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Bisoprolol-containing adhesive patch

A technology of bisoprolol and patches, applied in the field of patches containing bisoprolol, can solve the problems of reduced adhesive force, patch coloring and the like, and achieve the effect of inhibiting the decrease of adhesive force

Inactive Publication Date: 2016-04-20
NITTO DENKO CORP +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] However, these patches have problems in that the patches are colored during storage and the adhesive force is reduced

Method used

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  • Bisoprolol-containing adhesive patch
  • Bisoprolol-containing adhesive patch
  • Bisoprolol-containing adhesive patch

Examples

Experimental program
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Effect test

Embodiment 1～4

[0060] 15.1 parts by weight of the first polyisobutylene (viscosity average molecular weight: 4,000,000), 26.1 parts by weight of the second polyisobutylene (viscosity average molecular weight: 55,000), 27.4 parts by weight of a tackifier (alicyclic saturated hydrocarbon resin with a softening point of 140°C) 30 parts by weight of liquid organic components (isopropyl myristate), 1.4 parts by weight of bisoprolol, and 400 parts by weight of toluene were mixed and dissolved to prepare a toluene solution. In addition, as said bisoprolol, the bisoprolol after purification or the bisoprolol which added the hydrochloride of bisoprolol and controlled the hydrochloride content was used. The content of the hydrochloride contained in the bisoprolol (=100×the amount of the hydrochloride contained in the bisoprolol / (the total amount of the hydrochloride contained in the bisoprolol and bisoprolol) )) are shown in Table 1. The obtained toluene solution was coated on a liner made of polyeth...

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Abstract

The present invention relates to a bisoprolol-containing adhesive patch that is provided with: a support body; and an adhesive layer that contains bisoprolol and an adhesive and that is stacked on one surface of the support body. The bisoprolol-containing adhesive patch is characterized by the halogen atom content within the adhesive layer being 0.01-100 weight ppm. The present invention makes it possible to minimize decreases in adhesive strength, discoloration, and the like in a bisoprolol-containing adhesive patch during storage thereof.

Description

technical field [0001] The present invention relates to a bisoprolol-containing patch for sustainably absorbing bisoprolol in a living body through the skin. Background technique [0002] In recent years, various skin-adhesive patches for administering drugs into a living body through the skin have been developed, and among these, patches containing drugs exhibiting systemic pharmacological actions have attracted attention. These patches are obtained by forming an adhesive layer in which various percutaneously absorbable drugs are mixed with an adhesive such as an acrylic adhesive or a rubber adhesive on a support, and sticking to the skin allows the drug to pass through the skin. The skin is continuously absorbed in the body and exerts excellent pharmacological effects. [0003] However, these patch preparations have problems in that the patch preparations are colored during storage and the adhesive force is lowered. [0004] In order to suppress such coloring, for exampl...

Claims

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Application Information

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IPC IPC(8): A61K31/138A61K9/70A61P9/12
CPCA61K9/7053A61K31/138A61P9/12A61K9/7061
Inventor 青柳和宏雨山智石仓准漆原直子立川悠田中智也岩男美宏播摩润关谷纯一天笠克昭桥本壮史畑英之
Owner NITTO DENKO CORP
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