90 results about "Neuropsychiatric disease" patented technology

The invention provides a cyclohexane derivative or stereoisomer or salt and preparation and application thereof. The structure of the cyclohexane derivative is as shown in the formula IB. it shows through pharmacological testing results that the cyclohexane derivative has strong affinity to D3 receptor and 5-hydroxytryptamine but has weak affinity to D2 receptor, shows high selectivity to D3 / D2 receptors and achieves unexpected effects. The cyclohexane derivative is a novel therapeutic for treating neuropsychiatric diseases and has good clinical application prospect and social benefit. The preparation method is simple and feasible, is suitable for industrial production and has great application value.

Compounds of general formula (I): R1-Wn-Xm-AA1-AA2-AA3-AA4-AA5-AA6-AA7-AA8-AA9-Yp-Zq-R2 (I) their stereoisomers, mixtures thereof and / or their cosmetically or pharmaceutically acceptable salts, preparation processes, cosmetic or pharmaceutical compositions which contain them and their use in medicine, particularly in the treatment and / or prevention of pain, inflammation, itching, neurological, compulsive and / or neuropsychiatric diseases and / or disorders and in processes of treatment and / or care of the skin, hair and / or mucous membranes mediated by neuronal exocytosis.

Provided are a fluorine-containing amino acid prodrug represented by general formula (I) that makes a fluorine-containing amino acid which is a group 2 metabotropic glutamate receptor agonist into a prodrug, or a pharmaceutically acceptable salt thereof. More specifically, provided is a prodrug that increases the in vivo exposure and enhances the oral absorbability and other mucosal absorbability of a parent compound that acts on group 2 metabotropic glutamate receptors as an agent for the treatment or prevention of diseases in which group 2 metabotropic glutamate receptors are said to be involved, such as: schizophrenia, anxiety disorder and its related diseases, depression, bipolar disorder, epilepsy, developmental disorders, sleep disorders, and other neuropsychiatric diseases; and drug dependence, cognitive disorders, Alzheimer's disease, Huntington's chorea, Parkinson's disease, movement disorders associated with muscular rigidity, cerebral ischemia, cerebral insufficiency, spinal cord disorders, cephalopathy, and other neurological diseases.