2432 results about "Anti inflammation" patented technology

This invention discloses new krill oil compositions characterized by having high amounts of phospholipids, astaxanthin esters and / or omega-3 contents. The krill oils are obtained from krill meal using supercritical fluid extraction in a two stage process. Stage 1 removes the neutral lipid by extracting with neat supercritical CO2 or CO2 plus approximately 5% of a co-solvent. Stage 2 extracts the actual krill oils by using supercritical CO2 in combination with approximately 20% ethanol. The krill oil materials obtained are compared with commercially available krill oil and found to be more bioeffective in a number of areas such as anti-inflammation, anti-oxidant effects, improving insulin resistances and improving blood lipid profile.

An internal dry powder delivery system through a working channel of an endoscopic cannula for directly applying the powder form medication to an internal tissue / organ site, includes an elongated tubular delivery channel and a powder supply device for producing pressurized gas mixing with the dry powder for feeding to form a mixture of dry powder and pressurized gas delivering to an internal tissue / organ site through the delivery channel via endoscopic cannula. It ensures a smooth powder release by preventing liquid from accumulation at the tip of the delivery channel and offers physicians a new powder form drug delivery method via endoscope. Also, it offers new minimal invasive application by directly and precisely applying the powder format drug to the internal sites of human gastrointestinal organ via endoscope to achieve hemostasis, anti-inflammation, anti-ulcer and anti-tumor treatment, etc.

Methods of mitigating acne include exposing an expanse of skin to light; terminating the exposure of the skin to the light; and applying a benefit agent to the expanse of skin after a delay following the termination. The light exposure may be for a period of less than about one hour, and the light may be suitable for either (a) exciting porphyrins associated with the expanse of skin into an energetic state suitable for destroying acne-causing micro-organisms, or (b) for heating lipids present in sebaceous glands within the expanse of skin in order to modulate the flow of sebum in said sebaceous glands, or (c) for reducing inflammation. The benefit agent is suitable for either (a) providing anti-microbial action that is complementary to either said modulating of said sebum by said band of light, or complementary to said reduction of inflammation by said light or (b) providing sebum-modulating action that is complementary to either said destruction of said acne-causing microorganisms or complementary to said reduction of inflammation by said light; or (c) providing anti-inflammation that is complementary to either said modulating of said sebum by said band of light, or complementary to said destruction of said acne-causing microorganisms. These treatments may be repeated, as necessary.

The invention discloses a nanocomposite of silver, chitosan and / or a chitosan derivative and a preparation method thereof. The preparation method comprises the steps of evenly mixing the chitosan and / or the chitosan derivative fine powder with silver nitrate fine powder and fully grinding for 1-3 hours with the weight proportion of the chitosan and / or the chitosan derivative to the silver nitrate of 100: 0.0005-0.5; adding a reducing agent with the reduction equivalence ratio of the reducing agent to the silver nitrate of 1: 1-2: 1 and fully grinding for 2-6 hours, thereby obtaining the nanocomposite of the silver, chitosan and / or the chitosan derivative with the silver particle size of 1-100nm. The nanocomposite has the effects of promoting wound healing, stopping bleeding, alleviating pain, anti-inflammation and sterilization, can be used for treating female vaginitis, cervicitis, cervical erosion, bedsores, skin ulcers, burns, scalds, trauma and other skin inflammation, tinea manus and pedis and the like, and can also be used for preparing a variety of trauma dressings, such as thin films, sponges, gynecological suppositories, patches and the like.

The present invention discloses a preparation method of an antiphlogistic and antisticking stanching sponge. The preparation method includes the following steps: through the cross linking of polyvinyl alcohol, chitosan gel microspheres are fixed on the inner wall of a sponge, the sponge is then soaked in antiphlogistic solution and antisticking solution, and finally, the PVA / drug-loaded chitosan antiphlogistic and antisticking stanching sponge is prepared. The antiphlogistic and antisticking stanching sponge prepared by the method can be trimmed according to the size of an operative cavity in order to be placed into the corresponding part, the pressure on the circumference is uniform, blood can be thoroughly stanched, and the injury on the mucous membrane of the operative cavity is little. The antiphlogistic and antisticking stanching sponge prepared by the method, which has good antiphlogistic, stanching and antisticking functions, biocompatibility, and mechanical and anti-oedema properties, can promote the injured tissues to have strong recovering capability, prevent rebleeding and avoid the inevitable potential virus hazard caused by glutin and animal collagen proteins, so the use safety is greatly improved, and moreover, the antiphlogistic and antisticking stanching sponge can alleviate the pain and discomfort suffered by patients. The antiphlogistic and antisticking stanching sponge is expected to substitute the import products and have remarkable social and economic benefits.

The present disclosure relates to drug eluting devices, and their uses. The drug eluting devices can allow for perfusion during deployment. The coatings the may contain bioactive materials which elute once deployed in a patient and can have anti-proliferative, anti-inflammation, or anti-thrombotic effects. Sol gel technology can be used to coat the devices.

The invention discloses an anti-inflammation active component group of a stomatitis clearing preparation and an analysis method. Fingerprint characteristic spectra of the component group are constructed and are applied to detecting the quality of the stomatitis clearing preparation. The analysis method which is a quality detecting method particularly includes detecting the quality of the stomatitis clearing preparation by the aid of a detection index which is anti-inflammation efficacy; uniformly designing difference samples with different component proportions; acquiring fingerprint characteristic data of the difference samples by the aid of UFLC-Q-TOF-MS / MS (ultrafast liquid chromatography-quadrupole-time of flight-mass spectrometry / mass spectrometry) technologies; acquiring anti-inflammation activity data of the preparation. The relevance between chemical components of the difference samples and the efficacy is comprehensively analyzed by the aid of the mathematical statistics method, accordingly, 29 anti-inflammation efficacy active components can be determined, and the fingerprint characteristic spectra of the component group can be constructed. Compared with the prior art, the anti-inflammation active component group and the analysis method have the advantages that the active component group is analyzed on the basis of the relevance between the spectra and the efficacy, accordingly, the quality of raw medicinal materials, semi-finished products and finished products can be directly, objectively, scientifically and comprehensively monitored in production procedures, and the effectiveness and the quality consistency of the products can be guaranteed.

An apparatus for ablating deposits along the blood vessel of human and animals is disclosed. The apparatus has an extracting and pressurizing unit for extracting blood from a supply vessel and pressurizing it plus a downstream delivering and injecting unit for delivering and injecting the filtered and pressurized source blood into a blood vessel under treatment. Besides inducing a blood circulation and having ablation devices like ultrasound and RF heating, the apparatus ablates the deposits from a nearby portion of the vessel. The characteristics of selective ablation and self-termination make the proposed apparatus safe and effective in treating early-stage atherosclerosis. A DC discharging device can be included to neutralize excess surface charge generation on the wounded healthy tissues following ablation for disinfection and anti-inflammation. Placement of the blood extracting point just downstream of the blood injecting point insures thorough collection and removal of blood-clogging plaque and calcification fragments.

The invention relates to a chitosan / polyvinyl alcohol (PVA) porous composite material. The material is prepared from the following raw materials in percentage by weight: 1-5% of chitosan, 10-30% of PVA, 1-5% of acetic acid, 5-10% of inorganic acid, 5-10% of cross-linking agent, 6-10% of foaming agent, 0.5-2% of antibacterial agent, 1-5% of softening agent and the like. The preparation method of the material comprises the following steps: stirring for fully dissolving the PVA; pouring the dissolved PVA into the dissolved chitosan, adding the inorganic acid, the cross-linking agent, the foaming agent, the softening agent and the antibacterial agent to the obtained mixed solution, heating the solution to 90-100 DEG C, and pouring the solution into a die for continuously reacting at the temperature of 60-100 DEG C for 6-15 hours; and finally cooling and washing the obtained product with distilled water. The obtained material has the characteristics of good biocompatibility, excellent antibacterial effect, strong liquid absorption capability, biodegradability, good adhesion to skin and the like, and has functions of rapid hemostasis, antibiosis, anti-inflammation and acceleration of wound healing, thus the material is suitable for serving as various wound dressings.

The invention discloses an antibacterial antivirus Chinese medicinal composition for the animal, comprising the following main medicament ingredients: scutellaria extract, honeysuckle extract, isatis root extract and glycyrrhiza extract. the pharmaceutical composition of the invention can be made into premix, injection, oral liquid or granula, also can be made into feedstuff premix adding into the feedstuff. the chinese medicinal composition of the invention is a pure Chinese medicinal compound preparation which has the antibacterial, anti-inflammation, antivirus and immunity-reinforced functionsand wide application range, can effectively prevent and treat various livestock and poultry diseases caused by the virus and the bacteria, such as piggyyellow-white dysentery, swine plague, infectious pleuropneumonia, asthma, canker, circovirus, swine influenza, white diarrhea, newcastle disease, bursa of Fabricius, egg drop syndrome, duck serositis and the like, and has fast effect and remarkable curative effect.

The invention relates to an aroniamelanocarpa fruit wine and a brewing method thereof. The fruit of aroniamelanocarpa is taken as raw material and is made into fruit juice, fruit wine microzyme is selected for use and put into the fruit juice according to the proportion being 5-10% of the weight of the fruit juice, and the aroniamelanocarpa fruit wine is brewed with the alcohol content of 5-13% (v / v) and the total sugar content of 4.0-80.0g / L. The brewing technique of the invention comprises preparing the fruit juice, inoculation and fermentation, aging and store maturity, purifying wine body as well as filtration and sterilization, and the most advanced fermenting and purifying technique can be adopted by the production. The product of the invention has unique flavor, slightly acerbic and fresh taste, mellow mouthfeel, pleasing aroma and wide applicable people. The fruit wine contains multiple nutritional functional components such as anthocyanin, flavone, polyphenol active substance, vitamins antioxidant, mineral composition, polyoses, organic acid and the like which are rich in the fruit of aroniamelanocarpa, and has good effects of oxidation resistance, ageing prevention, blood pressure regulation, vessel relaxing, blood-fat reduction, anti-inflammation and detoxification, radiation resistance, etc.

The present invention is concerned with an anti-inflammation analgesic preparation which contains a specific 3-0-substituted ascorbic acid as an active ingredient, shows excellent anti-inflammation analgesic effects and is excellent in shelf life, safety to a skin and endermic absorptivity of the active ingredient.

The present invention discloses a drug 'Jinling Xiaoyan Oral Liquor' made up by using 23 Chinese medicinal materials of toosendan fruit, corydalis tuber, codonopsis root, atractylodes root, white poria and others. It can be used for effectively curing acute and chronic gastritis, peptic ulcer, acute and chronic hepatitis, chelecystitis and pancreatis, etc. and its therapeutic effect is reliable.

Present invention features a novel use of Lactobacillus for treating type 2 diabetes, wherein the Lactobacillus is Lactobacillus reuteri GMNL-89 with the deposition numbers of BCRC 910340 and CCTCC M 207154 and comprises of live, dead bacteria or supernatant of the bacterial culture(s) and a pharmaceutically acceptable vehicle. The invention also discloses the efficacies of the indicated Lactobacillus strain including anti-oxidative enzyme activity, anti-inflammation, reduction of blood glucose level, reduction of triglycerides, reduction of total cholesterol, reduction of LDL, increase of HDL and improve insulin utilization.

The invention discloses a hydrogen therapeutic apparatus which comprises a water-electrolysis hydrogen generator, an air chamber, an air blower I, an air blower II, an air storage chamber, a mixing chamber, a flow sensor and a hydrogen concentration monitor, wherein a hydrogen collecting conduit of the water-electrolysis hydrogen generator is communicated with the air chamber; the air chamber is communicated with an air inlet of the air blower I; an air outlet of the air blower I is communicated with the mixing chamber; an air outlet of the air blower II is communicated with the air storage chamber; an air outlet of the air storage chamber is communicated with the mixing chamber; the mixing chamber is provided with a conveyer pipe; the flow sensor is arranged on a pipeline connecting the air storage chamber and the mixing chamber; and the hydrogen concentration monitor is arranged on the conveyer pipe. Through the invention, the hydrogen generated by the water-electrolysis hydrogen generator is blown into the mixing chamber, and air is blown into the air storage chamber and then conveyed into the mixing chamber; the hydrogen / oxygen mixed gas is introduced into a conduit at a patient end and used for treating the patient; and the hydrogen therapeutic apparatus takes full advantage of the antioxidant, anti-inflammation and anti-necrosis effects of hydrogen and can be used for treating and preventing multiple diseases.

The present invention belongs to the field of medicine, and particularly relates to a novel curcumin pharmaceutical preparation, which comprises a solid dispersion, a micellar preparation, SMEDDS and a nanometer emulsion. According to the present invention, by increasing the solubility and the bioavailability of curcumin, the curcumin pharmaceutical preparation can effectively utilize the pharmacological effects of anti-oxidation, anti-inflammation, anti-cancer, apoptosis induction, antiangiogenesis, neuroprotection, anti-microorganism, liver and kidney protection, vascular formation inhibition, myocardial infarction prevention, blood glucose lowering, anti-rheumatism and the like of the curcumin.

The invention discloses a hygienic disinfectant wet tissue and a preparation method thereof, and belongs to the technical field of wet tissues. The hygienic disinfectant wet tissue is prepared through the following steps: preparing a wetting solution by utilizing the following components in percentage by weight: 0.1-10% of wood seed extract, 0-5% of humectant, 0-5% of antibacterial agent, 0-5% of decontaminant, 0-5% of emollient, and the balance of purified water; and soaking non-woven fabric cloth or cotton cloth into the wetting solution, or spraying the wetting solution on the non-woven fabric cloth or cotton cloth so as to obtain the hygienic disinfectant wet tissue. According to the invention, because the wood seed extract contains the skin protection ingredient tannin, the extract acts as the ingredient of the wetting solution, has natural, non-toxic, environmentally-friendly performance characteristics and the like, is a favorable disinfectant appliance, and is especially suitable for rabo vermelho of babies; and the humectant, the antibacterial agent, the decontaminant, the emollient and the like are added into the wetting solution, and can generate effects rapidly for skin problems of dermatitis, eczema, bedsore, rabo vermelho of babies and the like, and the hygienic disinfectant wet tissue and the preparation method thereof also have the obvious effects of decontamination, anti-inflammation and pain relieving, bacteriostasis and itching prevention, and skin protection.

An apparatus for ablating deposits along the blood vessel of human and animals is disclosed. The apparatus has an extracting and pressurizing unit for extracting blood from a supply vessel and pressurizing it plus a downstream delivering and injecting unit for delivering and injecting the filtered and pressurized source blood into a blood vessel under treatment. Besides inducing a blood circulation and having ablation devices like ultrasound and RF heating, the apparatus ablates the deposits from a nearby portion of the vessel. The characteristics of selective ablation and self-termination make the proposed apparatus safe and effective in treating early-stage atherosclerosis. A DC discharging device can be included to neutralize excess surface charge generation on the wounded healthy tissues following ablation for disinfection and anti-inflammation. Placement of the blood extracting point just downstream of the blood injecting point insures thorough collection and removal of blood-clogging plaque and calcification fragments.

The present invention provides to an isoxazoline derivative of formula (I), the pharmaceutically acceptable salts, esters and stereochemically isomeric forms thereof, and the use of the derivative in inhibiting the activity of caspases. The present invention also provides a pharmaceutical composition for preventing inflammation and apoptosis which comprise the isoxazoline derivative, pharmaceutically acceptable salts, esters and stereochemically isomeric forms thereof and the process for preparing the same. The derivative according to the present invention can be effectively used in treating diseases due to caspases, such as, for example the disease in which cells are abnormally died, dementia, cerebral stroke, AIDS, diabetes, gastric ulcer, hepatic injury by hepatitis, sepsis, organ transplantation rejection reaction and anti-inflammation.

The invention discloses a cosmetic composition with an acne treatment function and a preparation method thereof.The cosmetic composition comprises, by weight, (a) 2-20% of humectants, (b) 0.05-5% of thickener, (c) 2-15% of emollient, 0.02-3% of emulsifier, (e) 0.5-5% of anti-inflammatory agent, (f) 2-20% of skin conditioner, (g) 0.01-0.1% of essential oil and (h) 30-90% of deionized water.By the cosmetic composition, the problems of excessive sebum secretion, keratosis follicularis, pore blockage, acne related bacterial infection and oil degradation resulting in inflammation are solved, and the efficacy of bacteriostasis, anti-inflammation and oil control is achieved.

The invention belongs to the technical field of extraction of Chinese herbal medicine, and particularly relates to a herba centellae extract with anti-inflammation and anti-sensitivity effects. The herba centellae extract is prepared by adopting the following preparation method: S1. adding ethanol into herba centellae powder for extraction, carrying out ultrasonic assisted extraction, then centrifuging or filtering, and collecting a filtrate; S2. adding activated carbon to the filtrate obtained in step 1 for decoloring, centrifuging, and collecting a decolored filtrate; S3. concentrating the decolored filtrated obtained in step 2, adding a chitosan liquid for decontamination, filtering, and collecting a decontaminated filtrate; S4. adding macroporous adsorption resin to the decontaminated filtrate for purification, and eluting with ethanol to obtain an eluent; S5. concentrating, desalting and drying the eluent obtained in step 4 to obtain the herba centellae extract, wherein in S1, the concentration of ethanol is 60-90%, the ultrasonic power is 228W-380W, and the material-to-liquid ratio is 1:20-80. The herba centellae extract provided by the invention has remarkable anti-inflammation and anti-sensitivity effects, is prominent in oxidation resistant and free radical removal effects, and can be widely applied to skin care products with anti-inflammation and anti-sensitivity effects.

The invention discloses nutrient gel for sterilizing and healing a wound surface and belongs to the technical field of anti-bacteria gel. The nutrient gel for sterilizing and healing the wound surface is prepared from hydroxyethyl cellulose, chitosan and derivatives thereof, guanidine polymers, glycerinum and compound amino acid. The hydroxyethyl cellulose serves as a gel substrate, the gel which is used for sterilizing and healing the wound surface and contains the guanidine polymers, the chitosan and derivatives thereof and the compound amino acid is prepared through a simple process, and the nutrient gel has good skin compliance, is non-irritant, has sterilization and anti-inflammation functions, provides a certain nutrition support for the wound surface, effectively promotes healing and recovery of the wound surface, has no side effects and is safe and environment-friendly.

The invention pertains to the field of daily chemical industry and discloses a Chinese herbal toothpaste made from bletilla striata. The Chinese herbal toothpaste made from bletilla striata contains a toothpaste matrix which comprises paeonol and bletilla striata or the bletilla striata polysaccharide. The toothpaste has the functions of antibiosis, anti-inflammation, promotion of wound healing, hemostasis and the like, therefore, the toothpaste can be applied to preventing and treating oral diseases and dental diseases such as ulcerative stomatitis, throat irritation, periodontitis, gingivitis, dental caries, oral malodor and the like, and provides a new toothpaste for health care of oral cavity.

The invention discloses an oxidation chitosan graft modified porcine dermal collagen micro-nano fiber membrane and a preparation method thereof. The oxidation chitosan graft modified porcine dermal collagen micro-nano fiber membrane is characterized in that the preparation method comprises the steps: by applying an electrostatic spinning technology and using traceable purified porcine dermis as a raw material and hexafluoroisopropanol as a solvent, stirring at 4-10 DEG C until the mixture is transparent, formulating to obtain electrostatic spinning mother liquor with concentration of 0.5-10%, and directly spinning to obtain the porcine dermal collagen micro-nano fiber membrane; then performing graft modification on the porcine dermal collagen micro-nano fiber membrane by using oxidation chitosan, thereby finally obtaining the oxidation chitosan graft modified porcine dermal collagen micro-nano fiber membrane. A membrane material not only has good bio-compatibility, biodegradability and mechanical properties, but also has anti-oxidation effects, antibacterial activities, anti-inflammation / wound healing promotion effects, anti-cancer / anti-tumor effects and antiviral effects of chitosan, is significantly better than a collagen composite membrane material prepared by using collagen as the raw material, and can be widely applied to the preparation of biomedical materials such as hemostatic materials, tissue engineering scaffold materials, biological dressings and the like.

The invention relates to the technical field of hyaluronic acid products, in particular to a hyaluronic acid mouth care film. The dry film contains the following components in percentages by weight: 10% to 50% of sodium hyaluronate, 10% to 40% of zinc hyaluronate and 10% to 40% of hydrolytic sodium hyaluronate. Hyaluronic acid and derivatives thereof are taken as film-forming materials of the mouth film, so that the mechanical property of the film is obviously improved, and the flexibility is strengthened; the hyaluronic acid and derivatives thereof are taken as main active ingredients of the mouth film and have various biological activities, and the hyaluronic acid has the effects of relieving release, promoting absorption and synergistically interacting for other added active ingredients; besides the biological activities of sodium hyaluronate, the zinc hyaluronate has higher anti-bacteria and anti-inflammation effects, and is more beneficial to mouth health, mouth disease prevention and treatment and throat nursing; the product disclosed by the invention is light in weight, small in size and convenient to carry and transport.

The invention belongs to the field of cosmetics and skin care products and discloses an acne-removing composition, a skin care product and a preparation method thereof. The acne-removing composition comprises mangosteen peel, thyme and fructus aurantii. Bacteriostatic experiments of propionibacterium acnes prove that the traditional Chinese medicine composition is good in inhibitory effect on the propionibacterium acnes, the three medicinal materials of the composition have a synergic anti-inflammation effect, and the composition is fast to become effective and good in effect. The acne-removing skin care product comprises the acne-removing composition, oldenlandia diffusa, salviae miltiorrhizae, honeysuckle stem, Chinese honey locust seed, tea tree essential oil and the like. The acne-removing skin care product does not contain ethanol and is safe and mild. Experiments prove that the skin care product is evident in acne treating effect, high in cure rate, natural and mild and capable of being used for a long time. The preparation method of the skin care product is simple to operate and suitable for large-scale production.

The invention provides an anastomat for gastrointestinal tract anastomosis surgery and a production method thereof. The anastomat comprises an anastomosis nail and a base and is divided into two types, namely a combined type and an independent type. The anastomat is composed of degradable materials and medical barium sulfate and can be finally disintegrated to be powder to be removed from the body after being used up. An envelope is formed on the outer surface of the anastomat through polyacrylic resin and contains medicines such as sulfonamides and quinolones antisepsis and anti-inflammation medicines and adrenobazonum, dicynone and other hemostasis medicines, and the envelope can selectively perform medicine slow release and controlled release according to different pH physiological environments of gastrointestinal tracts.

The invention discloses a method for synthesizing a novel tetracyclic diterpene compound from stevioside, which is cost-efficient and feasible. The compound is represented by a general formula (I), wherein the definitions of R1, R2, X, Y are shown in the specification. The invention discloses a potential application value of the compound in the aspects of anti-tumor and anti-inflammation and a detailed preparation method of the compound as well as physical data of Fourier transform infrared spectroscopy (FT-IR), hydrogen nuclear magnetic resonance spectroscopy (1 HNMR), mass spectrometry (MS) and the like.

The invention discloses compound plant essential oil with effects of repelling mosquitos, relieve itching and subsiding swellings. The compound plant essential oil comprises the following raw materials: artemisia vulgaris oil, lemon essential oil, eucalyptus citriodora oil, clove essential oil, camellia seed essential oil, catnip essential oil, thyme essential oil, geranium essential oil, rosemaryessential oil, castor oil, citronella oil, litsea oil, lavender essential oil, lithospermum essential oil, clary sage essential oil, mentha spicata essential oil, cypress essential oil, platycladus orientalis essential oil, calendula officinalis essential oil, cedarwood essential oil, juniper berry essential oil, wild chrysanthemum essential oil, leonurus japonicus essential oil, eucommia ulmoides essential oil, jasmine essential oil, eucalyptus essential oil, valeriana officinalis essential oil, rose essential oil, osmanthus fragrans essential oil and lemongrass oil. The compound plant essential oil has obvious mosquito repelling effect, high itching relieving and swelling subsiding speeds, remarkable improvement effects on eczema improving suppuration, herpes, pimples, swelling furuncleand itching skin as well as obvious anti-bacterial and anti-inflammation functions.

The invention discloses a skin care composition which comprises at least one component for promoting blood circulation to remove blood stasis, at least one antisepsis and anti-inflammation component, at least one skin conditioner and at least one muscle generation skin care agent according to the mass ratio of (0.1-50):(0.1-30):(0.1-80):(0.1-30), wherein the component for promoting blood circulation to remove blood stasis is one or a combination of several of ginger juice, snake oil, a radix angelicae extract, a nux vomica extract, a natural copper extract, a sangusis draconis extract, a caulis spatholobi extract, frankincense essential oil, myrrh essential oil, sesame oil, sheep suet, salviae miltiorrhizae, radix notoginseng, a red peony root extract, trogopterus dung, safflower oil, lithospermum essential oil, an angelica sinensis extract, puffball powder, plant soot, orange peel and lavender essential oil. The invention also provides a facial tissue with the skin care composition. The facial tissue can be carried by a user and is used for nursing and improving a chilblain affected part, and the skin improving effect at the affected part is obvious.