419results about How to "Good medicine" patented technology

The invention discloses a nitrogen-containing fused heterocycle compound shown by a formula I, a pharmaceutically acceptable salt thereof, or enantiomers, diastereoisomers, tautomers, solvates, metabolic precursors or prodrugs of the nitrogen-containing fused heterocycle compound and the pharmaceutically acceptable salt thereof, or a pharmaceutical composition containing the nitrogen-containing fused heterocycle compound and an application of the nitrogen-containing fused heterocycle compound. The nitrogen-containing fused heterocycle compound disclosed by the invention has relatively good antitumor activity.

A system and method for coordinated evaluation and prescription of unregulated therapeutic substances in a supervised medical environment, wherein the unregulated therapeutic substances, derived from natural products, are initially qualified as a therapeutic option to traditional prescription and OTC medicines. The implementation of the system and method of qualification and prescription of unregulated therapeutic substances is performed within the context of a mainstream medical care environment comprising an established health care management system wherein patient subscribers, within a given system, elect to participate in a trial evaluation under the supervision of the medical professional responsible for their care. Upon successful completion of the evaluation, the patient is empowered, with his medical professional's approval, to adopt the unregulated therapeutic substances for treatment of his illness or condition, and the established health care management system is obligated to reimburse such patient for such unregulated therapeutic substances.

The invention provides a method for breeding medical ground beetles and belongs to the technical field of medical animal breeding. The method for breeding the medical ground beetles comprises the steps of control over a place of a breeding party, temperature and humidity, management of breeding fodder, breeding soil of the ground beetles, an egg reservation of the ground beetles and incubation of eggs, management of larvae of the ground beetles and medium-sized ground beetles, management of copulation, management of adults, prevention and treatment of diseases and pests, collection and processing of the ground beetles and finished product storage of the ground beetles. The method for breeding the medical ground beetles accords with the original wild life habits of the ground beetles, the growth and breeding speed of the ground beetles is greatly increased, and the ground beetles are good in medical property, strong in efficacy, good in quality and high in market selling price.

A field-like ecological livestock farm comprises fences, wherein an open cultivation zone and an incubation zone are arranged inside the fences; in the open cultivation zone, cultivation ridges and bait cultivation ditches are arranged alternately; and the incubation zone is provided with a plurality of breeding jars. The cultivation ridges are higher than the ground plane, the cross section of each cultivation ridge is trapezoid, tiles or bricks are arranged at the tops of the cultivation ridges, and gaps are reserved among the tiles or bricks. The field-like ecological cultivation farm and a field-like ecological cultivation method have the following characteristics that; the cultivation method is based on the combination of main food comprising high protein foods and meat and complementary food comprising insects in the food chain such as earthworm, Tenebrio molitor L. and/or ground beeltle; the cultivation farm meets the field life habit of centipede, thus the disease resistance of centipede can be greatly increased and the growing and breeding speed of centipede can be accelerated; and the adult has good drug property, high efficacy, good quality and high market price.

The invention provides a rhizoma polygonati planting method and application of same in plantation of polygonatum multiflorum. The method comprises the steps of selecting land and preparing soil, conducting treatment of the roots of rhizoma polygonati, planting, conducting water and fertilizer management in the later period, weeding and conducting pests management, and harvesting. The method changes the technical status quo of extensive plantation of rhizoma polygonati in the prior art, and provides a scientific, integrated and systematic technical scheme to the soil, base fertilizer, plant and root treatment in the planting process, the field management after the planting and other crucial factors. According to the polygonatum multiflorum planted by applying the method, the Rhizoma polygonati seedling can grow to the height of 120cm, the Rhizoma polygonati yield per mu increases by more than 4 times, and even as high as 10 times. As being tested, the Rhizoma polygonati planted by applying the method has a good drug property and a good anti-disease capability, a sugar content attaining more than 10 and even reaching as high as 12 with a good quality which far surpasses the sugar content standard of Rhizoma polygonati stipulated in Dictionary of Chinese Medicine. The method is suitable for large scale promotion and plantation, thus achieving the stable yield and high yield effect of Rhizoma polygonati plantation.

The invention relates to a long-effecting exenatide (Exendin-4) analogue and a synthetic method thereof. The Exendin-4 is modified to obtain the Exendin-4 analogue with longer pharmacologic action time, the synthesis of target polypeptide is quickly realized through an orthogonally protection strategy solid-phase synthesis method, and a crude product is purified and freeze-dried to obtain the Exendin-4 analogue.

The invention relates to a cockroach and eupolyphaga large-scale mixed breeding technique and belongs to a method for breeding specific animals. A cockroach and eupolyphaga mixed breeding method is characterized in that: 1, breeding environment, a pool which is a precursor of a three-dimensional greenhouse feeding pond is adopted; 2, food stuffs feeding, wherein adults and larvae of the eupolyphaga and the cockroach have the same food stuffs such as wheat bran, rice chaff, green vegetables, carrots, rice paste, pumpkins, pericarp, leaves and the like; and the food stuffs based on the green materials are fed for one time every 2 to 3 days and more dried materials such as the wheat bran are fed; 3, management of larval and middle-aged cockroaches, wherein larvae are not required to be separated from eggmass at the early stage after reproduction of the cockroach; and management of larval and middle-aged eupolyphaga is that the larvae are separated from eggmass after being incubated; and 4, prevention and control of diseases and insect damage, wherein the natural enemies of the cockroach and the eupolyphaga during artificial culture are ants, mice, spiders, chickens, ducks, birds and the like; and the diseases and insect damage are prevented in advance and treated actively. The cockroach and eupolyphaga large-scale mixed breeding technique has the advantages of accordance with the original wild life habit of the cockroach and greatly increasing growth speed and reproductive speed of the cockroach, along with high medicament properties, strong effect, excellent quality and high market price.

The invention discloses a pyrazolo[1, 5-a]pyridine compound with the structure characteristic shown in the formula (I) or its pharmaceutically acceptable salt, stereoisomer or prodrug molecule and a use thereof. The compound has good in-vitro anti-tubercle bacillus activity, has the minimal inhibitory concentration (MIC) less than 0.1 micrograms per milliliter and partial MIC of 0.01 micrograms per milliliter and has strong inhibition effects on a clinically sorted multi-drug-resistant tuberculosis (MDR-TB) strain. In an in-vivo experiment, at a dosage of 20mg/kg/d, the pyrazolo[1, 5-a]pyridine compound can effectively eliminate H37Ra infection in a mouse and is a novel anti-tuberculosis compound.

The invention relates to a class of long-acting glucagon-like peptide-1 (GLP-1) analog and a synthesis method thereof. The GLP-1 analogue with longer pharmacological action time is obtained by modifying GLP-1. The synthesis of target polypeptide is quickly achieved by a orthogonal protection strategy solid phase synthesis method. The crude product is purified and lyophilized to obtain the GLP-1 analog.

Disclosed are applications of Bouchardatine and Bouchardatine derivative in preparation of an anti-obesity and fatty liver-relieving drug. The structural fomulas of the Bouchardatine and the Bouchardatine derivative are shown in a pattern (I), to be specific, R is -(CH<2>)<n>R<1>, R<1>is substituted phenyl, heterocyclic radical or substituted amidogen, and n is equal to 0, 1, 2 or 3. By the use of the Bouchardatine and the Bouchardatine derivative, differentiation of pre-adipocyte 3T3-L1 is restrained so as to reduce lipid accumulation in adipocyte 3T3-L1; lipid accumulation, caused by sodium oleate, in hepatoma carcinoma cells is reduced, zooblast triglyceride level is lowered, and anti-obesity and fatty liver-relieving effect is achieved.

The present invention discloses a piperazine (piperidine) cyclohexyl derivative and applications of the piperazine (piperidine) cyclohexyl derivative in treatment of neuropsychiatric diseases. According to the present invention, the pharmacological experiment results show that the piperazine (piperidine) cyclohexyl derivative provides high affinity with a dopamine D2 receptor, a dopamine D3 receptor, a serotonin 5-HT1A receptor and a serotonin 5-HT2A receptor, provides good D3/D2 receptor selectivity and good 5-HT1A/5-HT2A receptor selectivity, and provides low affinity with alpha receptor; the in vivo test results show that the preferred compound has characteristics of good anti-schizophrenia effect, good pharmacokinetic property, low side effect, low acute toxicity and high safety, and has the development value of being adopted as the novel efficient and low-toxic anti-neuropsychiatric disease; and the piperazine (piperidine) cyclohexyl derivative is a compound represented by the structural general formula (I), or a geometric isomer, an optical isomer, a salt, a hydrate or a solvate thereof. The formula (I) is defined in the specification.

The invention discloses a method for preparing codonopsis pilosula preserved fruit. The method comprises the procedures of immersing, air-curing, curing, stewing and baking. The immersing procedure can remove part of the astringent taste of codonopsis pilosula. During the curing, vinegar is added in honeydews to completely remove the astringent taste of the codonopsis pilosula. Technical indexes of the method are strictly controlled. The prepared codonopsis pilosula preserved fruit well keeps nutrient components, has good drug properties, and is appropriately hard, sweet and suitable for daily eating.

We offer a fibrinogen-lowering agent comprising a compound having an angiotensin II antagonistic activity, a prodrug thereof, or a salt thereof. Because of having an excellent effect of lowering fibrinogen, the above fibrinogen-lowering agent is useful as a prophylactic or therapeutic agent for various diseases caused by hyperfibrionogenemia, etc.

Disclosed are an antiviral compound and a use thereof in the preparation of a medicament for the treatment of virus infections. Specifically, the present invention relates an imidazole derivative for treating respiratory syncytial virus infection.

The invention discloses an amidophenyl-1,3,4-oxadiazole compound shown in the formula (I). The invention also discloses a preparation method of the amidophenyl-1,3,4-oxadiazole compound. The preparation method comprises that an amino-compound II and a substituted aliphatic acid III are condensed to form the amidophenyl-1,3,4-oxadiazole compound. The invention also discloses a use of the amidophenyl-1,3,4-oxadiazole compound I in preparation of a drug for treating type II diabetes. The amidophenyl-1,3,4-oxadiazole compound has a non-AMP structure type, can reduce side-effect risk, can obviously inhibit FBPase in a molecule level, can substantially inhibit glucose generation in a cell level, and has good cell viability and good druggability.

The invention discloses a biphenyl compound as well as a preparation method and medical application thereof, the structure of the biphenyl compound is shown as a formula (I) or a formula (II), and thebiphenyl compound or pharmaceutically acceptable salt, tautomer, meso-isomer, raceme, stereoisomer, metabolite, metabolite precursor, prodrug or solvate thereof is a PD-L1 inhibitor. The compound hasa remarkable inhibiting effect on the interaction of PD-1 and PD-L1 protein, so that the compound can be applied to the preparation of PD-L1 inhibitors and immunomodulator drugs for preventing or treating tumors, autoimmune diseases, organ transplant rejection, infectious diseases and inflammatory diseases.

The invention provides an indocyanine green albumin conjugate preparation and a preparation method thereof. An injection mainly contains indocyanine green, albumin and a surfactant. The preparation prepared by the method has tumor targeting, significantly improves drug efficacy and reduces toxicity, and has good biocompatibility, and good stability; and a preparation process is simple, and suitable for industrialized mass production, and has broad application prospects.