External application preparation containing tulobuterol pharmaceutical composition

Abstract

The present invention discloses an external application preparation containing a tulobuterol pharmaceutical composition, particularly a skin external application preparation containing a tulobuterol and crotamiton pharmaceutical composition. According to the present invention, by adding crotamiton, the solubility of tulobuterol is increased, the use of organic solvents is effectively avoided, theactive substance loss caused by the evaporation of the organic solvent is reduced, and the stability of the preparation is increased, such that the treatment effect of the drugs cannot be affected inthe case of the long-term storage while the environmental pollution is reduced, and the adverse reactions of the patient after the medication are reduced.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to an external preparation for skin, in particular to an external preparation containing tulobuterol pharmaceutical composition and a preparation method thereof. Background technique [0002] Tulobuterol (also known as clobuterol, Tulobuternl), is a selective beta 2 - Receptor agonist, which has a strong and long-lasting effect on dilating bronchial smooth muscle, but has a weak stimulating effect on the heart. It has certain anti-allergic effects, promotes bronchial cilia movement, and relieves cough and expectorant. It is used to relieve bronchial asthma, acute and chronic bronchitis, Emphysema, silicosis, pneumoconiosis [0003] and other symptoms of respiratory obstruction. There has been great progress in the development of tulobuterol dosage forms. Aerosols, tablets, dry syrup, ointments, emulsions and patches of tulobuterol have been developed both at home and ab...

AI Technical Summary

Problems solved by technology

However, the drug's initial transdermal rate is slow, and long-term storage is that the solubility of tulobuterol to synthetic rubber adhesives is reduced, and the microcrystals produced are insoluble in adhesives, have poor stability, and are prone to crystallization.

At the same time, synthetic rubber is very irritating to the skin, and long-term use can easily cause skin allergies

[0005] In order to solve the problem of stability and sustained release of tulobuterol, researchers have improved the materials of the adhesive, such as using polyacrylic pressure-sensitive adhesive or polyisobutylene pressure-sensitive adhesive, but the preparation method used needs to The pressure-sensitive adhesive is dissolved in an organic solvent, and then the solvent is removed. This method inevitably leads to the loss of active ingredients when the solvent is volatilized, which affects the efficacy of the drug.

Document CN03129630.0 discloses a drug storage preparation that does not contain organic solvents. The patch prepared according to the technology disclosed in this document is prone to crystallization, and the drug penetration rate cannot meet the clinical drug standards.

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