Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Medicinal composition and application thereof

A composition and pharmaceutical technology, applied in the field of medicine, to achieve the effect of improving neurological function of traumatic brain injury, improving memory impairment, and prolonging the time

Active Publication Date: 2013-12-04
北京茗泽中和药物研究有限公司
View PDF1 Cites 5 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The People's Republic of China "Pharmacopoeia" 2010 edition included natural borneol (dextroborneol), moxa tablet (left-rotated borneol), borneol (synthetic borneol), but there is no prior art that can be changed to 2-borneol Description or research for the treatment and or prevention of cognitive impairment
[0018] And, also do not see the report that both are used simultaneously as active ingredient in the prior art

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Medicinal composition and application thereof
  • Medicinal composition and application thereof
  • Medicinal composition and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Example 1 Effects on Brain Dysfunction Caused by Traumatic Brain Injury in Mice

[0034] 1 Materials and methods:

[0035] 1.1 Experimental materials:

[0036] Animals ICR mice, SPF grade, half male and half female, weighing (20±2) g, were provided by Beijing Weitong Lihua Experimental Animal Technology Co., Ltd. There were 5 mice per cage, and the mice had free access to water and food before the experiment.

[0037] 1.2 Drugs

[0038] (+)-2-Bornyl alcohol, purity 99.5%, batch number: 20130201.

[0039] The purity of (-)-2-camphor, 99.2%, batch number: 20130501.

[0040] 2-Bornyl alcohol, purity 99.3%, batch number: 20130501.

[0041] 4-Hydroxy-2-oxo-1-pyrrolidineacetamide, purity 99.5%, batch number: 20130301.

[0042] (S)-4-Hydroxy-2-oxo-1-pyrrolidineacetamide, purity 99.3%, batch number: 20130501.

[0043] Nimodipine, provided by Tianjin Central Pharmaceutical Co., Ltd., 30mg / tablet, batch number: 20111206.

[0044] 1.3 Experimental method: Preparation of t...

Embodiment 2

[0062] Example 2 Protective effect on traumatic brain injury learning and memory impairment in rats

[0063] 2.1 Materials: healthy SPF grade male SD rats, 280±10g.

[0064] 2.2 Method:

[0065] Grouping and administration: Rats were randomly divided into 13 groups according to body weight, namely sham operation control group, brain injury model group, (±)-2-camphor group, (+)-2-camphor group, (-)-2 -Bornyl alcohol group, 4-hydroxy-2-oxo-1-pyrrolidineacetamide group, (S)-4-hydroxy-2-oxo-1-pyrrolidineacetamide group, 4-hydroxy-2-oxo Generation-1-pyrrolidineacetamide plus 2-camphor group, 4-hydroxy-2-oxo-1-pyrrolidineacetamide plus (+)-2-camphor group, 4-hydroxy-2-oxo- 1-pyrrolidineacetamide plus (-)-2-camphor group, (S)-4-hydroxy-2-oxo-1-pyrrolidineacetamide plus (±)-2-camphor group, (S) -4-Hydroxy-2-oxo-1-pyrrolidineacetamide plus (+)-2-camphor group, (S)-4-hydroxy-2-oxo-1-pyrrolidineacetamide plus (-) -2-Bornyl alcohol group.

[0066] Administration method: each admini...

Embodiment 3

[0075] Example 3 Effects on Learning Ability of Scopolamine-Induced Dementia Mice

[0076] 3.1 Materials:

[0077] drug:

[0078] Haberin (Huperzine A Tablets), Henan Tailong Pharmaceutical Co., Ltd. Yuzhong Pharmaceutical Factory, specifications: 50ug*24 tablets / box. Keep away from light, seal, and store in a cool and dry place. Production batch number: 100713.

[0079] Scopolamine Hydrobromide Injection: Shanghai Hefeng Pharmaceutical Co., Ltd., batch number: 1103121.

[0080] Healthy clean ICR mice, 5-6 weeks old, 18-22g, male and female, 144. Purchased from Beijing Weitong Lihua Experimental Animal Technology Co., Ltd., feeding conditions: light 12 hours / day, temperature 20-25°C, relative humidity 40-70%. Mice were housed in cages, 6 / cage.

[0081] Instrument: Chengdu Taimeng DT200 mouse platform jumping instrument

[0082] 3.2 Experimental method:

[0083] Dosage and grouping:

[0084] As shown in Table 6, the mice were randomly divided into 14 groups according...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
diameteraaaaaaaaaa
diameteraaaaaaaaaa
purityaaaaaaaaaa
Login to View More

Abstract

The invention relates to a medicinal composition, in particular to a composition comprising 4-hydroxyl-2-oxo-1-pyrrolidine acetamine and 2-borneol, and application of the composition in medicines for preventing and / or treating cognition impairment. The composition provided by the invention can remarkably improve a cerebral trauma neural function of a rat and can remarkably prolong the time of passive activities. The composition provided by the invention plays a role in improving dysmnesia of the rat, caused by scopolamine, and can remarkably improve cognitive disorder of the rat, caused by cerebral ischemia. The composition has a remarkable effect in preventing and / or treating cognition impairment.

Description

technical field [0001] The invention relates to a pharmaceutical composition, especially a pharmaceutical composition containing more than one active ingredient, and its application in medicine, belonging to the field of medicine. Background technique [0002] Nootropics, also known as cereboactivedrugs, are a new class of central nervous system drugs that can promote learning and enhance memory. Gluurgea defines nootropicdrug for the first time. Nootropic drugs require selective action on the cerebral cortex, and have the characteristics of selectively activating, protecting and promoting the recovery of damaged nerve cell functions. [0003] 4-Hydroxy-2-oxo-1-pyrrolidineacetamide, also known as oxiracetam, has a molecular formula of C6H10N2O3 and a molecular weight of 158.16. Its chemical structure is shown in formula (1): [0004] Formula 1), [0005] 4-Hydroxy-2-oxo-1-pyrrolidineacetamide is a new nootropic drug, a GABOB derivative nootropic drug, which can improve ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4015A61P25/28A61P25/00A61K31/045
Inventor 李鹏坤
Owner 北京茗泽中和药物研究有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com