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Compound medicine preparation for treating refractory hypertension

A pharmaceutical preparation and high blood pressure technology, applied in the field of medicine, can solve the problems of poor patient compliance, fear of side effects, etc., and achieve the effects of lowering blood pressure, simplifying medication, and facilitating taking

Inactive Publication Date: 2017-11-03
卢广荣
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Research also shows that the types of antihypertensive drugs patients take are closely related to their compliance. Patients often do not take their medicines according to the doctor's advice due to fear of the side effects of multiple drugs. The more types of drugs prescribed by the doctor, the worse the patient's compliance

Method used

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  • Compound medicine preparation for treating refractory hypertension
  • Compound medicine preparation for treating refractory hypertension
  • Compound medicine preparation for treating refractory hypertension

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Randomized Controlled Trial of Curative Effect of Compound Preparation of the Present Invention (Each Tablet Containing Ganoderma Polysaccharide 75mg)

[0019] 1 drug preparation

[0020] Experimental drug: Ganoderma lucidum polysaccharide compound antihypertensive tablets, each tablet containing 75 mg of Ganoderma polysaccharide + 10 mg of nifedipine + 25 mg of captopril + 25 mg of hydrochlorothiazide + 25 mg of atenolol.

[0021] Control drug: compound antihypertensive tablets without Ganoderma lucidum polysaccharide, each tablet containing 10 mg of nifedipine + 25 mg of captopril + 25 mg of hydrochlorothiazide + 25 mg of atenolol.

[0022] 2 clinical data

[0023] 2.1 Diagnostic criteria

[0024] According to the diagnostic criteria of the "Guidelines for the Prevention and Treatment of Hypertension in China", patients with essential hypertension (EH) who have been routinely taking three drugs such as nifedipine, captopril, hydrochlorothiazide, and atenolol for mor...

Embodiment 2

[0058] Randomized Controlled Trial of Curative Effect of Compound Preparation of the Present Invention (Each Tablet Containing Ganoderma Polysaccharide 500mg)

[0059] 1 drug preparation

[0060] Experimental drug: Ganoderma lucidum polysaccharide compound antihypertensive tablet, each tablet containing 500 mg of Ganoderma polysaccharide + 10 mg of nifedipine + 25 mg of captopril + 25 mg of hydrochlorothiazide + 25 mg of atenolol.

[0061] Control drug: compound antihypertensive tablets without Ganoderma lucidum polysaccharide, each tablet containing 10 mg of nifedipine + 25 mg of captopril + 25 mg of hydrochlorothiazide + 25 mg of atenolol.

[0062] 2 clinical data

[0063] 2.1 Diagnostic criteria

[0064] With embodiment 1.

[0065] 2.3 General Information

[0066] 60 cases met the above diagnostic criteria, including 43 males and 17 females. The oldest is 73 years old and the youngest is 46 years old. The longest history of hypertension was 32 years, and the shortest ...

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Abstract

The invention discloses a compound medicine preparation for treating refractory hypertension, which is mainly prepared from the following components in parts by weight: 50 to 500 parts of ganoderan, 5 to 10 parts of nifedipine, 12.5 to 50 parts of captopril, 10 to 50 parts of hydrochlorothiazide and 12.5 to 100 parts of atenolol. According to the compound medicine preparation provided by the invention, the ganoderan is compounded with multiple antihypertensive drugs of conventional multiple-treatment to prepare a convenient-to-take compound preparation; the beneficial effects of synergetic antihypertensive effect and mutual side effect relieving / offsetting effect of the ganoderan and the four medicines are realized, the compliance of standardized medicine-taking of refractory hypertension patients is obviously improved, the therapeutic effect of obviously reducing the blood pressure level of the refractory hypertension or even realizing up-to-standard blood pressure control on part of the patients are achieved, and a novel convenient-to-take compound antihypertensive drug is provided for simplifying the drug use of the refractory hypertension patients and effectively reducing the blood pressure level.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a compound pharmaceutical preparation for treating refractory hypertension. Background technique [0002] Ordinary hypertensive patients can effectively control their blood pressure through conventional treatment, but some patients cannot effectively control their blood pressure with conventional treatment. This type of hypertension is generally called refractory hypertension. The latest study on the sample population of hypertensive patients shows that among the hypertensive population in my country, 11.7% of the hypertensive population cannot reach the target blood pressure after using more than 3 antihypertensive drugs including diuretics, and 0.8% cannot reach the target blood pressure after using more than 5 antihypertensive drugs %. This means that even with the use of various antihypertensive drugs, 12.5% ​​of hypertensive patients still suffer from refractory hypertension and thei...

Claims

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Application Information

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IPC IPC(8): A61K31/715A61K31/4422A61K31/401A61K31/549A61K31/165A61P9/12
Inventor 卢广荣
Owner 卢广荣
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