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Transdermal absorption preparation for treating asthma

A technology for transdermal absorption preparations and plasticizers, which is applied in the field of pharmaceutical preparations, can solve problems such as the increase in the impurity content of active ingredients, and achieve the effects of reducing the production of pharmaceutical magazines, enhancing plasticity, and improving plasticity.

Active Publication Date: 2019-08-13
BEIJING TIDE PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Then, tulobuterol, the active ingredient of the drug, is a small molecular compound with a low melting point. Excessively high temperature will lead to the degradation of the active ingredient and the increase of the impurity content.

Method used

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  • Transdermal absorption preparation for treating asthma
  • Transdermal absorption preparation for treating asthma
  • Transdermal absorption preparation for treating asthma

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] The composition of the prescription is as follows:

[0045] Preparation components Content (parts) DURO-TAK 87-2287 60.2 Toloterol 4.8 Diethanolamine Lauric Acid 3.0 EUDRAGIT ® RE 100

[0046] Preparation method: weigh EUDRAGIT in the prescribed amount ® RE 100 is placed in a container, and the prescribed amount of ethyl acetate is added to stir the solution to obtain EUDRAGIT ® RE 100 solution; weigh the prescribed amount of acrylate pressure-sensitive adhesive and hydrogenated rosin glyceride into a container, add the freshly prepared EUDRAGIT ® RE 100 solution was stirred to obtain a binder solution; the prescribed amount of tulobuterol was added to the prescribed amount of ethanol to dissolve, and then the prescribed amount of diethanolamine lauric acid and diisopropanolamine were added to continue stirring and dissolving. Obtain tulobuterol ethanol solution; mix tulobuterol ethanol solution with adhesive solution to obtain a co...

Embodiment 2

[0048] The composition of the prescription is as follows:

[0049] Preparation components Content (parts) DURO-TAK 87-2287 55.2 Toloterol 4.8 Diethanolamine Lauric Acid 3.0 EUDRAGIT ® RE

[0050] Preparation method: weigh EUDRAGIT in the prescribed amount ® RE is placed in a container, and the ethyl acetate of the prescription amount is added to stir the solution to obtain EUDRAGIT ® RE solution; weigh the prescribed amount of acrylate pressure-sensitive adhesive and rosin glyceride into the container, add the freshly prepared EUDRAGIT ® RE solution is stirred to obtain a binder solution; the tulobuterol of the prescription quantity is added to the ethanol of the prescription quantity for dissolving, and then the diethanolamine lauric acid and diisopropanolamine of the prescription quantity are added to continue stirring and dissolving to obtain Tulobuterol ethanol solution; mix the tulobuterol ethanol solution with the adhesive solution t...

Embodiment 3

[0052] The composition of the prescription is as follows:

[0053] Preparation components Content (parts) DURO-TAK 87-2510 54.2 Toloterol 4.8 Diethanolamine Lauric Acid 3.0 EUDRAGIT ® RE

[0054] Preparation method: weigh EUDRAGIT in the prescribed amount ® RE100 is placed in a container, and the prescribed amount of ethyl acetate is added to stir the solution to obtain EUDRAGIT ® RE solution; weigh the prescribed amount of acrylate pressure-sensitive adhesive and rosin glyceride into the container, add the freshly prepared EUDRAGIT ® RE 100 solution was stirred to obtain a binder solution; the prescribed amount of tulobuterol was added to the prescribed amount of ethanol to dissolve, and then the prescribed amount of diethanolamine lauric acid and diisopropanolamine were added to continue stirring and dissolving. Obtain tulobuterol ethanol solution; mix tulobuterol ethanol solution with adhesive solution to obtain a colloid mixed solution...

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Abstract

The invention discloses a transdermal absorption preparation for treating asthma. The preparation contains a supporting body, an adhesive layer and a protection layer. The adhesive layer comprises 28.65-57.31% of an acrylic ester pressure-sensitive adhesive, 10.74-25.07% of viscosity-increasing resin, 3.58-14.33% of a plasticizer, and a tulobuterol as an active substance according to the total mass of the adhesive. In addition, the preparation further contains a transdermal accelerant for accelerating the transdermal absorption and a stabilizer for improving the stability of the pharmaceuticalpreparation.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and relates to an external skin preparation for treating asthma, in particular to an external skin preparation of tulobuterol. Background technique [0002] Asthma is a chronic inflammatory disease in which various cells and cellular components play important roles. This inflammation causes recurrent symptoms such as wheezing, shortness of breath, chest tightness, and coughing in patients, and the symptoms are most severe at night and in the morning; it is often accompanied by reversible airway obstruction of varying degrees; it also causes the patient's bronchi to respond to various stimuli Increased sex. According to statistics, the number of asthmatics in my country is estimated to be about 20 million, of which the incidence rate of children aged 0-14 is about 2%. [0003] At present, the most effective bronchodilators for the treatment of asthma are β2-adrenergic receptor agonists...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61K47/32A61K31/137A61P11/06
CPCA61K9/7076A61K9/7053A61K31/137
Inventor 蒲晓蕾卢迪吴昀高莹呼瑞田莉莉
Owner BEIJING TIDE PHARMA
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