66results about How to "Improve memory impairment" patented technology

The present invention provides compositions and methods for ameliorating neurological, attention, or memory disorders and improving learning and cognition through the delivery of insulin A-chain and analogs thereof to a subject. Insulin A-chain, peptides comprising the 21 amino acid sequence GIVEQ CCASV CSLYQ LENYC N (SEQ ID NO:1), and functional analogs thereof are disclosed to modulate neurological activity when administered to a subject. The methods of the invention can be used to prevent or treat neurological disorders as well as improve memory retention and acquisition. The invention includes pharmaceutical compositions comprising a therapeutically or prophylactically effective amount of insulin A-chain peptide or a functional analogs thereof.

The present invention relates to kind one ginsenoside Rg2 preparing process suitable for industrial production, and gradient salt separation process with simple operation is used in substituting traditional silicon gel chromatography process. The present invention also relates to medicine composition with ginsenoside Rg2 as active component and its application in medicine for preventing and treating dementia, depression, peripheral circulation disturbance and related diseases.

The invention discloses a small molecular polypeptide TAT-siP-PTPN1-HA and application thereof in preparation of a medicament for treating or preventing senile dementia. An artificially synthesized TAT protein transduction structural domain and an siP-PTPN1-HA fusion protein polypeptide TAT-siP-PTPN1-HA are used, TAT can carry the siP-PTPN1-HA protein polypeptide to pass through a blood-brain carrier via blood to be absorbed by neurons, and by applying the small molecular polypeptide TAT-siP-PTPN1-HA to an in-vivo senile dementia model, the biological action of blocking the binding of miR-124 and protein tyrosine phosphatase, non-receptor type 1, PTPN1 3'-non-coding sequence (3'-untranslated region, 3'-UTR) can be effectively realized, the expression of PTPN1 is further effectively reversed, excessive phosphorylation of microtube-associated protein tau and amyloid protein deposition, as well as animal learning and memory disorders represented by an senile dementia model animal are improved, and a new direction is provided for further development of the medicaments for clinical treatment of senile dementia.

The invention relates to a traditional Chinese medicine for treating schizophrenia and treating the side effect caused by antipsychotics and a preparation method thereof. The traditional Chinese medicine comprises the following raw medicines according to the proportion by weight: 10-17 ophiopogon roots, 7-14 medlar, 3-10 earthworms, 10-18 kudzu roots, 3-10 arillus longan, 7-14 lycopodium calvatum, 4-11 lotus leaf, 7-14 flos albiziae, 3-10 chrysoidine, 4-11 dates, 4-14 grass-leaved sweetflag, 4-11 radix curcumae and 7-14 liquorice. The dosage form comprises granules, sirup, tablets, capsules and oral liquid. The preparation method is as follows: adding water to boil to obtain liquid medicine, concentrating, filtering, adding antiseptic, subpackaging and sterilizing to obtain the oral liquid. The traditional Chinese medicine has the functions of nourishing Yin and clearing away the heart fire, tonifying the kidney and the brain as well as promoting blood circulation and removing obstruction in channels and the advantages of low cost, remarkable curative effect and no side effect, thereby achieving the aims of mainly treating muffing, fremitus, lags in response, witless expression, retardation of thinking, achexia, fidgety and confusion, talk nonsense, uncommunication, hygrostomia and indifference of patients suffering from schizophrenia, improving the memory impairment, promoting the recovery of psychopathy and preventing or reducing the recrudescency of psychopathy.

The invention relates to an application of levetiracetam injection in preparation of nootropic drugs. At present, levetiracetam is an antiepileptic drug with a very good curative effect, and researches find that the drug has a better curative effect in the nootropic aspect. The invention aims to further explore the application of the levetiracetam injection in the nootropic aspect, which has the advantages of quick drug effect, strong practicability and storability, compared with oral preparations.

The invention relates to a medicinal composition, in particular to a composition comprising 4-hydroxyl-2-oxo-1-pyrrolidine acetamine and 2-borneol, and application of the composition in medicines for preventing and/or treating cognition impairment. The composition provided by the invention can remarkably improve a cerebral trauma neural function of a rat and can remarkably prolong the time of passive activities. The composition provided by the invention plays a role in improving dysmnesia of the rat, caused by scopolamine, and can remarkably improve cognitive disorder of the rat, caused by cerebral ischemia. The composition has a remarkable effect in preventing and/or treating cognition impairment.

The invention relates to the field of biochemical engineering, in particular to a traditional Chinese medicine composition with a blood sugar reduction effect, and a preparation method and application of the traditional Chinese medicine composition. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 2-6 parts of ginseng, 2-6 parts of astragalus mongholicus, 1-5 parts of Chinese wolfberries, 2-6 parts of mulberry leaves, 2-8 parts of guava leaves and 1-5 parts of Chinese yam. The traditional Chinese medicine composition with the bloodsugar reduction effect adopts various kinds of medicinal and edible food, can be eaten for a long term and prevent and assist in treatment of hyperglycemia, has a small side effect and a better treatment effect, takes effect quickly and has a very good prevention or treatment effect on diabetes mellitus and complications of the diabetes mellitus.

The invention provides a lactobacillus paracasei Jlus66 microbial inoculum with a function of improving memory disorder and application, and belongs to the technical field of functional microorganisms. Experiments show that the dietary supplement lactobacillus paracasei strain Jlus66 can improve brain hippocampal neuron injury caused by long-term high-fat diet, increase neurotrophic factor BDNF expression and inhibit learning and memory ability weakening, and has the function of improving memory disorder. Therefore, the lactobacillus paracasei strain Jlus66 has the potential of developing the product for improving the memory disorder function, can be used as an auxiliary product of the existing treatment medicine and treatment method, and has great application value.

The invention discloses a synthesis method for preparing a huperzine A intermediate, which comprises the following steps: carrying out substitution at the alpha site of the carbonylic group by using 1,4-cyclohexyl diketone ethylene glycol and N,N-dimethylformamide dimethyl acetal as raw materials to obtain a substitution product, cyclizing the substitution product under the action of methyl cyanoacetate to obtain a cyclization product, and decarboxylating the cyclization product under the action of a strong base to obtain 2-carbonyl-6-ethylene ketal-5,7,8-dihydro-quinoline. The method has the advantages of fewer synthesis reaction steps, mild reaction conditions, low requirements for operating personnel and low environmental pollution, greatly lowers the raw material cost, and is simple to operate and convenient for refinement; and the obtained 2-carbonyl-6-ethylene ketal-5,7,8-dihydro-quinoline has high quality and high yield.

The invention provides an acylated derivative for an ornithine and aspartate dipeptide compound or an officinal salt thereof, a preparation method thereof, a medicine composition containing the derivative or the officinal salt thereof, and the application of the derivative or the officinal salt thereof for preparing medicines for preventing or curing hyperammonemia or liver diseases, particularlyhepatic encephalopathy. Experimental results definitely indicate that the concentration of blood ammonia can be obviously reduced after administration for the acylated derivative for the ornithine andaspartate dipeptide compound, the acylated derivative takes effect quickly by preferably compared with LOLA, subsequent dysmnesia after TAA-induced rat liver injury can be obviously improved, and theacylated derivative for the dipeptide has a certain treatment effect on hyperammonemia or liver diseases, particularly hepatic encephalopathy.

The invention relates to agaricus blazei murill polypeptide as well as a preparation method and an application thereof, and belongs to the technical field of natural active products. The preparation method comprises the following steps: extraction: taking an agaricus blazei murill fruiting body, adding water for homogenization, performing ultrasound extraction and centrifugation, and obtaining supernate, salting out: adding ammonium sulfate into the supernate for salting out and sediment, and taking a sediment for dialysis to form a dialysate, and purification: separating the dialysate throughan ion-exchange column to form a crude extract, and purifying the crude extract through a sephadex column to form the agaricus blazei murill polypeptide. The agaricus blazei murill polypeptide prepared according to the method has obvious bioactivity and can improve animal dysmnesia and learning capacity.

The invention relates to a composition for treating a degenerative disease. For solving the technical problems that an existing medicament can not reverse pathological changes of the degenerative disease and the treatment effect is not ideal, the adopted technical scheme is that the composition comprises royal jelly acid or a royal jelly acid derivative and ginkgo leaves in the ratio according to parts by weight of (0.1-10): (1-100). The composition has the technical effects that the royal jelly acid or the royal jelly acid derivative, gamma-aminobutyric acid or a gamma-aminobutyric acid derivative and the ginkgo leaves can play respective roles and simultaneously realize synergy, thereby significantly increasing the overall functions, effectively improving lipid metabolism caused by organism deterioration of old people, making up for defects of insufficient secretion of in-vivo synthesis, increasing brain blood supply, achieving the effects of effectively treating and delaying the progress of the degenerative disease, improving memory and cognitive dysfunction of a patient and greatly improving the quality of life of the patient with the degenerative disease (P<0.01).

The invention provides a pharmaceutical composition for the treatment of dementia and a preparation method thereof. The pharmaceutical composition comprises bilobalide and one or two or a combination of ginkgolide A and ginkgolide C. The pharmaceutical composition containing bilobalide provided by the invention has a neuroprotective effect in many aspects, including promoting nerve growth, improving the memory function of the elderly and preventing the occurrence of dementia, etc. Experiments show that the product has certain role to improve memory impairment in mice in the treatment of Alzheimer's disease.