction timeOrganic compound preparationCarbonyl compound preparation by oxidationChemical structureAlcohol
The invention provides a method for preparing beta-arylamino alcohol drugs such as tulobuterol, clorprenaline, dichloroisoprenaline and sotalol. The beta-arylamino alcohol drugs have a chemical structure represented by a formula 4 shown in the description. The method comprises the following steps: (1) reacting arylethanone represented by a formula 1 shown in the description with a halogenating agent and sulfoxide to obtain arylglyoxal represented by a formula 2 shown in the description and or 1,1-dihydroxyarylethanone represented by a formula 3 shown in the description; and (2) performing a nucleophilic addition reaction on the arylglyoxal represented by the formula 2 and / or the 1,1-dihydroxyarylethanone represented by the formula 3 and an amine compound having a chemical formula of R1-NH2, and performing a reductive amination reaction in the presence of a reducing agent to obtain the beta-arylamino alcohol drugs.
Owner:BEIJING UNIV OF CHEM TECH
Percutaneous-absorption tulobuterol controlled release patch and preparation method thereof
ActiveCN108236606AImprove solubilityExtended release timeOrganic active ingredientsOrganic non-active ingredientsControlled releaseReflux
The invention relates to a percutaneous-absorption patch utilizing an anti-asthma drug tulobuterol as an active component. The tulobuterol patch can be prepared by the steps of dissolving tulobuterol,a pressure-sensitive adhesive and a film-forming agent into a good solvent, heating for reflux, uniformly coating a back lining with the mixture by virtue of a coating device, and drying so as to obtain the tulobuterol patch. The tulobuterol patch is characterized in that a percutaneous absorption preparation is capable of continuously controlling the release of tulobuterol and simultaneously hasthe characteristics that the storage stability is long, and tulobuterol is not formed in a drug layer. According to the method provided by the invention, the tulobuterol patch can be effectively produced.
Owner:INST OF MATERIA MEDICA AN INST OF THE CHINESE ACAD OF MEDICAL SCI
Tulobuterol-containing aquogel patch and preparation method thereof
InactiveCN101590028BModerate viscosityCohesive stabilityOrganic active ingredientsRespiratory disorderOrganic acidDistilled water
Owner:SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
An immunoelectrochemical sensor for detecting seven β-adrenergic receptor agonists, its preparation method and application
ActiveCN106645699BHigh sensitivityEasy to handleMaterial electrochemical variablesAdrenergic receptor agonistsElectrochemistry
The invention discloses an immune-electrochemistry sensor for detecting seven beta-adrenergic receptor agonists, and a manufacture method and application of the immune-electrochemistry sensor. The immune-electrochemistry sensor comprises a substrate glass electrode, and a film layer and a detection layer which sequentially coat the surface of the substrate glass electrode, wherein the material of the detection is a beta-agonist general hapten 4-(4-(2-terttert-butylamino) 1-ethoxy) phenylbutyric acid solution. The method comprises the following steps: firstly dispensing graphene / chitosan dispersion liquid on the surface of the clean substrate glass electrode, drying to form a film formation layer, dispensing the 4-(4-(2-terttert-butylamino) 1-ethoxy) phenylbutyric acid solution on the surface of the film layer, and then drying. The sensor is based on the cross immunoreactions of a beta-agonist broad specificity antibody on various beta-agonists, and can realize the detection of seven beta-agonists including clenbuterol, salbutamol, mabuterol, brombuterol, cimbuterol, tulobuterol and terbutaline.
Owner:NANJING NORMAL UNIVERSITY
Tulobuterol transdermal patch and preparation method thereof
InactiveCN113018279ATimely supplementImprove solubilityOrganic active ingredientsPharmaceutical non-active ingredientsTransdermal patchAdhesive
The invention discloses a tulobuterol transdermal patch and a preparation method thereof. The patch comprises a medicine storage layer, the medicine storage layer comprises a first adhesive layer containing amorphous tulobuterol; and a second adhesive layer which is arranged below the first adhesive layer, is in contact with the first adhesive layer and comprises tulobuterol crystals, wherein the solubility of tulobuterol of the first adhesive layer is 2-8 times that of tulobuterol of the second adhesive layer. The medicine storage layer adopts a mixed matrix composed of a polyacrylate pressure-sensitive adhesive and an acrylate-rubber copolymer adhesive according to a specific content, the solubility of the tulobuterol medicine in the matrix can be enhanced, and the tulobuterol medicine exists in the first adhesive layer in an amorphous supersaturated state, so that the initial transdermal rate of the tulobuterol medicine can be remarkably enhanced; the tulobuterol crystals of the second adhesive layer are used for timely supplementing released medicines, so that the initial transdermal rate is remarkably improved, and meanwhile, long-time (48-72 hours) continuous approximate constant-speed transdermal administration is maintained.
Owner:苏州肌之究极医药科技有限公司
Tulobuterol containing pressure-sensitive adhesive, transdermal paster, and its preparing method and use
ActiveCN1297257CLow costImprove productivityOrganic active ingredientsRespiratory disorderMolten stateTransdermal patch
The present invention discloses a transcutaneous plaster containing tulobuterol, its preparation method and application. The pressure-sensitive adhesive used by said invention is a hot-melt pressure-sensitive adhesive whose melting point is 50-250 deg.C. the described hot-melt pressure-sensitive adhesive is an adhesive made up by using thermoplastic polymer as main raw material, and hs the hot-melting and pressure-sensitive double characteristics. Said product contains no organic solvent, and its coating speed is quick, and its cost is low.
Owner:YABAO PHARMA GRP CO LTD
Adhesive skin patch
InactiveUS20110135709A1Stably dissolveEffective absorptionBiocideOrganic active ingredientsMeth-Double bond
The present invention provides an adhesive skin patch that permits excellent and prolonged percutaneous absorption of tulobuterol and that can be stably applied to the skin for a long period of time with less skin irritation. The adhesive skin patch comprises a base material and a medicated layer provided on one surface of the base material. The medicated layer contains 1 to 30% by weight of a resolvent, 40 to 98% by weight of a pressure-sensitive adhesive, and tulobuterol. The resolvent contains an aliphatic alcohol having a branched-chain structure or a double bond in its C8 to C30 carbon chain. The pressure-sensitive adhesive is a copolymer obtained by copolymerizing monomers containing 70% by weight or more of an alkyl(meth)acrylate whose alkyl group has 6 to 20 carbon atoms.
Owner:SEKISUI CHEM CO LTD
Tulobuterol crystal form and preparation method thereof
ActiveCN112707829AOrganic active ingredientsOrganic compound preparationPhysical chemistryEthyl acetate
The invention provides a tulobuterol crystal form and a preparation method thereof. The preparation method comprises the following steps of: dissolving tulobuterol in ethyl acetate and other good solvents, dropwisely adding n-heptane and other poor solvents into the system, filtering, taking the filter cake, and drying the filter cake to obtain the tulobuterol crystal form crystal. The crystal form is high in purity and good in stability, has superiority in process production, and is suitable for long-term storage in the preparation process.
Owner:SHANDONG DYNE MARINE BIOTECHCAL PHARM HLDG CO LTD +1
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