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Herba centellae extract with anti-inflammation and anti-sensitivity effects and application thereof

A Centella asiatica extract and efficacy technology, which is applied to medical preparations, anti-inflammatory agents, drug combinations and other directions containing active ingredients, can solve the problems of low content of active ingredients, cumbersome extraction steps, complicated extraction equipment, etc. Simple, short purification time, and the effect of reducing extraction time

Active Publication Date: 2017-01-11
GUANGDONG MARUBI BIOLOGICAL TECH CO LTD
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The Chinese patent with the publication number CN 101455693 discloses a method for extracting the total glucosides of Centella Asiatica from Centella asiatica by percolation technology. The extraction method does not further purify the crude extract, and the content of functional components is low; the publication number is The Chinese patent of CN101456894 discloses a method for preparing the total aglycone of Centella asiatica by hydrolyzing the total glycosides of Centella asiatica. The method needs a large amount of acid and alkali and the raw material for the preparation is asiaticoside; the Chinese publication number CN 103079573 The patent discloses a method for preparing a high-purity asiaticoside composition by using Centella asiatica. The method adopts fixed-bed countercurrent extraction technology to repeatedly extract asiaticoside, and obtains relatively high-purity asiaticoside through purification with reagents such as methanol and methyl isobutyl ketone. For high-purity asiaticoside, the extraction equipment is complex and the extraction steps are cumbersome

Method used

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  • Herba centellae extract with anti-inflammation and anti-sensitivity effects and application thereof
  • Herba centellae extract with anti-inflammation and anti-sensitivity effects and application thereof
  • Herba centellae extract with anti-inflammation and anti-sensitivity effects and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] A centella asiatica extract with anti-inflammatory and soothing effects is prepared according to the following steps:

[0053] (1) Raw material pretreatment: crush Centella asiatica through a 30-mesh sieve;

[0054] (2) Extraction: The sieved Centella asiatica powder was heated and extracted with 85% ethanol, the ratio of solid to liquid was 1:50 (w / v), the extraction temperature was 60°C, ultrasonic assisted extraction, ultrasonic power 320W, extracted twice , 80 min each time, combined the extraction filtrate, and the above extraction filtrate was suction filtered or centrifuged with a diatomaceous earth filter cake at a centrifugal speed of 4000 rpm for 8 min;

[0055] (3) Decolorization: Add 1.5% activated carbon by mass to the filtrate obtained in step (2), decolorize at 40°C for 25 minutes, and filter the decolorized filtrate through a diatomite filter cake or centrifuge at a centrifugal speed of 4000 rpm for 5 minutes;

[0056] (4) Concentration: Concentrate the...

Embodiment 2

[0063] A centella asiatica extract with anti-inflammatory and soothing effects is prepared according to the following steps:

[0064] (1) Raw material pretreatment: crush Centella asiatica through a 30-mesh sieve;

[0065] (2) Extraction: The sieved Centella asiatica powder was heated and extracted with 60% ethanol, the ratio of solid to liquid was 1:50 (w / v), the extraction temperature was 60°C, ultrasonic assisted extraction, ultrasonic power 320W, extracted twice , 80 min each time, combined the extraction filtrate, and the above extraction filtrate was suction filtered or centrifuged with a diatomaceous earth filter cake at a centrifugal speed of 4000 rpm for 8 min;

[0066] (3) Decolorization: Add 1.5% activated carbon by mass to the filtrate obtained in step (2), decolorize at 40°C for 25 minutes, and filter the decolorized filtrate through a diatomite filter cake or centrifuge at a centrifugal speed of 4000 rpm for 5 minutes;

[0067] (4) Concentration: Concentrate the...

Embodiment 3

[0091] Embodiment 3: A kind of skin care essence prepared by using the centella asiatica extract prepared in embodiment 1, made of the following raw materials in mass percentage:

[0092] (1) Natural extracts: the 1.5% centella asiatica extract of Example 1, the commercially available 1.5% purslane extract;

[0093] (2) Alcohols: 2% butanediol, 3% glycerin;

[0094] (3) Sugars: 0.2% xanthan gum, 0.1% sodium hyaluronate;

[0095] (4) High molecular polymer: 0.4% acrylic acid (ester) / C10-30 alkanol acrylate crosslinked polymer, 0.3% hydroxyethyl acrylate / sodium acryloyl dimethyl taurate copolymer;

[0096] (5) Grease: 3% isononyl isononanoate;

[0097] (6) Silicone oil: 2% cyclopentasiloxane;

[0098] (7) Other additives: 0.1% disodium ethylenediaminetetraacetic acid (EDTA-2Na), 0.2% aminomethylpropanol;

[0099] (8) Deionized water: the balance.

[0100] The preparation method of the skin care essence is as follows:

[0101] (1) Put hydroxyethyl acrylate / sodium acrylo...

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Abstract

The invention belongs to the technical field of extraction of Chinese herbal medicine, and particularly relates to a herba centellae extract with anti-inflammation and anti-sensitivity effects. The herba centellae extract is prepared by adopting the following preparation method: S1. adding ethanol into herba centellae powder for extraction, carrying out ultrasonic assisted extraction, then centrifuging or filtering, and collecting a filtrate; S2. adding activated carbon to the filtrate obtained in step 1 for decoloring, centrifuging, and collecting a decolored filtrate; S3. concentrating the decolored filtrated obtained in step 2, adding a chitosan liquid for decontamination, filtering, and collecting a decontaminated filtrate; S4. adding macroporous adsorption resin to the decontaminated filtrate for purification, and eluting with ethanol to obtain an eluent; S5. concentrating, desalting and drying the eluent obtained in step 4 to obtain the herba centellae extract, wherein in S1, the concentration of ethanol is 60-90%, the ultrasonic power is 228W-380W, and the material-to-liquid ratio is 1:20-80. The herba centellae extract provided by the invention has remarkable anti-inflammation and anti-sensitivity effects, is prominent in oxidation resistant and free radical removal effects, and can be widely applied to skin care products with anti-inflammation and anti-sensitivity effects.

Description

technical field [0001] The invention belongs to the technical field of extracting Chinese herbal medicines, and more specifically relates to a centella asiatica extract with anti-inflammatory and soothing effects and its application. Background technique [0002] Centella asiatica, also known as Lianmo grass, Calla hoofensis, Bengdawan, etc., is the dry or rooted whole plant of the Umbelliferae plant Centella asiatica. Centella asiatica is widely distributed in China, mainly in South China, East China, Central South and Southwest China. [0003] Centella asiatica has a long history of being used as medicine in my country. People have accumulated rich experience in the field of traditional Chinese medicine for a long time. Centella asiatica was first recorded in "Shen Nong's Materia Medica". It is cold in nature, non-toxic, and belongs to the liver, spleen, and kidney meridians. It has the functions of promoting blood circulation, reducing swelling and relieving pain, and has...

Claims

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Application Information

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IPC IPC(8): A61K8/9789A61K8/891A61K8/81A61K8/73A61K8/44A61K8/41A61K8/37A61K8/34A61Q19/08A61Q19/00A61P29/00A61P37/08
CPCA61K8/345A61K8/37A61K8/41A61K8/44A61K8/73A61K8/735A61K8/8152A61K8/8188A61K8/891A61K8/97A61K2800/82A61Q19/005A61Q19/08
Inventor 孙连立刘露裴运林聂艳峰
Owner GUANGDONG MARUBI BIOLOGICAL TECH CO LTD
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