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Compound antihypertensive medicament

A technology of high blood pressure and compound preparations, applied in the field of medicine, can solve the problems of inaccurate clinical dosage, influence of drug efficacy, increase of side effects, etc., and achieve the effect of improving antihypertensive efficacy, less adverse reactions, and good antihypertensive effect

Inactive Publication Date: 2010-06-30
JIANGSU JIBEIER PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] The product of the present invention overcomes that when nifedipine and atenolol are used clinically, the dosage of the drug is increased to ensure the curative effect when a single drug is used alone, resulting in a significant increase in side effects; , and the use of inaccurate clinical dosages affects the defects of drug efficacy

Method used

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  • Compound antihypertensive medicament
  • Compound antihypertensive medicament

Examples

Experimental program
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Effect test

Embodiment 1

[0032] A compound preparation containing the following components:

[0033] Nifedipine 10mg

[0034] Atenolol 25mg

[0035] Starch 40mg

[0036] Calcium Sulfate 20mg

[0037] Talc 2mg

[0038] Silica 1.5mg

[0039] Carboxymethyl Starch Sodium 2mg

[0040] Magnesium stearate 0.5mg

[0041] This embodiment can be made into compound nifedipine-atenolol tablet, and the preparation method can adopt the preparation method of common pharmaceutical preparations.

Embodiment 2

[0043] A compound preparation containing the following components:

[0044] Nifedipine 20mg

[0045] Atenolol 50mg

[0046] Starch 40mg

[0047] Calcium Sulfate 20mg

[0048] Talc 2mg

[0049] Silica 1.5mg

[0050] Carboxymethyl Starch Sodium 2mg

[0051] Magnesium stearate 0.5mg

[0052] This embodiment can be made into compound nifedipine-atenolol tablet, and the preparation method can adopt the preparation method of common pharmaceutical preparations.

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Abstract

The invention discloses a compound preparation for treating hypertension, which comprises 5-30mg of nifedipine and 12.5-75mg of atenolol. The product of the invention overcomes the defect that a side effect is markedly enhanced caused by increasing the medicament dosage for ensuring the curative effect when the nifedipine and the atenolol are clinically used at present and one medicament is singly used, and provides a new compound preparation. The nifedipine and the atenolol are combined, and the curative effect has synergistic and complementary actions; the tolerance of patients is increased, the compliance is improved, the dosage is decreased, an adverse reaction is lightened, and the compound preparation is convenient to take and has low price.

Description

technical field [0001] The invention relates to the technical field of medicine and discloses a compound antihypertensive drug. Background technique [0002] Hypertension is the most common cardiovascular disease and a major public health problem worldwide. my country currently has about 100 million hypertensive patients. According to the epidemiological survey in 1991, the awareness rate of hypertension in my country's urban and rural areas was 36% and 13%, and the treatment rate was 17% and 5%, respectively. The form of hypertension prevention and treatment is quite severe. According to the forecast of WTO, by 2020, non-communicable diseases will account for 79% of the causes of death in my country, among which cardiovascular diseases will take the first place. [0003] Commonly used drugs for the treatment of hypertension include the calcium antagonist nifedipine and the β-blocker atenolol. Nifedipine (Nifedipine), the chemical name is 2,6-dimethyl-1,4-dihydro-3,5-pyri...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4422A61K31/165A61P9/12
Inventor 徐丽娟吴修艮陈进高瑞银聂丽云朱月华
Owner JIANGSU JIBEIER PHARMA
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