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Method for preparing medicine for treating hypertension with Radix Paeoniae Alba, Dendrobium officinale and Irbesartan

A technology of Dendrobium candidum and high blood pressure, which is applied in the field of drug preparation and can solve problems such as the compatibility and use of traditional Chinese medicine

Active Publication Date: 2021-04-09
HANGZHOU DANHE PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the use of traditional Chinese medicine, these two traditional Chinese medicines are rarely used in combination.

Method used

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  • Method for preparing medicine for treating hypertension with Radix Paeoniae Alba, Dendrobium officinale and Irbesartan
  • Method for preparing medicine for treating hypertension with Radix Paeoniae Alba, Dendrobium officinale and Irbesartan
  • Method for preparing medicine for treating hypertension with Radix Paeoniae Alba, Dendrobium officinale and Irbesartan

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Proportions by weight: 800 parts of Dendrobium officinale, 600 parts of Radix Paeoniae Alba, 7.5 parts of irbesartan, 400 g of Dendrobium officinale, 300 g of Radix Paeoniae Alba, and 3.75 g of irbesartan conforming to the 2015 edition of "Chinese Pharmacopoeia".

[0038] Grind Radix Paeoniae Alba into powder, add 70% ethanol of 7 times the total crude drug amount, and extract under reflux for 1 hour, extract twice, and extract the residue with water after alcohol extraction;

[0039] The residue after alcohol extraction of Paeoniae Alba was extracted twice with water: the first water extraction: add 10 times the amount of crude drug in water, extract at 100°C for 1 hour; the second water extraction: add 10 times the total amount of crude drug in water, Extract at 100°C for 1 hour. The aqueous extracts were combined and concentrated. Combine Paeoniae Alba Alcoholic Extract and Water Extract.

[0040] Grind Dendrobium officinale into powder, add Dendrobium officinale p...

Embodiment 2

[0042] Proportions by weight: 800 parts of Dendrobium officinale, 200 parts of Radix Paeoniae Alba, 7.5 parts of irbesartan, 400 g of Dendrobium officinale, 100 g of Radix Paeoniae Alba, and 3.75 g of irbesartan conforming to the 2015 edition of "Chinese Pharmacopoeia".

[0043] Grind Radix Paeoniae Alba into powder, add 70% ethanol of 7 times the total crude drug amount, and extract under reflux for 1 hour, extract twice, and extract the residue with water after alcohol extraction;

[0044] The residue after alcohol extraction of Paeoniae Alba was extracted twice with water: the first water extraction: add 10 times the amount of crude drug in water, extract at 100°C for 1 hour; the second water extraction: add 10 times the total amount of crude drug in water, Extract at 100°C for 1 hour. The aqueous extracts were combined and concentrated. Combine Paeoniae Alba Alcoholic Extract and Water Extract.

[0045] Grind Dendrobium officinale into powder, add Dendrobium officinale p...

Embodiment 3

[0047] Proportions by weight: 800 parts of Dendrobium officinale, 3200 parts of Radix Paeoniae Alba, 7.5 parts of irbesartan, 100 g of Dendrobium officinale, 400 g of Radix Paeoniae Alba, and 0.9375 g of irbesartan conforming to the 2015 edition of "Chinese Pharmacopoeia".

[0048] Grind Radix Paeoniae Alba into powder, add 70% ethanol of 7 times the total crude drug amount, and extract under reflux for 1 hour, extract twice, and extract the residue with water after alcohol extraction;

[0049] The residue after alcohol extraction of Paeoniae Alba was extracted twice with water: the first water extraction: add 10 times the amount of crude drug in water, extract at 100°C for 1 hour; the second water extraction: add 10 times the total amount of crude drug in water, Extract at 100°C for 1 hour. The aqueous extracts were combined and concentrated. Combine Paeoniae Alba Alcoholic Extract and Water Extract.

[0050] Grind Dendrobium officinale into powder, add Dendrobium officinal...

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Abstract

The invention relates to medicine preparation technology, and aims to provide a method for preparing medicine for treating hypertension with white peony root, dendrobium officinale and irbesartan. Including: grind white peony root into powder and extract with alcohol, extract the residue after alcohol extraction with water, and combine the concentrated extract; grind Dendrobium officinale into powder, add irbesartan powder to the combined extract and mix evenly; add excipients , to prepare medicines for the treatment of high blood pressure. In the present invention, the extract of Alba Paeoniae Alba and its water extraction method combined with Dendrobium officinale powder have an outstanding curative effect on hypertension, and the Alcoholic Paeoniae Alba and Water Extraction Method can reduce the loss of components and improve the effectiveness compared with conventional water extraction, and can promote the complete recovery of Radix Paeoniae Alba. The combination of Dendrobium officinale and Paeoniae Alba can not only quickly reduce blood pressure, but also stabilize blood pressure in the medium and long term, and adjust and restore the balance of Yin and Yang. The combination of traditional Chinese medicine and western medicine can obtain the curative effect similar to the conventional dosage of western medicine antihypertensive drugs under the condition of using less dosage of western medicine, greatly expanding the application prospect.

Description

technical field [0001] The invention relates to medicine preparation technology, in particular to a method and application of preparing medicine for treating hypertension with white peony root, dendrobium officinale and irbesartan. Background technique [0002] Hypertension is a common high incidence clinically, which has serious harm to the heart, brain, kidney and other important organs. Western medicine treatment of hypertension still lacks the medicine for adjusting body constitution and can adjust blood pressure (depressor). The antihypertensive treatment of modern medicine is all symptomatic treatment. Currently commonly used antihypertensive drugs include calcium channel blockers (CCBs), angiotensin-converting enzyme inhibitors (ACEIs), angiotensin II receptor blockers (ARBs), diuretics, and β-blockers. , still can not completely prevent the progression of hypertension and its secondary lesions. Most hypertensive patients need two or more antihypertensive drugs to ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8984A61P9/12A61K31/4184
CPCA61K31/4184A61K36/65A61K36/71A61K36/8984A61K2236/333A61K2236/39A61K2236/51A61K2236/53A61P9/12A61K2300/00
Inventor 吴悦吴人照
Owner HANGZHOU DANHE PHARM CO LTD
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