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Application of nicotinamide adenine dinucleotide to prepare drug for treating inflammatory pain

A technology of nicotinamide adenine and dinucleotide, which is applied in the direction of drug combination, non-central analgesics, antipyretics, etc., can solve the side effects that limit clinical application, and the ineffectiveness of non-steroidal anti-inflammatory drugs on inflammatory pain Obvious issues

Inactive Publication Date: 2017-10-10
TONGJI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the ineffective effect of non-steroidal anti-inflammatory drugs on inflammatory pain, many side effects limit their clinical application.

Method used

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  • Application of nicotinamide adenine dinucleotide to prepare drug for treating inflammatory pain
  • Application of nicotinamide adenine dinucleotide to prepare drug for treating inflammatory pain
  • Application of nicotinamide adenine dinucleotide to prepare drug for treating inflammatory pain

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Nicotinamide adenine dinucleotide has an analgesic effect on formalin-induced inflammatory pain. The following pharmacodynamic experiments further illustrate the role of nicotinamide adenine dinucleotide in formalin-induced inflammatory pain Has a therapeutic effect.

[0021] The experimental animals were 20g ICR mice, which were purchased from the Experimental Animal Center of Tongji University. Feeding conditions: standard feed, room temperature maintained at (24±2)°C, humidity 50-60%, daily light and dark time 12h each, before the experiment, The animals were placed in the experimental environment for 3 days to acclimatize.

[0022] Take 30 ICR mice (male, about 20g), and randomly divide them into five groups, 6 in each group, respectively: normal saline group (intrathecal injection, 10ul), morphine group (intrathecal injection, 350nmol / L, 10ul) , nicotinamide adenine dinucleotide group (Sigma-Aldrich company, the concentration is 8mmol / L, 80mm / L, 800mmol / L respecti...

Embodiment 2

[0024] Nicotinamide adenine dinucleotide has an analgesic effect on inflammatory pain in mice induced by complete Freund's adjuvant, which will be further explained through pharmacodynamic experiments below.

[0025] Take 18 ICR mice (male, about 20g), and divide them into two groups at random, namely the normal saline group (intrathecal injection, 10ul), the nicotinamide adenine dinucleotide group (80mmol / L, intrathecal injection, 10ul ). On the third day after injection of complete Freund's adjuvant into the soles of mice, physiological saline and nicotinamide adenine dinucleotide were administered intrathecally, and conventional von Frey fiber filaments were used to measure by up and down method, and the administration was determined respectively After 15min, 30min, 45min, 1h, 2h, 3h, 6h mechanical threshold, the results are as follows figure 2 As shown, compared with the normal saline group, the nicotinamide adenine dinucleotide group inhibited the inflammatory pain indu...

Embodiment 3

[0027] Nicotinamide adenine dinucleotide has an analgesic effect on inflammatory pain in mice induced by complete Freund's adjuvant, which will be further explained through pharmacodynamic experiments below.

[0028] Eighteen ICR mice (male, about 20 g) were taken and randomly divided into two groups. They were normal saline group (subcutaneous injection, 20ul) and nicotinamide adenine dinucleotide group (80mmol / L, subcutaneous injection, 20ul). On the third day after injection of complete Freund's adjuvant into the soles of the mice, physiological saline and 80 mmol / L nicotinamide adenine dinucleotide were subcutaneously administered to the soles of the mice, and measured by the up and down method using conventional vonFrey fiber filaments, respectively. Measuring the mechanical threshold at 15min, 30min, 45min, 1h, 2h, 3h, 6h after administration, the results are as follows image 3 As shown, compared with the saline group, the nicotinamide adenine dinucleotide group inhibi...

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Abstract

The invention relates to an application of nicotinamide adenine dinucleotide to prepare drug for treating inflammatory pain. The modern pharmacological experiment proves that after injecting nicotinamide adenine dinucleotide to an ICR mouse, the nicotinamide adenine dinucleotide has analgesic effect to the inflammatory pain induced by formalin or complete Freund's adjuvant; it indicates that the nicotinamide adenine dinucleotide can be applied to treat inflammatory pain.

Description

technical field [0001] The invention belongs to the application of nicotinamide adenine dinucleotide, in particular to the application of nicotinamide adenine dinucleotide in preparing medicine for treating inflammatory pain. Background technique [0002] Inflammatory pain is caused by inflammation caused by peripheral tissue damage caused by trauma, bacterial or viral infection, and surgery, and is mainly characterized by increased sensitivity of damaged tissue to thermal and mechanical stimuli. Inflammatory pain has a long course of disease and is difficult to cure. Patients suffer from great mental and physical pain, which seriously affects the quality of life of patients and brings a heavy economic burden to patients. Due to its diverse etiology and complex pathogenesis, resulting in a high incidence rate, it is difficult to cure and has become one of the most challenging problems in clinical medicine. At present, drug treatment is the most common and main means of cont...

Claims

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Application Information

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IPC IPC(8): A61K31/7084A61P29/00
Inventor 张玲陈艺洋殷卫海
Owner TONGJI UNIV
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