5110 results about "Solvent extraction" patented technology

The preferred exemplary embodiments in the present application provide formulations and methods for the delivery of drugs, particularly drugs of abuse, having an abuse-relevant drug substantially confined in the core and a non-abuse relevant drug in a non-core region. These formulations have reduced potential for abuse. In the formulation, preferably the abuse relevant drug is an opioid and the non-abuse relevant drug is acetaminophen or ibuprofen. More preferably, the opioid is hydrocodone, and the non-abuse relevant analgesic is acetaminophen. In certain preferred embodiments, the dosage forms are characterized by resistance to solvent extraction; tampering, crushing or grinding. Certain embodiments of the inventions provide dosage forms that provide an initial burst of release of drug followed by a prolonged period of controllable drug release.

The present invention relates to compositions for oral administration. The invention preferably comprises at least one abuse-resistant drug delivery composition for delivering a drug having potential for dose dumping in alcohol, related methods of preparing these dosage forms, and methods of treating a patient in need thereof comprising administering the inventive compositions to the patient. Most preferably, the dosage form includes verapamil. These formulations have reduced potential for abuse. In another formulation, preferably the abuse relevant drug is an opioid and the non-abuse relevant drug is acetaminophen or ibuprofen. More preferably, the opioid is hydrocodone, and the non-abuse relevant analgesic is acetaminophen. In certain preferred embodiments, the dosage forms are characterized by resistance to solvent extraction; tampering, crushing or grinding. Certain embodiments of the inventions provide dosage forms that provide an initial burst of release of drug followed by a prolonged period of controllable drug release.

Acrylic Modified Fluoropolymers based on vinylidene fluoride polymers are disclosed wherein the acrylic phase is capable of entering into crosslinking reactions. The final cured products provide superior solvent extractability resistance to the fluoropolymer phase.

The disclosure relates to a melt-blown non-woven fabric based on cellulose esters, with fibers of mean diameter less than about 10 microns. The fabric contains 0-10 wt. % extractable softener, has a reflection factor determined according to DIN 53 145 Part I (1992) of more than 60% and the cellulose ester has a degree of substitution DS of about 1.5-3.0. The softener is preferably water-extractable. A melt-blown non-woven fabric is produced with the cellulose ester as follows: a cellulose ester, cellulose acetate, with a DS of about 1.5-3.0, in particular 1.7-2.7, is mixed with softener in a weight ratio of about 2:1 to 1:4 and simultaneously heated and melted. The mixture of softener and cellulose ester has a melting index MFI (210 / 2.16) according to DIN 53 735 of about 400 to 5 g / 10 min., in particular 300 to 50 g / 10 min. The melt is worked in a melt-blown spinning device into a melt-blown non-woven fabric and the softener is then extracted with a softener solvent to leave a proportion of 0-10 wt. %. The melt-blown non-woven fabric is especially suitable as a filter material.

This invention discloses new krill oil compositions characterized by having high amounts of phospholipids, astaxanthin esters and / or omega-3 contents. The krill oils are obtained from krill meal using supercritical fluid extraction in a two stage process. Stage 1 removes the neutral lipid by extracting with neat supercritical CO2 or CO2 plus approximately 5% of a co-solvent. Stage 2 extracts the actual krill oils by using supercritical CO2 in combination with approximately 20% ethanol. The krill oil materials obtained are compared with commercially available krill oil and found to be more bioeffective in a number of areas such as anti-inflammation, anti-oxidant effects, improving insulin resistances and improving blood lipid profile.

Lignin polymers having distinctive properties, including a generally high molecular weight and generally homogeneous size distribution, as well as preservation of native reactive side groups, are isolated by solvent extraction of plant materials. Methods for isolation of lignin polymers, and for use of the isolated lignin polymers are disclosed. Compositions containing lignin isolated from plant materials, such as carbon fiber composites, resins, adhesive binders and coatings, polyurethane-based foams, rubbers and elastomers, plastics, films, paints, nutritional supplements, food and beverage additives are disclosed. Xylose and xylose derivatives, furfural, fermentable sugars, cellulose and hemi-cellulose products may be used directly or further processed. The lignin polymers and other plant-derived products disclosed herein may be produced in abundance at low cost, and may be used as substitutes for feedstocks originating from fossil fuel or petrochemical sources in the manufacture of various products.

The present invention belongs to the field of hollow material preparing technology, and is especially the preparation process of hollow ball of inorganic matter, metal, organic matter and composite structure with hollow polymer ball as template. The present invention prepares composite hollow ball through combining hollow polymer ball template with sol-gel, deposition reaction, oxidation-reduction process and through forced interface process or surface deposition process; and obtain hollow ball of inorganic matter, metal and organic matter through high temperature sintering or selective solvent extraction to eliminate template polymer. The control of hollow ball structure and size and the compounding of several kinds of matters may be realized through controlling reactant activity, material feeding mode, reactant concentration and circulating reaction process. The hollow ball has excellent dispersivity, high strength and size stability. The present invention also relates to the application of these hollow structure materials.

Solvent extraction is used to remove wax and contaminants from an iron-based Fischer-Tropsch catalyst in a natural circulation continuous-flow system. The wax-free catalyst is then subjected to controlled oxidation to convert the iron to its initial oxidized state, Fe2O3. Reactivation of the oxide catalyst precursor is carried out by addition of synthesis gas.

The present invention relates to compositions for oral administration. The invention preferably comprises at least one abuse-resistant drug delivery composition for delivering a drug having potential for dose dumping in alcohol, related methods of preparing these dosage forms, and methods of treating a patient in need thereof comprising administering the inventive compositions to the patient. Most preferably, the dosage form includes verapamil. These formulations have reduced potential for abuse. In another formulation, preferably the abuse relevant drug is an opioid and the non-abuse relevant drug is acetaminophen or ibuprofen. More preferably, the opioid is hydrocodone, and the non-abuse relevant analgesic is acetaminophen. In certain preferred embodiments, the dosage forms are characterized by resistance to solvent extraction; tampering, crushing or grinding. Certain embodiments of the inventions provide dosage forms that provide an initial burst of release of drug followed by a prolonged period of controllable drug release.

Lignin polymers having distinctive properties, including a generally high molecular weight and generally homogeneous size distribution, as well as preservation of native reactive side groups, are isolated by solvent extraction of plant materials. Methods for isolation of lignin polymers, and for use of the isolated lignin polymers are disclosed. Compositions containing lignin isolated from plant materials, such as carbon fiber composites, resins, adhesive binders and coatings, polyurethane-based foams, rubbers and elastomers, plastics, films, paints, nutritional supplements, food and beverage additives are disclosed. Xylose and xylose derivatives, furfural, fermentable sugars, cellulose and hemi-cellulose products may be used directly or further processed. The lignin polymers and other plant-derived products disclosed herein may be produced in abundance at low cost, and may be used as substitutes for feedstocks originating from fossil fuel or petrochemical sources in the manufacture of various products.

Disclosed is a process for the upgrading and demetallizing of heavy oils and bitumens. A crude heavy oil and / or bitumen feed is supplied to a solvent extraction process 104 wherein DAO and asphaltenes are separated. The DAO is supplied to an FCC unit 106 having a low conversion activity catalyst for the removal of metals contained therein. The demetallized distillate fraction is supplied to a hydrotreater 110 for upgrading and collected as a synthetic crude product stream. The asphaltene fraction can be supplied to a gasifier 108 for the recovery of power, steam and hydrogen, which can be supplied to the hydrotreater 110 or otherwise within the process or exported. An optional coker 234 can be used to convert excess asphaltenes and / or decant oil to naphtha, distillate and gas oil, which can be supplied to the hydrotreater 220.

The invention generally relates to purification of carbon nanomaterials, particularly fullerenes, by removal of PAHs and other hydrocarbon impurities. The inventive process involves extracting a sample containing carbon nanomaterials with a solvent in which the PAHs are substantially soluble but in which the carbon nanomaterials are not substantially soluble. The sample can be repeatedly or continuously extracted with one or more solvents to remove a greater amount of impurities. Preferred solvents include ethanol, diethyl ether, and acetone. The invention also provides a process for efficiently separating solvent extractable fullerenes from samples containing fullerenes and PAHs wherein the sample is extracted with a solvent in which both fullerenes and PAHs are substantially soluble and the sample extract then undergoes selective extraction to remove PAHs. Suitable solvents in which both fullerenes and PAHs are soluble include o-xylene, toluene, and o-dichlorobenzene. The purification process is capable of treating quantities of combustion soot in excess of one kilogram and can produce fullerenes or fullerenic soot of suitable purity for many applications.

Porous polymers having a plurality of openings or chambers that are highly convoluted, with each chamber being defined by multiple, thin, flat partitions are produced by a new gel enhanced phase separation technique. In a preferred embodiment, a second solvent is added to a polymer solution, the second solvent causing the solution to gel. The gel can then be shaped as needed. Subsequent solvent extraction leaves the porous polymeric body of defined shape. The porous polymers have utility as medical prostheses, the porosity permitting ingrowth of neighboring tissue. The present technique also enhances shape-making capability, for example, of bifurcated vascular grafts, which feature a common entrance region but two or more exit regions.

A process for extracting carotenoids from a carotenoid-containing starting material produced by microorganisms is described. Said starting material is admixed with edible solvent to effectuate the transfer of carotenoids. Separation of the carotenoid-enriched edible solvent is improved by the formation of a "cake", composed of said carotenoid-containing particulate solids, and, as required, a certain quantity of suitable filtration aid to modify the cake's consistency. Mechanical aids accelerate the separation of the carotenoid-enriched edible solvent. Said mixture may be hydrated to aid the removal of solids and gums from the carotenoid containing edible solvent. The carotenoid-enriched edible solvent is filtered though said cake to reduce the particulate load including any undesirable microbial load. A counter-current process increases the carotenoid concentration of the extract. The carotenoid-enriched edible solvent can be used as an ingredient in human and animal foodstuffs and dietary supplements for the possible prevention and treatment of illnesses and diseases.

A process for leaching laterite ores containing limonite and saprolite. Sufficient mineral acid is added to a slurry of limonite which is leached at atmospheric pressure to dissolve most of the soluble non-ferrous metals and soluble iron. After adding saprolite the slurry is further leached at a temperature above the normal boiling point and at a pressure above atmospheric pressure for a time sufficient to leach most of the contained nickel in the saprolite and to precipitate most of the iron in solution. The pressure of the slurry is then reduced, and nickel and / or cobalt is subsequently recovered from the leach solution by solvent extraction, resin-in-pulp or other ion exchange, sulfide or hydroxide precipitation, or other recovery method.

A process for producing levulinic acid and its esters from biomass is disclosed comprising: (i) feed preparation module characterized by subjecting biomass to a high-temperature refining treatment; (ii) hydrolysis reaction module that facilitates the hydrolysis of biomass to its respective sugars and their subsequent transformation to levulinic acid, formic acid, furfural, and char as well as facilitates the separation of lignin-based char by-product; (iii) product separation and recovery module utilizing a solvent extraction technique such as using furfural by-product as extracting solvent; and (iv) optionally, conversion of levulinic acid to levulinate ester. When desired, the disclosed process may be integrated into existing pulp mills.

A method for the extraction, separation, fractionation and purification of biopolymers from plant materials using supercritical and / or subcritical solvent extractions is disclosed. Specifically, the process can be used for the separation of resins and rubber from guayule shrub (Parthenium argentatum), and other rubber and / or resin containing plant materials, using supercritical solvent extraction, for example supercritical carbon dioxide extraction. Additionally, polar and / or non-polar co-solvents can be used with supercritical carbon dioxide to enhance the selective extraction of resins and rubbers from the shrub.

An acellular soft tissue-derived matrix includes a collagenous tissue that has been delipidated and decellularized. Adipose tissue is among the soft tissues suitable for manufacturing an acellular soft tissue-derived matrix. Exogenous tissuegenic cells and other biologically-active factors may be added to the acellular matrix. The acellular matrix may be provided as particles, a slurry, a paste, a gel, or in some other form. The acellular matrix may be provided as a three-dimensional scaffold that has been reconstituted from particles of the three-dimensional tissue. The three-dimensional scaffold may have the shape of an anatomical feature and serve as a template for tissue repair or replacement. A method of making an acellular soft tissue-derived matrix includes steps of removing lipid from the soft tissue by solvent extraction and chemical decellularization of the soft tissue.

The method for recycling and processing worn-out lithium ion battery includes steps: (1) taking out pack of worn-out battery; (2) using crushing facilities to open up case of battery, and segregation through magnetic method; (3) dissolving wastes of pole core of battery by using acid, and separating out most of cobalt through ammonium oxalate depositing method; (4) cobalt and copper deposited in residual liquid is extracted through solvent extraction method. Adding sodium carbonate generates deposition to retrieve lithium. Advantages are: simple technique, on solving pollution of worn-out batteries, and reclaining resources at same time.

A method for the extraction, separation, fractionation and purification of biopolymers from plant materials using supercritical and / or subcritical solvent extractions is disclosed. Specifically, the process can be used for the separation of resins and rubber from guayule shrub (Parthenium argentatum), and other rubber and / or resin containing plant materials, using supercritical solvent extraction, for example supercritical carbon dioxide extraction. Additionally, polar and / or non-polar co-solvents can be used with supercritical carbon dioxide to enhance the selective extraction of resins and rubbers from the shrub.

The invention provides a process method for separating and purifying rare earth elements by solvent extraction. The method takes a mixed rare earth sulfate solution obtained from a rare earth ore treated by sulphuric acid as a raw material, directly adopts a nonsaponifiable P507 extraction agent or a synergistic extraction agent containing the P507 to completely extract rare earth in a material liquid into an organic phase, and then takes the organic phase as a rare earth material liquid to extract, separate and purify the rare earth or directly backextract to produce mixed chlorinated rare earth or rare earth nitrate. The process method is simple and flexible, does not saponify the organic phase during the extraction and separation process, does not produce ammonia nitrogen waste water, is easy to backextract middle and heavy rare earths, and has less consumption of acid and base and low production cost.

Preparation method and application of polycaprolactone / natural polymer composite porous scaffold, method: including preparation of polycaprolactone electrospun nanofiber membrane; (1) placing polycaprolactone electrospun nanofiber membrane in alkaline solution reaction, soaking and rinsing in deionized water; (2) putting the fiber membrane obtained in (1) into DMTMM or natural polymer solution of DTMMM to react, immersing and rinsing in deionized water, and then immersing in natural polymer for room temperature reaction, to remove Ionized water soaking and rinsing; (3) Evenly coating and casting the mixed solution of natural polymer materials on the fiber membrane obtained in (2), freeze-drying, and extracting the solvent; (4) Applying the double-layer scaffold obtained in (3) After soaking in the cross-linking room temperature reaction, soaking in deionized water, rinsing, and freeze-drying. The porous scaffold prepared by the invention is stable, has suitable pore diameter, good biocompatibility and fast degradation rate, and can be used for skin and clinical tissue and organ defect repair, reconstruction or wound dressing.

The invention relates to a preparation method of a hollow-structure metal or ceramic part, which comprises the following steps: selecting metal or ceramic powder as the raw material, mixing, and granulating to obtain a feed material; selecting a core material; injecting the core material into a die by co-injection molding to obtain a core in hollow shape, and injecting the metal or ceramic feed material to be completely coated on the core, thereby obtaining a green body; and carrying out solvent extraction and heating on the green body to remove the adhesive and core, and sintering to obtain the hollow-structure product. The invention implements one-step molding of the hollow metal or ceramic part; from the raw material to the product, the production cycle is short, and the automation degree of equipment is high, thereby greatly enhancing the efficiency and forming a randomly complex and completely hollow die cavity; and thus, the invention can be used for preparing a completely hollow part with no joint, greatly lowers the cost of the product, and is especially suitable for preparing hollow metal and ceramic parts.

The invention discloses a preparation method of mesophase carbon microspheres from coal liquefaction residues serving as raw materials, which comprises the following steps of: firstly carrying out solvent extraction on the coal liquefaction residues, then carrying out a series of processing to obtain refined asphalt with different contents of quinoline insoluble substances, and carrying out thermal polycondensation reaction on the refined asphalt in the presence of a chemical auxiliary agent and a nucleating accelerator at the temperature of 380-450 DEG C, the pressure of 0-5 MPa and the stirring rotation speed of 40-500 r / min for 1-20 hours to obtain the mesophase microspheres. According to the invention, the chemical auxiliary agent and the nucleating accelerator can be added during theheat treatment process to improve the yield and narrow the particle size distribution of the mesophase carbon microbeads, and the mesophase carbon microspheres are prepared from the coal liquefactionresidues serving as the raw materials and have the advantages of low cost, simple preparation process, high yield (up to 35%), narrow particle size distribution, good sphericity, etc.

The invention relates to a method for recycling and purifying platinum and rhodium from the waste materials containing platinum and rhodium, belonging to the noble metal chemical extracting technical field. The invention adopts the ion exchange method to eliminate the base metal and combines the solvent extraction technique and the leaching resin separation technique to separate and purify the noble metals of platinum and rhodium. The method is to recycle and purify the secondary resources of noble metals. The method has simple technique, convenient operation, high separation efficiency and high direct recovery rate. The ion exchange resin, the extracting agent and the leaching resin used in the method can be regenerated and recycled by simple methods; the emission is zero, thereby protecting the environment and contributing to the environmental protection.

A method for the preparation of high strength air-dried organic aerogels. The method involves the sol-gel polymerization of organic gel precursors, such as resorcinol with formaldehyde (RF) in aqueous solvents with R / C ratios greater than about 1000 and R / F ratios less than about 1:2.1. Using a procedure analogous to the preparation of resorcinol-formaldehyde (RF) aerogeis, this approach generates wet gels that can be air dried at ambient temperatures and pressures. The method significantly reduces the time and / or energy required to produce a dried aerogel compared to conventional methods using either supercritical solvent extraction. The air dried gel exhibits typically less than 5% shrinkage.

The present invention relates to a crystalline carotenoid compound, such as β-carotene, with a purity of at least 95% and with substantially no solvent enclosed in the crystal lattice. The present invention further describes a process to prepare such a highly pure crystalline carotenoid compound from microbial biomass, without the use of a solvent extraction and / or an anti-solvent crystallization process.

The development and application of a novel non-polar oil recovery process utilizing a non-dispersive solvent extraction method to coalesce and recover oil from a bio-cellular aqueous slurry is described herein. The process could apply to recovery of algal oil from a lysed algae slurry, recovery of Omega fatty acids from a bio-cellular aqueous feed, recovery of Beta-carotene from a bio-cellular aqueous feed and for the removal from produced water in oil production and similar type applications. The technique of the present invention utilizes a microporous hollow fiber (MHF) membrane contactor. The novel non-polar oil recovery process described herein can be coupled to a collecting fluid (a non-polar solvent such as heptane, a biodiesel mixture or the previously extracted oil) that is circulated through the hollow fiber membrane. In cases where the biodiesel mixture or the previously extracted oil is used the solvent recovery step (e.g. distillation) can be eliminated.

The present invention is a filtering and chemical separation device that performs the operations of solvent extraction and pervaporation in a single piece of equipment, configured as a spiral-wound membrane module, and provides for the replenishment of the solvent in the supported liquid membrane while the module continues in operation. It provides a solution to the problem of separating miscible compounds efficiently and with low energy requirements.