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Chitosan/polyvinyl alcohol (PVA) porous composite material and preparation method thereof

A technology of porous composite materials and polyvinyl alcohol, which is applied in medical science, absorbent pads, bandages, etc., can solve the problems of poor antibacterial and anti-inflammatory effects, and achieve excellent antibacterial effects, simple preparation process, and good adhesion

Inactive Publication Date: 2011-06-29
WEIHAI SHICHUANGXIN MATERIAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, various hemostatic materials have been prepared by modified polyvinyl alcohol materials on the market, which have excellent hemostatic effect, but poor antibacterial and anti-inflammatory effects
At present, there are few reports on chitosan / polyvinyl alcohol composite materials.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Raw material composition and weight ratio: 5% chitosan, 30% polyvinyl alcohol, 3% acetic acid, 5% hydrochloric acid, 5% formaldehyde, 10% sodium bicarbonate, 0.5% nano silver, 1% polyethylene oxide, and the rest is distilled water.

[0027] Put chitosan into a container with acetic acid aqueous solution and mix it at a temperature of 20-50°C until it is completely dissolved; put polyvinyl alcohol into water at 20-50°C until it dissolves completely, and then pour it into a certain amount of water. Measure hydrochloric acid, heat up to 60-100°C, and dissolve it completely under the action of mechanical stirring; pour it into a container containing chitosan aqueous solution, stir evenly, heat up to 60-100°C, add formaldehyde, sodium bicarbonate , nano-silver particles, and polyoxyethylene were put into a container containing the above mixture, and continued to react at 60-100° C. for 15 hours under mechanical stirring, cooled to room temperature, washed three times with di...

Embodiment 2

[0029] Raw material composition and weight ratio: chitosan 1%, polyvinyl alcohol 25%, acetic acid 1%, hydrochloric acid 5%, glutaraldehyde 5%, ammonium bicarbonate 6%, nano silver oxide 1%, emulsified silicone oil 2% , and the rest is distilled water.

[0030] Put chitosan into a container with acetic acid aqueous solution and mix it at a temperature of 20-50°C until it is completely dissolved; put polyvinyl alcohol into water at 20-50°C until it dissolves completely, and then pour it into a certain amount of water. Measure hydrochloric acid, raise the temperature to 60-100°C, and dissolve it completely under the action of mechanical stirring; Ammonium hydrogen, nano-silver oxide particles, and emulsified silicone oil are placed in a container containing the above mixture, and the reaction is continued at 60-100°C for 10 hours under mechanical stirring, cooled to room temperature, washed with distilled water three times, and vacuum-dried, and the product is cut into Prepare t...

Embodiment 3

[0032] Raw material composition and weight ratio: 3% chitosan, 10% polyvinyl alcohol, 2% acetic acid. 10% sulfuric acid, 5% paraformaldehyde, 10% calcium carbonate, 2% silver sulfadiazine, 803% Tween, and the rest is distilled water.

[0033] Put chitosan into a container with acetic acid aqueous solution and mix it at a temperature of 20-50°C until it is completely dissolved; put polyvinyl alcohol into water at 20-50°C until it dissolves completely, and then pour it into a certain amount of water. Measure sulfuric acid, raise the temperature to 60-100°C, and dissolve it completely under the action of mechanical stirring; Put calcium, silver sulfadiazine particles, and Tween 80 into a container containing the above mixture, continue to react at 60-100°C for 6 hours under mechanical stirring, cool to room temperature, wash with distilled water three times, and dry in vacuum. Cut the product into the corresponding shape to prepare the required samples.

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Abstract

The invention relates to a chitosan / polyvinyl alcohol (PVA) porous composite material. The material is prepared from the following raw materials in percentage by weight: 1-5% of chitosan, 10-30% of PVA, 1-5% of acetic acid, 5-10% of inorganic acid, 5-10% of cross-linking agent, 6-10% of foaming agent, 0.5-2% of antibacterial agent, 1-5% of softening agent and the like. The preparation method of the material comprises the following steps: stirring for fully dissolving the PVA; pouring the dissolved PVA into the dissolved chitosan, adding the inorganic acid, the cross-linking agent, the foaming agent, the softening agent and the antibacterial agent to the obtained mixed solution, heating the solution to 90-100 DEG C, and pouring the solution into a die for continuously reacting at the temperature of 60-100 DEG C for 6-15 hours; and finally cooling and washing the obtained product with distilled water. The obtained material has the characteristics of good biocompatibility, excellent antibacterial effect, strong liquid absorption capability, biodegradability, good adhesion to skin and the like, and has functions of rapid hemostasis, antibiosis, anti-inflammation and acceleration of wound healing, thus the material is suitable for serving as various wound dressings.

Description

technical field [0001] The invention relates to a medical biological material, in particular to a chitosan / polyvinyl alcohol porous composite material with antibacterial and anti-inflammatory functions and a preparation method thereof. Background technique [0002] We know that chitosan has excellent properties such as good biocompatibility, antibacterial, hemostasis and promotion of wound healing, biodegradability and good adhesion to the skin. Chitosan has broad application prospects in wound dressings, hemostatic materials, tissue engineering scaffolds, and drug release. However, chitosan has poor mechanical properties. [0003] Polyvinyl alcohol is a water-soluble synthetic polymer with strong liquid absorption capacity and no leakage. At present, various hemostatic materials have been prepared from modified polyvinyl alcohol materials on the market, which have excellent hemostatic effects, but poor antibacterial and anti-inflammatory effects. At present, there are fe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L29/04C08L5/08C08K13/02C08J9/08C08J3/24A61L15/28A61L15/24A61L15/42A61L15/44
Inventor 万风云
Owner WEIHAI SHICHUANGXIN MATERIAL TECH
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