159results about How to "Improve water solubility" patented technology

The present invention discloses one kind of anticorrosive hydrophilic paint, which consists of prime paint A and surface paint B. The prime paint A consists of modified epoxy resin, modified acrylic resin, amino resin, butyl glycol ether, distilled water, etc; and the surface paint B consists of functional monomer in the structure of CH2=CR1-R2-CH2-CHR3-CH2SO3M, methacrylic acid, hydroxyl acrylate, initiator, distilled water, etc. The anticorrosive hydrophilic paint has high corrosion resistance, high hydrophilicity, high water tolerance, high solvent tolerance and other advantages. It may be painted to the surface of aluminum and aluminum alloy product, especially heat exchanger of air conditioner.

The disclosed preparation method for chitose / chitosan oligosaccharide with low molecular weight as 0.18-15mega and well water-solubility comprises: preparing water-soluble chitosan by acetylization; degrading the product with non-specific hydrolase while controlling the enzyme dosage and reaction time; adjusting the degraded product pH value to 8-9 with KOH or NaOH solution; depositing with ethanol, cleaning, and vacuum drying the final product with free amidogen that can promote wound healing, restrains tumor cell growth and improves human immunity. Compared with prior art, this invention is convenient to control for wide application.

The invention provides a method for preparing a macroporous reticulated polyvinyl alcohol spherical vector. The method comprises the following steps: firstly, polyvinyl alcohol, calcium carbonate, sodium alginate and water are mixed in a certain mass proportion, and stirring is performed for full dissolution of the polyvinyl alcohol and uniform mixture, and then white PVA sol is obtained; secondly, the sol obtained is added into saturated boric acid solution containing 3 percent of calcium chloride by a peristaltic pump, and PVA gel beads are formed, cleaned by water and then placed into diluted hydrochloric acid solution for dipping until no air bubble is generated; thirdly, a spherical vector is thrown into glutaral pentanedial water solution and adjusted into acidity so as to generate crosslinking reaction to form a more stable crosslinking structure; and fourthly, the spherical vector is dipped into water and cleaned into neutrality, and then the white macroporous reticulated PVA spherical vector with elasticity is obtained. The macroporous reticulated polyvinyl alcohol vector prepared by the method has stable macroporous reticulated structure and good hydrophilicity, physical and chemical stability and anti-biological degradability, is suitable for immobilized enzymes and microorganisms so as to form a plurality of bed-shaped bioreactors, and is used in the modern bioengineering field such as sewage treatment and so on.

The invention discloses a bacteriostatic hydrocolloid dressing and a preparation method thereof. The dressing comprises a polyurethane film, a hydrophilic colloid layer and a peeling layer which are adhered in turn. The preparation method comprises the following steps of: mixing a medical grade rubber substrate, gelatin, mineral oil, an antioxidant, sodium carboxymethyl cellulose, calcium alginate, a tackifier, O-carboxymethyl chitosan and dried nano-silver powder uniformly to obtain a blend; uniformly coating the obtained blend on the polyurethane film to form the hydrophilic colloid layer; covering the peeling layer on the hydrophilic colloid layer; and stamping to obtain the bacteriostatic hydrocolloid dressing. The bacteriostatic hydrocolloid dressing of the invention has high bacteriostasis, and simultaneously has the characteristics of high capacity of absorbing transudate, waterproofness, air permeability, firm adhesion, high compliance, capability of meeting diversified requirements on complicated wound, and simple and easily-implemented preparation method.

The invention provides a method for preparing a macroreticular polyvinyl alcohol foam carrier, which comprises the steps: polyvinyl alcohol, limestone and water are mixed and stirred to lead the polyvinyl alcohol to be fully and evenly dissolved; the mixture is added with dilute hydrochloric acid for acidification and is frothed to have foramen; by adopting the circulation of freezing-unfreezing, and refreezing-unfreezing again, macroreticular polyvinyl alcohol gel foam is formed; then, the polyvinyl alcohol gel foam is cut into pieces and is dipped into the dilute hydrochloric acid with the mass concentration of 0.5-1% until no bubble is generated; the polyvinyl alcohol is caused to form more stable cross-linked structure by chemical crosslinking reaction; after that, the polyvinyl alcohol is soaked in water to be washed to be neutrality, so that the white macroreticular polyvinyl alcohol foam carrier is obtained. The macroreticular polyvinyl alcohol foam carrier prepared by the invention has stable macroreticular structure, takes on good hydrophilicity, physical and chemical durability as well as biological degradability resistance, is applicable to immobilized enzyme and microorganism to form a bioreactor with multiple bed types, and can be used in the fields of modern biological engineering such as sewage disposal, etc.

The present invention is process of preparing water soluble epoxy resin curing agent. The preparation process includes the following steps: 1. ring-opening reaction of polyethylene glycol and bisphenol A type epoxy resin under the action of catalyst to produce modified epoxy resin with epoxy groups in two ends; 2. dropping the modified epoxy resin into polyethylene polyamine to produce end amino-epoxy addition compound; 3. dropping compound 501 into the addition compound to produce end capping product; and 4. dropping organic acid into the end capping product to form salt and adding certain amount of water to produce the water soluble epoxy resin curing agent. The synthesized curing agent has high water solubility, capacity of well controlling reaction with polybasic amine and high flexibility.

An ethoxylate ester quaternary ammonium salt has chemical structural formula as follows, wherein R is C6-C22 saturated or unsaturated straight-chain or branched-chain alkyl; X represents an alkylated anion; n is the number of hydroxyethyl in the ester quaternary ammonium salt, and is 0, 2 or 3; n+b=3; b is 1, 2 or 3; and m is the number of ethoxyl, and is 1-30. The method has advantages of high conversion rate and good selectivity. The product has high content of active matters.

The invention discloses a glucose-containing platinum complex for treating tumors and a preparation method thereof. The compound is represented by a formula (I). Tests prove that the complex disclosed by the invention and a medicine prepared from the complex have high water solubility and tumor target effect and can be used conveniently in clinic.

The invention discloses an acrylic acid composition coating, which consists of acrylic emulsion, a catalyst, a curing agent, an adhesion promoter, a wetting agent, a pH value regulator, an antifoaming agent, a diluent, an aid and deionized water. The acrylic acid composition coating is prepared by the following steps of: adding other solvents into the mixture of the deionized water and the acrylic emulsion in turn; fully stirring and regulating the pH value; and the like. The acrylic acid composition coating is applied to coating an aluminum foil of an aluminum fin of a heat exchanger of an air-conditioner and coating automobiles and other metal surfaces, has the advantages of excellent water-solubility resistance, punching oil resistance and solvent resistance, excellent forming property, heat resistance, and anti-bend performance, no odor and low cost, and does not turn white or fall off under long-term strongly acidic environment.

The invention discloses a method for preparing wrapped nanometer zero-valent iron with modified graphene oxide as a carrier. The method comprises the following steps that firstly, wrapped nanometer zero-valent iron is prepared; secondly, graphene oxide is modified; thirdly, the obtained modified graphene oxide is added to water, graphene oxide suspension liquid is obtained after ultrasonic dispersion is conducted for one to three hours, then the obtained wrapped nanometer zero-valent iron is added to the graphene oxide suspension liquid, filtering, washing and drying are conducted after stirring is conducted sufficiently, and then the wrapped nanometer zero-valent iron adsorbent with the modified graphene oxide as the carrier is obtained. According to the method, cheap and harmless tea polyphenol, agar and water soluble starch are taken as the surface modifier to prepare the wrapped nanometer zero-valent iron, and the target pollutant removal rate is increased; the surface of the graphene oxide is modified by means of covalent bonds, the maximum Cr6+ absorption capacity of the modified graphene oxide is 390 mg / g, and the absorption capacity is greatly improved by one to two times.

The invention relates to celastrol, a celastrol derivative, a method for preparing the celastrol derivative, biogenetic salt prepared from the celastrol derivative serving as a raw material, and application of the celastrol derivative to the preparation of an antitumor medicine. The celastrol derivative has a structure shown as a formula I, wherein R1 is H, C1-C6 straight-chain or branched-chain alkyl, benzyl and benzyl with a substituent group on a benzene ring; and R2 or R3 are independent C5-C6 cyclic hydroxyl, C1-C6 chain alkyl, phenyl and substituted phenyl respectively, or R2 and R3 are cyclized with N, and the cycle is hexahydric cyclic heterocycle containing N or O. The celastrol derivative has high antitumor activity, stability and water solubility. The celastrol derivative can be salified with one of medically acceptable inorganic acids (such as hydrochloric acid, sulfuric acid and phosphoric acid) or organic acids (citric acid, cinnamic acid, succinic acid and the like); and the salt has high water solubility.

An inclusion compound of cefuroxime axetil with high solubility, stability and activity contains cefuroxime axetil and the pharmacologically acceptable cyclodextrin chosen from alpha-cyclodextrin, beta-cyclodextrin, gamma-cyclodextrin and their derivatives. Its preparing process is also disclosed.

The invention discloses antibacterial nanofibers or master batches and a preparation method thereof, including components of an antibacterial polymer resin solution and the preparation method of the antibacterial nanofibers or master batches. The antibacterial nanofibers or master batches are characterized by being formed through electrostatic spinning, melt-blowing, fibrillation and two-component compound methods on antibacterial polymer resin solution. Photosensitive molecules in the antibacterial nanofibers or the antibacterial master batches are antibacterial, do not generate a dissolution phenomenon, and are high in efficiency, wide in spectrum and antibacterial; the high temperature resistance of an organic antibacterial agent material is effectively provided; and the application range of an antibacterial agent is further expanded.

The invention discloses a PEGylated scutellarin compound and a preparation method thereof. The PEGylated scutellarin compound is as the shown formula (IV) and the PEGylated scutellarin compound can be applied to preparing medicaments applied to treating cerebral thrombosis, cerebral infarction, cerebral apoplexy, sequelaes caused by cerebral apoplexy, coronary heart disease or angina. Compared with the original scutellarin compound, the water solubility of the scutellarin compound is increased obviously; simultaneously, pharmacodynamics experiment on the mice model of cerebral ischemia-reperfusion shows that: compared with the original medicament, the biological activity of the scutellarin promedicament is strengthened obviously.

The invention discloses a production process of extraction soybean peptide and isoflavone from bean sprout, comprising refining, filtering, acid precipitation, centrifugal separation for protein solution, purified water call back, decolor, desalination, call back, enzymatic hydrolysis, ion exchange, drying concentration to get soybean peptide; desalination, resin adsorption, alcohol washing, dealcoholization, drying concentration to centrifugal separated whey solution to get soybean isoflavone. The invention adopts bean sprout as raw material and percolation technique by ultrafiltration membrane, which can not only save energy and recycle waste water, but also can realize cleaner production with discharge of waste water reduced.

The invention discloses a preparation method of a colloidal solution of nano-ZnO. The method comprises the following steps: mixing an aqueous modified cellulose solution having a concentration of 0.001-100g / L with a zinc salt solution having a concentration of 0.01-100g / L according to a volume ration of 1:10-100:1, wherein the modified cellulose is dialdehyde hydehydroxypropyl methyl cellulose obtained through the selective oxidation of the secondary hydroxyl groups in the C2 and C3 positions of hydroxypropyl methyl cellulose; and slowly adding an alkaline solution for adjusting the pH value to 8.5-11.5, and stirring at 20-90DEG C for 1-600min until reaction completion in order to obtain the colloidal solution of nano-ZnO having an average particle size of 1-100nm. The prepared nano-ZnO has the advantages of ultrahigh stability, antibiosis and ultraviolet resistance, good biocompatibility and good biodegradability, and can be applied to the coat field, the textile field, the medical health field and the like.

A composite medicine with high solubility, stability and activity and low hemolytic irritation contains cefteram ester and the pharmacologically acceptable dextrin chosen from beta-cyclodextrin and its derivatives. Its preparing process is also disclosed.

The invention discloses a cationic styrene acrylate emulsion as well as a preparation method and application thereof. The preparation method comprises the following steps: (a) mixing (methallyl) acrylate, (methallyl) styrene and (methallyl) acrylic acid to obtain a mixed monomer a; (b) mixing emulsifier, initiator and water to obtain an aqueous solution b; (c) mixing a cationic monomer and water to obtain an aqueous solution c; (d) adding the mixed monomer a into the emulsifier, the initiator and the water to mix to obtain a mixed monomer solution d; and (e) adding the mixed monomer a into the emulsifier, the initiator and the water to react, dropwise adding the solution d, the emulsifier, the aqueous solution b and the aqueous solution c to react, and neutralizing by using an alkaline solution to obtain a product; the cationic monomer is selected from p-vinyl-benzyl-trimethyl ammonium chloride or p-methyl-benzyl-trimethyl ammonium chloride. The adsorption and the retention of emulsion on the surface fiber of paper are improved, the surface strength of the paper is remarkably enhanced, and the Cobb value of an ash bottom whiteboard is remarkably reduced.

The invention belongs to a carbon material anti-oxidation coating technique, and relates to a preparation method for a carbon material anti-oxidation coating. The coating mainly comprises 30 to 50 percent of SiC, 1 to 10 percent of Al(OH)3, 15 to 35 percent of SiO2 and 5 to 40 percent of kaolin, and is prepared by the following steps: dissolving Al(OH)3 in H3PO4 in a proportion of 5 to 15 ml / g; adding water into the mixture to dilute the mixture and then mixing the diluted mixture with the other components by stirring; brushing the obtained coating material on a surface of the carbon material; curing the coating in a baking box at a low temperature for use. When a mark needs to be displayed on the surface of the carbon material, 10 to 40 percent of TiO2 powder is added into the coating. By using the method, the anti-oxidation coating of compact structure and high anti-oxidation performance can be formed through only one brushing process and one curing process in the baking box at a low temperature; and the anti-oxidation coating is oxidized for 15 hours in static air of 700 DEG C with weight-loss ratio no more than 1 percent; therefore, the method is particularly suitable for rapid anti-oxidation processing in the actual production of the carbon material.

The invention discloses a water-soluble acrylic resin which comprises functional monomers, (methyl)acrylic acid, (methyl)hydroxyalkyl acrylate, acrylamide, an initiator, a reducer and water. The waterborne resin can not become yellow, has the advantages of high outdoor weather resistance, favorable dispersity for pigment, low cost, favorable water solution resistance, favorable punching oil resistance, favorable solvent resistance, high formability, favorable heat resistance, favorable bending resistance, no odor and simple production technique, and is in the leading position in China. The water-soluble acrylic resin can be widely used for surface coating of aluminum and aluminum alloy products, and especially for coating surfaces of heat exchanger fins of air conditioners.

The invention discloses a liquidambaric acid or ursolic acid nano-granule, a preparation method and an application thereof. The liquidambaric acid or ursolic acid nano-granule is prepared by the following steps: taking the liquidambaric acid or ursolic acid as a core material, taking one or two mixtures of the gelatin, B-cyclodextrin, rubusoside, soluble starch, stevioside and thea saponin as a wall material, wherein the mass ratio of the core material to the wall material is 1:(5-100). The preparation method is an ultrasonic high-speed refiner method or a high energy ball milling method. By adopting the liquidambaric acid or ursolic acid nano-granule, the cell permeability can be improved and the growths of the human colon carcinoma cell HT-29, the human prostate cancer cell DU145 or the human breast cancer cell MDA-MB-231 can be inhibited.

The invention discloses a polyacrylonitrile modified starch nano-fiber and a preparation method thereof. The method comprises the following steps: preparing a starch grafted acrylonitrile polymer; dissolving the polymer into an organic solvent to prepare an electrostatic spinning liquid; and preparing the polyacrylonitrile modified starch nano-fiber by adopting an electrostatic spinning process, wherein (1) gelatinizing starch in an aqueous solution under N2 protection, and initiating the acrylonitrile to perform free radical polymerization with ceric ammonium nitrate under an acid condition to obtain a starch grafted acrylonitrile; (2) preparing electrostatic spinning liquid from the substance obtained in the step (1) for electrostatic spinning; and (3) preparing the polyacrylonitrile modified starch nano-fiber by adopting an electrostatic spinning process under a condition that the spinning environment temperature is 30-60 DEG C. The polyacrylonitrile modified starch nano-fiber preapred by adopting the method has a diameter of 80-600nm, and has relatively uniform diameter, does not have beading or fracturing; and the hydrophobic property, spinning property and film forming property of the material can be reinforced.

The invention relates to the technical field of wood plastic composite materials and particularly relates to a halogen-free flame-retardant PBT / PP (polybutylece terephthalate / propylene)-based wood plastic composite material and a preparation method thereof. The wood plastic composite material is prepared from the following raw materials in parts by weight: 20-30 parts of polybutylene terephthalate, 10-20 parts of propylene, 28-35 parts of melamino-formaldehyde modified plant fibers, 18-23 parts of coated ammonium polyphosphate, 1-3 parts of a 4A molecular sieve, 4-8 parts of maleic anhydride grafted polyolefin, 2-3 parts of a lubricant, 0.2-0.5 part of an antioxidant and 0.2-0.5 part of a light stabilizer. The wood plastic composite material provided by the invention is high in mechanical strength, and vertical combustion of a sample bar which is 1.6mm thick passes UL-94V-0 grade, the tensile strength reaches 36.3MPa, the bending strength reaches 48.8MPa, the thermal deformation temperature is 144.8 DEG C, and the long-term using temperature reaches up to 120 DEG C.

The invention discloses an astragaloside water-soluble derivative, namely astragaloside acid or medicinal salt, ester and amide of the astragaloside acid, with the structure shown in the formula 1. According to the defects that water solubility of astragaloside is poor, so that bioavailability of astragaloside is affected, and astragaloside cannot be developed into a single-component medicine, special alcoholic hydroxyl groups in astragaloside molecules are directionally oxidized into carboxyl groups ingeniously, and the astragaloside water-soluble derivative, namely astragaloside acid is prepared. A preparation method is simple in step, mild in reaction condition, small in side reaction, high in yield, easy to implement and suitable for large-scale production. The astragaloside water-soluble derivative, namely astragaloside acid or medicinal salt, ester and amide of the astragaloside acid, with the structure shown in the formula 1 has a protective function on hypoxia injuries of cardiac muscle cells cultured in vitro, and can be used for preventing and / or treating relevant cardiovascular diseases. The formula 1 is defined in the description.

The invention discloses a method for symbiotic rotational culture of rice, crayfishes, ducks and crabs, and relates to the field of agricultural ecological cultivation. The method comprises the following steps: in the middle ten days of January, digging cultivation ditches around a rice field, planting waterweed and typha angustifolia, arranging an anti-escape net around the rice field, placing juvenile crayfishes into the rice field in the first ten days of April, artificially cultivating rice seedlings in a greenhouse in the middle ten days of May, transplanting the seedlings into the rice field, irrigating water into the rice field, adding a nutrient into the water, placing juvenile crabs into the cultivation ditches and the rice field in the middle ten days of July, feeding ducks in abreeding shed in the last ten days of August, arranging fences on the periphery of a rice stubble field in the first ten days of November, and breeding the ducks in the rice field. The ducks, the crayfishes and the crabs are cultured alternately, the utilization rate of the rice field is increased, furthermore, mutual swallowing of the cultured products can be prevented, the rice and the culturedproducts mutually provide nutrients for each other, effective circulation of an ecological system is realized, resources are reasonably utilized, and the culture cost is saved.

The invention relates to a preparation method of a water-soluble natural bacteriostatic agent, and belongs to the application field of natural product active ingredients. Particularly, the invention relates to a preparation method of a water-soluble cyclodextrin using a derivative of hexahydro beta-acid of beta-acid in lupulus. According to the method, nine kinds of different cyclodextrin including hexahydro beta-acid, alpha-cyclodextrin, beta-cyclodextrin, gamma-cyclodextrin and derivatives thereof and the like are used for inclusion; the cyclodextrin inclusion compound capable of improving the water solubility of the hexahydro beta-acid is obtained; according to requirements, the compound can be used in food proportioning, beverage proportioning, cosmetics, washing and caring articles and feed products for improving the anti-corrosion performance and the health care effect of the products.

A method for reducing the transmittance of ultraviolet radiation through an intraocular lens to 10% or less at 370 nm by (a) polymerizing a mixture comprising: at least one first monomer and a second monomer comprising a trisaryl-1,3,5-triazine moiety, (b) forming an optic portion from the copolymer wherein the second monomer is present in about 0.10 to about 0.20 percent by weight of the overall polymer and wherein the optic portion of the intraocular lens displays essentially the same physical properties such as, for example, refractive index as the optic portion of the intraocular lens formed from the polymerized mixture of (a) without the second monomer, but otherwise identical conditions. Additionally, a method for preventing the transmittance of at least 90% of ultraviolet radiation at 370 nm through a foldable intraocular lens comprising: (a) incorporating a monomer comprising a 4-(4,6-diphenyl-1,3,5-triazin-2-yl)-3-hydroxyphenoxy moiety into at least one polymer and (b) forming the polymer into a material suitable for use as an intraocular lens, wherein the monomer comprising a 4-(4,6-diphenyl-1,3,5-triazin-2-yl)-3-hydroxyphenoxy moiety comprises 0.10 to 0.15 weight percent of the overall dry polymer.

The invention discloses a biodegradable redox sensitive polymer and a preparation method and application thereof. The biodegradable redox sensitive polymer adopts a core-shell structure, the hydrophilic end,namely an outer shell, is hyaluronic acid, and the hydrophobic end, namely an inner core, is vitamin E succinate. Thehyaluronic acid and the vitamin E succinate are connected by using a disulfide bond as a connecting bridge to prepare the polymer having a redox response property, and the polymer can form nanomicelles spontaneously in water through hydrophilic and hydrophobicacting forces and has the advantages of good biodegradability, small toxic and side effects, good responsiveness and the like; the polymer forms the nanomicelles in water through the hyaluronic acid and the natural vitamin E succinate existing in a human body, so that loading of a variety of medicines can be achieved; and the polymer has a good application prospect in the field of medicine science.

The invention belongs to the technical field of medicines and particularly relates to vortioxetine p-hydroxy benzoate comprising an anhydrous crystal form and a hydrate crystal form of vortioxetine p-hydroxy benzoate as well as a preparation method and application of vortioxetine p-hydroxy benzoate. The preparation method comprises the following steps of reacting vortioxetine and p-hydroxy benzoic acid in an organic solvent or a mixed solvent system of an organic solvent and water to produce salt, carrying out heat preservation or cooling and crystallizing to obtain vortioxetine p-hydroxy benzoate. The solubility, stability, flowability, compressibility and the like of prepared vortioxetine p-hydroxy benzoate are greatly improved compared with those of vortioxetine, which is conductive to preparing pharmaceutical preparations and improving the quality.