Application method of radix paeoniae alba to preparation of drug for treating high blood pressure
An application method and a technology for hypertension are applied in the application field of Radix Paeoniae Alba in the preparation of drugs for treating hypertension, and achieve the effects of improving effectiveness, accelerating blood pressure reduction, and improving antihypertensive curative effect.
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Embodiment 1
[0028] Take 500g of Radix Paeoniae Alba in accordance with the 2015 edition of "Chinese Pharmacopoeia", grind it into powder, add 70% ethanol with 7 times the total amount of crude drug, and extract it under reflux for 1 hour, and extract twice;
[0029] The residue after alcohol extraction was extracted twice with water: the first water extraction: add water 10 times the total crude drug amount, extract at 100°C for 1 hour; the second water extraction: add water 10 times the total crude drug amount, 100 °C extraction for 1 hour. The aqueous extracts were combined and concentrated.
[0030] Alcohol extraction and water extraction are respectively concentrated, and the extracts are combined, and suitable excipients are added according to pharmaceutical routines to make Paeoniae Alba Tablets. For Example 1 sample. Orally, the daily dosage for adults is equivalent to 8g of crude drug (it can be as small as 2g of crude drug, and can be as large as 32g of crude drug).
Embodiment 2
[0032] Take 500g of Radix Paeoniae Alba in accordance with the 2015 edition of "Chinese Pharmacopoeia", grind it into powder, add 70% ethanol with 7 times the total amount of crude drug, and extract it under reflux for 1 hour, extract twice, and extract the residue after alcohol extraction twice with water;
[0033] Two gradient heating extraction methods were used for water extraction: the first water extraction: add water 10 times the total amount of crude drugs, extract at 100°C for 1 hour; the second water extraction: add water 10 times the total amount of crude drugs, 121 °C extraction for 1 hour. The aqueous extracts were combined and concentrated.
[0034] After the alcohol extraction and the water extraction are respectively concentrated, the extracts are combined, and suitable excipients are added according to pharmaceutical routines to prepare Baishao granules. Be embodiment 2 samples. Orally, the daily dosage for adults is equivalent to 8g of crude drug (it can be...
Embodiment 3
[0036] Take 500g of Radix Paeoniae Alba in accordance with the 2015 edition of "Chinese Pharmacopoeia", grind it into powder, add 70% ethanol extraction of 7 times the total crude drug amount for 24 hours, extract twice, and extract the residue after alcohol extraction with water;
[0037] Two times of water extraction: the first water extraction: adding water 10 times the total amount of crude drugs, extracting at 100°C for 1 hour; the second water extraction: adding water 10 times the amount of crude drugs, extracting at 100°C for 1 hour. The aqueous extracts were combined and concentrated.
[0038] After the alcohol extraction and the water extraction are respectively concentrated, the extracts are combined, and suitable excipients are added according to pharmaceutical routines to prepare Baishao granules. Be embodiment 3 samples. Orally, the daily dosage for adults is equivalent to 8g of crude drug (it can be as small as 2g of crude drug, and can be as large as 32g of cru...
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