113 results about "Hypertensive medications" patented technology

Synthesis of antihypertensive Lopli intermediate 4-carbonyl-(S)-proline derivative is carried out by taking 4-carbonyl-L-proline derivative as raw material, and reacting it with oxidant to obtain the final product under action of 2,2,6,6-tetramethyl nitro-oxide free radical piperidine compound. It's simple, has gentle reactive condition and high recovery rate, and can be used for industrial production.

The invention relates to a compound control-released percutaneous medicine plaster for treating high blood pressure and its preparation method, wherein the paste comprises laminated back lining layer, a pressure-sensitive adhesive framework form medicament-containing layer and a protective film, wherein the compound medicament comprises diuretics, central alpha-acceptor excitant and cirumferential alpha-receptor blocking agent, beta-receptor blocking agent, calcium antagonist and any two of the five categories of medicament for influencing angiotensin II formation and treating high blood pressure. The invention may realize medicine administration once in front of chest or behind the ears, wherein homeostasis blood concentration can be reached.

Methods of using a genetic polymorphic variation in the human beta-1 adrenergic receptor gene as a drug response marker are presented. Determining the presence or absence of the A145G genetic variation in the human beta-1 adrenergic receptor gene is useful in predicting an individual's relative response to different antihypertensive drugs; optimizing antihypertensive treatment for an individual; selecting candidate human subjects for participation in clinical trials involving antihypertensive drugs; and, predicting the relative responses among a plurality of individuals to an antihypertensive drug.

The invention relates to a sacubitril potassium salt crystal form B. The crystal form has the advantages of small hygroscopicity, simple preparation method, easy control of the crystal form, and good stability, and is suitable for preparing various preparations; the invention also relates to the preparing method of the sacubitril potassium salt crystal form B, a pharmaceutical composition containing the sacubitril potassium salt crystal form B, and a use of the sacubitril potassium salt crystal form B in preparing drugs for prevention or treatment of chronic heart failure or hypertension.

A traditional Chinese medicine for treating hypertension relates to the technical field of hypertension treating medicines, and is characterized by comprising the following compositions in parts by weight: 10-30 parts of eucommia, 20-40 parts of ligusticumwallichii, 20-40 parts of alismaorientalis, 20-40 parts of rhizomaatractylodis, 20-40 parts of dipsacusasperoides, 10-30 parts of cornusofficinalis, 5-15 parts of uncaria, 5-15 parts of rhizomagastrodiae, 40-80 parts of raw radix astragali, 10-30 parts of salvia miltiorrhiza, 20-40 parts of radix ophiopogonis and 10-20 parts of radix pseudostellariae. The traditional Chinese medicine is capable of treating hypertension disease, furthest reducing cardio cerebrovascular accident incidence rate and mortality, and prolonging the life of patients, and has the advantages of being good in medicine property, good in safety, pure natural, free of pollution and free of side effect.

The invention relates to the application of southernwood used for preparing a medicine for treating the primary hypertension, belonging to the application of medicines. The southernwood of the invention is used for preparing the medicine for treating the primary hypertension, and accounts for 100 percent according to parts by weight in the medicine for treating the primary hypertension. The invention provides a novel medical application of the southernwood considered as the traditional medicine, and the southernwood used for preparing the medicine for treating the primary hypertension has favorable medical effect and no toxic side effect.

The invention discloses a compound medicine preparation for treating refractory hypertension, which is mainly prepared from the following components in parts by weight: 50 to 500 parts of ganoderan, 5 to 10 parts of nifedipine, 12.5 to 50 parts of captopril, 10 to 50 parts of hydrochlorothiazide and 12.5 to 100 parts of atenolol. According to the compound medicine preparation provided by the invention, the ganoderan is compounded with multiple antihypertensive drugs of conventional multiple-treatment to prepare a convenient-to-take compound preparation; the beneficial effects of synergetic antihypertensive effect and mutual side effect relieving / offsetting effect of the ganoderan and the four medicines are realized, the compliance of standardized medicine-taking of refractory hypertension patients is obviously improved, the therapeutic effect of obviously reducing the blood pressure level of the refractory hypertension or even realizing up-to-standard blood pressure control on part of the patients are achieved, and a novel convenient-to-take compound antihypertensive drug is provided for simplifying the drug use of the refractory hypertension patients and effectively reducing the blood pressure level.

A traditional Chinese medicine formula for treatment of hypertension relates to the technical field of drugs for treating hypertension, and the traditional Chinese medicine formula is characterized by comprising the following components in parts by weight: 40-50 parts of eucommia ulmoides, 25-35 parts of ligusticum wallichii, 25-35 parts of rhizoma alismatis, 20-40 parts ofrhizoma atractylodis, 10-15 parts of fructus cormi, 5-15 parts of uncaria, 5-15 parts of gastrodia elata, 50-70 parts of astragali radix, 15-25 parts of salvia miltiorrhiza 25-35 parts ofradix ophiopogonis and 10-20 parts of radix pseudostellariae; the traditional Chinese medicine formula can treat the hypertension, reduce the incidence rate of heart and cerebral vessel accidents and death rate in a maximum limit, and prolong the life of patients, and is good in drug potency, good in safety, purely natural, and free of pollution and side effect.

The inVention belongs to the technical field of products for diagnosing and treating high blood pressure, in particular to a wearable high blood pressure real-time diagnosis and treatment integrated system with controllable drug release. The system comprises a wearable blood pressure monitoring deVice and a micro-needle controllable drug doser, the wearable blood pressure monitoring deVice comprises a hand ring worn on a wrist part, a graphene pressure sensor, a signal processing module, a data storage module, a data transmission module and a battery are arranged on the hand ring; the micro-needle controllable drug doser comprises an arm belt worn on an arm part, a high blood pressure drug micro needle , an instruction receiVing and controllable release module and a micro-needle storage module arranged on the arm belt. The system has the adVantages of conVenient use, accurate diagnosis and treatment, and can carry out immediate and accurate dose according to abnormal conditions of blood pressure while monitoring blood pressure, so as to realize timely and effectiVe control of blood pressure and effectiVely improVe the effect of high blood pressure treatment.

The invention discloses an effective fraction of plantain seeds, as well as a preparation method and an application thereof. The effective fraction of plantain seeds is obtained by separating and purifying a plantain seed ethanol extract with a macroporous resin and contains hispidulin A and acteoside; and the weight ratio of hispidulin A to acteoside ranges from 1:1 to 1:5 and the sum weight of hispidulin A and acteoside accounts for 40% to 80% of the total weight of the effective fraction. The effective fraction of plantain seeds, disclosed by the invention, can promote the secretion of insulin and reduce fasting blood-glucose levels and can also effectively reduce blood pressure in animals and reduce blood plasma angiotensin II level, shows good medicinal values in treatment of diabetes and hypertension, and can be used alone or in combination with pharmaceutically-acceptable carriers to prepare pharmaceutical formulations for treating diabetes and / or hypertension.

Patients which are treated with stimulants (e.g., CNS stimulants, sympathomimetic amine, or anorectic / anorexigenic), such as patients being treated for attention deficit / hyperactivity disorder or obesity, often are at risk in developing high blood pressure. Similarly, patients which are treated with analgesics such as non-steroidal anti-inflammatory drugs (NSAIDs) over an extended period of time risk developing high blood pressure. These and other iatrogenic therapies (therapies which inadvertently cause an increase in, e.g., blood pressure) are addressed by providing the patient with one or more antihypertensive drugs, most preferably calcium channel blockers, during the treatment period. The CNS or NSAIDs can be provided separately or together with the antihypertensive drugs or as part of a combined composition. The adjunctive therapy can prevent or reduces cardiovascular disease and other complications of high blood pressure attendant with these iatrogenic therapies.

The invention relates to the technical field of medicaments, in particular to an extraction method of a nettle extract. The yield of the nettle extract obtained by the extraction method is 46.5 to 49.6 percent. The nettle extract can be used for preparing the medicaments for treating prostatitis, prostatomegaly, benign hyperplasia of prostate or high blood pressure and can effectively treat prostatitis, prostatomegaly, benign hyperplasia of prostate or high blood pressure. The effective rate of the nettle extract on acute prostatitis is 93.33 percent; the effective rate of the nettle extract on chronic prostatitis is 90.33 percent; the effective rate of the nettle extract on prostatomegaly is 89.0 percent; the effective rate of the nettle extract on benign hyperplasia of prostate is 90.67 percent; and the effective rate of the nettle extract on high blood pressure is 91.0 percent.

The invention provides a compound for enhancing space coupling degree of an endothelial cell ion channel complex TRPV4-KCa2.3 and application thereof in resisting hypertension. The compound has the advantages that by finding the structure domain of interaction sites of the endothelial cell ion channel complex TRPV4-KCa2.3, the specific compound which can simultaneously act on the two action sites is prepared; the space coupling degree of the complex TRPV4-KCa2.3 can be enhanced by the compound, and the important meaning is realized for the research and development of hypertension drugs.

The invention provides traditional Chinese medicine for efficiently treating hypertension and a preparation method thereof, and relates to the technical field of drugs for treating hypertension. The traditional Chinese medicine is characterized in that the composition comprises the following components: 10-30 g of eucommia, 5-10 g of pangolin scales, 20-40 g of dipsacus root, 10-30 g of cornus officinalis sieb et zucc, 5-15 g of uncaria, 5-15 g of gastrodia elata, 40-60 g of astragali radix, 20-40 g of puerarin, 15-25 g of salviae miltiorrhizae, 20-40 g of medlar and 20-40 g of radix ophiopogonis. The preparation method comprises the following steps: soaking the drugs for 30 minutes to 1 hour, cooking the drugs at a big fire and cooking the drugs at a slow fire for about 30 minutes; pouring the cooked decoction, adding water in the drugs, boiling and cooking the drugs at slow fire for 30 minutes, mixing the decoction obtained at twice, and taking the same in twice. The traditional Chinese medicine disclosed by the invention can be used for treating hypertensive disorders, reducing the occurrence rate and death rate of heart and cerebral vessels to the maximum and prolonging the life of patients, and is good in drug properties, good in safety, pure natural, free of pollution and free of side effect.

A retrospective pharmacogenetic analysis was conducted in an attempt to evaluate potential association between genetic variation and outcome of a clinical trial of efficacy of aliskiren as an antihypertensive agent. Forty-eight polymorphisms were examined in twelve genes from the renin-angiotensin-aldosterone system (RAS) or previously implicated in blood pressure regulation. Significant associations were seen between one polymorphism in the angiotensin converting enzyme (ACE) gene, two polymorphisms in the angiotensin II type 2 receptor (AGTR2) gene, and clinical parameters of mean sitting diastolic and systolic blood pressure decrease. These effects were not found with irbesartan and placebo treatment, but instead were specific to aliskiren treatment.

The present invention relates to a new crystal form of sacubi trimethamine salt, which has high purity, low hygroscopicity and good solubility, and is suitable for preparing various preparations; the present invention also relates to the preparation of the new crystal form The method, the pharmaceutical composition containing the new crystal form, and the use of the new crystal form in the preparation of drugs for preventing or treating chronic heart failure or hypertension.

The invention belongs to the field of biological medicines and relates to a primary hypertension resistance medicine. The medicine is prepared from major raw materials, namely panax notoginseng, salvia miltiorrhiza and American ginseng and has a better pressure reduction effect. The medicine can be prepared into any clinically or pharmaceutically acceptable dosage form, preferably an oral preparation.

Patients which are treated with stimulants (e.g., CNS stimulants, sympathomimetic amine, or anorectic / anorexigenic), such as patients being treated for attention deficit / hyperactivity disorder or obesity, often are atrisk in developing high blood pressure. Similarly, patients which are treated with analgesics such as non-steroidal anti-inflammatory drugs (NSAIDs) over an extended period of time risk developing high blood pressure. These and other iatrogenic therapies (therapies which inadvertently cause an increase in, e.g., blood pressure) are addressed by providing the patient with one or more antihypertensive drugs, most preferably calcium channel blockers, during the treatment period. The CNS or NSAIDs can be provided separately or together with the antihypertensive drugs or as part of a combined composition. The adjunctive therapy can prevent or reduces cardiovascular disease and other complications of high blood pressure attendant with these iatrogenic therapies.

The invention relates to a method for preparing a micro-ecological preparation and an application thereof. At present, hypertension needs to be controlled by medicines with side effect. By cloning a hydrogen sulfide generation enzyme gene to an expression carrier and converting the carrier into a receptor bacterium, the invention obtains an engineering strain which can express a hydrogen sulfide generation enzyme with high efficiency, and the micro-ecological preparation is prepared after culture and is used as the base material of a medicine for treating hypertension. The method comprises thefollowing concrete steps: cloning the hydrogen sulfide generation enzyme gene into the expression carrier; converting the expression carrier into a receptor cell to obtain a converter; and culturingthe converter until the logarithmic growth later period and collecting thalli as the micro-ecological preparation, namely, a live thallus carrying the hydrogen sulfide generation enzyme gene. By the application of the micro-ecological preparation prepared by the method as hypertension medicine, a patient can ingest a little lactose or other auxiliary food every day, and the engineering strain cannormally grow and propagate in the intestinal tract, thereby frequent administration is not needed, and no side effect exists.

The invention provides a compound anti-cancer drug comprising statin drugs and thiazine drugs. Statin drugs are safe and effective hypercholesteremia-controlling drugs widely used in clinic, and can inhibit 3-hydroxy-3-methyl coenzyme A (HMG-CoA) reductase. Hydrochlorothiazide is a thiazine diuretic and antihypertensive drug. The invention shows that low-dose combined administration of atorvastatin and hydrochlorothiazide can more effectively inhibit growth of prostate cancer cells, pancreatic cancer cells, and colon cancer cells than single high-dose administration.

The invention discloses a compound preparation for treating hypertension, which comprises 5-30mg of nifedipine and 12.5-75mg of atenolol. The product of the invention overcomes the defect that a side effect is markedly enhanced caused by increasing the medicament dosage for ensuring the curative effect when the nifedipine and the atenolol are clinically used at present and one medicament is singly used, and provides a new compound preparation. The nifedipine and the atenolol are combined, and the curative effect has synergistic and complementary actions; the tolerance of patients is increased, the compliance is improved, the dosage is decreased, an adverse reaction is lightened, and the compound preparation is convenient to take and has low price.

The invention provides a medication method and a kit of an antihypertensive drug irbesartan. The method comprises the following steps: respectively designing multiple amplification primers and extension primers according to a plurality of to-be-detected target SNP loci; preparing a multiplex amplification primer reaction system and an extension primer reaction system; in a reaction system, using aplurality of primers for simultaneously and respectively carrying out amplification and single base extension reaction on a plurality of target SNP sites; carrying out flight time mass spectrometry analysis on a product obtained after the single base extension reaction, identifying genotypes of SNP related to different drug metabolism according to products of extension primers with different molecular weights represented by mass spectrometry peaks, and guiding medication of the antihypertensive drug irbesartan. The invention also provides the detection kit using the method. The SNP locus related to metabolism of the antihypertensive drug irbesartan can be detected, and the SNP locus has the advantages of being low in cost, free of probe synthesis, short in consumed time, simple and convenient in result analysis and extremely wide in application field.

The invention provides a detection product for judging individualized medication of nifedipine by using an extension primer with different molecular weights at different single nucleotide polymorphism(SNP) sites, detecting a plurality of sites at the same time through matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS), and finally distinguishing the individualized medication of the antihypertensive drug nifedipine. A preparation method comprises the following steps: respectively designing multiple amplification primers and extension primers according to a plurality of to-be-detected target SNP loci; preparing a multiplex amplification primer reaction system and an extension primer reaction system; in a reaction system, using a plurality of primersfor simultaneously and respectively carrying out amplification and single base extension reaction on a plurality of target SNP sites; carrying out time-of-flight mass spectrometry analysis on a product after the single base extension reaction, identifying genotypes of SNP related to different drug metabolism according to products of extension primers with different molecular weights represented by a mass spectrum peak, and guiding individualized medication of the antihypertensive drug nifedipine. The product can detect three SNP sites related to nifedipine metabolism at the same time, and hasthe advantages of low cost, no need of probe synthesis, short time consumption, simple and convenient result analysis and extremely wide application field.

The invention relates to a method of using coconut cake globulin as a raw material to prepare ACE inhibiting peptide. The method includes: selecting mature old coconut, and treating the same to obtain degreased coconut cake powder; extracting coconut cake globulin, and performing compound enzyme hydrolysis and centrifugal separation to prepare polypeptide original extract; separating out five polypeptide components from the polypeptide original extract, collecting the fifth polypeptide component, and further separating and purifying to obtain 12 polypeptide components; further subjecting the ninth component to carbon 18 analytical column-reversed phase high performance liquid chromatographic separation to obtain two pure peptides, wherein ACE inhibition rate of each pure peptide is higher than 70%. The coconut cake globulin is used as a substrate, the ACE inhibiting peptide higher than 95% in purity is prepared by adopting technologies of compound enzymolysis, gel chromatography separation and reversed phase high performance liquid chromatography purification, the ACE inhibiting peptide can be used as an ingredient of natural anti-hypertension drugs, can be added into food to prevent and treat food-borne hypertension, is conducive to realizing comprehensive utilization and deep processing of coconut and can powerfully promote development of coconut industry of China.

The invention discloses a preparation method of a medicine for treating hypertension and relates to the preparation method of the medicine for treating hypertension. The preparation method comprises the following steps of: firstly, adding ethanol to soak waternut culm, heating up the mixed solution until the mixed solution is reflowed, filtering the mixed solution, collecting the filtrate for future use, carrying out reflux extraction on the filter residue twice, combining the filtrates, filling the combined filtrate to a rotary evaporator, and recycling the ethanol under reduced pressure; and secondly, putting residual thick paste in a rotary bottle to an evaporating dish, drying the thick paste in a water bath, putting the dried thick paste to a drying box, obtaining the ethanol-extraction substance dry paste by drying, pulverizing the dry paste to obtain granular powder with active ingredients, namely completing the preparation process. According to the preparation method disclosed by the invention, the hypertension ethanol extract has a good effect for treating renal hypertension and better safety, so that a new scheme is provided for developing the traditional Chinese medicine neurogenic hypertension drug, and a novel strategy is provided for treating the hypertension. The prepared medicine for treating the hypertension can be used for effectively reducing blood pressure and reducing systolic pressure more remarkably relative to diastolic pressure, is free of side effects, not capable of damaging visceral organs after being taken for a long time, small in drug dependence and safer in drug use.

The invention provides milk candies for the adjuvant therapy of high blood pressure. The milk candies comprises the following components in parts by weight: 30-50 parts of white granulated sugar, 20-40 parts of maltose, 20-40 parts of cream, 10-20 parts of milk powder, 15-25 parts of edible gelatin, 4-6 parts of cassia seed, 4-6 parts of raw flos sophorae, 4-6 parts of puerarin, 4-6 parts of uncaria, 2-4 parts of radix scutellariae, 2-4 parts of hawthorn and 2-4 parts of apocynum venetum. The milk candies for the adjuvant therapy of the high blood pressure, provided by the invention, have good treatment effect in combination with high blood pressure medicines and good tolerance for patients; after the milk candies are eaten for a period of time, the high blood pressure medicines can be gradually reduced, and the burden of kidneys is reduced; the natural products for preparing the milk candies are low in cost and rich in sources; a preparation method of the milk candies is simple and low in cost; the components of the milk candies are matched with one another, so that the blood pressure can be effectively reduced.

The invention provides a method and a kit for guiding medication of nitrendipine and atenolol. The method comprises the following steps: respectively designing multiple amplification primers and extension primers according to 10 to-be-detected target SNP loci; preparing a multiplex amplification primer reaction system and an extension primer reaction system; in the reaction systems, simultaneouslyand respectively carrying out amplification and single-base extension reaction on the 10 target SNP loci by using a plurality of sets of primers; and carrying out time-of-flight mass spectrometry analysis on a product after the single base extension reaction, identifying genotypes of SNP related to different drug metabolism according to products of extension primers with different molecular weights represented by a mass spectrum peak, and guiding the medication of antihypertensive drug nitrendipine and atenolol. Meanwhile, the invention provides the detection kit using the method. The methodcan simultaneously detect the 10 SNP loci related to metabolism of the antihypertensive drug nitrendipine and atenolol, and has the advantages of low cost, no need of probe synthesis, short time consumption, simple and convenient result analysis and extremely wide application field.

The invention provides a method utilizing extension primers with different molecular weights at different SNP (single nucleotide polymorphism) sites to detect multiple sites related to metabolism of an antihypertensive drug lacidipine by MALDI-TOF-MS (matrix-assisted laser desorption ionization time-of-flight mass spectrometry) and guide medication of lacidipine finally as well as a kit. The method comprises steps as follows: designing multiple amplification primers and extension primers respectively according to six target SNP sites to be detected; preparing a multi-amplification primer reaction system and an extension reaction system; performing amplification and single-base extension reactions on the six target SNP sites by multiple primers simultaneously respectively; performing time-of-flight mass spectrometry on products obtained after the single-base extension reaction, identifying genetypes of SNPs related to different drug metabolisms according to products, represented by massspectrum peaks, of extension primers with different molecular weights, and guiding the medication of the antihypertensive drug lacidipine. Meanwhile, the invention provides a detection kit utilizingthe method. The SNP sites related to metabolism of six antihypertensive drug lacidipine can be detected simultaneously, and the method has the advantages of low cost, no need of probe synthesis, low time consumption, simple and convenient result analysis and quite wide application field.