The invention relates to polymethoxyflavonoids for treating skin papillomatosis. Active ingredients of polymethoxyflavonoids include 5,7,3',4'-tetramethoxyflavone, 5,7,3',4',5'-pentamethoxyflavone, 5,6,7,3',4',5'-hexamethoxyflavone and the like. The skin papillomatosis is formed by inducing an ICR mouse with dimethylbenzanthracene and triamine (2-picolyl), and then treated by 5mumol / L 5,7,3',4'-tetramethoxyflavone, 5mumol / L 5,7,3',4',5'-pentamethoxyflavone and 5mumol / L 5,6,7,3',4',5'-hexamethoxyflavone respectively compared with an induction group, so that the quantity of skin tumors of the mouse can be reduced by 24.2%, 42.5% and 54.2% respectively.